scholarly journals Spindle Cell Lipoma Occurring in the Buccal Mucosa: An Unusual Location of This Benign Lipomatous Neoplasm

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Noala Vicensoto Moreira Milhan ◽  
Ana Sueli Rodrigues Cavalcante ◽  
Yonara Maria Freire Soares Marques ◽  
Yasmin Rodarte Carvalho ◽  
Ana Lia Anbinder
Keyword(s):  
Buccal Mucosa ◽  
Smooth Surface ◽  
Spindle Cell ◽  
Histopathological Examination ◽  
Immunohistochemical Analysis ◽  
Final Diagnosis ◽  
Spindle Cell Lipoma ◽  
Mature Adipose Tissue ◽  
Spindle Cells ◽  
History Of

Spindle cell lipoma is a benign lipomatous neoplasm, which rarely occurs in the oral cavity. The aims of this paper are to report a case of spindle cell lipoma located in buccal mucosa and discuss the main clinical, histological, and immunohistochemical findings of this entity. Thus, we report a 4-year history of an asymptomatic smooth surface nodule in an elderly Caucasian man with clinical hypothesis of fibroma. The histopathological examination showed spindle cells, mature adipose tissue, and many mast cells in a stroma of connective tissue presenting ropey collagen fibers bundles. After immunohistochemical analysis, the final diagnosis was spindle cell lipoma.

scholarly journals Spindle Cell Lipoma: A Case Report And Review Of Literature

2013 ◽  
Vol 10 (2) ◽  
pp. 92-95 ◽  
Author(s):  
P Chandrashekar ◽  
M Jose ◽  
M Dadhich ◽  
L Chatra ◽  
V Holla
Keyword(s):  
Medical Journal ◽  
Case Report ◽  
Spindle Cell ◽  
Histopathological Examination ◽  
English Literature ◽  
Review Of Literature ◽  
Spindle Cell Lipoma ◽  
Collagen Fibres ◽  
Spindle Cells ◽  
Rare Lesion

Oral spindle cell lipoma is a rare lesion and until now only 26 cases have been reported in English literature. In this article we report a case of oral spindle cell lipoma presented to our institution in July 2011, as an asymptomatic solitary growth of the buccal mucosa in a 58 year old male patient. On histopathological examination the lesion exhibited an admixture of adipocytes and spindle cells with collagen fibres and numerous mast cells. Kathmandu University Medical Journal | Vol.10 | No. 2 | Issue 38 | Apr – June 2012 | Page 92-95 DOI: http://dx.doi.org/10.3126/kumj.v10i2.7353

scholarly journals Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (Lythognathus mormyrus)

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3413
Author(s):  
Massimo Orioles ◽  
Marco Galeotti ◽  
Pierpaolo Patarnello ◽  
Stefano Pizzolitto ◽  
Donatella Volpatti
Keyword(s):  
Spindle Cell ◽  
Giant Cells ◽  
Collagen Fibers ◽  
Sea Bream ◽  
Spindle Cell Lipoma ◽  
Marine Aquaculture ◽  
Spindle Cells ◽  
Adipocytic Tumors ◽  
Abundant Cytoplasm ◽  
The Masses

Cutaneous neoplasms affecting wild striped bream (Lythognathus mormyrus) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging between 0.5–4.0 cm. Histologically, all the neoplastic lesions were located in the stratum spongiosum of the dermis and were surrounded by a thin capsule of connective tissue. The tumors were predominantly composed of adipocytes grouped and surrounded by a thin net of fibroblasts and collagen fibers. In some lipomas a mixture of adipocytes and uniform spindle cells were also observed. Fibroblasts and collagen fibers, or spindle cells, showing few mitotic figures were mainly observed in other nodules. Three of the tumors showed bands of cells with elongated nuclei. Five neoplasms differed from the classic spindle cell lipoma due to the presence of scattered giant cells. These cells presented acidophilic abundant cytoplasm with multiple hyperchromatic nuclei showing a concentric “floret-like” arrangement. The tumors were further characterized by ultrastructural observations that allowed ruling out the presence of virus-like particles within the lesions. Histological features of the masses lead to the identification of four prevalent patterns of neoplasms: lipoma, fibrolipoma, spindle cell lipoma (SCL), and atypical spindle cell-like lipoma (ASCL). The different neoplasms could arise from the transformation of mesenchymal cells of dermal origin. To the author’s knowledge, this is the first report describing key differential histological and ultrastructural features of these neoplasms in striped sea bream.

