HBV Infection Status and the Risk of Cholangiocarcinoma in Asia: A Meta-Analysis

Background. The inconsistent finding was between hepatitis B virus (HBV) infections and cholangiocarcinoma (CCA). This meta-analysis is to explore this relationship in Asia.Methods. A literature search was performed using PubMed, Web of Science, and Cochrane Library to October 30, 2015. Pooled incidence rate and OR with 95% CI were calculated using STATA 11.0.Results. Thirty-nine studies were included. The pooled incidence rate of CCA patients with HBV infection was 31% (95% CI 22%–39%). The pooled OR showed increased risk of CCA incidence with HBV infection (OR = 2.72, 95% CI 1.90–3.88), especially in ICC (OR = 3.184, 95% CI 2.356–4.302), while it showed no risk in ECC (OR = 1.407, 95% CI 0.925–2.141). Also, the pooled OR showed increased risk of ICC and ECC incidence (OR = 6.857, 95% CI 4.421–10.633 and OR = 1.740, 95% CI 1.260–2.404) in patients with HBsAg+/HBcAb+. The pooled OR showed increased risk of ICC incidence (OR = 1.410, 95% CI 1.095–1.816) in patients with HBsAg−/HBcAb+.Conclusion. It is suggested that HBV infection is associated with an increased risk of CCA in Asia. Two HBV infection models (HBsAg+/HBcAb+ and HBsAg−/HBcAb+) increase the risk of CCA, and patients with HBsAg−/HBcAb+ also had a risk of ICC. This trial is registered with PROSPEROCRD42015029264.

Download Full-text

Possible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic review

British Journal Of Nutrition ◽

10.1017/s0007114514002839 ◽

2014 ◽

Vol 112 (11) ◽

pp. 1751-1768 ◽

Cited By ~ 10

Author(s):

S. Fiorino ◽

L. Bacchi-Reggiani ◽

S. Sabbatani ◽

F. Grizzi ◽

L. di Tommaso ◽

...

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Antiviral Activity ◽

Hbv Infection ◽

Cochrane Library ◽

Viral Pathogen ◽

Increased Risk ◽

B Virus ◽

Chronic Hbv

Hepatitis B virus (HBV) infection represents a serious global health problem and persistent HBV infection is associated with an increased risk of cirrhosis, hepatocellular carcinoma and liver failure. Recently, the study of the role of microRNA (miRNA) in the pathogenesis of HBV has gained considerable interest as well as new treatments against this pathogen have been approved. A few studies have investigated the antiviral activity of vitamin E (VE) in chronic HBV carriers. Herein, we review the possible role of tocopherols in the modulation of host miRNA with potential anti-HBV activity. A systematic research of the scientific literature was performed by searching the MEDLINE, Cochrane Library and EMBASE databases. The keywords used were ‘HBV therapy’, ‘HBV treatment’, ‘VE antiviral effects’, ‘tocopherol antiviral activity’, ‘miRNA antiviral activity’ and ‘VE microRNA’. Reports describing the role of miRNA in the regulation of HBV life cycle,in vitroandin vivoavailable studies reporting the effects of VE on miRNA expression profiles and epigenetic networks, and clinical trials reporting the use of VE in patients with HBV-related chronic hepatitis were identified and examined. Based on the clinical results obtained in VE-treated chronic HBV carriers, we provide a reliable hypothesis for the possible role of this vitamin in the modulation of host miRNA profiles perturbed by this viral pathogen and in the regulation of some cellular miRNA with a suggested potential anti-HBV activity. This approach may contribute to the improvement of our understanding of pathogenetic mechanisms involved in HBV infection and increase the possibility of its management and treatment.

