scholarly journals Correlates of Adverse Outcomes in Abdominally Obese Individuals: Findings from the Five-Year Followup of the Population-Based Study of Health in Pomerania

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Nele Friedrich ◽  
Harald J. Schneider ◽  
Ulrich John ◽  
Marcus Dörr ◽  
Sebastian E. Baumeister ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Regression Models ◽  
Kidney Diseases ◽  
Premature Death ◽  
Population Based ◽  
Serum Glucose ◽  
Adverse Outcomes ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Increased Risk

Background. Abdominal obesity is a major risk factor of cardiovascular disease (CVD), type 2 diabetes (T2DM), and premature death. However, it has not been resolved which factors predispose for the development of these adverse obesity-related outcomes in otherwise healthy individuals with abdominal obesity.Methods. We studied 1,506 abdominal obese individuals (waist-to-height ratio (WHtR) ≥ 0.5) free of CVD or T2DM from the population-based Study of Health in Pomerania and assessed the incidence of CVD or T2DM after a five-year followup. Logistic regression models were adjusted for major cardiovascular risk factors and liver, kidney diseases, and sociodemographic status.Results. During follow-up time, we observed 114 and 136 new T2DM and CVD cases, respectively. Regression models identified age, waist circumference, serum glucose, and liver disease as predictors of T2DM. Regarding CVD, only age, unemployment, and a divorced or widowed marital status were significantly associated with incident CVD. In this subgroup of obese individuals blood pressure, serum glucose, or lipids did not influence incidence of T2DM or CVD.Conclusion. We identified various factors associated with an increased risk of incident T2DM and CVD among abdominally obese individuals. These findings may improve the detection of high-risk individuals and help to advance prevention strategies in abdominal obesity.

scholarly journals Dietary and lifestyle inflammatory scores are associated with increased risk of metabolic syndrome in Iranian adults

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Hossein Farhadnejad ◽  
Karim Parastouei ◽  
Hosein Rostami ◽  
Parvin Mirmiran ◽  
Fereidoun Azizi
Keyword(s):  
Metabolic Syndrome ◽  
Positive Association ◽  
Population Based ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Increased Risk ◽  
Confounding Variables ◽  
Adjusted Model ◽  
Diet And Lifestyle

Abstract Background In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population-based study. Methods A total of 1625 participants without MetS were recruited from among participants of the Tehran Lipid and Glucose Study(2006–2008) and followed a mean of 6.1 years. Dietary data of subjects were collected using a food frequency questionnaire at baseline to determine LIS and DIS. Multivariable logistic regression models, were used to calculate the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across tertiles of DIS and LIS. Results Mean ± SD age of individuals (45.8 % men) was 37.5 ± 13.4 years. Median (25–75 interquartile range) DIS and LIS for all participants was 0.80 (− 2.94, 3.64) and 0.48 (− 0.18, − 0.89), respectively. During the study follow-up, 291 (17.9 %) new cases of MetS were identified. Based on the age and sex-adjusted model, a positive association was found between LIS (OR = 7.56; 95% CI 5.10–11.22, P for trend < 0.001) and risk of MetS, however, the association of DIS and risk of MetS development was not statistically significant (OR = 1.30;95% CI 0.93–1.80, P for trend = 0.127). In the multivariable model, after adjustment for confounding variables, including age, sex, body mass index, physical activity, smoking, and energy intake, the risk of MetS is increased across tertiles of DIS (OR = 1.59; 95% CI 1.09–2.33, P for trend = 0.015) and LIS(OR = 8.38; 95% CI 5.51–12.7, P for trend < 0.001). Conclusions The findings of the current study showed that greater adherence to LIS and DIS, determined to indicate the inflammatory potential of diet and lifestyle, are associated with increased the risk of MetS.

Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population‐based study

2019 ◽  
Vol 46 (8) ◽  
pp. 695-701 ◽  
Author(s):  
Ju Hee Han ◽  
Ji Hyun Lee ◽  
Kyung Do Han ◽  
Ha‐Na Kim ◽  
Chul Hwan Bang ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Population Based ◽  
Population Based Study ◽  
Increased Risk

scholarly journals General and central obesity operate differently as predictors of falls requiring medical care in older women: a population-based cohort study in Spain

2020 ◽  
Author(s):  
Ygor Hermenegildo-López ◽  
Helena Sandoval-Insausti ◽  
Carolina Donat-Vargas ◽  
Jose Ramón Banegas ◽  
Fernando Rodríguez-Artalejo ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Medical Care ◽  
Older Women ◽  
Abdominal Obesity ◽  
Regression Models ◽  
Population Based ◽  
Normal Weight ◽  
General Obesity ◽  
Logistic Regression Models ◽  
Overweight Women

Abstract Objectives to examine the association of general and abdominal obesity with falls, falls requiring medical care and falls with fractures in older women. Design a population-based prospective cohort of 1,185 women aged ≥60 in Spain, followed up from 2008 to 2010 through 2012. Measures weight, height and waist circumference were measured at baseline using standardised techniques. Participants were classified according to body mass index as normal weight (&lt;25), overweight (25–29.9) and general obesity (≥30). Abdominal obesity was defined as waist circumference &gt;88 cm. In 2012, participants reported the falls experienced in the previous year. Logistic regression models were mutually adjusted for general and abdominal obesity and for main confounders. Results in this cohort of older women, a total of 336 women experienced falls, 168 of them had falls requiring medical care and 64 falls with fractures. For falls, no association was found with general obesity nor abdominal obesity. However, compared with normal weight, overweight women had a decreased risk for falls requiring medical care [odds ratio (OR) 0.57; 95% confidence interval (CI) 0.34–0.94] and for falls with fractures (OR 0.27; 95% CI 0.12–0.63). The corresponding values for general obesity were 0.44 (0.24–0.81) and 0.30 (0.11–0.82). Abdominal obesity was positively associated with falls requiring medical care (OR 1.82; 95% CI 1.12–2.94) and falls with fractures (OR 2.75; 95% CI 1.18–6.44). Conclusions in older women, general obesity may protect from falls requiring medical care and falls with fractures. On the contrary, abdominal obesity increased the risk of suffering from types of falls.

scholarly journals Prevalence and population structure of Staphylococcus aureus nasal carriage in healthcare workers in a general population. The Tromsø Staph and Skin Study

2012 ◽  
Vol 141 (1) ◽  
pp. 143-152 ◽  
Author(s):  
K. OLSEN ◽  
M. SANGVIK ◽  
G. S. SIMONSEN ◽  
J. U. E. SOLLID ◽  
A. SUNDSFJORD ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Logistic Regression ◽  
Population Structure ◽  
Regression Models ◽  
Healthcare Workers ◽  
Nasal Carriage ◽  
Population Based ◽  
Family Status ◽  
Logistic Regression Models ◽  
Increased Risk

SUMMARYHealthcare workers (HCWs) may be a reservoir for Staphylococcus aureus transmission to patients. We examined whether HCW status is associated with S. aureus nasal carriage and population structure (spa types) in 1302 women (334 HCWs) and 977 men (71 HCWs) aged 30–69 years participating in the population-based Tromsø Study in 2007–2008. Multivariable logistic regression models were used. While no methicillin-resistant S. aureus (MRSA) was isolated, overall, 26·2% of HCWs and 26·0% of non-HCWs were S. aureus nasal carriers. For women overall and women residing with children, the odds ratios for nasal carriage were 1·54 [95% confidence interval (CI) 1·09–2·19] and 1·86 (95% CI 1·14–3·04), respectively, in HCWs compared to non-HCWs. Moreover, HCWs vs. non-HCWs had a 2·17 and 3·16 times higher risk of spa types t012 and t015, respectively. This supports the view that HCWs have an increased risk of S. aureus nasal carriage depending on gender, family status and spa type.

