scholarly journals Simultaneous Intercalation of 1-Naphthylacetic Acid and Indole-3-butyric Acid into Layered Double Hydroxides and Controlled Release Properties

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Shifeng Li ◽  
Yanming Shen ◽  
Min Xiao ◽  
Dongbin Liu ◽  
Lihui Fan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Butyric Acid ◽  
Layered Double Hydroxides ◽  
Ph Value ◽  
Release Kinetics ◽  
Release Formulation ◽  
Pseudo Second Order ◽  
Controlled Release Formulations ◽  
Naphthylacetic Acid ◽  
Double Hydroxides

Controlled release formulations have been shown to have potential in overcoming the drawbacks of conventional plant growth regulators formulations. A controlled-release formulation of 1-naphthylacetic acid (NAA) and indole-3-butyric acid (IBA) simultaneous intercalated MgAl-layered double hydroxides (LDHs) was prepared. The synthetic nanohybrid material was characterized by various techniques, and release kinetics was studied. NAA and IBA anions located in the gallery of MgAl-LDHs with bilayer arrangement, and the nanohybrids particles were of typical plate-like shape with the lateral size of 50–100 nm. The results revealed that NAA and IBA have been intercalated into the interlayer spaces of MgAl-LDHs. The release of NAA and IBA fits pseudo-second-order model and is dependent on temperature, pH value, and release medium. The nanohybrids of NAA and IBA simultaneously intercalated in LDHs possessed good controlled release properties.

scholarly journals Synthesis of Hybrid Organic-Inorganic Hydrotalcite-Like Materials Intercalated with Duplex Herbicides: The Characterization and Simultaneous Release Properties

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 5086
Author(s):  
Sheikh Ahmad Izaddin Sheikh Mohd Ghazali ◽  
Is Fatimah ◽  
Farah Liyana Bohari
Keyword(s):  
Controlled Release ◽  
Basal Spacing ◽  
X Ray Diffraction ◽  
Order Model ◽  
Release Formulation ◽  
X Ray ◽  
Release Property ◽  
Pseudo Second Order ◽  
Dichlorophenoxy Acetic Acid ◽  
Double Hydroxides

In this study, a controlled-release formulation of duplex herbicides, namely, 2,4,5-trichlorophenoxybutyric acid (TBA) and 3,4-dichlorophenoxy-acetic acid (3,4D), was simultaneously embedded into Zn-Al-layered double hydroxides (LDHs). The resulting nanohybrid Zinc-Aluminium-3,4D-TBA (ZADTX) was composed of a well-ordered crystalline layered structure with increasing basal spacing from 8.9 Å to 20.0 Å in the Powder X-ray Diffraction (PXRD) with 3,4D and TBA anions located in the gallery of LDHs with bilayer arrangement. The release of 3,4D and TBA fit the pseudo-second-order model. This duplex nanohybrid possessed a well-controlled release property (53.4% release from TBA and 27.8% release from 3,4D), which was highly effective, requiring the use of a small quantity and, hence, environmentally safer.

Optimization Study to Develop Once-a-day Controlled Release Formulation of Metoclopramide with Predictable Design Space

1970 ◽  
Vol 1 (1) ◽  
pp. 71-76
Author(s):  
Rajesh Dubey ◽  
Udaya K. Chowdary ◽  
Venkateswarlu V.
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Design Space ◽  
Release Kinetics ◽  
Release Profile ◽  
Release Formulation ◽  
Linear Effect ◽  
Controlled Release Formulation ◽  
The Difference ◽  
Face Centered

A controlled release formulation of metoclopramide was developed using a combination of hypromellose (HPMC) and hydrogenated castor oil (HCO). Developed formulations released the drug over 20 hr with release kinetics following Higuchi model. Compared to HCO, HPMC showed significantly higher influence in controlling the drug release at initial as well as later phase. The difference in the influence can be explained by the different swelling and erosion behaviour of the polymers. Effect of the polymers on release was optimized using a face-centered central composite design to generate a predictable design space. Statistical analysis of the drug release at various levels indicated a linear effect of the polymers’ levels on the drug release. The release profile of formulations containing the polymer levels at extremes of their ranges in design space was found to be similar to the predicted release profile

Antibiotic-anionic Clay Matrix Used for Drug Controlled Release

2018 ◽  
Vol 69 (2) ◽  
pp. 321-323
Author(s):  
Georgeta Zegan ◽  
Elena Mihaela Carausu ◽  
Loredana Golovcencu ◽  
Alina Sodor Botezatu ◽  
Eduard Radu Cernei ◽  
...  
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Bioactive Molecules ◽  
Drug Controlled Release ◽  
Anionic Clays ◽  
Anionic Clay ◽  
Toxicological Studies ◽  
High Efficient ◽  
Clay Matrix ◽  
Double Hydroxides

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.

