scholarly journals Anticancer Drug-Incorporated Layered Double Hydroxide Nanohybrids and Their Enhanced Anticancer Therapeutic Efficacy in Combination Cancer Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Tae-Hyun Kim ◽  
Gyeong Jin Lee ◽  
Joo-Hee Kang ◽  
Hyoung-Jun Kim ◽  
Tae-il Kim ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Cancer Treatment ◽  
Layered Double Hydroxide ◽  
Anticancer Drugs ◽  
Therapeutic Efficacy ◽  
Reconstruction Method ◽  
Dependent Manner ◽  
Cellular Delivery ◽  
Potential Measurement ◽  
Double Hydroxide

Objective. Layered double hydroxide (LDH) nanoparticles have been studied as cellular delivery carriers for anionic anticancer agents. As MTX and 5-FU are clinically utilized anticancer drugs in combination therapy, we aimed to enhance the therapeutic performance with the help of LDH nanoparticles.Method. Anticancer drugs, MTX and 5-FU, and their combination, were incorporated into LDH by reconstruction method. Simply, LDHs were thermally pretreated at 400°C, and then reacted with drug solution to simultaneously form drug-incorporated LDH. Thus prepared MTX/LDH (ML), 5-FU/LDH (FL), and (MTX + 5-FU)/LDH (MFL) nanohybrids were characterized by X-ray diffractometer, scanning electron microscopy, infrared spectroscopy, thermal analysis, zeta potential measurement, dynamic light scattering, and so forth. The nanohybrids were administrated to the human cervical adenocarcinoma, HeLa cells, in concentration-dependent manner, comparing with drug itself to verify the enhanced therapeutic efficacy.Conclusion. All the nanohybrids successfully accommodated intended drug molecules in their house-of-card-like structures during reconstruction reaction. It was found that the anticancer efficacy of MFL nanohybrid was higher than other nanohybrids, free drugs, or their mixtures, which means the multidrug-incorporated LDH nanohybrids could be potential drug delivery carriers for efficient cancer treatment via combination therapy.

scholarly journals Zingiber officinale Extract (ZOE) Incorporated with Layered Double Hydroxide Hybrid through Reconstruction to Preserve Antioxidant Activity of ZOE against Ultrasound and Microwave Irradiation

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1281 ◽  
Author(s):  
Hyoung-Jun Kim ◽  
Su-Bin Lee ◽  
Ae-Jin Choi ◽  
Jae-Min Oh
Keyword(s):  
Antioxidant Activity ◽  
Microwave Irradiation ◽  
Layered Double Hydroxide ◽  
Radical Scavenging ◽  
Zingiber Officinale ◽  
Microwave Treatment ◽  
Reconstruction Method ◽  
Potential Measurement ◽  
Double Hydroxide ◽  
Ray Patterns

We prepared Zingiber officinale extract (ZOE) incorporated in a layered double hydroxide (LDH) hybrid through a reconstruction method in order to preserve the antioxidant activity of ZOE from ultrasound and microwave irradiation. X-ray patterns, infrared spectroscopy, and scanning electron microscopy suggested that ZOE moieties were encapsulated in the interparticle space of reconstructed LDH, thus preserving its intact structure. Dynamic light scattering and zeta-potential measurement also supported the hypothesis that ZOE moieties were located in the interparticle pore of LDH rather than at the surface of LDH particles. Thermogravimetry analysis revealed that thermal stability of encapsulated ZOE could be enhanced by LDH encapsulation. Radical scavenging assay showed that antioxidant activity of ZOE–LDH hybrid was increased after ultrasound and microwave irradiation, while ZOE itself dramatically lost its antioxidant activity upon ultrasound and microwave treatment.

Synthesis and Characterization of Methyl-Red/Layered Double Hydroxide (LDH) Nanocomposite

2009 ◽  
Vol 79-82 ◽  
pp. 493-496 ◽  
Author(s):  
Jian Qiang Liu ◽  
Xing Cheng Zhang ◽  
Wan Guo Hou ◽  
You Yong Dai ◽  
Hongdi Xiao ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
Lamellar Structure ◽  
Guest Molecule ◽  
High Thermal Stability ◽  
Reconstruction Method ◽  
Methyl Red ◽  
Element Analysis ◽  
Ft Ir ◽  
Double Hydroxide

In this paper, the intercalation of methyl-red (MR) into Mg/Al (ratio=2:1) layered double hydroxide (LDH) was carried out using reconstruction method to obtain MRLDH nanocomposite material. Its chemical composition, crystal structure and appearance were characterized by XRD, FT-IR, TEM, TG-DTA and element analysis. It has been found that the MRLDH still keeps the typical lamellar structure, and the guest MR has inserted into the layers of the host LDH. The MRLDH’s disassembly temperature is higher more than 70°C than that of guest molecule MR, so it can be used as a new dye with high thermal stability.

