scholarly journals Bednar Tumour Occurring after Malignant Melanoma Excision

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Amedeo Ferlosio ◽  
Monia Di Prete ◽  
Piero Rossi ◽  
Elena Campione ◽  
Augusto Orlandi
Keyword(s):  
Subcutaneous Tissue ◽  
Primary Melanoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Clinical History ◽  
Final Diagnosis ◽  
Melanoma Metastasis ◽  
Spindle Cells ◽  
History Of ◽  
In Transit

We report the case of a seventy-four-year-old man with a slow-growing 2 cm mass on the back that arose near the surgical scar of previously excised melanoma, invasive to a Breslow depth of 3 mm. Preoperative clinical diagnosis was “in-transit” melanoma metastasis. After surgical excision, histopathologic examination revealed a dermal nodular proliferation of spindle cells arranged in storiform pattern, with mild pleomorphism, infiltrating around appendages and into the subcutaneous tissue. Immunohistochemical investigation documented diffuse positivity for CD34 and vimentin of spindle cells. Scattered dendritic cells, containing dark pigment in varying proportion and positive for S100, Melan-A and HMB-45, were also observed. A final diagnosis of Bednar tumour was formulated. Subsequently, the patient developed numerous metastases from the primary melanoma and died after 18 months. Bednar tumour is a rare pigmented variant of dermatofibrosarcoma protuberans of intermediate malignant potential. The presence of pigmented cells in Bednar tumour requires careful differential diagnosis with malignant or benign pigmented skin tumours. The clinical history of a Bednar tumour developing close to the scar of a previous melanoma gives the opportunity of a critical and intriguing discussion about the potential origin of pigmented cells in this rare variant of dermatofibrosarcoma protuberans.

scholarly journals Acute Truncal Lymphedema Secondary to Axillary Metastatic Melanoma Presenting Like Cellulitis

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Shelley J. E. Hwang ◽  
Benjamin Y. Kong ◽  
Shaun Chou ◽  
Deepal Wakade ◽  
Matteo S. Carlino ◽  
...  
Keyword(s):  
Primary Melanoma ◽  
Surgical Excision ◽  
Axillary Lymph Node Metastasis ◽  
The Body ◽  
Axillary Lymph ◽  
Cutaneous Metastases ◽  
Node Metastasis ◽  
Systemic Antibiotic Therapy ◽  
In Transit ◽  
Infrequent Event

There are reported cases of diphencyprone used in treating cutaneous metastases of melanoma. Here, we report a patient with previous primary melanoma on his left back treated with surgical excision and lymphadenectomy, followed by radiotherapy for the recurrent tumor on the primary site. Despite radiotherapy and treatment with dabrafenib and trametinib, in-transit metastases have developed and topical diphencyprone was applied to these metastases. Six weeks later, the patient developed fever and a spreading erythematous tender indurated plaque covering the left side of the body including axillae, back, and flank, clinically suggestive of cellulitis. Systemic antibiotic therapy did not improve the condition and a biopsy showed sparse lymphocytic infiltrate. With the diagnosis of possible acute lymphedema, a CT scan was requested that showed significant axillary lymph node metastasis. The fever was considered secondary to dabrafenib and trametinib therapy. This case highlights that, in patients with lymphadenectomy, atypical forms of lymphedema on the body may appear. Truncal lymphedema is an infrequent event.

scholarly journals Left atrial appendage aneurysm

2019 ◽  
Vol 30 (3) ◽  
pp. 495-496
Author(s):  
Bo Jiang ◽  
Xi Wang ◽  
Feng Liu ◽  
Long Song
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
Atrial Appendage ◽  
Progressive Dyspnoea ◽  
Atypical Chest Pain ◽  
History Of ◽  
Left Atrial Appendage Aneurysm ◽  
Masson Staining

Abstract Left atrial appendage aneurysm is an infrequent abnormality presenting as atrial tachyarrhythmias, progressive dyspnoea, atypical chest pain and systemic thromboembolism. Surgical excision is considered to prevent fatal complications, even in asymptomatic cases. We describe the case of a 44-year-old woman with a history of acute cerebral infarction caused by emboli from a giant left atrial appendage aneurysm, which is the largest one reported to date. Histopathology and Masson staining confirmed the final diagnosis.

scholarly journals Pleomorphic Adenoma and Trauma: a Case Report With Rare Clinical Presentation