Download Full-text

Obesity is associated with severe disease and mortality in patients with coronavirus disease 2019 (COVID-19): a meta-analysis

BMC Public Health ◽

10.1186/s12889-021-11546-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zixin Cai ◽

Yan Yang ◽

Jingjing Zhang

Keyword(s):

Mechanical Ventilation ◽

Fixed Effects ◽

Web Of Science ◽

Meta Analysis ◽

Severe Disease ◽

Cochrane Library ◽

Risk Of Infection ◽

Icu Admission ◽

Increased Risk ◽

Nonobese Patients

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to global research to predict those who are at greatest risk of developing severe disease and mortality. The aim of this meta-analysis was to determine the associations between obesity and the severity of and mortality due to COVID-19. Methods We searched the PubMed, EMBASE, Cochrane Library and Web of Science databases for studies evaluating the associations of obesity with COVID-19. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Meta-regression analyses were conducted to estimate regression coefficients. Results Forty-six studies involving 625,153 patients were included. Compared with nonobese patients, obese patients had a significantly increased risk of infection. (OR 2.73, 95% CI 1.53–4.87; I2 = 96.8%), hospitalization (OR 1.72, 95% CI 1.55–1.92; I2 = 47.4%), clinically severe disease (OR 3.81, 95% CI 1.97–7.35; I2 = 57.4%), mechanical ventilation (OR 1.66, 95% CI 1.42–1.94; I2 = 41.3%), intensive care unit (ICU) admission (OR 2.25, 95% CI 1.55–3.27; I2 = 71.5%), and mortality (OR 1.61, 95% CI 1.29–2.01; I2 = 83.1%). Conclusion Patients with obesity may have a greater risk of infection, hospitalization, clinically severe disease, mechanical ventilation, ICU admission, and mortality due to COVID-19. Therefore, it is important to increase awareness of these associations with obesity in COVID-19 patients.

Download Full-text

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

10.21203/rs.2.20240/v1 ◽

2020 ◽

Author(s):

Roohollah Sharifi ◽

Sajjad Jahedi ◽

Hamid Reza Mozaffari ◽

Mohammad Moslem Imani ◽

Masuod Sadeghi ◽

...

Keyword(s):

Dental Caries ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Control Group ◽

Case Group ◽

Caries Risk ◽

Increased Risk ◽

Dental Caries Susceptibility ◽

Review Manager

Abstract Background This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility.Methods We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software.Results A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group.Conclusions The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.

Download Full-text

Combined Effects of tDCS and Language/Cognitive Intervention on the Naming of Dementia Patients: A Systematic Review and Meta-Analysis

Iranian Journal of Public Health ◽

10.18502/ijph.v49i5.3199 ◽

2020 ◽

Author(s):

Haewon BYEON

Keyword(s):

Cognitive Training ◽

Literature Search ◽

Web Of Science ◽

Meta Analysis ◽

Cognitive Intervention ◽

Scientific Basis ◽

The Other ◽

Cochrane Library ◽

Combined Effects ◽

Dementia Patients

Background: The evidence of transcranial direct current stimulation (tDCS) treatment effects on dementia is still insufficient. This study aimed to prove the scientific basis of tDCS by conducting a meta-analysis of previous studies that examined the effects of tDCS on the naming of patients with dementia. Methods: The literature search was conducted for publications published from Jan 2000 to Jun 2019 using four academic databases (PubMed, Web of Science, MEDLINE, and Cochrane Library). This study found 129 publications by searching academic databases according to the PRISMA protocol. Among them, irrelevant studies were excluded, and finally, 4 studies were meta-analyzed. Results: The score of the quality assessment on five studies ranged from 21 to 26 points, rated good or better. Meta-analysis results, tDCS had no significant effect on the improvement of naming ability of dementia. On the other hand, the effect size of the tDCS intervention + language/cognitive training was significant ‘large effect (SMD=0.72, 95% CI: 0.05, 1.39)’. Conclusion: This combination of tDCS and language/cognitive training significantly improved the naming ability of dementia patients.

