scholarly journals Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Amel Benammar Elgaaied ◽  
Donato Cascio ◽  
Salvatore Bruno ◽  
Maria Cristina Ciaccio ◽  
Marco Cipolla ◽  
...  
Keyword(s):  
Fluorescence Intensity ◽  
Gold Standard ◽  
Added Value ◽  
Computer Assisted ◽  
Computer Aided Detection ◽  
Preliminary Results ◽  
Cad System ◽  
Cross Border ◽  
Cross Border Cooperation ◽  
Better Than

Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of a CAD (Computer Aided Detection) solution and for the assessment of its added value, in order to be applied along with an Immunologist as a second Reader in detection of autoantibodies. This CAD system is able to identify on IIF images the fluorescence intensity and the fluorescence pattern. Preliminary results show that CAD, used as second Reader, appeared to perform better than Junior Immunologists and hence may significantly improve their efficacy; compared with two Junior Immunologists, the CAD system showed higher Intensity Accuracy (85,5% versus 66,0% and 66,0%), higher Patterns Accuracy (79,3% versus 48,0% and 66,2%), and higher Mean Class Accuracy (79,4% versus 56,7% and 64.2%).

scholarly journals External economic activity of the leading sectors of the marine economy of the Pacific Russia: current trends of the crossborder cooperation

2021 ◽  
Vol 885 (1) ◽  
pp. 012025
Author(s):  
A V Moshkov ◽  
O S Kornienko
Keyword(s):  
Natural Resource ◽  
Geographical Location ◽  
Fish Farming ◽  
Added Value ◽  
Asia Pacific ◽  
Pacific Region ◽  
Cross Border ◽  
Current Trends ◽  
The Pacific ◽  
Cross Border Cooperation

Abstract Pacific Russia is a region with a unique natural resource and economic potential, where effective socio-economic development is possible due to its favourable economic and geographical location and cross-border cooperation in the Asia-Pacific region. An important role in the development of foreign economic cooperation belongs to the sectors of the marine industry. At the same time, it should be noted that the commodity structure of exports from the Pacific region of Russia is dominated by products with low added value, and in the structure of imports, on the contrary, manufacturing products. The current trends in cross-border cooperation are due to the current structure of production in Pacific Russia, the influence of natural resource and transport factors, and the demand of foreign consumers. In Pacific Russia, there are coastal (Pacific) “Northern” and “Southern” socio-economic zones - in the “Northern”, there is the highest share of mining, production and distribution of electricity; in the “Southern” – a high share of fishing and fish farming, manufacturing, services, transport and communications.

scholarly journals Is Contrast Enhanced Ultrasonography a useful tool in a beginner’s hand? How much can a Computer Assisted Diagnosis prototype help in characterizing the malignancy of focal liver lesions?

2017 ◽  
Vol 19 (3) ◽  
pp. 252 ◽  
Author(s):  
Tudor Voicu Moga ◽  
Alina Popescu ◽  
Ioan Sporea ◽  
Mirela Danila ◽  
Ciprian David ◽  
...  
Keyword(s):  
Clinical Data ◽  
Focal Liver Lesions ◽  
Computer Assisted ◽  
Liver Lesions ◽  
Classification Rate ◽  
Cad System ◽  
Computer Assisted Diagnosis ◽  
Contrast Enhanced ◽  
Assisted Diagnosis ◽  
Better Than

Aim: Contrast enhanced ultrasound (CEUS) improved the characterization of focal liver lesions (FLLs), but is an operatordependent method. The goal of this paper was to test a computer assisted diagnosis (CAD) prototype and to see its benefit in assisting a beginner in the evaluation of FLLs.Material and method: Our cohort included 97 good quality CEUS videos[34% hepatocellular carcinomas (HCC), 12.3% hypervascular metastases (HiperM), 11.3% hypovascular metastases (HipoM), 24.7% hemangiomas (HMG), 17.5% focal nodular hyperplasia (FNH)] that were used to develop a CAD prototype based on an algorithm that tested a binary decision based classifier. Two young medical doctors (1 year CEUS experience), two experts and the CAD prototype, reevaluated 50 FLLs CEUS videos (diagnosis of benign vs. malignant) first blinded to clinical data, in order to evaluate the diagnostic gap beginner vs. expert. Results: The CAD classifier managed a 75.2% overall (benign vs. malignant) correct classification rate. The overall classification rates for the evaluators, before and after clinical data were: first beginner-78%; 94%; second beginner-82%; 96%; first expert-94%; 100%; second expert-96%; 98%. For both beginners, the malignant vs. benign diagnosis significantly improved after knowing the clinical data (p=0.005; p=0,008). The expert was better than the beginner (p=0.04) and better than the CAD (p=0.001). CAD in addition to the beginner can reach the expert diagnosis. Conclusions: The most frequent lesions misdiagnosed at CEUS were FNH and HCC. The CAD prototype is a good comparing tool for a beginner operator that can be developed to assist the diagnosis. In order to increase the classification rate, the CAD system for FLL in CEUS must integrate the clinical data.

scholarly journals Added Value of Cross-Border Cooperation (CBC) for the Georgia-Azerbaijan Border Regions

2020 ◽  
pp. 147-164
Author(s):  
Tinatini Dvalishvili
Keyword(s):  
Problem Solving ◽  
Practical Problem ◽  
Local Communities ◽  
Added Value ◽  
Border Regions ◽  
Cross Border ◽  
Local Municipalities ◽  
Material Benefits ◽  
Cross Border Cooperation ◽  
Traditional Understanding

The European context of cooperation across borders demonstrates how it engages all stakeholders from a variety of territorial levels in an intensive, collaborative dialog. This approach makes bordering regions more resilient to current and predictable threats, and is largely focused on the practical problem-solving of local needs. Regardless of the (non)material benefits the European cross-border perspective provides, the situation remains very different in the Azerbaijan-Georgia cross-border reality, where the traditional understanding of borders continues to prevail. A field inquiry has shown that territorial local communities have not had a homogenous attitude towards the borderline and their neighbors, and that local municipalities lack the power and credibility to deal with local challenges autonomously. Unlike the European CBC, this cross-border context does not include the elements of bottom-up cross-border planning and locally institutionalized forms of collaboration.