Extramedullary haematopoiesis presenting as a periportal mass

2020 ◽  
Vol 13 (7) ◽  
pp. e235064
Author(s):  
Faranak Rafiee ◽  
Sara Haseli ◽  
Seyed Hamed Jafari ◽  
Pooya Iranpour
Keyword(s):  
Bone Marrow ◽  
Abdominal Pain ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Extramedullary Haematopoiesis ◽  
Abdominal Ct ◽  
Rare Presentation ◽  
Abdominal Ct Scan ◽  
History Of ◽  
Vague Abdominal Pain

Extramedullary haematopoiesis (EMH) is defined as haematopoiesis occurring in organs outside the bone marrow. The liver is one of the rare sites of EMH, and to the best of our knowledge, a few cases of adult EMH of the liver have been reported in the last 20 years. Here, we reported the case of a 68-year-old man with a known history of myelofibrosis presented with vague abdominal pain. An abdominal CT scan showed a hypoattenuating periportal mass encasing the portal vein. The final diagnosis of EMH was made through the histopathological examination. This is a rare presentation of EMH, which may be easily mistaken for other pathologies such as metastases. Familiarity with this type of presentation aids in correctly diagnosing it in an appropriate clinical setting.

scholarly journals Left Supraclavicular Spindle Cell Lipoma

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Oladejo Olaleye ◽  
Bertram Fu ◽  
Ram Moorthy ◽  
Charles Lawson ◽  
Myles Black ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Excisional Biopsy ◽  
Neurological Deficits ◽  
Excision Biopsy ◽  
Low Grade ◽  
Spindle Cell Lipoma ◽  
Rare Presentation ◽  
Spindle Cells ◽  
Immuno Histochemistry ◽  
Rare Benign Tumour

Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males. They compose of fat, CD34 positive spindle cells, and ropey collagen on a myxoid matrix. This case highlights a rare presentation of SCL and the need for pre-operative diagnosis.Case Report. A 63-year-old gentleman presented with a pre-existing left supraclavicular mass that had recently increased in size. FNA and CT Scans were performed and results discussed in the mutidisciplinary team meeting. Excisional biopsy was recommended.Radiology. CT neck showed a left supraclavicular mass of fatty density with fine internal septations. A low-grade liposarcoma could not be excluded.Histopathology. FNA was indeterminate. Histology of specimen showed bland spindle cells with no evidence of malignancy. Immuno-histochemistry showed SCL with CD34 positivity and negative staining on CDK4 and p16.Management. Excision biopsy of the mass was performed which was technically difficult as the mass invaginated around the brachial plexus. The patient recovered well post-operatively with no neurological deficits.Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

scholarly journals Angiomyolipoma of colon: unusual presentation

2019 ◽  
Vol 6 (6) ◽  
pp. 2204
Author(s):  
Vidhyachandra Gandhi ◽  
Swapnil Karnik ◽  
Nitin Pai ◽  
Sujai Hegde
Keyword(s):  
Spindle Cell ◽  
Histopathological Examination ◽  
Cell Type ◽  
Mesenchymal Tumors ◽  
Left Hemicolectomy ◽  
Mature Adipose Tissue ◽  
Polypoidal Lesion ◽  
Descending Colon ◽  
One Year ◽  
Kidney Angiomyolipoma

Angiomyolipomas are benign mesenchymal tumors mostly arising from the kidney. Angiomyolipoma of the colon is extremely rare. Here we report the findings of a 72 years gentleman who presented with recurrent episodes of abdominal pain and fullness of one year duration. Colonoscopy was suggestive of polypoidal lesion in the descending colon. CECT abdomen revealed a colocolic intussusception in the descending colon with lipoma as a leading point. He underwent a standard left hemicolectomy. Histopathological examination showed that the tumor of 5.7 cm in diameter included smooth muscle (spindle cell type), mature adipose tissue, and vessels, and therefore a diagnosis of angiomyolipoma was made. We believe this is the second report of colonic angiomyolipoma presenting with colocolic intussusception. 