Download Full-text

Oral Complications of Chemotherapy on Paediatric Patients with Cancer: A Systematic Review and Meta-Analysis

Medical Sciences Forum ◽

10.3390/msf2021005025 ◽

2021 ◽

Vol 5 (1) ◽

pp. 25

Author(s):

Ana Sofia Alves ◽

Gunel Kizi ◽

Ana Raquel Barata ◽

Paulo Mascarenhas ◽

Irene Ventura

Keyword(s):

Systematic Review ◽

Incidence Rate ◽

Web Of Science ◽

Meta Analysis ◽

Paediatric Oncology ◽

Cochrane Library ◽

Patients With Cancer ◽

Search Results ◽

Oral Complications ◽

Paediatric Patients

The goal of cancer treatment is to fight and/or control cancer. The aim of this study was to review and meta-analyse the incidence of main oral complications in paediatric oncology during chemotherapy. The search results were obtained from B-on, Web of Science, Scopus, Cochrane Library and PubMed databases. Of 1032 articles potentially relevant, 13 were included in this review. The overall incidence of caries, gingivitis, ulcers, mucositis, and candidiasis was 67.8%, 55.6%, 44.2%, 41.6%, and, 29.5%, respectively. During chemotherapy, paediatric patients with cancer present higher incidence of caries and gingivitis. Incidence rate meta-analysis show high heterogeneity. More studies should be done to reduce uncertainty.

Download Full-text

COX-2 gene rs689466 polymorphisms associated with increased risk of colorectal cancer among Caucasians

10.21203/rs.3.rs-17753/v1 ◽

2020 ◽

Author(s):

Hui Zhao ◽

Chen Chen ◽

Mohammad Amzad Ali

Keyword(s):

Colorectal Cancer ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Case Control Studies ◽

Increased Risk ◽

Potential Case ◽

Cox 2 ◽

Stratified Analysis ◽

Strength Of Association

Abstract Background Several studies have reported the Cyclooxygenase 2 (COX-2) rs689466 polymorphism as a susceptibility locus of colorectal cancer (CRC), but their findings are inconsistent. Thus, this meta-analysis was performed to more accurately identify the effects of this polymorphism on CRC risk. Methods Potential case-control studies on EMBASE, Google of Scholar, Web of Science, Cochrane Library, and PubMed were searched. The strength of association was quantified by pooled odds ratio and 95% confidence interval. Totally 16 articles involving 8,998 cases and 11,917 controls were included. Results None of the five tested genetic models revealed any significant association between rs689466 polymorphism and CRC risk. Stratified analysis by ethnicity uncovered a significant association between this polymorphism and higher CRC risk in Caucasians, but not in Asians. In addition, we found high expression of COX-2 was associated with better overall survival for all CRC patients. Conclusion To sum up, the COX-2 rs689466 polymorphism may be related with susceptibility to CRC in Caucasians. This finding should be verified by larger-size studies with different ethnic groups.

Download Full-text

Systemic lupus erythematosus and risk of sexual dysfunction: A systematic review and Meta-Analysis

Lupus ◽

10.1177/0961203320974081 ◽

2020 ◽

pp. 096120332097408

Author(s):

Zhao Jin ◽

Cong Yang ◽

Chu Xiao ◽

Zizhen Wang ◽

Suxin Zhang ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Sexual Dysfunction ◽

Lupus Erythematosus ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Control Group ◽

Systemic Lupus ◽

Increased Risk

Objective To systematically review and summarize the available literature regarding the association between systemic lupus erythematosus (SLE) and sexual dysfunction (SD) in both sexes. Methods We retrieved relevant studies from the following databases: PubMed, Embase, Cochrane Library, and Web of Science. Two reviewers independently reviewed the studies in our sample, assessed their validity, and extracted relevant data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity. Results Our search resulted in a sample of eight eligible studies, which involved 758 patients in the SLE group and 1724 individuals in the control group. The pooled RR for the increased risk for SD compared to those in the control group was 1.80 (95%CI 1.12-2.87). Subgroup analysis by sex revealed that males (pooled RR = 2.98, 95%CI 2.41-3.68) had a higher risk of SD compared to females (pooled RR = 1.56, 95%CI 0.99-2.48). Females with SLE had significantly lower values in FSFI compared to the healthy individuals (WMD=-0.224, 95%CI -0.441 to -0.078). Age of participants and the quality of studies might influence the results. Conclusions Our meta-analysis suggests that SLE is significantly associated with an increased risk of sexual dysfunction. It is of great urgency to implement for active interventions that aimed to treat or prevent SD among SLE patients.