2021 ◽  
Author(s):  
Basma Morsy ◽  
Eglal Moussa ◽  
Nourhan Aly ◽  
Enas Omar ◽  
Samar El Achy
Keyword(s):  
Pleomorphic Adenoma ◽  
Salivary Gland Tumor ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
Gland Tumor ◽  
Case Presentation ◽  
Patient Reported ◽  
History Of ◽  
Dna Alterations ◽  
Immunohistochemical Analyses

Abstract BackgroundPleomorphic adenoma (PA) is the most common benign salivary gland tumor. Many factors have been implicated in the etiology of PA, one of which is genetic alteration in PLAG1 and HMGA2 genes. Few cases were reported about PAs appearing in patients with history of trauma or denture wear.Case presentationA 73-year-old female patient presented to the clinic with a gradually increasing mass that appeared two months ago in the upper left labial vestibule. The patient reported wearing a maxillary complete denture for 15 years. Clinical examination revealed a typical denture fissuratum, so surgical excision was the treatment of choice. Upon excision, a fully encapsulated mass was exposed and sent for histological and immunohistochemical analyses that confirmed a final diagnosis of PA.ConclusionThis case suggests a contributory role for trauma in the development of PA, following DNA alterations or through oxidative stress resulting from Chronic Mechanical Irritation (CMI).

INTRAOSSEOUS ANGIOLIPOMA OF THE CRANIUM

Neurosurgery ◽  
2009 ◽  
Vol 64 (1) ◽  
pp. E189-E190 ◽  
Author(s):  
Kenny Yu ◽  
James Van Dellen ◽  
Philip Idaewor ◽  
Federico Roncaroli
Keyword(s):  
Clinical Presentation ◽  
Subcutaneous Tissue ◽  
Rare Condition ◽  
Surgical Excision ◽  
Benign Tumors ◽  
Complete Surgical Excision ◽  
History Of ◽  
Titanium Cranioplasty ◽  
Intraosseous Lesion ◽  
Slow Growing

Abstract OBJECTIVE We describe an intraosseous angiolipoma of the cranium and discuss the outcome. Angiolipomas are benign tumors that consist of mature adipose tissue and abnormal vessels. They occur predominantly in the subcutaneous tissue of the trunk and upper limbs. Only 4 examples of intraosseous angiolipomas have been reported in the literature, all of which involved the mandible and ribs. CLINICAL PRESENTATION A 39-year-old man presented with a right parietal swelling. The patient initially refused surgery; thus it was possible to follow this case for 11 years, allowing us to evaluate the natural history of this rare condition. INTERVENTION Complete surgical excision of the intraosseous lesion was achieved with a titanium cranioplasty performed at intervals. Fifteen months after surgery, no recurrence was seen. CONCLUSION This is the first known report of intraosseous angiolipoma of the cranium. Angiolipomas are rare, benign, slow-growing tumors with an excellent prognosis. On preoperative neuroimaging, they may mimic intraosseous angiomas, lipomas, or intraosseous meningiomas. Total resection is curative.

Intraneural Nodular Fasciitis of the Dorsal Scapular Nerve: Case Report and Review of the Literature

2021 ◽  
Author(s):  
Ivan Domazet ◽  
Niko Njiric ◽  
Antonia Jakovcevic ◽  
Andrija Bitunjac ◽  
Krešimir Domazet ◽  
...  
Keyword(s):  
Case Report ◽  
Subcutaneous Tissue ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Left Shoulder ◽  
Nodular Fasciitis ◽  
History Of ◽  
Magnetic Resonance Imaging Mri ◽  
Histopathologic Analysis ◽  
Rare Diagnosis

Abstract Background Nodular fasciitis is a benign neoplasm occurring predominantly in the subcutaneous tissue. There have been nine intraneural occurrences described in the literature. Case report A 37-year-old woman presented with numbness and tenderness in her left shoulder and scapula and a slightly dropped left shoulder, without history of trauma. A magnetic resonance imaging (MRI) of the cervical spine showed a well-circumscribed oval mass deep to the levator scapula muscle. Due to persisting symptoms and an unknown nature of the process, surgical excision was performed, and histopathologic analysis confirmed diagnosis of a benign fibroblastic/myofibroblastic neoplasm, nodular fasciitis. The postoperative course was uneventful and the patient was without symptoms at 4 months of follow-up. Methods We reviewed the available literature (PubMed, Google Scholar), with nine published cases of intraneural nodular fasciitis. The reported clinical, radiologic, and histopathologic parameters were evaluated and compared. Discussion Most of the cases reported in the literature were symptomatic, with tenderness and palpability being the main symptoms. Six of the reported cases occurred in the forearm, whereas three were in the leg. To the best of our knowledge, ours is the first reported case of nodular fasciitis occurring in the trunk. Ours is the only case to display desmin positivity, which supports the reactive hypothesis of nodular fasciitis. Conclusion Intraneural nodular fasciitis is an extremely rare diagnosis. Due to its benign natural course, a multidisciplinary approach with this extremely rare diagnosis in mind is needed to avoid overtreatment.

