Bioassay Directed Isolation and Biological Evaluation of Compounds Isolated fromRubus fairholmianusGard.
Keyword(s):
Thein vitroandin silicoanalysis ofRubus fairholmianusacetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds. Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays. The promising results of this investigation emphasize the importance of usingR. fairholmianusin the treatment of radical generated disorders mainly cancer and other inflammatory diseases.
2018 ◽
Vol 15
(2)
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pp. 127-135
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2014 ◽
Vol 2014
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pp. 1-12
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2012 ◽
Vol 8
(1)
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pp. 26-33
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2018 ◽
Vol 10
(5)
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pp. 39
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