scholarly journals Oral Complications of Chemotherapy on Paediatric Patients with Cancer: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 5 (1) ◽  
pp. 25
Author(s):  
Ana Sofia Alves ◽  
Gunel Kizi ◽  
Ana Raquel Barata ◽  
Paulo Mascarenhas ◽  
Irene Ventura
Keyword(s):  
Systematic Review ◽  
Incidence Rate ◽  
Web Of Science ◽  
Meta Analysis ◽  
Paediatric Oncology ◽  
Cochrane Library ◽  
Patients With Cancer ◽  
Search Results ◽  
Oral Complications ◽  
Paediatric Patients

The goal of cancer treatment is to fight and/or control cancer. The aim of this study was to review and meta-analyse the incidence of main oral complications in paediatric oncology during chemotherapy. The search results were obtained from B-on, Web of Science, Scopus, Cochrane Library and PubMed databases. Of 1032 articles potentially relevant, 13 were included in this review. The overall incidence of caries, gingivitis, ulcers, mucositis, and candidiasis was 67.8%, 55.6%, 44.2%, 41.6%, and, 29.5%, respectively. During chemotherapy, paediatric patients with cancer present higher incidence of caries and gingivitis. Incidence rate meta-analysis show high heterogeneity. More studies should be done to reduce uncertainty.

scholarly journals Cytomegalovirus seroprevalence among blood donors: a systematic review and meta-analysis

2021 ◽  
Vol 49 (8) ◽  
pp. 030006052110346
Author(s):  
Tiruneh Adane ◽  
Solomon Getawa
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Blood Donors ◽  
Web Of Science ◽  
Meta Analysis ◽  
Google Scholar ◽  
Cochrane Library ◽  
Blood Products ◽  
Specific Antibodies

Background Screening for cytomegalovirus (CMV)-specific antibodies is not routine in some settings. Thus, transfusion of blood products poses risks for susceptible individuals. Objectives To investigate the global pooled CMV seroprevalence among volunteer blood donors. Methods This systematic review and meta-analysis was performed according to PRISMA guidelines. The databases searched included Embase, Google Scholar, Medline, PubMed, Web of Science, and Cochrane Library. Data were extracted independently and analyzed using STATA version 11. Results The global seroprevalence of CMV IgG, CMV IgM, and both CMV IgM and IgG was 83.16% (95% confidence interval [CI]: 78.55–87.77%, I2 = 99.5%), 13.77% (95% CI: 11.59–15.95%, I2 = 98.8%), and 23.78% (95% CI: 10.50–37.06%, I2 = 98.7), respectively. Conclusion The global seroprevalence of CMV was high among blood donors. Therefore, regular CMV screening should be conducted to identify CMV-seronegative blood donors.

Lower Income Levels Correlate With Increased Prevalence of Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis

2021 ◽  
Author(s):  
Qiong He ◽  
Mengyuan Zhang ◽  
Yongle Wang ◽  
Jin Zhang ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gestational Diabetes ◽  
Low Income ◽  
Web Of Science ◽  
Meta Analysis ◽  
Income Level ◽  
Cochrane Library ◽  
Lower Income ◽  
Middle Income ◽  
Income Levels

Abstract BackgroundIncome level is an important factor that influences the occurrence of gestational diabetes. Thus, this systematic review and network meta-analysis aimed at evaluating the correlation between income levels and the prevalence of gestational diabetes. MethodsRelevant published studies were searched in Pubmed, Web of Science, Cochrane library, and Ovid from the establishment time of database to January 3, 2020. Finally, 13 eligible clinical studies involving 1,817,801 women were selected from a total of 3776 studies and included in this study. The statistical softwares Revman5.3 and Stata14.0 were used to compare the prevalence of gestational diabetes in five different income levels; low, lower middle, medium, upper middle, and high. ResultsThe incidences of gestational diabetes in people with different economic income levels were: high income <middle income <upper middle income <lower middle income <low income. ConclusionThere is no linear correlation between income levels and incidences of gestational diabetes. However, the overall prevalence of gestational diabetes is inversely proportional to income level, that is, the higher the income level, the lower the prevalence of gestational diabetes.

scholarly journals Outcomes of Macrosurgical Versus Microsurgical Vasovasostomy in Vasectomized Men: a Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
M. Duijn ◽  
J. A. van der Zee ◽  
Y. Bachour
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Meta Analysis ◽  
Descriptive Analysis ◽  
Pregnancy Rates ◽  
Primary Data ◽  
Cochrane Library ◽  
Microscopical Technique ◽  
Vasectomy Reversal ◽  
The Cochrane Library

