Serum Osteocalcin Is Associated with Inflammatory Factors in Metabolic Syndrome: A Population-Based Study in Chinese Males

Osteocalcin (OCN) was potentially associated with inflammatory factors, so we explored the metabolic role in this association in general population. Our findings suggest that OCN was positively associated with IgG while inversely associated with C3, both of which were probably mediated by obesity. Moreover, serum OCN was inversely associated with hsCRP in men with impaired fasting glucose, hyperglycemia, or metabolic syndrome, while its association with IgE was significantly observed in men with a normal metabolic profile.

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Association between electronic cigarette use and metabolic syndrome in the Korean general population: A nationwide population-based study

PLoS ONE ◽

10.1371/journal.pone.0237983 ◽

2020 ◽

Vol 15 (8) ◽

pp. e0237983

Author(s):

Taeyun Kim ◽

Hyunji Choi ◽

Jihun Kang ◽

Jehun Kim

Keyword(s):

Metabolic Syndrome ◽

General Population ◽

Population Based ◽

Electronic Cigarette ◽

Cigarette Use ◽

Population Based Study

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Prevalence and risk factors of diabetes and impaired fasting glucose among university applicants in Eastern China: findings from a population-based study

Diabetic Medicine ◽

10.1111/dme.12473 ◽

2014 ◽

Vol 31 (10) ◽

pp. 1194-1198 ◽

Cited By ~ 4

Author(s):

C. Hao ◽

C. Zhang ◽

W. Chen ◽

Z. Shi

Keyword(s):

Risk Factors ◽

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Eastern China ◽

Population Based ◽

Population Based Study

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Influence of occupation type on the association between sleep duration and impaired fasting glucose: results from a Chinese population-based study

BMJ Open ◽

10.1136/bmjopen-2020-042066 ◽

2021 ◽

Vol 11 (6) ◽

pp. e042066

Author(s):

Qingyun Lu ◽

Shangxi Wu ◽

Shiyu Wang ◽

Jing Xiao

Keyword(s):

Glucose Metabolism ◽

Gender Difference ◽

Sleep Duration ◽

Impaired Fasting Glucose ◽

Chinese Population ◽

Fasting Glucose ◽

Positive Association ◽

Population Based ◽

Secondary Outcome ◽

Population Based Study

ObjectivesSystematic evaluation of the influence of occupation type on the association between sleep–glucose metabolismDesignA cross-sectional study.SettingThe Nantong Metabolic Syndrome Study is a Chinese population-based study.Participants20 502 participants aged 18–74 years old.InterventionNo intervention.Primary and secondary outcome measuresImpaired fasting glucose (IFG).ResultsA total of 1503 participants (7.33%) with a slightly longer sleep duration had IFG. After being stratified according to occupation, a sleep duration of ≥10 hours daily corresponded to a 1.321-fold risk of IFG (95% CI 1.071 to 1.628, p=0.0092) among moderate and heavy physical workers compared with those with a daily sleep duration of 7–9 hours. There was no significant relationship between sleep and IFG among other types of workers. Moreover, we discovered a gender difference in the influence of occupation on the sleep–IFG. A positive association among moderate and heavy physical men and a negative association among light or sedentary men were established, but not in unemployed men. However, a positive association was evident only in unemployed women; there was no significant association among other occupations.ConclusionThis study highlights the role of occupation in the relationship of sleep–glucose metabolism. A gender difference was found to have been influenced by occupational types on the sleep–metabolic association.

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Diabetes, impaired fasting glucose and their relations to plasma pro-inflammatory cytokines: a population-based study in China

Diabetic Medicine ◽

10.1111/j.1464-5491.2010.03122.x ◽

2010 ◽

Vol 27 (12) ◽

pp. 1461-1463 ◽

Cited By ~ 3

Author(s):

H. Zuo ◽

Z. Shi ◽

X. Hu ◽

M. Wu ◽

Z. Guo ◽

...