Download Full-text

Worldwide Incidence of Colorectal Cancer, Leukemia, and Lymphoma in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis

Gastroenterology Research and Practice ◽

10.1155/2016/1632439 ◽

2016 ◽

Vol 2016 ◽

pp. 1-18 ◽

Cited By ~ 7

Author(s):

Chelle L. Wheat ◽

Kindra Clark-Snustad ◽

Beth Devine ◽

David Grembowski ◽

Timothy A. Thornton ◽

...

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Inflammatory Bowel Disease ◽

Incidence Rate ◽

Bowel Disease ◽

Meta Analysis ◽

Cochrane Library ◽

Increased Risk ◽

Inflammatory Bowel ◽

Substantial Heterogeneity

Background/Aims. Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC). In addition, there may be an association between leukemia and lymphoma and IBD. We conducted a systematic review and meta-analysis of the IBD literature to estimate the incidence of CRC, leukemia, and lymphoma in adult IBD patients.Methods. Studies were identified by a literature search of PubMed, Cochrane Library, Medline, Web of Science, Scopus, EMBASE, and ProQuest Dissertations and Theses. Pooled incidence rates (per 100,000 person-years [py]) were calculated through use of a random effects model, unless substantial heterogeneity prevented pooling of estimates. Several stratified analyses and metaregression were performed to explore potential study heterogeneity and bias.Results. Thirty-six articles fulfilled the inclusion criteria. For CRC, the pooled incidence rate in CD was 53.3/100,000 py (95% CI 46.3–60.3/100,000). The incidence of leukemia was 1.5/100,000 py (95% CI −0.06–3.0/100,000) in IBD, 0.3/100,000 py (95% CI −1.0–1.6/100,000) in CD, and 13.0/100,000 py (95% CI 5.8–20.3/100,000) in UC. For lymphoma, the pooled incidence rate in CD was 0.8/100,000 py (95% CI −0.4–2.1/100,000). Substantial heterogeneity prevented the pooling of other incidence estimates.Conclusion. The incidence of CRC, leukemia, and lymphoma in IBD is low.

Download Full-text

Height and Risk of Hip Fracture: A Meta-Analysis of Prospective Cohort Studies

BioMed Research International ◽

10.1155/2016/2480693 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8

Author(s):

Zhihong Xiao ◽

Dong Ren ◽

Wei Feng ◽

Yan Chen ◽

Wusheng Kan ◽

...

Keyword(s):

Hip Fracture ◽

Cohort Studies ◽

Prospective Cohort ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Response Analysis ◽

Prospective Cohort Studies ◽

Increased Risk ◽

The Cochrane Library

The association between height and risk of hip fracture has been investigated in several studies, but the evidence is inconclusive. We therefore conducted this meta-analysis of prospective cohort studies to explore whether an association exists between height and risk of hip fracture. We searched PubMed and EMBASE, Web of Science, and the Cochrane Library for studies of height and risk of hip fracture up to February 16, 2016. The random-effects model was used to combine results from individual studies. Seven prospective cohort studies, with 7,478 incident hip fracture cases and 907,913 participants, were included for analysis. The pooled relative risk (RR) was 1.65 (95% confidence interval (CI): 1.26–2.16) comparing the highest with the lowest category of height. Result from dose-response analysis suggested a linear association between height and hip fracture risk (P-nonlinearity = 0.0378). The present evidence suggests that height is positively associated with increased risk of hip fracture. Further well-designed cohort studies are needed to confirm the present findings in other ethnicities.

Download Full-text

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

10.21203/rs.2.20240/v3 ◽

2020 ◽

Author(s):

Roohollah Sharifi ◽

Sajjad Jahedi ◽

Hamid Reza Mozaffari ◽

Mohammad Moslem Imani ◽

Masuod Sadeghi ◽

...

Keyword(s):

Dental Caries ◽

Web Of Science ◽

Meta Analysis ◽

Cochrane Library ◽

Control Group ◽

Case Group ◽

Caries Risk ◽

Increased Risk ◽

Dental Caries Susceptibility ◽

Review Manager

Abstract Background: This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility. Methods: We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software. Results: A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group. Conclusions: The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.

Download Full-text