scholarly journals 1402Thyroid stimulating hormone (TSH) is associated with general and abdominal obesity in girls during puberty

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Yingying Wang
Keyword(s):  
Logistic Regression ◽  
Abdominal Obesity ◽  
Regression Models ◽  
Population Based ◽  
Thyroid Stimulating Hormone ◽  
General Obesity ◽  
Logistic Regression Models ◽  
The Impact ◽  
Serum Tsh ◽  
Stimulating Hormone

Abstract Background Childhood is an important public health issue. Although both thyroid hormone and menarche are known to play a role in body metabolism and energy expenditure, no population-based study has been conducted to investigate the impact of TSH on adipogenesis among population-based girls around puberty. Methods A multi-stage cluster sampling method was used to select one junior middle school from each of 4 study areas: Minhang District in Shanghai, Haimen City in Jiangsu Province, Yuhuan City and Deqing County in Zhejiang Province. A total of 474 girls aged 11 to 14 years from 4 schools were enrolled. Information on demographic factors and puberty stage were collected, and anthropometric measurements and thyroid hormones were determined. Multivariate logistic regression models were used to assess the associations of Thyroid stimulating hormone (TSH) with the risk of obesity measured by body mess index (BMI) and waist circumference (WC). Results Of the 474 girls, the prevalences of BMI-based general obesity and WC-based abdominal obesity were 19.8% (94/474) and 21.7% (103/474), respectively. Compared with normal weight girls, the mean serum TSH concentration was significantly higher in BMI-based general overweight or obese girls (P = 0.037), but not in WC-based central overweight or obese girls (P = 0.173). In the multiple logistic regression models, for girls with highest tertile of serum TSH concentration relative to those in the lowest tertile, the odds ratios were 2.58 (95% CI 1.32 to 5.04) and 2.50 (95% CI 1.30 to 4.81) for overweight or obesity based on BMI and WC after adjustment for puberty stage and other covariates. Conclusions Serum TSH concentration was positively associated with both general and abdominal obesity in school-age girls and the association was independent of puberty. Key messages thyroid stimulating hormone; general obesity; central obesity; school-aged girls; puberty

scholarly journals Perinatal use and discontinuation of disease-modifying anti-rheumatic drugs and biologics in women with rheumatoid arthritis: a cohort study

Rheumatology ◽  
2019 ◽  
Vol 59 (7) ◽  
pp. 1514-1521
Author(s):  
Nevena Rebić ◽  
Eric C Sayre ◽  
Enav Z Zusman ◽  
Neda Amiri ◽  
Corisande Baldwin ◽  
...  
Keyword(s):  
Maternal Age ◽  
Regression Models ◽  
Birth Outcome ◽  
First Trimester ◽  
Population Based ◽  
Singleton Pregnancy ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Medication Discontinuation ◽  
Synthetic Dmards

Abstract Objectives To characterize the utilization and discontinuation of medications before, during and after pregnancy among women with RA. Methods We used population-based administrative data to identify women with RA who had a singleton pregnancy ending in delivery between 1 January 2002 and 31 December 2012. We assessed the utilization of RA medications, namely, conventional synthetic DMARDs, biologics, glucocorticosteroids and NSAIDs, across six windows spanning 24 and 12 months before the start of pregnancy, each trimester of pregnancy and 12 months post-pregnancy. We defined medication discontinuation as no prescription in a given window following a prescription in the preceding window and evaluated predictors using logistic regression models, calculating adjusted odds ratios (ORs) and 95% CIs. Results We studied 1730 pregnancies in 1301 women with RA (mean age at delivery 31.4 ± 5.4 years). We observed substantial medication discontinuation, particularly in the first trimester, with discontinuation of antimalarials in 57.3% of patients, azathioprine 59.1%, sulfasalazine 69.5% and biologics 50.8%. Factors inversely associated with discontinuation of antimalarials in the first trimester were maternal age [OR 0.90 (95% CI 0.86, 0.95)] and number of rheumatology visits [OR 0.86 (95% CI 0.75, 0.97)] and for biologics, prior adverse birth outcome [OR 0.22 (95% CI 0.05, 0.95)]. Conclusion Our population-based study shows frequent discontinuation of medications for RA, particularly in the first trimester. Findings indicate a need to educate women with RA who are planning pregnancy on the benefits and risks of medications during pregnancy.

