scholarly journals A Comparison of Pattern of Pregnancy Loss in Women with Infertility Undergoing IVF and Women with Unexplained Recurrent Miscarriages Who Conceive Spontaneously

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Vidya A. Tamhankar ◽  
Beiyu Liu ◽  
Junhao Yan ◽  
Tin-Chiu Li
Keyword(s):  
Pregnancy Loss ◽  
Loss Rate ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Male Factor ◽  
Recurrent Miscarriages ◽  
Group I ◽  
Tubal Factor ◽  
Group Ii ◽  
Male Factors

Objective. Women with infertility and recurrent miscarriages may have an overlapping etiology. The aim of this study was to compare the pregnancy loss in pregnancies after IVF treatment with spontaneous pregnancies in women with recurrent miscarriages and to assess differences related to cause of infertility.Methods. The outcome from 1220 IVF pregnancies (Group I) was compared with 611 spontaneous pregnancies (Group II) in women with recurrent miscarriages. Subgroup analysis was performed in Group I based on cause of infertility: tubal factor (392 pregnancies); male factor (610 pregnancies); and unexplained infertility (218 pregnancies).Results. The clinical pregnancy loss rate in Group I (14.3%) was significantly lower than that of Group II (25.8%,p<0.001) and this was independent of the cause of infertility. However the timing of pregnancy loss was similar between Groups I and II. The clinical pregnancy loss rate in Group I was similar in different causes of infertility.Conclusions. The clinical pregnancy loss rate following IVF treatment is lower than that of women with unexplained recurrent miscarriages who conceived spontaneously. This difference persists whether the infertility is secondary to tubal factors, male factors, or unexplained cause.

Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders

2009 ◽  
Vol 91 (1) ◽  
pp. 106-109 ◽  
Author(s):  
Banu Kumbak ◽  
Ulun Ulug ◽  
Burcak Erzik ◽  
Hande Akbas ◽  
Mustafa Bahceci
Keyword(s):  
Pregnancy Loss ◽  
Loss Rate ◽  
Poor Responder ◽  
Clinical Pregnancy

Combined treatment of prednisone and hydroxychloroquine may improve outcomes of frozen embryo transfer in antinuclear antibody-positive patients undergoing IVF/ICSI treatment

Lupus ◽  
2021 ◽  
pp. 096120332110558
Author(s):  
Rui Gao ◽  
Wei Deng ◽  
Cheng Meng ◽  
Kemin Cheng ◽  
Xun Zeng ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Transfer ◽  
Pregnancy Loss ◽  
Loss Rate ◽  
Implantation Rate ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer ◽  
Clinical Pregnancy Rate ◽  
High Quality ◽  
Biochemical Pregnancy

Background The influence of anti-nuclear antibody (ANA) on induced ovulation was controversial, and the effect of prednisone plus hydroxychloroquine (HCQ) treatment on frozen embryo transfer outcomes of in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) for ANA-positive women was unclear. Methods Fifty ANA-positive women and one-hundred ANA-negative women matched for age and anti-Mullerian hormone (AMH) were included from a Reproductive Medical Central of a University Hospital. Sixty-one oocytes pick-up (OPU) cycles in ANA+ group and one-hundred OPU cycles in ANA− group were compared; 30 frozen embryo transfer cycles without treatment and 66 with prednisone plus HCQ treatment among ANA-positive women were compared. Results There was no statistical difference in number of retrieved oocytes (13.66 ± 7.71 vs 13.72 ± 7.23, p = .445), available embryos (5.23 ± 3.37 vs 5.47 ± 3.26, p = .347), high-quality embryos (3.64 ± 3.25 vs 3.70 ± 3.52, p = .832), and proportion of high-quality embryos (26.5% vs. 26.7%, p = .940). Biochemical pregnancy rate (33.3% vs. 68.2%, p < .05), clinical pregnancy rate (20.0% vs. 50.1%, p < .05), and implantation rate (5.6% vs. 31.8%, p < .05) were lower, and pregnancy loss rate (83.3% vs. 23.1%, p < .05) was higher in patients with treatment than no treatment. Conclusion The influence of ANA on number of retrieved oocytes, available embryos, high-quality embryos, and proration of high-quality embryos was not found. The treatment of prednisone plus HCQ may improve implantation rate, biochemical pregnancy rate, and clinical pregnancy rate, and reduce pregnancy loss rate in frozen embryo transfer outcomes for ANA-positive women.