AbstractIn order to restore fertility by vasectomy reversal, vasovasostomy (VV) is one of the most chosen options. During this procedure, the vas deferens is anastomosed either by a macro- or microscopical technique. Up to date, it is unknown which of these techniques shows best overall post-procedure patency and pregnancy rates. The purpose of this systematic review and meta-analysis is to reach a consensus on which technique is best for vasovasostomy and thereby better counsel patients and practitioners. A systematic review and meta-analysis on macroscopic and microscopic VV for vasectomy reversal was performed. PubMed, The Cochrane Library, Embase, and Web of Science were systematically searched from inception until 2019. Studies and associated data were evaluated by two reviewers. Primary, data on post-operative patency and pregnancy rates, interval to reversal, and post-operative complications were extracted. Proportions (95% CI) and heterogeneity scores (I2) were calculated, using a random effects model. A total of 8305 patients were included by 25 studies. Descriptive analysis showed higher post-operative patency (80.5% vs 91.4%) and pregnancy rates (47.7% vs 73.3%) after microscopic vasovasostomy. Meta-analysis produced post-operative patency proportions of 0.80 (95% CI, 0.76–0.84) and 0.88 (95% CI, 0.83–0.92) after macro- and microscopic VV respectively. Proportions of post-operative pregnancy were 0.43 (95% CI, 0.35–0.50) after macroscopic VV and 0.47 (95% CI, 0.31–0.62) after microsurgical VV. Microscopic VV is associated with higher post-operative patency and pregnancy rates compared to macroscopic vasovasostomy. However, further research is needed because of shortage in high methodological quality and variety.

scholarly journals Efficacy of four hollow nail rhombic fixation for the treatment of patients with femoral neck fractures: A protocol of systematic review and meta-analysis

2020 ◽  
Author(s):  
Qing-hui Ji ◽  
Yu Xue ◽  
Jie Miao ◽  
Zhi-xin Reng ◽  
Yu-fei Yuan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Femoral Neck ◽  
Web Of Science ◽  
Meta Analysis ◽  
Femoral Neck Fractures ◽  
Cochrane Library ◽  
Publication Date ◽  
Study Quality ◽  
Efficacy And Safety ◽  
Randomized Controlled

Abstract Background : This study aims to assess the efficacy of four hollow nail rhombic fixation (FHNRF) for the treatment of patients with femoral neck fractures (FNF). Methods : A literature search in MEDLINE, Scopus, Web of Science, EMBASE, Cochrane Library, ProQuest, Thesis and Dissertation Catalog, Cumulative Index to Nursing and Allied Health Literature, and China National Knowledge In­frastructure will be performed from inception through February 29, 2020. This study will not apply limitations to the language and publication date. All potential randomized controlled trials (RCTs) that identify the efficacy and safety of FHNRF for the treatment of patients with FNF. Two contributors will separately examine searched records, extract essential data, and assess study quality using Cochrane risk of bias tool. Any opposition between two authors will be settled by a third contributor. We will employ RevMan 5.3 software for statistical analysis. Discussion : This study will summarize high quality RCTs to assess the efficacy and safety of FHNRF for the treatment of patients with FNF. It will help to determine whether or not FHNRF is effective and safety for the treatment of patients with FNF. Systematic review registration CRD42020168378.

scholarly journals Cardiac Arrhythmias in Patients with COVID-19: A Systematic review and Meta-analysis

2020 ◽  
Author(s):  
Omar Hamam ◽  
Ahmed Goda ◽  
Moustafa Eldalal ◽  
Amr Ussama ◽  
Mostafa Fahmy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Cardiac Arrhythmia ◽  
Cardiac Arrhythmias ◽  
Early Identification ◽  
Web Of Science ◽  
Meta Analysis ◽  
Great Influence ◽  
Cochrane Library ◽  
Significant Heterogeneity

Background: Cardiac arrhythmia cannot be overlooked in patients with coronavirus disease 2019 (COVID-19) as it carries a great influence on the outcomes. Hence, this study aimed to build concrete evidence regarding the incidence of cardiac arrhythmia in patients with COVID-19. Methods: We performed a systematic search for trusted databases/search engines including PubMed, Scopus, Cochrane library and web of science. After screening, the relevant data were extracted and the incidences from the different included studies were pooled for meta-analysis. Results: Nine studies were finally included in our study consisting of 1445 patients. The results of meta-analysis showed that the incidence of arrhythmia in patients with COVID-19 was 19.7% with 95% confidence interval (CI) ranging from 11.7 to 27.6%. There was also a significant heterogeneity (I2 = 94.67%). Conclusion: Cardiac arrhythmias were highly frequent in patients with COVID-19 and observed in 19.7% of them. Appropriate monitoring by electrocardiogram with accurate and early identification of arrhythmias is important for better management and outcomes.