scholarly journals Carcinosarcoma of lung

2013 ◽  
Vol 3 (5) ◽  
pp. 419-421
Author(s):  
S Neupane ◽  
T Pathak ◽  
S Bastola ◽  
S Shrestha ◽  
CB Pun
Keyword(s):  
Spindle Cell ◽  
Histopathological Examination ◽  
Small Cell ◽  
Brush Cytology ◽  
Cell Component ◽  
Squamous Cells ◽  
Spindle Cell Component ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Pulmonary Carcinosarcoma

Primary carcinosarcoma of the lung is exceedingly rare. It is described as malignancy composed of a mixture of carcinoma and sarcoma elements. The sarcomatous element is usually spindle cell but may contain cartilage, bone or skeletal muscle. We report a case of pulmonary carcinosarcoma in a 66 years male who presented with cough, chest pain on exertion, anorexia and weight loss. Brush cytology revealed poorly differentiated non-small cell carcinoma. Histopathological examination showed proliferation of malignant spindle cells containing bone and malignant cartilage admixed with areas of keratinized squamous cells with few foci of ill-defined glandular structure. On immunohistochemistry, carcinomatous component of tumor showed positivity for cytokeratin AE1/AE3 and spindle cell component were positive for vimentin. These findings led to diagnosis of carcinosarcoma. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 419-421 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7873

Atypical Spindle Cell Lipomatous Lesion Resected From Patient With History of CLL

2020 ◽  
Vol 86 (9) ◽  
pp. 1208-1211
Author(s):  
Chase J. Wehrle ◽  
J. Will Daigle ◽  
Asad Ullah ◽  
Suash Sharma ◽  
Edmond F. Ritter ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Lymphocytic Leukemia ◽  
Left Shoulder ◽  
Spindle Cell Lipoma ◽  
Atypical Lipomatous Tumor ◽  
Lipomatous Tumor ◽  
Adipocytic Tumors ◽  
History Of ◽  
Pathologic Analysis ◽  
Mdm2 Amplification

Atypical spindle cell lipomatous neoplasm, also known as well-differentiated spindle cell liposarcoma, represents a newly discovered entity of adipocytic tumors. Recent research has shown this tumor variant to be more related to spindle cell lipoma, rather than the originally hypothesized atypical lipomatous tumor spectrum. Here we present a case of a 58-year-old man with a history of chronic lymphocytic leukemia with an enlarging mass on the posterior left shoulder, initially hypothesized to be a benign lipoma. However, magnetic resonance imaging showed a large, multiseptated, heterogeneous mass concerning for soft tissue sarcoma. After resection, pathologic analysis showed cells closely resembling spindle cell lipoma, with additional cellular and fascicular zones containing lipoblasts and mitotic figures. Molecular analysis showed no MDM2 amplification. This lack of amplification indicates this tumor is distinctly different from an atypical lipomatous tumor, which characteristically displays MDM2 amplification. However, tumor expression of RB1 was normal. The majority of atypical spindle cell lipomatous neoplasms are associated with RB1 deletions. We conclude that we have a unique example of an atypical spindle cell lipomatous tumor.

scholarly journals A 37 mm Spindle Cell Lipoma on the Floor of the Mouth

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Eve Malthiery ◽  
Valérie Costes-Martineau ◽  
Marie-Alix Fauroux ◽  
Jacques-Henri Torres
Keyword(s):  
Oral Cavity ◽  
Local Anesthesia ◽  
High Frequency ◽  
Spindle Cell ◽  
Spindle Cell Lipoma ◽  
Functional Consequence ◽  
Histological Features ◽  
Floor Of The Mouth ◽  
Spindle Cells ◽  
Male Patients