scholarly journals A population based study of surgeon characteristics associated with the uptake of contemporary techniques in renal surgery

2013 ◽  
Vol 7 (9-10) ◽  
pp. 576 ◽  
Author(s):  
Stanley A Yap ◽  
Shabbir M.H. Alibhai ◽  
David Margel ◽  
Robert Abouassaly ◽  
Narhari Timilshina ◽  
...  
Keyword(s):  
Regression Models ◽  
Surgical Techniques ◽  
Population Based ◽  
Academic Status ◽  
Renal Surgery ◽  
Population Based Study ◽  
Logistic Regression Models ◽  
Ontario Cancer Registry ◽  
Renal Tumours ◽  
Underlying Mechanisms

Introduction: We have witnessed the slow uptake of many contemporary techniques in the surgical management of renal tumours. We sought to evaluate surgeon-level characteristics associated with the uptake of laparoscopy, partial nephrectomy (PN) and adrenal-sparing approaches in surgically managing these tumours.Methods: Using the Ontario Cancer Registry, we identified surgeons treating renal cell carcinoma (RCC) in the province of Ontario, Canada between 2002 and 2004. We then classified individuals within this cohort as either high or low utilizers of laparoscopy, PN or adrenal-sparing approaches. Further variables analyzed included academic status, surgeon graduation year and surgical volume status. We then used univariable and multivariable logistic regression models to assess predictors of uptake.Results: We evaluated a total of 108 surgeons for their uptake of both laparoscopy and adrenal-sparing approaches and 94 surgeonsfor their uptake of PN. We identified 32 surgeons (30%) as high users of laparoscopy. Predictors of uptake of laparoscopy included graduation year after 1990 (odds ratio [OR] 4.81, confidence interval [CI] 1.57-14.8) and high-surgeon volume (OR 4.33, CI1.60-10.4). We identified 41 surgeons (44%) as high users of PN. The only predictor of uptake of PN was academic status (OR 5.83,CI 1.96-17.3). We identified 69 surgeons (65%) as high users of adrenal-sparing approaches, but did not identify any significant predictors for uptake in this group.Discussion: We identify unique factors contributing to the uptake of distinct surgical techniques in the management of RCC. This information sheds lights on the underlying mechanisms and helps us understand how to further encourage the dissemination of these practices.

P1863KNOWLEDGE ABOUT CHRONIC KIDNEY DISEASE AND THE WAYS OF PREVENTION: A POPULATION-BASED STUDY IN NORTHEAST BRAZIL

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Geraldo Bezerra da Silva Junior ◽  
Michelle Jacintha Cavalcante Oliveira ◽  
Alyne Suellen Silva Pedrosa ◽  
Gabriel Araújo Pereira ◽  
Isis Holanda Pinheiro Vilela ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Diseases ◽  
Public Health Problem ◽  
Population Based ◽  
Healthcare Sector ◽  
Northeast Brazil ◽  
Population Based Study ◽  
Novel Technologies ◽  
Increased Risk