The Prediction of Sperm Chromatin Structure Assay (SCSA) Parameters for Outcomes of Intrauterine Insemination

2020 ◽  
Author(s):  
Jiangman Gao ◽  
Liying Yan ◽  
Ying Huang ◽  
Hui Jiang ◽  
Yuanyuan Wang ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Pregnancy Loss ◽  
Loss Rate ◽  
Intrauterine Insemination ◽  
Sperm Concentration ◽  
Clinical Pregnancy ◽  
Sperm Chromatin ◽  
Sperm Dna Fragmentation ◽  
Female Age ◽  
Sperm Dna

Abstract Background: Many studies have assessed the association between sperm DNA fragmentation and outcomes of ART. But the published papers have not offered enough evidence about whether sperm DNA fragmentation tests could make suggestions to predict intrauterine insemination (IUI) outcomes. The aim of this study was to assess whether the sperm chromatin structure assay (SCSA) parameters, sperm DNA fragmentation index (DFI) and high DNA stainability (HDS), could be used as predictors for treatment outcomes in IUI program.Methods: A retrospective cohort study was conducted at a large reproductive medicine center. 1139 IUI cycles from 1139 couples were studied. The association of SCSA parameters with the clinical pregnancy and early pregnancy loss after IUI were analyzed. Results: Clinical pregnancy rate per cycle in DFI<15%, 15%≤DFI<30%, and DFI≥30% groups were 11.1%, 7.3%, and 8.9%, respectively, with no statistical differences between the groups (P=0.127). Pregnancy loss rate were 24.3%, 27.6%, and 14.3%, respectively, with no statistical differences (P=0.762). Clinical pregnancy rate per cycle in HDS≤15% and HDS>15% groups were 9.8% and 7.5%, respectively, with no significant difference (P=0.468), and the pregnancy loss rate were 26.2% and 0, respectively, and also no statistical difference (P=0.191). Multivariate logistic regression analysis showed a higher rate of clinical pregnancy in couples with a younger female (OR=0.90, 95% CI: 0.83-0.97, P=0.007), and in couples with a male who had higher sperm concentration after washing (OR=1.02, 95% CI: 1.00-1.04, P=0.035). A higher risk of pregnancy loss was observed with increased female age (OR= 1.43, 95% CI:1.09-1.89, P=0.010) and lower sperm concentration after washing (OR= 0.92, 95% CI: 0.84-0.99, P= 0.029). Conclusions: Sperm DFI and HDS were not significantly correlated with clinical pregnancy and pregnancy loss in cycles of IUI. Female age and motile sperm concentration had statistically significant effects on both clinical pregnancy and pregnancy loss after IUI treatment.

scholarly journals Outcome of Intra Uterine Insemination in Sahara International Fertility Centre Pokhara, Nepal

2018 ◽  
Vol 1 (2) ◽  
pp. 105-109
Author(s):  
Gir Dhari Sharma ◽  
Rajesh Adhikari ◽  
Shyam Sundar Parajuly ◽  
Kalpana Gautam Adhikari
Keyword(s):  
Success Rate ◽  
Pregnancy Rate ◽  
Intrauterine Insemination ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Clinical Pregnancy Rate ◽  
Reproductive Age ◽  
Male Factor ◽  
Ovulatory Dysfunction ◽  
Ejaculatory Dysfunction