Keyword(s):

Inflammatory Cytokines ◽

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Population Based ◽

Population Based Study ◽

Pro Inflammatory Cytokines

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609 B-type natriuretic peptide testing for structural heart disease screening: a general population-based study

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(05)80381-9 ◽

2005 ◽

Vol 4 (1) ◽

pp. 138-139

Keyword(s):

Heart Disease ◽

General Population ◽

Natriuretic Peptide ◽

Structural Heart Disease ◽

Population Based ◽

Disease Screening ◽

Population Based Study

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Lymphoproliferative malignancies in patients with neurofibromatosis 1

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-021-01856-8 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Christina Bergqvist ◽

François Hemery ◽

Arnaud Jannic ◽

Salah Ferkal ◽

Pierre Wolkenstein

Keyword(s):

General Population ◽

Medical History ◽

Hodgkin Lymphoma ◽

Incidence Rate ◽

Population Based ◽

Neurofibromatosis 1 ◽

Population Based Study ◽

Non Hodgkin Lymphoma ◽

History Of

AbstractNeurofibromatosis 1 (NF1) is an inherited, autosomal-dominant, tumor predisposition syndrome with a birth incidence as high as 1:2000. A patient with NF1 is four to five times more likely to develop a malignancy as compared to the general population. The number of epidemiologic studies on lymphoproliferative malignancies in patients with NF1 is limited. The aim of this study was to determine the incidence rate of lymphoproliferative malignancies (lymphoma and leukemia) in NF1 patients followed in our referral center for neurofibromatoses. We used the Informatics for Integrated Biology and the Bedside (i2b2) platform to extract information from the hospital’s electronic health records. We performed a keyword search on clinical notes generated between Jan/01/2014 and May/11/2020 for patients aged 18 years or older. A total of 1507 patients with confirmed NF1 patients aged 18 years and above were identified (mean age 39.2 years; 57% women). The total number of person-years in follow-up was 57,736 (men, 24,327 years; women, 33,409 years). Mean length of follow-up was 38.3 years (median, 36 years). A total of 13 patients had a medical history of either lymphoma or leukemia, yielding an overall incidence rate of 22.5 per 100,000 (0.000225, 95% confidence interval (CI) 0.000223–0.000227). This incidence is similar to that of the general population in France (standardized incidence ratio 1.07, 95% CI 0.60–1.79). Four patients had a medical history leukemia and 9 patients had a medical history of lymphoma of which 7 had non-Hodgkin lymphoma, and 2 had Hodgkin lymphoma. Our results show that adults with NF1 do not have an increased tendency to develop lymphoproliferative malignancies, in contrast to the general increased risk of malignancy. While our results are consistent with the recent population-based study in Finland, they are in contrast with the larger population-based study in England whereby NF1 individuals were found to be 3 times more likely to develop both non-Hodgkin lymphoma and lymphocytic leukemia. Large-scale epidemiological studies based on nationwide data sets are thus needed to confirm our findings.

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Dietary and lifestyle inflammatory scores are associated with increased risk of metabolic syndrome in Iranian adults

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00648-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Hossein Farhadnejad ◽

Karim Parastouei ◽

Hosein Rostami ◽

Parvin Mirmiran ◽

Fereidoun Azizi

Keyword(s):

Metabolic Syndrome ◽

Positive Association ◽

Population Based ◽

Population Based Study ◽

Logistic Regression Models ◽

Increased Risk ◽

Confounding Variables ◽

Adjusted Model ◽

Diet And Lifestyle

Abstract Background In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population-based study. Methods A total of 1625 participants without MetS were recruited from among participants of the Tehran Lipid and Glucose Study(2006–2008) and followed a mean of 6.1 years. Dietary data of subjects were collected using a food frequency questionnaire at baseline to determine LIS and DIS. Multivariable logistic regression models, were used to calculate the odds ratio (ORs) and 95 % confidence interval (CI) of MetS across tertiles of DIS and LIS. Results Mean ± SD age of individuals (45.8 % men) was 37.5 ± 13.4 years. Median (25–75 interquartile range) DIS and LIS for all participants was 0.80 (− 2.94, 3.64) and 0.48 (− 0.18, − 0.89), respectively. During the study follow-up, 291 (17.9 %) new cases of MetS were identified. Based on the age and sex-adjusted model, a positive association was found between LIS (OR = 7.56; 95% CI 5.10–11.22, P for trend < 0.001) and risk of MetS, however, the association of DIS and risk of MetS development was not statistically significant (OR = 1.30;95% CI 0.93–1.80, P for trend = 0.127). In the multivariable model, after adjustment for confounding variables, including age, sex, body mass index, physical activity, smoking, and energy intake, the risk of MetS is increased across tertiles of DIS (OR = 1.59; 95% CI 1.09–2.33, P for trend = 0.015) and LIS(OR = 8.38; 95% CI 5.51–12.7, P for trend < 0.001). Conclusions The findings of the current study showed that greater adherence to LIS and DIS, determined to indicate the inflammatory potential of diet and lifestyle, are associated with increased the risk of MetS.

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