Thematic Priorities For Sustainable Development of Ukraine-Romania Cross-Border Cooperation (The Case Study of Chernivtsi Region)

2020 ◽  
pp. 205-219
Author(s):  
Valentyna Bohatyrets ◽  
Liubov Melnychuk ◽  
Yaroslav Zoriy
Keyword(s):  
Foreign Policy ◽  
Quantitative Research ◽  
Legal Framework ◽  
Cultural Development ◽  
Cross Border ◽  
Strategic Orientations ◽  
The Impact ◽  
Further Development ◽  
Cross Border Cooperation ◽  
The Eu

This paper seeks to investigate sustainable cross-border cooperation (CBC) as a distinctive model of interstate collaboration, embedded in the neighboring borderland regions of two or more countries. The focus of the research revolves around the establishment and further development of geostrategic, economic, cultural and scientific capacity of the Ukrainian-Romanian partnership as a fundamental construct in ensuring and strengthening the stability, security and cooperation in Europe. This research highlights Ukraine’s aspirations to establish, develop and diversify bilateral good-neighborly relations with Romania both regionally and internationally. The main objective is to elucidate Ukraine-Romania cross-border cooperation initiatives, inasmuch Ukraine-Romania CBC has been stirring up considerable interest in terms of its inexhaustible historical, cultural and spiritual ties. Furthermore, the similarity of the neighboring states’ strategic orientations grounds the basis for development and enhancement of Ukraine-Romania cooperation. The authors used desk research and quantitative research to conclude that Ukraine-Romania CBC has the impact not only on the EU and on Ukraine multi-vector foreign policy, but it also has the longer-term global consequences. In the light of the current reality, the idea of introducing and reinforcing the importance of Cross-Border Cooperation (CBC) sounds quite topical and relevant. This research considers a number of explanations for Ukraine-Romania Cross-Border Cooperation as a key element of the EU policy towards its neighbors. Besides, the subject of the research is considered from different perspectives in order to show the diversity and complexity of the Ukraine-Romania relations in view of the fact that sharing common borders we are presumed to find common solutions. As the research has demonstrated, the Ukraine-Romania cross border cooperation is a pivotal factor of boosting geostrategic, economic, political and cultural development for each participant country, largely depending on the neighboring countries’ cohesion and convergence. Significantly, there is an even stronger emphasis on the fact that while sharing the same borders, the countries share common interests and aspirations for economic thriving, cultural exchange, diplomatic ties and security, guaranteed by a legal framework. The findings of this study have a number of important implications for further development and enhancement of Ukraine-Romania cooperation. Accordingly, the research shows how imperative are the benefits of Romania as a strategic partner for outlining top priorities of Ukraine’s foreign policy.

scholarly journals Performance of Seven Consumer Sleep-Tracking Devices Compared with Polysomnography

SLEEP ◽  
2020 ◽  
Author(s):  
Evan D Chinoy ◽  
Joseph A Cuellar ◽  
Kirbie E Huwa ◽  
Jason T Jameson ◽  
Catherine H Watson ◽  
...  
Keyword(s):  
Performance Measures ◽  
Gold Standard ◽  
High Performance ◽  
Sleep Stage ◽  
Sleep Laboratory ◽  
Sleep Assessment ◽  
Sleep Condition ◽  
Different Populations ◽  
Tracking Devices ◽  
Better Than

Abstract Study Objectives Consumer sleep-tracking devices are widely used and becoming more technologically advanced, creating strong interest from researchers and clinicians for their possible use as alternatives to standard actigraphy. We therefore tested the performance of many of the latest consumer sleep-tracking devices, alongside actigraphy, versus the gold-standard sleep assessment technique, polysomnography (PSG). Methods In total, 34 healthy young adults (22 women; 28.1 ± 3.9 years, mean ± SD) were tested on three consecutive nights (including a disrupted sleep condition) in a sleep laboratory with PSG, along with actigraphy (Philips Respironics Actiwatch 2) and a subset of consumer sleep-tracking devices. Altogether, four wearable (Fatigue Science Readiband, Fitbit Alta HR, Garmin Fenix 5S, Garmin Vivosmart 3) and three non-wearable (EarlySense Live, ResMed S+, SleepScore Max) devices were tested. Sleep/wake summary and epoch-by-epoch agreement measures were compared with PSG. Results Most devices (Fatigue Science Readiband, Fitbit Alta HR, EarlySense Live, ResMed S+, SleepScore Max) performed as well as or better than actigraphy on sleep/wake performance measures, while the Garmin devices performed worse. Overall, epoch-by-epoch sensitivity was high (all ≥0.93), specificity was low-to-medium (0.18-0.54), sleep stage comparisons were mixed, and devices tended to perform worse on nights with poorer/disrupted sleep. Conclusions Consumer sleep-tracking devices exhibited high performance in detecting sleep, and most performed equivalent to (or better than) actigraphy in detecting wake. Device sleep stage assessments were inconsistent. Findings indicate that many newer sleep-tracking devices demonstrate promising performance for tracking sleep and wake. Devices should be tested in different populations and settings to further examine their wider validity and utility.

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