Gabapentin Treatment for Neuropathic Pain in a Child with Sciatic Nerve Injury

There are a restricted number of studies about usage of gabapentin for neuropathic pain treatment of pediatric patients. We shared a 12-year-old male case with severe neuropathic pain that hindered the rehabilitation programme for the loss of muscle power and movement limitation. Neuropathic pain developed after peripheral sciatic damage due to firearm traumatisation did not respond to other medical treatments but healed nearly completely after gabapentin usage.

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Involvement of protein isoprenylation in neuropathic pain induced by sciatic nerve injury in mice

Neuroscience Letters ◽

10.1016/j.neulet.2014.01.039 ◽

2014 ◽

Vol 564 ◽

pp. 27-31 ◽

Cited By ~ 2

Author(s):

Masahiro Ohsawa ◽

Junpei Mutoh ◽

Shohei Yamamoto ◽

Hiroaki Hisa

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Nerve Injury ◽

Sciatic Nerve Injury ◽

Protein Isoprenylation

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Sophocarpine Attenuates Chronic Constriction Sciatic Nerve Injury-induced Neuropathic Pain in Mice by Inhibiting the HMGB1/TLR4/NF-κB Signaling Pathway

Iranian Red Crescent Medical Journal ◽

10.5812/ircmj.94716 ◽

2019 ◽

Vol 21 (9) ◽

Author(s):

Shaoju Jin ◽

Songtao Xu ◽

Rong Wang ◽

Tingting Wang ◽

Kunpeng Guo ◽

...

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Signaling Pathway ◽

Nerve Injury ◽

Sciatic Nerve Injury

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The Application of Pulsed Radiofrequency to Dorsal Root Ganglion Ameliorates Neuropathic Pain by Reducing CCL2 Expression in the Early Stage After Sciatic Nerve Injury in Rats

10.21203/rs.3.rs-119934/v1 ◽

2020 ◽

Author(s):

Cheng-Fu wan ◽

Bo-Han zhang ◽

Dao-Song Dong ◽

Tao Song

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Nerve Injury ◽

Dorsal Root ◽

Early Stage ◽

Sciatic Nerve Injury ◽

Pulsed Radiofrequency ◽

Sprague Dawley ◽

Expression Levels ◽

Ccl2 Expression

Abstract Background: Neuropathic pain (NP) can be treated effectively using pulsed radiofrequency (PRF). NP development and maintenance involves the essential neurotransmitter chemokine c-c motif ligand 2 (CCL2). The present study aimed to determine whether PRF regulated CCL2 expression in sciatic nerve injury (SNI) model rats.Methods: Sprague-Dawley rats were divided randomly into a sham group, an SNI group, and a PRF group. In the PRF group, L5 dorsal root ganglia received PRF treatment. After paw withdrawal mechanical threshold (PWMT) was examined, the expression levels of CCL2 and nuclear factor kappa B (NF-κB) in spinal dorsal horn were determined.Results: The PWMT in PRF group increased significantly compared with that of the SNI group (P < 0.05). The CCL2 and NF-κB expression levels in the PRF group were significant lower than those in the SNI group (P < 0.05).Conclusion: NP was effectively alleviated by PRF-mediated reductions in CCL2 expression via inhibition of NF-κB activation in the spinal cord of SNI model rats.

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The Effect of Prior Nerve Block on Neuropathic Pain Induced by Partial Sciatic Nerve Injury in Rats

PAIN RESEARCH ◽

10.11154/pain.12.131 ◽

1997 ◽

Vol 12 (2) ◽

pp. 131-137

Author(s):

Takumi Nagaro ◽

Kazushi Takaishi ◽

Hitoshi Kojo ◽

Elizabeth A Disbrow ◽

John H Eisele

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Nerve Injury ◽

Nerve Block ◽

Sciatic Nerve Injury

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Spinal Ninjurin2 contributes to the neuropathic pain via NF-κB-mediated neuroinflammation in the spared sciatic nerve injury rats

International Immunopharmacology ◽

10.1016/j.intimp.2021.107918 ◽

2021 ◽

Vol 99 ◽

pp. 107918

Author(s):

Hai-Ming Guo ◽

Yu Zhang ◽

Yan Zhang ◽

Peng-Fei Jiao ◽

Xiao-Chong Fan ◽

...

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Nerve Injury ◽

Sciatic Nerve Injury

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Gabapentin and NMDA receptor antagonists interacts synergistically to alleviate allodynia in two rat models of neuropathic pain

Scandinavian Journal of Pain ◽

10.1515/sjpain-2018-0083 ◽

2018 ◽

Vol 18 (4) ◽

pp. 687-693 ◽

Cited By ~ 4

Author(s):

Tiansheng Shi ◽

Jing-Xia Hao ◽

Zsuzsanna Wiesenfeld-Hallin ◽

Xiao-Jun Xu

Keyword(s):

