scholarly journals Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
M. R. Lopes ◽  
Paula A. B. Ribeiro ◽  
Priscila Ledur ◽  
Gabriela C. Souza ◽  
Nadine Clausell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Failure ◽  
Vitamin D ◽  
Physical Function ◽  
Vitamin D Deficiency ◽  
Handgrip Strength ◽  
Activity Level ◽  
Exercise Intolerance ◽  
Diabetic Patients ◽  
Patients With Heart Failure

Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C,n=25), vitamin sufficient, diabetes (DS-DM,n=18), vitamin deficient, no diabetes (DD-C,n= 63), and vitamin deficient, diabetes (DD-DM,n=40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups(P=0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m)versusDD-DM (309 ± 116 m);P=0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM(P=0.074)even after being adjusted to physical activity(P=0.069). Vitamin D deficiency can influence physical function in HF diabetic patients.

scholarly journals Trajectories of frailty, physical function, and physical activity levels in elderly patients with heart failure

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michitaka Kato ◽  
Shintaro Ono ◽  
Hiromasa Seko ◽  
Toshiya Tsukamoto ◽  
Yasunari Kurita ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Failure ◽  
Elderly Patients ◽  
Physical Function ◽  
Activity Levels ◽  
Patients With Heart Failure ◽  
Physical Activity Levels

The Effects of Vitamin D Supplementation on Physical Function and Quality of Life in Older Patients With Heart Failure

2010 ◽  
Vol 3 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Miles D. Witham ◽  
Linda J. Crighton ◽  
Neil D. Gillespie ◽  
Allan D. Struthers ◽  
Marion E.T. McMurdo
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Vitamin D ◽  
Physical Function ◽  
Older Patients ◽  
Vitamin D Supplementation ◽  
Patients With Heart Failure

scholarly journals Associations between kidney function and outcomes following cardiac rehabilitation in patients with heart failure

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
N Hamazaki ◽  
K Kamiya ◽  
K Nozaki ◽  
T Ichikawa ◽  
M Yamashita ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Rehabilitation ◽  
Physical Function ◽  
Hospital Discharge ◽  
Kidney Function ◽  
Exercise Intolerance ◽  
Kidney Dysfunction ◽  
Clinical Events ◽  
Patients With Heart Failure ◽  
The Impact

Abstract Background Kidney dysfunction is considered one of the most prevalent comorbidities in patients with heart failure (HF). A combination of HF and kidney dysfunction is associated with peripheral muscle impairment, exercise intolerance, and poor prognosis. Conversely, cardiac rehabilitation (CR) for HF patients has been recognized to improve their clinical outcomes. However, the impact of kidney function on responses to CR in patients with HF is still unclear. Purpose This study aimed to investigate the associations between baseline kidney function and outcomes following CR including changes in physical function and prognosis in HF patients. Methods We reviewed a total of 3,727 patients who were admitted for HF treatment and underwent comprehensive CR during hospitalization. In addition to clinical characteristics, we assessed the kidney function using estimated glomerular filtration rate (eGFR) based on serum creatinine level at hospital discharge as baseline. The quadriceps strength (QS) and 6-minute walk distance (6MWD) were measured as muscle strength and functional capacity, respectively, at baseline. We also remeasured these parameter 5 months after hospital discharge in patients who participated in outpatient CR. The association between participation in outpatient CR and composite outcome of all-cause death and/or unplanned readmission were assessed using the multivariate Cox proportional hazard models in a subgroup of baseline eGFR. We also compared the changes in QS and 6MWD (ΔQS and Δ6MWD) between the eGFR stages. Results During the median follow-up period of 1.9 years, all-cause death/readmission occurred in 1604 (43.0%) patients, and their rate of incidence was 20.9/100 person-years. Out of studied patients, 1,585 (42.5%) patients participated in outpatient CR that was significantly associated with lower incidences of all-cause clinical events in patients with both eGFR ≥60 (adjusted hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.60–0.89, P=0.002) and eGFR <60 (adjusted HR: 0.88, 95% CI: 0.78–0.99, P=0.045), but those with an eGFR <60 showed significant interaction between CR participation and adverse clinical events (interaction P<0.035, Figure 1). Among the outpatient CR participants, QS and 6MWD were significantly higher after 5-month CR than those at baseline (P<0.001, respectively), but the low baseline eGFR correlated with low ΔQS and Δ6MWD (trend P<0.001, respectively) even after adjustment for clinical confounding factors (Figure 2). Conclusions Although the outcomes following CR is affected by baseline kidney function, outpatient CR is significantly associated with the positive change in physical function and better prognosis in HF patients with low kidney function. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran

2013 ◽  
Vol 17 (4) ◽  
pp. 803-809 ◽  
Author(s):  
Maryam Rafraf ◽  
Saadat Karimi Hasanabad ◽  
Mohammad Asghari Jafarabadi
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Blood Glucose ◽  
Vitamin D Deficiency ◽  
Energy Intake ◽  
Adolescent Girls ◽  
Fasting Blood Glucose ◽  
Activity Level ◽  
Vitamin D Status

AbstractObjectiveTo investigate vitamin D status and its association with components of the metabolic syndrome (MetS) in adolescent girls attending high school in Boukan, Iran during winter 2012.DesignA cross-sectional study.SettingHigh schools of Boukan city, Iran.SubjectsA sample of 216 girls aged 14–17 years was selected by multistage random sampling from four districts of Boukan. Weight, height, waist circumference, blood pressure, daily energy intake, physical activity and serum 25-hydroxyvitamin D (25(OH)D), fasting blood glucose, TAG and HDL-cholesterol levels of all participants were evaluated. Serum 25(OH)D level <20 ng/ml was defined as vitamin D deficiency.ResultsMean serum 25(OH)D was 7·26 (sd 2·81) ng/ml and 96 % of the participants had vitamin D deficiency. According to age-modified definitions of the National Cholesterol Education Program Adult Treatment Panel III, MetS was diagnosed in 10·6 % of the participants. In multivariable regression analysis after adjustment for BMI, energy intake and physical activity level, serum 25(OH)D was inversely associated with fasting blood glucose (β = −0·143, P = 0·04). No significant relationship was found between serum 25(OH)D and other components of MetS.ConclusionsThe high prevalence of vitamin D deficiency warrants national polices and interventions towards improving this major health problem among adolescent girls. Low 25(OH)D level was significantly associated with increased fasting blood glucose. Prospective studies are needed to determine the effects of vitamin D deficiency on the development of MetS and related metabolic diseases in adolescent girls.

scholarly journals Vitamin D deficiency is a predictor of reduced survival in patients with heart failure; vitamin D supplementation improves outcome

2012 ◽  
Vol 14 (4) ◽  
pp. 357-366 ◽  
Author(s):  
Israel Gotsman ◽  
Ayelet Shauer ◽  
Donna R. Zwas ◽  
Yaron Hellman ◽  
Andre Keren ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Supplementation ◽  
Patients With Heart Failure

scholarly journals Vitamin D Levels, Body Composition, and Metabolic Factors in Asian Indians: Results from the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Pilot Study

2018 ◽  
Vol 72 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Janet M. Chiang ◽  
Frank Z. Stanczyk ◽  
Alka M. Kanaya
Keyword(s):  
Physical Activity ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Body Composition ◽  
Vitamin D Deficiency ◽  
Asian Indians ◽  
Fasting Glucose ◽  
Activity Level ◽  
Metabolic Factors

Background/Aims: Asian Indians have a high prevalence of vitamin D deficiency and metabolic syndrome. Vitamin D deficiency is associated with an increased risk of cardiovascular disease and diabetes. Methods: We performed a cross-sectional study of 150 Asian Indians (50% male) from the San Francisco Bay Area. We assessed the association between 25-OH vitamin D (25-OHD) levels and vitamin D deficiency with body composition (anthropometric and radiographic measures) and metabolic outcomes. Results: In both men and women, the presence of vitamin D deficiency was associated with higher systolic (p = 0.004) and diastolic (p = 0.01) blood pressure, and fasting glucose (p = 0.01). Only in women, vitamin D deficiency status was associated with higher body mass index (BMI), waist-to-hip ratio, visceral fat area, and hepatic fat content after adjusting for age, income, and physical activity level. In women, 25-OHD was also associated with fasting glucose after adjusting for age, income, and physical activity and further adjusting for BMI and waist circumference (β –2.1, 95% CI –0.86 to –0.01, p = 0.04). This association between vitamin D deficiency and metabolic parameters was not significant in men. Conclusions: A lower level of 25-OHD and vitamin D deficiency were associated with higher levels of metabolic factors among Asian Indians. Our findings suggest that 25-OHD metabolism may differ by the distribution of adipose tissue and involve previously unexplored pathways accounting for the variability in the role of vitamin D in cardiovascular disease.

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

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