scholarly journals Prealbumin/CRP Based Prognostic Score, a New Tool for Predicting Metastasis in Patients with Inoperable Gastric Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Ali Esfahani ◽  
Nima Makhdami ◽  
Elnaz Faramarzi ◽  
Mohammad Asghari Jafarabadi ◽  
Alireza Ostadrahimi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Nutritional Status ◽  
Global Assessment ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Survival Duration ◽  
Subjective Global Assessment ◽  
Future Studies ◽  
Gastric Cancer Patients ◽  
Larger Sample

Background.There is a considerable dissimilarity in the survival duration of the patients with gastric cancer. We aimed to assess the systemic inflammatory response (SIR) and nutritional status of these patients before the commencement of chemotherapy to find the appropriate prognostic factors and define a new score for predicting metastasis.Methods.SIR was assessed using Glasgow Prognostic Score (GPS). Then a score was defined as prealbumin/CRP based prognostic score (PCPS) to be compared with GPS for predicting metastasis and nutritional status.Results.71 patients with gastric cancer were recruited in the study. 87% of patients had malnutrition. There was a statistical difference between those with metastatic (n=43) and those with nonmetastatic (n=28) gastric cancer according to levels of prealbumin and CRP; however they were not different regarding patient generated subjective global assessment (PG-SGA) and GPS. The best cut-off value for prealbumin was determined at 0.20 mg/dL and PCPS could predict metastasis with 76.5% sensitivity, 63.6% specificity, and 71.4% accuracy. Metastatic and nonmetastatic gastric cancer patients were different in terms of PCPS (P=0.005).Conclusion.PCPS has been suggested for predicting metastasis in patients with gastric cancer. Future studies with larger sample size have been warranted.

Patient-generated subjective global assessment versus nutritional risk screening 2002 for gastric cancer in Chinese patients

2020 ◽  
Vol 16 (3) ◽  
pp. 4475-4483 ◽  
Author(s):  
Dong Yang ◽  
Zhichao Zheng ◽  
Yan Zhao ◽  
Tao Zhang ◽  
Yong Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Global Assessment ◽  
Nutritional Risk ◽  
Subjective Global Assessment ◽  
Pyloric Obstruction ◽  
Gastric Cancer Patients ◽  
Nutritional Risk Screening 2002 ◽  
Nutritional Risk Screening

Aim: Patient-Generated Subjective Global Assessment (PG-SGA) and Nutritional Risk Screening 2002 (NRS2002) are used to evaluate patients’ nutritional status. Materials & methods: The data of 114 gastric cancer patients with pyloric obstruction treated between July 2016 and July 2017 were assessed retrospectively. Results: Based on clinical evaluation, 70.1% had malnutrition, with 61.4% at nutritional risk by NRS2002 and 66.7% by PG-SGA. The area under the receiver operating characteristic curve was 0.858 for PG-SGA and 0.706 for NRS2002. Sensitivity and specificity were 89 and 85% for PG-SGA and 78 and 76% for NRS2002. In both assessments, patients at risk showed more postoperative complications. Conclusion: PG-SGA was more suitable for evaluating the preoperative nutritional status of gastric cancer patients with pyloric obstruction, with higher diagnostic efficacy.

Prognostic value of modified Glasgow Prognostic Score (mGPS) and neutrophil-lymphocyte ration (NLR) after curative resection for gastric cancer.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 295-295
Author(s):  
Yusuke Shimodaira ◽  
Sachie Koike ◽  
Yusuke Takahashi ◽  
Masao Okada ◽  
Kaori Hayashibara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Curative Resection ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Rank Test ◽  
Independent Predictive Factor ◽  
Gastric Cancer Patients

295 Background: Several biomarkers based on serum chemistry have been reported to be associated with the prognosis of several types of cancers. This retrospective study aimed to investigate the prognostic value of preoperative mGPS and NLR after curative resection for gastric cancer. Methods: A total of 295 patients who underwent curative gastrectomy for primary gastric cancer at our institution from January 2013 to December 2017 were enrolled in this study. The mGPS was calculated by CRP and Alb using standard thresholds ( > 0.5 mg/dL for CRP and < 3.5 g/dL for Alb). The NLR was defined as absolute neutrophil count divided by absolute lymphocyte count. The survival curves of patients stratified by each parameter were plotted by the Kaplan-Meier method and compared by log-rank test. Multivariate Cox proportional hazards regression models were used to select parameters independently correlated with prognosis. Results: The median follow-up time was 36.7 months, and 29 patients died during follow-up. The estimated 5-year survival rate was 83.1%. Results from the univariate analyses showed mGPS2 (CRP > 0.5 mg/dL and Alb < 3.5 g/dL) was associated with poor survival while NLR and NLRc was not (P < 0.001, P = 0.506, and P = 0.423, respectively). In the multivariate analyses, the mGPS2 was identified as an independent predictive factor for OS in gastric cancer patients after curative resection (HR: 2.624; 95% CI: 1.058-6.505; P = 0.037). Conclusions: Preoperative mGPS2 was associated with worse survival after curative resection of gastric cancer patients. Based on our study, those with mPGS2 may be warranted to receive additional therapy or nutritional support to acquire better survival.