Spinal Cord ◽

Neuropathic Pain ◽

Nmda Receptor ◽

Side Effects ◽

Sciatic Nerve ◽

Nerve Injury ◽

Sciatic Nerve Injury ◽

Nmda Receptor Antagonists ◽

Receptor Antagonists ◽

Mk 801

Abstract Background and aims The clinical management of neuropathic pain remains a challenge. We examined the interaction between gabapentin and NMDA receptor antagonists dextromethrophan and MK-801 in alleviating neuropathic pain-like behaviors in rats after spinal cord or sciatic nerve injury. Methods Female and male rats were produced with Ischemic spinal cord injury and sciatic nerve injury. Gabapentin, dextromethorphan, MK-801 or drug combinations were injected with increasing doses. Mechanical response thresholds were tested with von Frey hairs to graded mechanical touch/pressure, and ethyl chloride spray was applied to assess the cold sensitivity before and after injuries. Results In spinally injured rats, gabapentin and dextromethorphan did not affect allodynia-like behaviors at doses of 30 and 20 mg/kg, respectively. In contrast, combination of 15 or 30 mg/kg gabapentin with dextromethorphan at 10 mg/kg produced total alleviation of allodynia to mechanical or cold stimulation. Further reducing the dose of gapapentin to 7.5 mg/kg and dextromethorphan to 5 mg/kg still produced significant effect. MK-801, another NMDA receptor antagonist, also enhanced the effect of gabapentin in spinally injured rats. Similar synergistic anti-allodynic effect between dextromethorphan and gabapentin was also observed in a rat model of partial sciatic nerve injury. No increased side effect was seen following the combination between gabapentin and dextromethorphan. Conclusions In conclusion, the present study suggested that combining NMDA receptor antagonists with gabapentin could provide synergistic effect to alleviate neuropathic pain and reduced side effects. Implications Combining NMDA receptor antagonists with gabapentin may provide a new approach in alleviating neuropathic pain with increased efficacy and reduced side effects.

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Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain

Pharmacological Reports ◽

10.1007/s43440-020-00137-8 ◽

2020 ◽

Vol 72 (5) ◽

pp. 1310-1322

Author(s):

Renata Zajaczkowska ◽

Klaudia Kwiatkowski ◽

Katarzyna Pawlik ◽

Anna Piotrowska ◽

Ewelina Rojewska ◽

...

Keyword(s):

Nervous System ◽

Neuropathic Pain ◽

Sciatic Nerve ◽

Nerve Injury ◽

Dorsal Root Ganglia ◽

Dorsal Root ◽

Pain Treatment ◽

Opioid Analgesic ◽

Intraperitoneal Administration ◽

Pain Symptoms

Abstract Background Treatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the peripheral nervous system to the central nervous system, are important for pathological nociception. A proper understanding of the significance and function of DRG and their role in pharmacotherapy can help to improve the treatment of neuropathic pain. Metamizole, also known as sulpyrine or dipyrone, is a non-opioid analgesic commonly used in clinical practice, but it is not used for neuropathic pain treatment. Methods Chronic constriction injury (CCI) of the sciatic nerve was induced in Wistar rats. Metamizole was administered intraperitoneally (ip) preemptively at 16 and 1 h before CCI and then twice a day for 7 days. To evaluate tactile and thermal hypersensitivity, von Frey and cold plate tests were conducted, respectively. Results Our behavioral results provide evidence that repeated intraperitoneal administration of metamizole diminishes the development of neuropathic pain symptoms in rats. Simultaneously, our findings provide evidence that metamizole diminishes the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury. These assays indicate, for the first time, that metamizole exerts antinociceptive effects on nerve injury-induced neuropathic pain at the DRG level. Conclusions Finally, we indicate that metamizole-induced analgesia in neuropathy is associated with silencing of a broad spectrum of cytokines in DRG. Our results also suggest that metamizole is likely to be an effective medication for neuropathic pain. Graphic abstract

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Ultramicronized Palmitoylethanolamide and Paracetamol, a New Association to Relieve Hyperalgesia and Pain in a Sciatic Nerve Injury Model in Rat

International Journal of Molecular Sciences ◽

10.3390/ijms21103509 ◽

2020 ◽

Vol 21 (10) ◽

pp. 3509 ◽

Cited By ~ 5

Author(s):

Alessio Filippo Peritore ◽

Rosalba Siracusa ◽

Roberta Fusco ◽

Enrico Gugliandolo ◽

Ramona D’Amico ◽

...

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Nerve Injury ◽

Cell Activation ◽

Sciatic Nerve Injury ◽

Sensory Function ◽

Mast Cell Activation ◽

Neuroprotective Effects ◽

New Association ◽

Ultramicronized Palmitoylethanolamide

Inflammation is known to be an essential trigger of the pathological changes that have a critical impact on nerve repair and regeneration; moreover, damage to peripheral nerves can cause a loss of sensory function and produces persistent neuropathic pain. To date, various potential approaches for neuropathic pain have focused on controlling neuroinflammation. The aim of this study was to investigate the neuroprotective effects of a new association of ultramicronized Palmitoylethanolamide (PEAum), an Autacoid Local Injury Antagonist Amide (ALIAmide) with analgesic and anti-inflammatory properties, with Paracetamol, a common analgesic, in a rat model of sciatic nerve injury (SNI). The association of PEAum–Paracetamol, in a low dose (5 mg/kg + 30 mg/kg), was given by oral gavage daily for 14 days after SNI. PEAum–Paracetamol association was able to reduce hyperalgesia, mast cell activation, c-Fos and nerve growth factor (NGF) expression, neural histological damage, cytokine release, and apoptosis. Furthermore, the analgesic action of PEAum–Paracetamol could act in a synergistic manner through the inhibition of the NF-κB pathway, which leads to a decrease of cyclooxygenase 2-dependent prostaglandin E2 (COX-2/PGE2) release. In conclusion, we demonstrated that PEAum associated with Paracetamol was able to relieve pain and neuroinflammation after SNI in a synergistic manner, and this therapeutic approach could be relevant to decrease the demand of analgesic drugs.

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