scholarly journals Peripheral Interleukin-1β Levels are Elevated in Chronic Tension-Type Headache Patients

2013 ◽  
Vol 18 (6) ◽  
pp. 301-306 ◽  
Author(s):  
Chris Della Vedova ◽  
Stuart Cathcart ◽  
Alan Dohnalek ◽  
Vanessa Lee ◽  
Mark R Hutchinson ◽  
...  
Keyword(s):  
Empirical Studies ◽  
Tension Type Headache ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genetic Changes ◽  
Chronic Tension Type Headache ◽  
Immune Mediators ◽  
Cytokine Levels ◽  
Healthy Control ◽  
Type Headache

BACKGROUND: Tension-type headache is the most common form of headache and its chronic form, chronic tension-type headache (CTTH), is one of the most difficult to treat. The etiology of CTTH is not well understood, but is believed to be multifactorial and to vary among individuals. In the present study, the authors sought to identify common mechanisms of CTTH pathology. Empirical studies have implicated various immunomodulatory cytokines as mediators of chronic pain disorders, including CTTH.OBJECTIVES: To determine the role of peripheral cytokines and genetic factors in the development of CTTH.METHODS: A panel of cytokines hypothesized to play a role in the pathogenesis of CTTH was measured using cytometric bead arrays and ELISAs in 56 individuals with CTTH and 42 healthy control participants between 18 and 65 years of age.RESULTS: Levels of interleukin (IL)-1β were significantly elevated in participants diagnosed with CTTH relative to healthy controls, while IL-18 levels were found to be significantly elevated in men with CTTH. Because the levels of these immune mediators were increased in the apparent absence of injury or infection, the authors sought to determine whether genetic changes were responsible for fluctuations in cytokine levels. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to determine individual genotypes at key single nucleotide polymorphism positions in theIL-1Bgene. No association was observed between CTTH and single nucleotide polymorphisms in the IL-1β gene.CONCLUSIONS: These findings suggest that increases in key proinflammatory cytokine levels are associated with CTTH and the pathology of the disorder involves sterile neurovascular inflammation.

Exteroceptive Suppression of Temporalis Muscle Activity: Findings in Headache

Cephalalgia ◽  
1993 ◽  
Vol 13 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Thomas-Martin Wallasch ◽  
Hartmut Göbel
Keyword(s):  
Muscle Activity ◽  
Silent Period ◽  
Tension Type Headache ◽  
Temporalis Muscle ◽  
Pharmacological Agents ◽  
Chronic Tension Type Headache ◽  
Exteroceptive Suppression ◽  
Headache Diagnosis ◽  
Secondary Phenomenon ◽  
Type Headache

Exteroceptive suppression of temporalis muscle activity was proposed by Schoenen and co-workers in 1987 as a tool in headache diagnosis and research. Their finding of a decreased or abolished second silent period (ES2) in chronic tension-type headache sufferers has been confirmed by several independent laboratories during the last five years. Temporalis silent periods have also been studied in various other types of headaches. Their modulation by neuropsychological factors and pharmacological agents has also been investigated as well as their retest reliability. The pathophysiological concept of muscle contraction in tension-type headache has been challenged by studies using temporalis silent periods. The exterocepfive suppression of temporalis muscle activity points unequivocally towards a central pathogenetic mechanism, although it remains unclear whether the abnormalities of temporalis ES2 represent the primary dysfunction or a secondary phenomenon in chronic tension-type headache.

The Local and Referred Pain From Myofascial Trigger Points in the Temporalis Muscle Contributes to Pain Profile in Chronic Tension-type Headache

2007 ◽  
Vol 23 (9) ◽  
pp. 786-792 ◽  
Author(s):  
César Fernández-de-las-Peñas ◽  
Hong-You Ge ◽  
Lars Arendt-Nielsen ◽  
Maria Luz Cuadrado ◽  
Juan A. Pareja
Keyword(s):  
Trigger Points ◽  
Tension Type Headache ◽  
Referred Pain ◽  
Temporalis Muscle ◽  
Myofascial Trigger Points ◽  
Chronic Tension Type Headache ◽  
Type Headache

scholarly journals Variables associated with sleep quality in chronic tension-type headache: A cross-sectional and longitudinal design

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197381 ◽  
Author(s):  
Elena Benito-González ◽  
Maria Palacios-Ceña ◽  
Juan J. Fernández-Muñoz ◽  
Matteo Castaldo ◽  
Kelun Wang ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Longitudinal Design ◽  
Tension Type Headache ◽  
Cross Sectional ◽  
Chronic Tension Type Headache ◽  
Type Headache

Chronic Tension-Type Headache in Children and Adolescents

Cephalalgia ◽  
2001 ◽  
Vol 21 (8) ◽  
pp. 830-836 ◽  
Author(s):  
Ishaq Abu-Arafeh
Keyword(s):  
Children And Adolescents ◽  
Clinical Features ◽  
Chronic Daily Headache ◽  
Adult Population ◽  
Tension Type Headache ◽  
Stressful Events ◽  
Chronic Tension Type Headache ◽  
Daily Headache ◽  
Ihs Criteria ◽  
Type Headache