Spindle cell lipoma (SCL) is a rare variety of lipoma that mostly arises in male patients and rarely affects the oral cavity. The floor of the mouth is an uncommon site for SCL, and very few cases have been reported in this location. A case of SCL is reported in a 70-year-old woman who had noticed a swelling of the floor of the mouth without any functional consequence. Both ultrasonography and RMI suggested a diagnosis of ranula, whereas clinical palpation showed a nonfluctuant mass. The lesion was excised under local anesthesia. A 37×32 mm encapsulated yellow mass was removed. Histological features (mature adipocytes and CD34+ spindle cells) led to a diagnosis of SCL. Medical imaging assessment of this lesion could have been influenced by the high frequency of the ranulas in the floor of the mouth. This case appears to be quite infrequent because of its location (floor of the mouth), its size (over 3.5 cm), and the patient’s gender (female).

MIMICKING SOFT TISSUE TUMOUR- SPINDLE CELL LIPOMA

2021 ◽  
pp. 111-113
Author(s):  
Lahari Sampangi Ram Reddy ◽  
Indira Galidevara ◽  
Kannan R
Keyword(s):  
Spindle Cell ◽  
Complex Mixture ◽  
Variable Number ◽  
Soft Tissue Tumour ◽  
Spindle Cell Lipoma ◽  
Posterior Aspect ◽  
Spindle Cells ◽  
Tissue Tumour ◽  
The Right ◽  
Slow Growing

Spindle cell lipomas (SCL) are slow-growing benign adipocyte tumours that are most commonly seen in (1) the upper back, posterior aspect of the neck, and shoulders . Both genders are affected, but it is more (1) prevalent in males between the ages of 40 and 70 . Spindle cell lipoma is a benign tumour that is frequently confused with (1) liposarcoma. SCLs account for approximately 1.5 percent of all lipomatous tumours reported, making them uncommon . They (2) have a morphology similar to other benign and malignant fatty/spindle cell or myxoid lesions . Microscopically, it is a complex mixture of lipocytes and uniform spindle cells embedded in a mucinous matrix and traversed by (2) a variable number of birefringent collagen bres . Due to the unusual presentation and similar morphology of tumours, early diagnosis is critical; thus, diagnosis is based on clinical examination and conrmed by histopathological ndings. Because SCL has a favourable prognosis, wide local (1) excision is the treatment of choice . This is a case report of a 52-year-old male with a similar presentation in the right upper limb.

scholarly journals Bednar Tumour Occurring after Malignant Melanoma Excision

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Amedeo Ferlosio ◽  
Monia Di Prete ◽  
Piero Rossi ◽  
Elena Campione ◽  
Augusto Orlandi
Keyword(s):  
Subcutaneous Tissue ◽  
Primary Melanoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Clinical History ◽  
Final Diagnosis ◽  
Melanoma Metastasis ◽  
Spindle Cells ◽  
History Of ◽  
In Transit

We report the case of a seventy-four-year-old man with a slow-growing 2 cm mass on the back that arose near the surgical scar of previously excised melanoma, invasive to a Breslow depth of 3 mm. Preoperative clinical diagnosis was “in-transit” melanoma metastasis. After surgical excision, histopathologic examination revealed a dermal nodular proliferation of spindle cells arranged in storiform pattern, with mild pleomorphism, infiltrating around appendages and into the subcutaneous tissue. Immunohistochemical investigation documented diffuse positivity for CD34 and vimentin of spindle cells. Scattered dendritic cells, containing dark pigment in varying proportion and positive for S100, Melan-A and HMB-45, were also observed. A final diagnosis of Bednar tumour was formulated. Subsequently, the patient developed numerous metastases from the primary melanoma and died after 18 months. Bednar tumour is a rare pigmented variant of dermatofibrosarcoma protuberans of intermediate malignant potential. The presence of pigmented cells in Bednar tumour requires careful differential diagnosis with malignant or benign pigmented skin tumours. The clinical history of a Bednar tumour developing close to the scar of a previous melanoma gives the opportunity of a critical and intriguing discussion about the potential origin of pigmented cells in this rare variant of dermatofibrosarcoma protuberans.

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