scholarly journals Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Hyoung-Jun Kim ◽  
Kitae Ryu ◽  
Joo-Hee Kang ◽  
Ae-Jin Choi ◽  
Tae-il Kim ◽  
...  
Keyword(s):  
Particle Size ◽  
Ferulic Acid ◽  
Anticancer Activity ◽  
Layered Double Hydroxide ◽  
Culture Media ◽  
Average Particle Size ◽  
Average Particle ◽  
Cellular Delivery ◽  
Double Hydroxide

We have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in anionic form. Micrsocopic results showed that the nanohybrids had average particle size of 150 nm with plate-like morphology. As the two nanohybridization routes involved crystal disorder and random stacking of layers, the nanohybrids showed slight alteration inz-axis crystallinity and particle size. The zeta potential values of pristine and nanohybrids in deionized water were determined to be positive, while those in cell culture media shifted to negative values. According to thein vitroanticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. Therefore we could conclude that the nanohybrids of ferulic acid and layered double hydroxide had cellular delivery property of intercalated molecules on cancer cell lines.

Layered double hydroxide nanomaterials as potential cellular drug delivery agents

2006 ◽  
Vol 78 (9) ◽  
pp. 1771-1779 ◽  
Author(s):  
Zhi Ping Xu ◽  
G. Q. (Max) Lu
Keyword(s):  
Drug Delivery ◽  
Layered Double Hydroxide ◽  
Recent Progress ◽  
Cellular Delivery ◽  
Paper Briefly ◽  
Efficient Delivery ◽  
Anionic Drugs ◽  
Double Hydroxide

This paper briefly reviews the recent progress in using layered double hydroxide (LDH) nanomaterials as cellular delivery agents. The advantages of LDHs as cellular delivery agents are summarized, and the processes of interaction/de-intercalation of anionic drugs (genes) into/from LDH nanoparticles are discussed. Then the cellular delivery of LDH-drug (gene) nanohybrids and subsequent intracellular processes are presumably proposed. At the end, some challenges and remarks for efficient delivery of drugs (genes) via LDH nanoparticles are provided to the best of our knowledge.

scholarly journals Nanocomposites of Magnetite and Layered Double Hydroxide for Recyclable Chromate Removal

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Gyeong-Hyeon Gwak ◽  
Min-Kyu Kim ◽  
Jae-Min Oh
Keyword(s):  
Layered Double Hydroxide ◽  
Magnetite Nanoparticles ◽  
X Ray Diffraction ◽  
Potential Measurement ◽  
X Ray ◽  
Force Microscopy ◽  
Atomic Force ◽  
House Of Cards ◽  
Double Hydroxide ◽  
Scanning Electron

Nanocomposites containing magnetic iron oxide (magnetite) nanoparticles and layered double hydroxide (LDH) nanosheets were prepared by two different methods, exfoliation-reassembly and coprecipitation, for aqueous chromate adsorbent. According to X-ray diffraction, scanning electron microscopy, and atomic force microscopy, both nanocomposites were determined to develop different nanostructures; LDH nanosheets well covered magnetite nanoparticles with house-of-cards-like structure in exfoliation-reassembly method, while coprecipitation resulted in LDH particle formation along with magnetite nanoparticles. Zeta-potential measurement also revealed that the magnetite surface was effectively covered by LDH moiety in exfoliation-reassembly compared with coprecipitation. Time, pH, concentration dependent chromate adsorption tests, and magnetic separation experiments exhibited that both nanocomposites effectively adsorb and easily collect chromate. However, exfoliation-reassembly nanocomposite was determined to be slightly effective in chromate removal by ~10%. Chromate adsorbed nanocomposites could be regenerated by treating with bicarbonate and the regenerated nanocomposites preserved ~80% of chromate adsorption efficacy after three times of recycling.

Co-delivery of doxorubicin and methotrexate by dendritic chitosan-g-mPEG as a magnetic nanocarrier for multi-drug delivery in combination chemotherapy

2017 ◽  
Vol 8 (47) ◽  
pp. 7333-7350 ◽  
Author(s):  
Mahdi Rahimi ◽  
Kazem D. Safa ◽  
Roya Salehi
Keyword(s):  
Drug Delivery ◽  
Combination Therapy ◽  
Cancer Treatment ◽  
Combination Chemotherapy ◽  
Anticancer Agents ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Synergistic Effects ◽  
Delivery Systems ◽  
Promising Strategy

Nanoparticulate drug delivery systems have the potential to improve the therapeutic efficacy of anticancer agents, and combination therapy is a promising strategy for clinical cancer treatment with synergistic effects.

Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs

Nano Research ◽  
2017 ◽  
Vol 11 (1) ◽  
pp. 195-205 ◽  
Author(s):  
Xuan Mei ◽  
Simin Xu ◽  
Tongyang Hu ◽  
Liuqi Peng ◽  
Rui Gao ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Double Hydroxide
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