scholarly journals Spindle Cell Lipoma Occurring in the Buccal Mucosa: An Unusual Location of This Benign Lipomatous Neoplasm

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Noala Vicensoto Moreira Milhan ◽  
Ana Sueli Rodrigues Cavalcante ◽  
Yonara Maria Freire Soares Marques ◽  
Yasmin Rodarte Carvalho ◽  
Ana Lia Anbinder
Keyword(s):  
Buccal Mucosa ◽  
Smooth Surface ◽  
Spindle Cell ◽  
Histopathological Examination ◽  
Immunohistochemical Analysis ◽  
Final Diagnosis ◽  
Spindle Cell Lipoma ◽  
Mature Adipose Tissue ◽  
Spindle Cells ◽  
History Of

Spindle cell lipoma is a benign lipomatous neoplasm, which rarely occurs in the oral cavity. The aims of this paper are to report a case of spindle cell lipoma located in buccal mucosa and discuss the main clinical, histological, and immunohistochemical findings of this entity. Thus, we report a 4-year history of an asymptomatic smooth surface nodule in an elderly Caucasian man with clinical hypothesis of fibroma. The histopathological examination showed spindle cells, mature adipose tissue, and many mast cells in a stroma of connective tissue presenting ropey collagen fibers bundles. After immunohistochemical analysis, the final diagnosis was spindle cell lipoma.

scholarly journals Maxillary cementoblastoma (true cementoma) and secondary aspergillosis in a horse

2018 ◽  
Vol 68 (1) ◽  
pp. 119-126
Author(s):  
De Miguel Ricardo ◽  
Molín Jéssica ◽  
Asín Javier ◽  
Solana María ◽  
Vázquez Francisco José ◽  
...  
Keyword(s):  
Organic Matrix ◽  
Clinical History ◽  
Final Diagnosis ◽  
Heterogeneous Distribution ◽  
Long Time ◽  
History Of ◽  
High Quality Information ◽  
The Cost ◽  
Slow Growing ◽  
Radiologic Evidence

Abstract Cementoblastoma is a rare, benign, expansive and slow-growing, mesenchymal odontogenic tumor. An eight year-old, Purebred Spanish Horse stallion with clinical history of chronic, refractory to treatment unilateral rhinitis and radiologic evidence of a radiopaque mass at the second premolar tooth root underwent intraoral surgery for tooth and mass extraction. The owner did not want to bear the cost of the histopathologic study and the samples were left unattended in a sterile recipient without a fixative solution for six years. Grossly the mass showed a hard consistence, greyish-whitish color and an irregular surface. Histologically, the mass consisted of an abundant deposit of eosinophilic cementum-like organic matrix with frequent basophilic reversal lines and heterogeneous distribution of empty lacunae. Surrounded by this organic matrix there were numerous fungal hyphae positive for Aspergillus fumigatus immunostaining. The final diagnosis was maxillary cementoblastoma with secondary aspergillosis. High-quality information has been obtained from long-time non-fixed tissues.

scholarly journals A rare case of adrenal collision tumor: Myelolipoma and schwannoma in the adrenal gland

2020 ◽  
Vol 8 ◽  
pp. 2050313X2092107 ◽  
Author(s):  
Mariangela Gomez ◽  
Rohin Mehta
Keyword(s):  
Adrenal Gland ◽  
Rare Case ◽  
Histopathological Examination ◽  
Benign Neoplasm ◽  
Surgical Excision ◽  
Clinical History ◽  
Collision Tumor ◽  
Adrenal Tumors ◽  
Acute Adrenal Insufficiency ◽  
History Of

