scholarly journals Urinary Catheterization May Not Adversely Impact Quality of Life in Multiple Sclerosis Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rebecca James ◽  
Heidi E. Frasure ◽  
Sangeeta T. Mahajan
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Negative Impact ◽  
Positive Impact ◽  
Foley Catheter ◽  
Urinary Catheterization ◽  
Urine Leakage ◽  
Multiple Sclerosis Patients ◽  
The Impact

Background. Multiple sclerosis (MS) healthcare providers (HCP) have undergone considerable educational efforts regarding the importance of evaluating and treating pelvic floor disorders, specifically, urinary dysfunction. However, limited data are available to determine the impact of catheterization on patient quality of life (QoL). Objectives. To describe the use of urinary catheterization among MS patients and determine the differences between those who report positive versus negative impact of this treatment on QoL. Methods. Patients were queried as part of the 2010 North American Research Committee On Multiple Sclerosis survey; topics included 1) urinary/bladder, bowel, or sexual problems; 2) current urine leakage; 3) current catheter use; 4) catheterizing and QoL. Results. Respondents with current urine leakage were 5143 (54.7%), of which 1201 reported current catheter use (12.8%). The types of catheters (intermittent self-catheterization and Foley catheter (indwelling and suprapubic)) did not differ significantly. Of the current catheter users, 304 (25.35%) respondents reported catheterization negatively impacting QoL, 629 (52.4%) reported a positive impact on QoL, and 223 (18.6%) reported neutral QoL. Conclusions. A large proportion of catheterized MS patients report negative or positive changes in QoL associated with urinary catheterization. Urinary catheterization does not appear to have a universally negative impact on patient QoL.

scholarly journals Positive impact of cladribine on quality of life in people with relapsing multiple sclerosis

2017 ◽  
Vol 24 (11) ◽  
pp. 1461-1468 ◽  
Author(s):  
Dayo Afolabi ◽  
Christo Albor ◽  
Lukasz Zalewski ◽  
Dan R Altmann ◽  
David Baker ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Positive Impact ◽  
Rank Correlation ◽  
Phase Iii ◽  
European Medicines Agency ◽  
Total N ◽  
The Impact ◽  
Relapsing Multiple Sclerosis

Background: A number of elements of the pivotal ‘cladribine tablets treating multiple sclerosis orally’ (CLARITY) trial have remained unpublished. Objective: To report the impact of cladribine on health-related quality of life (QoL) in people with relapsing multiple sclerosis (pwRMS). Methods: QoL data from the phase III trial of two different doses (3.5 and 5.25 mg/kg) of oral cladribine in pwRMS were acquired from the European Medicines Agency through Freedom of Information. Spearman’s rank correlation was used to analyse the relationship between baseline QoL scores and baseline Expanded Disability Status Scale (EDSS) scores. Responses of the Euro Quality of Life 5 Dimensions (EQ-5D) and Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaires were compared between treatment and control groups using univariate analyses of covariance. Results: In total, n = 5148 EQ-5D responses and n = 894 MSQOL-54 physical, mental health and dimension scores were extracted. Baseline EQ-5D indices correlated with EDSS scores. After 2 years, pwRMS taking 3.5 ( p = .001) and 5.25 mg/kg ( p = .022) reported significantly improved EQ-5D index scores compared with placebo. Positive, yet non-significant, differences were detected in MSQOL-54 scores between cladribine and placebo. Conclusion: Analysis of the CLARITY dataset suggests that, over and above its established clinical efficacy, cladribine leads to improved QoL over 96 weeks. ClinicalTrials.gov identifier: NCT00213135.

Impact of the Nature of Employment on the Quality of Working Life

2021 ◽  
pp. 170-188
Author(s):  
Vyacheslav Yu. Babyshev ◽  
◽  
Galina A. Barysheva ◽  
Thi Bich Ngoc Tran ◽  
Dao Thanh Binh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Positive Impact ◽  
Working Life ◽  
General Level ◽  
Quality Of Working Life ◽  
Part Time ◽  
The Impact ◽  
Positive Effect