In this study, the causes, predisposing factors and clinical features of chronic daily headache in children and adolescents were studied within the population of patients attending a specialist headache. The International Headache Society's (IHS) criteria for the diagnosis of chronic tension type headache (CTTH) were assessed for their applicability in the paediatric age group. Over a period of three years, demographic and clinical data were collected prospectively on all children who attended the clinic and suffered from daily attacks of headache. One hundred and fifteen children and adolescents (32% of all clinic population) had chronic daily headache, of whom 93 patients (81%) fulfilled the IHS criteria for the diagnosis of CTTH. They were between 3-15 years of age (mean: 11.1, SD: 2.3) and their female to male ratio was 1.2: 1. Around one third of the patients also suffered from migraine (mainly migraine without aura). The headache was described as mild in 60.9%, moderate 36.5% and severe 2.6%. Headache was located at the forehead in 53% or over the whole of the head in 29.6%. Pain was described as ‘just sore’ or dull by 73.9%. During attacks of headache, at least half the patients reported light intolerance, noise intolerance, anorexia or nausea. Thirty-two percent of patients had at least one underlying chronic disease that may have contributed to the pathogenesis of the CTTH. Eleven percent had serious stressful events related to family illnesses and in four patients headaches were triggered by family bereavement. Fourteen percent were investigated with neuroimaging and 22% were referred for clinical psychology assessment and management. In conclusion, CTTH is a common cause of headache in children attending a specialist headache clinic. The clinical features closely match those of adult population and the IHS criteria for the diagnosis of CTTH can be adapted for use in children. Predisposing stressful risk factors, physical or emotional, are present in a large proportion.

Chronic Tension-Type Headache

CNS Drugs ◽  
1995 ◽  
Vol 4 (2) ◽  
pp. 90-98 ◽  
Author(s):  
Alessandro S. Zagami
Keyword(s):  
Tension Type Headache ◽  
Chronic Tension Type Headache ◽  
Type Headache

Psychophysical testing in chronic migraine and chronic tension type headache: An observational study

Cephalalgia ◽  
2021 ◽  
pp. 033310242110603
Author(s):  
Ignacio Elizagaray-García ◽  
Gabriela F Carvalho ◽  
Tibor M Szikszay ◽  
Waclaw M Adamczyk ◽  
Gonzalo Navarro-Fernández ◽  
...  
Keyword(s):  
Chronic Migraine ◽  
Tension Type Headache ◽  
Headache Frequency ◽  
Chronic Tension Type Headache ◽  
Psychophysical Testing ◽  
Pressure Pain Thresholds ◽  
Type Headache ◽  
Neck Disability ◽  
Painful Area

Background Clinical presentation is the key to the diagnosis of patients with migraine and tension-type headache, but features may overlap when both become chronic. Psychophysical parameters may distinguish both conditions. We aimed to compare psychophysical aspects of patients with chronic migraine, chronic tension-type headache and headache-free controls, and to determine whether these can predict headache frequency. Methods An examiner blinded to the diagnosis assessed 100 participants (chronic migraine (n = 38), chronic tension-type headache (n = 31) and controls (n = 31)). Assessed variables included painful area, pressure pain thresholds, temporal summation, cervical range of motion, neck posture, headache and neck impact, quality of life, and kinesiophobia. Comparison between groups was performed with one-way ANOVA and multiple linear regression was used to assess the headache frequency predictors. Results We found differences of both headache groups compared to controls ( p < 0.01), but not between headache groups. Neck disability was a significant predictor of headache frequency for chronic tension-type headache (adjusted R2 = 0.14; β = 0.43; p = 0.03) and chronic migraine (adjusted R2 = 0.18; β = 0.51; p < 0.01). Conclusions Chronic tension-type headache and chronic migraine showed similar psychophysical results, but were significantly worse when compared to controls. The psychophysical examination did not discriminate between headache types. The variable best explaining headache frequency for both headache types was neck disability.

Assessment of Pain Modulatory and Somatosensory Profiles in Chronic Tension-Type Headache Patients

Pain Medicine ◽  
2021 ◽  
Author(s):  
Fernando G Exposto ◽  
Karina H Bendixen ◽  
Malin Ernberg ◽  
Flemming W Bach ◽  
Peter Svensson
Keyword(s):  
Pain Catastrophizing ◽  
Tension Type Headache ◽  
Pain Modulation ◽  
Normative Values ◽  
Healthy Controls ◽  
Single Session ◽  
Chronic Tension Type Headache ◽  
Type Headache ◽  
Underlying Pathophysiology

Abstract Objective The aim of this study was to thoroughly phenotype a group of chronic tension-type headache (CTTH) patients. Methods Fifteen CTTH patients diagnosed according to the International Classification of Headache Disorders–3 and 15 healthy controls were included in this study. Furthermore, 70 healthy controls were included to establish normative values. Quantitative sensory testing (QST), including temporal summation of pain (TSP), conditioned pain modulation (CPM), and psychological and sleep variables, was assessed in a single session. TSP and CPM were then combined to build pain modulation profiles (PMP) for each individual. Results No difference was found between groups for PMP, TSP, and CPM. However, 10 CTTH patients showed a pronociceptive PMP, with 8 related to a deficient CPM and 2 to both a deficient CPM and increased TSP. Increased cold detection thresholds were the most common sensory disturbance found in CTTH patients. Significant differences were seen between groups for pain catastrophizing, depression, and sleep quality although not all patient’s scores were above the clinically meaningful cutoffs. Conclusions In summary, CTTH patients presented with different PMP. These PMP may be related to increased TSP, deficient CPM, alterations in thermal detection that may be related to autonomic dysregulation, or a combination of all three. Overall, this suggests that due to their heterogeneous pathophysiology, CTTH patients should be managed according to their underlying pathophysiology and not with a one-size-fits-all approach.

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