Adrenal collision tumors refer to coexistence of two adjacent, but histologically distinct, neoplasms involving the adrenal gland without histologic admixture at the interface. Myelolipoma is a rare but benign neoplasm. As its name implies, displays both mature adipose tissue and hematopoietic elements. These are usually unilateral and asymptomatic. Schwannomas, tumors derived from the peripheral nerve sheath, are also uncommon lesions in the adrenal gland. Here, we present a rare case of a 65-year-old male with clinical history of abdominal aortic aneurysm who was found to have a 13-cm “incidentaloma” by interventional radiologist during his aortic endograft control. Giving the size of the mass, team decided to excise it, and histopathological examination was performed. While most incidentally discovered adrenal tumors are benign, surgical excision is recommended in large lesions to exclude malignancy, avoid hemorrhage, and/or acute adrenal insufficiency. Given the rarity of such entity, its clinical course and prognosis remains unclear.

Vulvar Leiomyomatosis: A Diagnostic Challenge Case Report

2020 ◽  
Vol 16 (1) ◽  
pp. 81-83
Author(s):  
Malihe Hasanzadeh ◽  
Somayeh Moeindarbari ◽  
Leila Mousavi Seresht ◽  
Amir Hosein Jafarian ◽  
Anahita Hamidi ◽  
...  
Keyword(s):  
Case Report ◽  
Virgin Female ◽  
Surgical Excision ◽  
Final Diagnosis ◽  
Definite Diagnosis ◽  
Diagnostic Challenge ◽  
Case Presentation ◽  
Smooth Muscle Tumors ◽  
History Of

Introduction: Vulvar leiomyomas are rare and usually misdiagnosed as Bartholin’s cyst on initial presentation. Leiomyoma of vulva accounts for only 0.03% of all gynecological neoplasm. Definite diagnosis is based on surgical excision of the tumor. The aim of this report is to introduce a case of leiomyoma of the vulva which was initially misdiagnosed as Bartholin’s cyst. Case Presentation: We present a case of a 36-year old virgin female (BMI>30) who was referred to the clinic with a 5-year history of left labial mass which was initially diagnosed as Bartholin’s cyst. The mass was removed and the pathologist confirmed that the final diagnosis was vulvar leiomyoma. Conclusion: Vulvar leiomyoma is usually misdiagnosed with Bartholin cyst and distinguishing between benign and malignant forms is confusing, so it is a diagnostic challenge. Surgical excision is the treatment of choice in all smooth muscle tumors of the vulva. Continuing follow-up after treatment is highly recommended.

scholarly journals Prehospital Prediction of a Time-sensitive Condition Among Patients With Dizziness Assessed by the Emergency Medical Service 

2020 ◽  
Author(s):  
Carl Magnusson ◽  
Julia Gärskog ◽  
Elin Lökholm ◽  
Jonny Stenström ◽  
Rickard Wetter ◽  
...  
Keyword(s):  
Emergency Medical Service ◽  
Medical Service ◽  
Clinical History ◽  
Final Diagnosis ◽  
Sudden Onset ◽  
Clinical Findings ◽  
Common Symptom ◽  
Emergency Medical ◽  
Increased Risk ◽  
History Of

Abstract Background: Dizziness is a relatively common symptom among patients who call for the emergency medical service (EMS).Methods: All patients assessed by the EMS and triaged using the rapid emergency triage and treatment system for adults code 11 (=dizziness) in the 660,000 inhabitants in the Municipality of Gothenburg, Sweden, in 2016, were considered for inclusion. The patients were divided into two groups according to the final diagnosis (a time-sensitive condition, yes or no).Results: There were 1,536 patients who fulfilled the inclusion criteria, of which 96 (6.2%) had a time-sensitive condition. The majority of these had an acute cerebrovascular disease. Eight predictors of a time-sensitive condition were identified. Three were associated with a reduced risk: 1) the dizziness was of a rotatory type, 2) the dizziness had a sudden onset and 3) increasing body temperature. Five were associated with an increased risk: 1) sudden onset of headache, 2) a history of head trauma, 3) symptoms of nausea or vomiting, 4) on treatment with anticoagulants and 5) increasing systolic blood pressure.Conclusion: Among 1,536 patients who were assessed by the EMS due to dizziness, 6.2% had a time-sensitive condition. On the arrival of the EMS, eight factors were associated with the risk of having a time-sensitive condition. They were linked to the type of symptoms, to clinical findings on the arrival of the EMS and to the recent clinical history.

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