A controlled release strategy of antifouling agent in coating based on intercalated layered double hydroxides

2016 ◽  
Vol 172 ◽  
pp. 105-108 ◽  
Author(s):  
Zhiyong Sun ◽  
Lianghua Gu ◽  
Jiyong Zheng ◽  
Jinwei Zhang ◽  
Li Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxides ◽  
Antifouling Agent ◽  
Double Hydroxides ◽  
Release Strategy

Preparation of Sodium Paeonolsilate Intercalated into Layered Double Hydroxides and its Release Properties

2015 ◽  
Vol 1095 ◽  
pp. 349-354 ◽  
Author(s):  
Liang Hua Gu ◽  
Hong Qing Song ◽  
Zhi Yong Sun ◽  
Ji Yong Zheng ◽  
Jin Wei Zhang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Kinetics ◽  
Molar Ratio ◽  
Burst Release ◽  
X Ray Diffraction ◽  
Release Process ◽  
Rate Determining Step ◽  
Release Ratio ◽  
Double Hydroxide ◽  
Double Hydroxides

A controlled release composite has been prepared by intercalation of sodium paeonolsilate (PAS) into Mg/Al layered double hydroxide (LDH) with the molar ratio (M2+/M3+) of 2:1. The powder X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) confirm the intercalation of PAS into the galleries of LDH. The chemical composites of PAS-LDH were revealed by elemental analysis. Release tests of the PAS-LDH composite showed that no burst release phenomenon occurred at the beginning stage and a high release ratio of PAS (89.8%) was obtained, exhibiting controlled release behavior. Furthermore, the parabolic diffusion model was used to simulate the release kinetics of PAS from the LDH carrier, indicating that the intraparticle diffusion via ion-exchange is the rate-determining step in the release process. It is significance in this work for introducing the PAS-LDH composite to develop antifouling materials with long-term activity.

scholarly journals A Comparative Study on The Adsorption Behavior of Congo Red on to ZnAl and ZnCr Layered Double Hydroxides

2020 ◽  
Vol 9 (2) ◽  
pp. 108-116
Author(s):  
Tarmizi Taher ◽  
◽  
Nyanyu Ummu Hani ◽  
Neza Rahayu Palapa ◽  
Risfidian Mohadi ◽  
...  
Keyword(s):  
Experimental Data ◽  
Surface Area ◽  
Adsorption Kinetics ◽  
Layered Double Hydroxides ◽  
Congo Red ◽  
Adsorption Process ◽  
Bet Surface Area ◽  
Pseudo Second Order ◽  
Ft Ir ◽  
Double Hydroxides

In this work, two synthetic layered double hydroxides (LDH) consists of Zn2+ as M2+ cation with different M3+ cation, i.e., Al3+ and Cr3+ were used as an adsorbent for Congo Red removal aqueous solution. Both Zn-Al and Zn-Cr LDH were characterized by X-ray diffraction, FT-IR, and BET surface area analyzer. The effect of contact time, initial dye concentration, and temperature were evaluated in a batch technique in order to investigate the characteristic of Congo Red adsorption onto both adsorbents. The experimental data were assessed according to the parameter of adsorption kinetics, isotherm, and thermodynamics. The results of LDH characterization showed that Zn-Al LDH has a higher interlayer distance than Zn-Cr LDH, although Zn-Cr LDH has a higher surface area. The FT-IR analysis indicated the interlayer space of both Zn-Cr and Zn-Al LDH was dominated by CO32- as the interlayer anion species. The adsorption kinetics study of Congo Red on both LDH revealed that the adsorption process followed the pseudo-second-order model. For the adsorption isotherm, the experimental data fit well with the Freundlich model rather than the Langmuir model. The thermodynamic study indicated that the adsorption process that occurred on both adsorbents was spontaneous with exothermic nature.

Sign in / Sign up

Export Citation Format

Share Document