Abstract Background and Aims The incidence and prevalence of chronic kidney disease (CKD) is increasing worldwide, and health literacy is an important goal of any program of health care. The aim of this study is to investigate the knowledge of the population in Brazil about CKD and the ways of prevention, as well as the use of novel technologies to achieve knowledge and get awareness on CKD. Method This is a population-based study conducted in two large urban centers in Northeast Brazil (Fortaleza city, Ceara, and Maceio city, Alagoas). We have applied a questionnaire with questions regarding the knowledge about CKD, its preventive measures, causes, and ways of diagnose (for example, what is “creatinine”?). We have also investigated the use of novel technologies, focused on applications (apps) to achieve information related to health (if the interviewed) already uses to get health information through apps and if they would like to. Sociodemographic information was also collected. Exclusion criteria were: people from the healthcare sector (because they would already have specialized knowledge about CKD, and we aimed to know what the general population know about CKD), people with CKD, other kidney diseases or medical conditions that could lead to the knowledge about CKD. Results A total of 1,147 individuals were interviewed, with a mean age of 38.7±16.0 years, and 621 (54.1%) were female. Regarding the questions about the knowledge about CKD (“Do you know what is chronic kidney disease?”), 442 (38.5%) was found to answer yes. When asked if they know what is creatinine, only 176 (15.3%) said yes. In relation to the risk factors for CKD, 466 (40.6%) answered to know which factors were associated with increased risk for CKD, and 587 (51.1%) said to know how to prevent CKD. Another question was about the use of applications (app) to healthcare, and 358 individuals (31.2%) said to use some type of app to take care of their health. We have also questioned if the interviewed would use applications to get information regarding CKD, and 773 (67.3%) said yes, they would like to. Conclusion CKD is a Public Health problem in Brazil, with huge costs to the health system. Prevention is the key determinant to decrease the disease burden to everyone, people, society and healthcare players. Awareness of CKD seem to be slowly increasing in our country, once a significant percentage of interviewed said to know the ways of prevention, but it is still far from ideal. Technology seem to be an interesting solution to achieve our goals in terms of prevention and treatment of CKD.

scholarly journals Diabetes mellitus as a risk factor for compression neuropathy: a longitudinal cohort study from southern Sweden

2020 ◽  
Vol 8 (1) ◽  
pp. e001298 ◽  
Author(s):  
Mattias Rydberg ◽  
Malin Zimmerman ◽  
Anders Gottsäter ◽  
Peter M Nilsson ◽  
Olle Melander ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Plasma Glucose ◽  
Regression Models ◽  
Cox Regression ◽  
Binary Logistic Regression ◽  
Population Based ◽  
Logistic Regression Models ◽  
Increased Risk

IntroductionCompression neuropathies (CN) in the upper extremity, the most common being carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE), are frequent among patients with diabetes mellitus (DM). Earlier studies have shown contradicting results regarding DM as a risk factor for CN. Thus, the aim of the present population-based, longitudinal study was to explore potential associations between DM, CTS, and UNE during long-term follow-up.Research design and methodsA total of 30 466 participants aged 46–73 years, included in the population-based Malmö Diet and Cancer Study during 1991–1996, were followed up in Swedish national registries regarding incident CTS and UNE until 2016. Associations between prevalent DM at baseline and incident CTS or UNE were calculated using Cox proportional hazard models, adjusted for baseline confounders, such as sex, age at study entry, smoking, hypertension, use of antihypertensive treatment, alcohol consumption, and body mass index (BMI). HbA1c and fasting plasma glucose levels had been measured at baseline in a subgroup of 5508 participants and were related to incident CTS and UNE in age and sex-adjusted binary logistic regression models.ResultsA total of 1081 participants developed CTS and 223 participants developed UNE during a median follow-up of 21 years. Participants with incident CTS or UNE had higher prevalence of DM and higher BMI at baseline. Using multivariate Cox regression models, prevalent DM at baseline was independently associated with both incident CTS (HR 2.10; 95% CI 1.65 to 2.70, p<0.0001) and incident UNE (HR 2.20; 95% CI 1.30 to 3.74, p=0.003). Higher levels of HbA1c and plasma glucose were associated with an increased risk for CTS, but not for UNE.ConclusionThis study establishes DM as a major risk factor in the development of both CTS and UNE. Furthermore, a higher BMI is associated with both CTS and UNE. Finally, hyperglycemia seems to affect the median and ulnar nerves differently.

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