Introduction: The incidence of infertility is about 10 to 15 % among reproductive age group. The cause of infertility may be either due to male factor or female factor or both. The main aim of this study was to evaluate the success rate of intrauterine insemination (IUI) in a private centre of Pokhara. Materials and Methods: This was a centre based retrospective study done in private fertility centre. Sub-fertile couples who were treated from January 1st 2015 to December 31st 2016 were enrolled for the study. Couples with unexplained male factor, ovulatory dysfunction, unilateral tubal occlusion and ejaculatory dysfunction were included in this study. Three hundred and eighty IUI cases were retrospectively reviewed. Clinical pregnancy rate was the primary outcome. Result: The success rate of IUI was 15.7%. It was higher among unexplained infertility cases. Clinical pregnancy rate was directly associated with the age of the patients, indications of infertility and number of cycles. Conclusion: Success rate of IUI in infertile couples who had unexplained infertility, tubal factor, ovulatory dysfunction was higher than male factor infertility and ejaculatory dysfunction.

scholarly journals Comparison of Serum Progesterone Levels of the Day of Frozen Embryo Transfers According to Type of Endometrial Preparation: A Monocentric, Retrospective Study

2020 ◽  
Author(s):  
Olivier Pouget ◽  
Irma Zuna ◽  
Marine Bonneau ◽  
Marie Laure Tailland ◽  
Sylvie Neveu-Ripart ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Pregnancy Loss ◽  
Loss Rate ◽  
Preparation Method ◽  
Endometrial Thickness ◽  
Clinical Pregnancy ◽  
Progesterone Level ◽  
Serum Progesterone ◽  
Endometrial Preparation ◽  
Artificial Cycle

Abstract Background: Live birth rate following embryo transfer is comparable between natural cycle and hormonal therapy. However, pregnancy loss rate appears elevated with hormonal therapy, possibly due to luteal insufficiency, characterised by a low level of serum progesterone in the luteal phase. The primary objective of this study, was to determine whether serum progesterone level on transfer day differed according to endometrial preparation method in patients undergoing frozen embryo transfer (FET). Secondary objectives were to compare the clinical pregnancy with foetal heartbeat rate and pregnancy loss rate according to endometrial preparation method and to compare the level of serum progesterone on the transfer day between pregnancy loss and pregnancy with foetal heartbeat.Methods: Forty-seven natural/stimulated cycles and 68 artificial cycle FET were retrospectively studied from May to December 2019 from a single French hospital. The primary endpoint was the level of serum progesterone on the day of FET. The type of infertility, aetiology, serum basal FSH, LH, oestradiol and AMH dosage, endometrial thickness, clinical pregnancy rate, pregnancy loss rate, and maternal and embryo characteristics were compared between natural/stimulated cycle (OS group) and artificial cycle (AC group). Results: Mean serum progesterone level on embryo transfer day was 25.47 ng/mL in the OS group versus 14.32 ng/mL AC group (p <0.0001). There was no significant difference in demographic and hormone characteristics (age, type of embryo, type of infertility, basal FSH, LH, oestradiol and AMH levels), endometrial thickness, number and type of embryos transferred, duration of infertility, pregnancy rate and pregnancy loss rate. Body mass index was lower in the OS group than AC group (22.9 kg/m2 vs 24.8 kg/m2, p=0.03). No difference was found in serum progesterone level between clinical pregnancy with foetal heartbeat and pregnancy loss (respectively 17.48 ng/mL vs 20.82 ng/mL, p=0.7 and 22 ongoing pregnancies and 12 pregnancy loss).Conclusions: Serum progesterone level on FET day is lower with endometrial preparation with artificial cycle than with a natural/stimulated cycle. Further research is necessary to determine if this difference has any relation with higher pregnancy loss rate with artificial cycle.

scholarly journals Chlamydia Trachomatis Infection as a Risk Factor of Infertility in Women

2021 ◽  
pp. 63-70
Author(s):  
Mohamed A. Sharaf ◽  
Shereen B. El-Bohoty ◽  
Hossam A. Hodeib ◽  
Dina G. El-Kholi
Keyword(s):  
Chlamydia Trachomatis ◽  
Statistical Significance ◽  
Developed Countries ◽  
Female Reproductive Tract ◽  
Secondary Infertility ◽  
Randomized Clinical Study ◽  
Group I ◽  
Significant Difference ◽  
Tubal Factor ◽  
Group Ii