Technological and demographic changes have actualized the question of the influence of the nature of employment and the parameters of the workplace on the quality of a person’s working life. A scientific review and analysis of the impact of current trends in employment modes on the quality of human life is presented. Based on the literature review, it has been concluded that if there is unanimity among scientists about the positive impact of the regime of protected and standard employment on the quality of life, there is active debate about the impact of the regime of vulnerable and precarious employment. Also, based on the analysis of the literature, it has been determined that people’s subjective satisfaction does not always coincide with a positive impact on the objective quality of life. The study is based on comparative and correlation analysis as a method for processing statistical data from the OECD, ILO and WB. The employment regimes were classified according to four enlarged groups: economic sectors, professions, status, and employment regime. The assessments of the quality of life were classified according to three indicators: the human development index, the quality of life index and the international happiness index. The most important factors in the development of the labor market, influencing the quality of working life, have been identified: parameters of the quality of the workplace (the level of wages, employment stability, qualifications of workers, the level of social and legal guarantees) and the general level of employment. The most reasoned point of view was revealed: the regime of standard protected employment (permanent full-time work under a formal contract) has a positive effect, and the regime of precarious work (various options for informal, temporary or part-time employment) has a negative impact on the quality of life. The protected employment regime (hired labor and selfemployment as an entrepreneur) has a positive effect, while the vulnerable employment regime (individual self-employment and intra-family employment) has a negative impact on the quality of life. The transition to a “new” economy and highly skilled jobs has a significant impact on the quality of working life. The opinion of experts about non-standard forms of employment as a single category is refuted. The positive influence of the mode of part-time employment on the quality of life is revealed, the contradictory influence of the mode of temporary employment on the quality of life is shown. Achievement of material well-being and sociopolitical stability to a large extent contradicts the subjective happiness of people and the protection of the environment.

scholarly journals The impact of disease characteristics on multiple sclerosis patients’ quality of life

2017 ◽  
Vol 39 ◽  
pp. e2017008 ◽  
Author(s):  
Aziz Rezapour ◽  
Abdollah Almasian Kia ◽  
Sahar Goodarzi ◽  
Mojtaba Hasoumi ◽  
Soraya Nouraei Motlagh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Disease Characteristics ◽  
Multiple Sclerosis Patients ◽  
The Impact

scholarly journals Psychological well-being in people with multiple sclerosis: a descriptive review of the effects obtained with mindfulness interventions

2021 ◽  
Author(s):  
Di Cara Marcella ◽  
Grezzo Denise ◽  
Palmeri Rosanna ◽  
Lo Buono Viviana ◽  
Cartella Emanuele ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Psychological Symptoms ◽  
Positive Impact ◽  
Well Being ◽  
Psychological Well Being ◽  
Pubmed Database ◽  
Mindfulness Interventions ◽  
The Impact

Abstract Multiple sclerosis is a neuroinflammatory and neurodegenerative disease causing several psychosocial problems that significantly impairs quality of life. The most common physical and mental symptoms are anxiety, depression, stress, fatigue, and pain. Several studies investigated the effectiveness of non-pharmacological approaches in improving psychological well-being. This review focused on the impact of mindfulness interventions in patients with multiple sclerosis to reduce psychopathological symptoms and improve well-being. We searched on PubMed database and screening references of included studies and review articles for additional citations. From initial 107 studies, only 8 met search criteria. Our studies showed the efficacy of mindfulness treatment with a reduction in depressive symptoms, a better quality of life (both mental and physical), and a decreased level of fatigue. Findings demonstrated that mindfulness is useful for the improvement of psychological symptoms and pain management and this improvement has also been shown to have a positive impact on the quality of life and coping and adaptation strategies. However, according to the poor available clinics evidence, on cannot conclude that mindfulness interventions are superior to other active interventions in the treatment of psychological symptoms of SM.

Research interrupted: The impact of the COVID-19 pandemic on multiple sclerosis research in the field of rehabilitation and quality of life

2021 ◽  
Vol 7 (3) ◽  
pp. 205521732110380
Author(s):  
Rebecca Maguire ◽  
Sinead Hynes ◽  
Barbara Seebacher ◽  
Valerie J Block ◽  
Kathy M Zackowski ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Negative Impact ◽  
Rank Test ◽  
Signed Rank ◽  
Competing Demands ◽  
Signed Rank Test ◽  
The Impact ◽  
Future Landscape