scholarly journals A Systematic Review and Meta-Analysis of Burnout Among Healthcare Workers During COVID-19

2021 ◽  
Vol 12 ◽  
Author(s):  
Sulmaz Ghahramani ◽  
Kamran Bagheri Lankarani ◽  
Mohammad Yousefi ◽  
Keyvan Heydari ◽  
Saeed Shahabi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Healthcare Workers ◽  
English Language ◽  
Web Of Science ◽  
Meta Analysis ◽  
Personal Accomplishment ◽  
Healthcare Personnel ◽  
Cochrane Library ◽  
Middle Income ◽  
Middle Income Countries

Burnout among healthcare personnel has been exacerbated by the COVID-19 pandemic's unique features. During the COVID-19 pandemic, this systematic review and meta-analysis aims to provide a complete assessment of the prevalence of burnout across various healthcare personnel. Until January 2021, systematic searches for English language papers were conducted using PubMed, Scopus, EMBASE, Web of Science, Cochrane Library, and ProQuest. Thirty observational studies were found after conducting systematic searches. The pooled overall prevalence of burnout was 52% [95% confidence interval (CI) 40–63%]. Pooled emotional exhaustion (EE), depersonalization (DP), and lack of personal accomplishment (PA) were 51% (95% CI 42–61%), 52% (95% CI 39–65%), and 28% (95% CI 25–31%), respectively. This study demonstrated that nearly half of the healthcare workers experienced burnout during the COVID-19 pandemic. In the studies that were included, non-frontline COVID-19 exposed healthcare personnel also experienced burnout. From high to lower middle-income countries, there was a gradient in the prevalence of total burnout, EE, and lack of PA. Further studies on burnout in low and lower-middle-income countries are suggested. A uniform diagnostic tool for the assessment of burnout is warranted.

scholarly journals The Prevalence of Musculoskeletal Disorders among Miners around the World: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Hadiseh Rabiei ◽  
Mahdi Malakoutikhah ◽  
Mohammad Hossein Vaziri ◽  
Ali Salehi Sahlabadi
Keyword(s):  
Systematic Review ◽  
Musculoskeletal Disorders ◽  
Web Of Science ◽  
Meta Analysis ◽  
Significant Problem ◽  
Statistical Software ◽  
Analysis Study ◽  
Search Results ◽  
The World

Background: Musculoskeletal disorders are responsible for significant problem for workers' health. The present study aimed to investigate the prevalence of musculoskeletal disorders among mining workers. Methods: This systematic review and meta-analysis study were designed in 2020 (from Jan to Mar). The researchers searched five international databases Medline/PubMed, ProQuest, Scopus, Embase and Web of Science. All analyzes were performed using STATA statistical software. Results: The search results were 447 articles and after screening stage finally 50 studies were included in review. The highest number of studies (26 studies) reported the prevalence of musculoskeletal disorders of upper back and 4 studies reported the prevalence of musculoskeletal disorders of the arms and ankles & feet. The results of meta-analysis based on prevalence in different organs showed that the highest prevalence of musculoskeletal disorders was in the upper back and the lowest in the knees with a prevalence of 50.39% (CI 95%: 31.23- 54.73%) and 16.03% (CI 95%: 11.78-20.28%), respectively. Conclusion: The prevalence of musculoskeletal disorders among miners is relatively high. Therefore, supervisors and mine managers should pay more attention to reducing musculoskeletal disorders and increasing the ergonomic level of mines in order to increase workers' health.

scholarly journals Association of UGT1A1*6 polymorphism with irinotecan-based chemotherapy reaction in colorectal cancer patients: a systematic review and a meta-analysis

2020 ◽  
Vol 40 (10) ◽  
Author(s):  
Xiaoyun Zhu ◽  
Ruchao Ma ◽  
Xin Ma ◽  
Gang Yang
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Lower Risk ◽  
Web Of Science ◽  
Late Onset ◽  
Meta Analysis ◽  
Cochrane Library ◽  
The World ◽  
Colorectal Cancer Patients ◽  
Allele Model