Background: C. trachomatis is known to cause damage to the female reproductive tract, primarily due to adhesions or obstructions of the fallopian tubes secondary to the inflammatory response. Tubal Factor of Infertility (TFI) is the main cause of infertility in 10-30% of cases in developed countries and C. trachomatis is the most common causative agent to TFI in the developed world. The aim of this study was to investigate the possible role of the chlamydial serology as a screening test for tubal infertility, by the detection of the anti-chlamydial IgG antibodies by using E.L.I.S.A. and study the benefit of using non-invasive methods to diagnose chlamydial infection. Materials and Methods: This prospective randomized clinical study was conducted on a (50) women complaining of Infertility due to Tubal Factor. The patient was randomly classified into two groups: (50)Group I: complaining primary or secondary infertility. Group II: including (25) patients pregnant and came for Antenatal care Results: Prevalence of different types of tubal factor in the study population was 12% in Distal block (DB), 10% Distal block plus peritubal adhesions (DB + PTA), 40% Hydrosalpinx (HS), 8% Hydrosalpinx plus peritubal adhesions (HS + PTA), 26% Proximal block (PB), 4% Peritubal adhesions (PTA). serum antichlamydial IgG level was significantly higher among group I (8.62 ±1.4) than group II (2.11±0.82). Also, 46% of group I had serum antichlamydial IgG positive vs. (12%) in group II with significant difference. Comparing positive C. trachomatis IgG with type of infertility, a total of 13 (57.7%) of those with primary infertility and 10 (42.3%) of those with secondary infertility tested positive. The difference was of no statistical significance (P=0.725). Conclusion: We can conclude that, Chlamydia trachomatis is a major factor in female infertility especially for tubal factor of infertility, serum Chlamydia trachomatis IgG assay could be used a predictive factor for tubal factor infertility.

scholarly journals Role of the total progressive motile sperm count (TPMSC) in different infertility factors in IUI: a retrospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e040563
Author(s):  
Haiyan Lin ◽  
Yu Li ◽  
Songbang Ou ◽  
Xuedan Jiao ◽  
Wenjun Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Live Birth ◽  
Retrospective Cohort ◽  
Outcome Measure ◽  
Sperm Count ◽  
Unexplained Infertility ◽  
Clinical Pregnancy ◽  
Male Factor Infertility ◽  
Motile Sperm ◽  
Male Factor

ObjectiveThe objective of this retrospective cohort study was to explore the optimal range of the total progressive motile sperm count (TPMSC) for live birth in couples with varying infertility diagnosis undergoing intrauterine insemination (IUI) in a university-affiliated teaching hospital.MethodsA total of 2647 couples and 5171 IUI cycles were included between January 2015 and December 2018. Of those, 1542 cycles were performed due to unexplained infertility, 1228 cycles due to anovulation, 1120 cycles due to mild male factor infertility and 122 cycles due to mild endometriosis. The primary outcome measure was live birth rate (LBR). The secondary outcome measure was clinical pregnancy rate (CPR).ResultsThe CPR and LBR were highest in patients with a diagnosis of anovulation compared with the other three groups of patients. The CPR and LBR in patients with unexplained, mild male factor and mild endometriosis were comparable. For the patients with mild male factor infertility, the CPR with prewash TPMSC of >75.0 M and postwash TPMSC of 65.10 M was above 10%, statistically significantly higher than other quartiles of TPMSC (p<0.05). The LBR with postwash TPMSC of >65.10 M was statistically significantly higher than other groups (p<0.05). However, in patients with unexplained infertility, the CPR and LBR were not statistically different in quartiles of TPMSC, being less than 10%. Overall, there was only one clinical pregnancy and no live birth in patients >40 years of age.ConclusionsIn conclusion, the infertility diagnosis plays a significant role for the patient undergoing IUI. Thus, the anovulatory patients benefitted most from IUI, irrespective of TPMSC. For patients with unexplained infertility, TPMSC does not affect the success rate of IUI. Overall,female patients more than 40 years old should not be referred to IUI.

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