Background The COVID-19 pandemic has likely had a negative impact on rehabilitation and quality of life (QoL) research in multiple sclerosis (MS). Method We explored perceived barriers to research among 87 researchers, representing 18 countries, both prior to and since COVID-19. Results A Wilcoxon signed-rank test found that significantly more researchers reported experiencing barriers to research since the onset of the pandemic compared to pre-COVID-19 (p < .001), with 78% of respondents reporting at least some barriers since COVID-19. The most commonly-cited barriers related to participant access (n = 38) and interruptions/delays to projects (n = 19). Although no gender differences were found in the number of barriers reported, female respondents were more likely to cite time or competing demands as barriers to research. Females were also more likely to perceive being negatively impacted by the pandemic compared to other genders (p = .007). Conclusions Implications for the future landscape of rehabilitation research in MS are discussed.

Type I interferons and the quality of life of multiple sclerosis patients. Results from a clinical trial on interferon alfa-2a

1999 ◽  
Vol 5 (5) ◽  
pp. 317-322 ◽  
Author(s):  
M W Nortvedt ◽  
T Riise ◽  
K M Myhr ◽  
H I Nyland ◽  
B R Hanestad
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Adverse Events ◽  
Interferon Alfa ◽  
Type I Interferons ◽  
Type I ◽  
Recombinant Interferon ◽  
Multiple Sclerosis Patients ◽  
The Impact

The objective of the study was to examine whether the beneficial effect of treatment of interferon alfa-2a on multiple sclerosis seen by magnetic resonance imaging is reflected in a corresponding improvement in the quality of life (QoL) and to address the impact of adverse events related to this treatment on the QoL. The study was a randomised double-blinded placebo-controlled treatment trial including 97 relapsing-remitting multiple sclerosis patients. Thirty-two patients received 4.5 MIU recombinant interferon alfa-2a, 32 patients received 9.0 MIU recombinant interferon alfa- 2a and 33 patients received placebo treatment for 6 months. All patients were followed up 6 months after end of treatment. QoL was assessed according to the eight scales of the SF-36 Health Survey and measured at baseline, month 3, 6 and 12. The effect found on MRI was not reflected in a corresponding change in the QoL. We found a relationship between the presence of new enhancing lesions and reduced QoL among the placebo patients, whereas this was not found among the patients treated with interferon. The presence of the adverse events fatigue, myalgia, headache and weakness were significantly negatively correlated to several of the QoL dimensions. Conclusively, the treatment with interferon alfa- 2a does not seem to improve the patients' QoL after 6 months of treatment, in spite of a marked effect measured by MRI. The treatment is followed by adverse events that negatively affected the QoL.

The Impact of Psychopedagogical Intervention on Quality of Life in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) Treated with Psychostimulant Medication

2017 ◽  
Vol 41 (S1) ◽  
pp. S215-S215
Author(s):  
C. Lima ◽  
D. Rodrigues ◽  
M. Silva ◽  
S. Rego
Keyword(s):  
Quality Of Life ◽  
Family Dynamics ◽  
Negative Impact ◽  
Positive Impact ◽  
Structured Interview ◽  
Qualitative Assessment ◽  
School Work ◽  
The Family ◽  
The Impact

Several studies have shown that ADHD has a significant negative impact on multiple domains of quality of life of children and adolescents, particularly in terms of behavioral, emotional and psychosocial quality of life. The psychopedagogical intervention can be therapeutic, preventive and promote educational inclusion. Moreover, it aims to address the learning process, how it is developed and how the individual relates himself to learning, both in the cognitive, social and emotional domains. Our purpose was to understand whether the psychopedagogical intervention influences the quality of life of adolescents with ADHD considering their pharmacological plans. The aim of this study was to evaluate the impact of a psychopedagogical intervention on quality of life of a sample of adolescents with ADHD taking into account their pharmacological plans (rubifen, ritalin, and concerta). We used quantitative and qualitative assessment measures: the KIDSCREEN-10, to measure the quality of life of these adolescents, and a semi-structured interview to assess the impact of a psychopedagogical intervention in the lives of these adolescents and their parents, respectively. The results showed that psychopedagogical intervention has a positive impact on the quality of life of adolescents with ADHD, as well as in the family dynamics. Due to the demands of school work (homework) and their negative impact on the family dynamics and consequently in the quality of life, the results corroborate the relevance of a psychopedagogical intervention to improve these areas. Thus, it appears that this type of intervention is very useful for adolescents with ADHD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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