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related deaths across the world. Irinotecan (IRI) is commonly used to treat CRC, and IRI-based chemotherapy is linked with adverse reaction and the efficacy of the treatment regimen. The gene UGT1A1 plays a central role in the IRI metabolic pathway. A polymorphism UGT1A1*6 has been widely researched which may be related to response of IRI-based chemotherapy in CRC. All relevant studies were strictly searched from PubMed, Embase, Cochrane Library and Web of Science databases to explore the associations between UGT1A1*6 and response of IRI-based chemotherapy with CRC. Nine articles comprising 1652 patients were included in the final combination. Meta-analysis showed G allele or GG had a lower risk of severe late-onset diarrhea compared with A/AA in allele model and homozygote model (G vs. A: OR = 0.53, 95% CI: 0.28–0.99, P=0.05; GG vs. AA: OR = 0.48, 95% CI: 0.23–0.99, P=0.05), no significant association was observed in other models. In addition, a significant association between UGT1A1*6 and neutropenia was observed in all models (G vs. A: OR = 0.57, 95% CI: 0.46–0.71, P=0.00; GG vs. AA: OR = 0.28, 95% CI: 0.17–0.45, P=0.01; GA vs. AA: OR = 0.42, 95% CI: 0.26–0.70, P=0.00; GG+GA vs. AA: OR = 0.32, 95% CI: 0.20–0.52, P=0.00; GG vs. AA+GA: OR = 0.40, 95% CI: 0.22–0.71, P=0.00), whereas, no relationship was found between UGT1A1*6 and clinical response among the different genotypes. UGT1A1*6 may be considered as a biomarker for IRI-based chemotherapy in CRC.

Diagnostic value of RNA for hepatocellular carcinoma: a network meta-analysis

2021 ◽  
Author(s):  
Zhuo Han ◽  
Keming Li ◽  
Jinyu Wu ◽  
Keyan Wang ◽  
Cuipeng Qiu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Noncoding Rna ◽  
Web Of Science ◽  
Meta Analysis ◽  
Circular Rna ◽  
Diagnostic Value ◽  
Cochrane Library ◽  
Retrieval Strategy ◽  
Diagnostic Efficacy

Aim: The aim of this study was to evaluate the capacity of RNA in the diagnosis of hepatocellular carcinoma (HCC). Methods: A systematic review was conducted from PubMed, Cochrane Library, EMBASE and Web of Science databases via well-designed retrieval strategy. Subsequently, the network meta-analysis was performed by the STATA software. Results: Through statistical analysis, the three hypotheses of the network meta-analysis were established. In view of these hypotheses, the diagnostic efficacy of the three markers in HCC (HCC vs healthy people) may be consistent, and the cumulative ranking results showed such a trend: circular RNA >long noncoding RNA >microRNA. Conclusion: Circular RNA may be most effective for diagnosing HCC across the three types of RNA.

scholarly journals Predictive and Prognostic Role of PD-L1 in Urothelial Carcinoma Patients with Anti-PD-1/PD-L1 Therapy: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Haoran Liu ◽  
Tao Ye ◽  
Xiaoqi Yang ◽  
Peng Lv ◽  
Xiaoliang Wu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urothelial Carcinoma ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Platinum Based Chemotherapy ◽  
Predictive And Prognostic Biomarker ◽  
The Cochrane Library ◽  
Predictive And Prognostic Value

Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma (UC). To evaluate the predictive and prognostic value of PD-L1 on response and survival in UC patients after cystectomy, chemotherapy, or anti-PD-1/PD-L1 therapy, a systematic review of PubMed, Embase, Web of Science, and the Cochrane Library was performed. A total of 2154 patients from 14 published studies were included. In all UC patients after cystectomy, tumour cell (TC) PD-L1 expression was not associated with the OS or PFS. For the subset of patients with organ-confined disease, TC PD-L1 expression significantly predicted OS after cystectomy (P=0.0004). There was no significant evidence of an association between TC PD-L1 status and ORR or OS for UC patients treated with platinum-based chemotherapy. For UC patients treated with anti-PD-1/PD-L1 therapy, TC PD-L1 expression≥5% could predict the response (P=0.005), but not for the 1% cut-off (P≥0.05). As for PD-L1 expression in tumour-inflating immune cells (TIICs), both subsets with IC2/3 vs. IC0/1 and IC1/2/3 vs. IC0 were associated with ORR to anti-PD-1/PD-L1 therapy. In the TIIC subset, IC2/3 vs. IC0/1 of PD-L1 was associated with higher CR (P=0.002), PR (P=0.04), and PD (P=0.007). Further, higher TIIC PD-L1 status benefited from longer PFS (P<0.001), but was not associated with OS in UC patients with anti-PD-1/PD-L1 therapy. Our study suggested that TIIC PD-L1 expression with 5% cut-off was valuable as a predictive and prognostic biomarker for ORR and PFS in UC patients with anti-PD-1/PD-L1 therapy.

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