Nutritional status and quality of life in patients with gastric cancer in China.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15508-e15508
Author(s):  
Hongli Li ◽  
Shaohua Ge ◽  
Yi Ba
Keyword(s):  
Quality Of Life ◽  
Gastric Cancer ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Assessment Tool ◽  
Subjective Global Assessment ◽  
Preliminary Assessment ◽  
European Organization ◽  
Gastric Cancer Patients

e15508 Background: The incidence of gastric cancer is much higher in China than in any other country. Although the overall survival rate of patients with gastric cancer has increased due to the advancements in multimodality management. However, significant morbidity, including loss of appetite, dysphagia, nausea, and vomiting is still associated with gastric cancer patients. These symptoms have a profound impact on nutritional status and quality of life in these patients. The primary objective of the present study was to assess the nutritional status and quality of life in gastric cancer patients. Methods: A preliminary assessment of patients’ nutritional status, quality of life, and medical characteristics was conducted using the Patient Generated Subjective Global Assessment (PG-SGA) and the European Organization for Research and Treatment of Cancer quality of life (QOL-C30, version 3) questionnaires. The PG-SGA is a clinical nutrition assessment tool used to evaluate oncology patients. The nutritional status of the patients fell into three groups by a score of PG-SGA-A, -B, and C. Results: A preliminary assessment of patients’ nutritional status, quality of life, and medical characteristics was conducted using the Patient Generated Subjective Global Assessment (PG-SGA) and the European Organization for Research and Treatment of Cancer quality of life (QOL-C30, version 3) questionnaires. The PG-SGA is a clinical nutrition assessment tool used to evaluate oncology patients. The nutritional status of the patients fell into three groups by a score of PG-SGA-A, -B, and C. Conclusions: These results suggest that the nutritional status of the patients with stomach cancer may impact on their QoL. It is necessary to develop nutritional intervention to improve QoL in gastric cancer patients.

scholarly journals Relationship between nutritional biomarkers and occlusal status in gastric cancer patients using the Eichner Index: A cross sectional study

2020 ◽  
Author(s):  
Atsushi Abe ◽  
Yu Ito ◽  
Hiroki Hayashi ◽  
Takanori Ishihama ◽  
Eri Umemura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Nutritional Status ◽  
Inflammatory Responses ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Dietary Counseling ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
The Mean ◽  
Class C

Abstract Background Systemic inflammatory responses and nutritional status are useful prognostic factors in patients with gastric cancer. Because oral hypofunction is a cause of undernutrition, we cross-sectionally investigated whether some nutritional biomarkers were affected by occlusal supporting zone status. Methods The study included 114 patients (85 men and 29 women) diagnosed with gastric cancer at Nagoya Ekisaikai Hospital between September 2014 and March 2019. Gastric cancer stage, body mass index (BMI), albumin levels, total lymphocyte counts, cholesterol levels, and C-reactive protein levels were evaluated in preoperative blood tests. Four kinds of nutritional biomarkers were evaluated; they are the Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio (NLR), prognostic nutrition index (PNI), and controlling nutritional status (CONUT). Oral conditions were assessed by determining the number of remaining teeth, occlusal supporting status based on the Eichner classification. Patients were assigned into three groups per their occlusal status, and mean values were compared using the Kruskal-Wallis test. Results The mean age and BMI were 72.2 ± 8.5 (50–89) years and 22.0 ± 3.6 (14.8–33.4), respectively. There were here were 42, 39, 23, and 10 stages I, II, III, and IV patients, respectively. The mean number of remaining teeth was 18.1 ± 9.5 teeth. According to the Eichner classification, there were 45, 42, and 27 patients in groups A, B, and C, respectively. There were significant differences in the GPS and NLR values, and CONUT frequencies between groups A and C (P = 0.033, P = 0.00097, P = 0.04, respectively) (Mann-Whitney U test). PNI values were lower in Group C with poor occlusal support zones than in Group A with stable occlusal support zones. Conclusions Reductions in occlusal supporting zones were associated with undernutrition. Notably, patients in Eichner Class C with few occlusal supporting zones had poor GPS, PNI, and CONUT values, and were found to be undernourished. Thus, patients with markedly reduced occlusal contacts are often undernourished and have advanced systemic inflammation, which may affect prognosis. Patients in the Eichner Class C group need interventions to improve nutritional status such as dietary counseling due to potential nutritional deficits experienced by this group of patients.

scholarly journals The importance of dysphagia screening and nutritional assessment in hospitalized patients

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Patrícia Amaro Andrade ◽  
Carolina Araújo dos Santos ◽  
Heloísa Helena Firmino ◽  
Carla de Oliveira Barbosa Rosa
Keyword(s):  
Nutritional Status ◽  
Global Assessment ◽  
Assessment Tool ◽  
Nutritional Assessment ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
The Body ◽  
Subjective Global Assessment ◽  
Cross Sectional ◽  
Knee Height

ABSTRACT Objective: To determine frequency of dysphagia risk and associated factors in hospitalized patients as well as to evaluate nutritional status by using different methods and correlate the status with scores of the Eating Assessment Tool (EAT-10). Methods: This was a cross-sectional study including 909 inpatients of a philanthropic hospital. For the diagnosis of dysphagia we used an adapted and validated Brazilian version of the Eating Assessment Tool (EAT-10). The nutritional status was evaluated through the subjective global assessment, and anthropometric measurements included weight, calf and arm circumference, and knee height. The Mann-Whitney test, associations using the Pearson’s χ2 and Spearman’s correlation were used to verify differences between the groups. Results: The prevalence of dysphagia risk was 10.5%, and aging was the associated factor with this condition. Patients at risk presented lower values of arm and calf circumference, variables that correlated inversely with the Eating Assessment Tool (EAT-10) score. Malnutrition was observed in 13.2% of patients based on the subjective global assessment and in 15.2% based on the Body Mass Index. Conclusion: Screening for dysphagia and malnutrition should be introduced in hospitals routine to avoid or minimize damages caused by dysphagia or malnutrition, especially among older people.

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