scholarly journals The Significance of Ultrasound in Determining Whether SHPT Patients Are Sensitive to Calcitriol Treatment

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Xing-xin Liang ◽  
Fan Li ◽  
Feng Gao ◽  
Chun-xiao Li ◽  
Xiao-hui Qiao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Elastic Modulus ◽  
Maximum Intensity ◽  
Parathyroid Glands ◽  
Ultrasound Images ◽  
Relative Maximum ◽  
Size Number ◽  
Accurate Definition ◽  
Definition Of ◽  
Susceptible Group

This study was to explore the significance of ultrasound in determining whether the patients with secondary hyperparathyroidism (SHPT) are sensitive to calcitriol treatment. According to the decrease value of parathyroid hormone (PTH), 42 SHPT patients were divided into two groups: drug susceptible group and drug insusceptible group. These 42 SHPT patients’ ultrasound images were retrospectively analyzed. The morphology, size, number, blood flow, elastic modulus, and perfusion of the parathyroid glands were correlated with drug therapeutic outcome (oral calcitriol). Most SHPT patients with drug susceptible showed volume <438.50 mm3and number ≤2, with 0-1 structural and vascular patterns, associated with Relative Maximum Intensity (RIMAX) <1.59 and elastic modulus <18.8 kPa, whereas most SHPT patients with drug insusceptible showed volume ≥438.50 mm3and number ≥3, with 2-3 structural and vascular patterns, associated with Relative Maximum Intensity (RIMAX) ≥1.59 and elastic modulus ≥18.8 kPa. Therefore, ultrasonography in SHPT allows an accurate definition of the morphology, size, number, blood flow, elastic modulus, and perfusion of the parathyroid glands and is useful in determining whether SHPT patients are sensitive to calcitriol treatment.

Resolution and measurement in the scanning electron microscope

1987 ◽  
Vol 45 ◽  
pp. 534-537 ◽  
Author(s):  
Michael T. Postek
Keyword(s):  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Engineering Design ◽  
Resolving Power ◽  
Practical Applications ◽  
Instrument Resolution ◽  
Accurate Definition ◽  
Definition Of ◽  
Scanning Electron ◽  
Better Than

The term ultimate resolution or resolving power is the very best performance that can be obtained from a scanning electron microscope (SEM) given the optimum instrumental conditions and sample. However, as it relates to SEM users, the conventional definitions of this figure are ambiguous. The numbers quoted for the resolution of an instrument are not only theoretically derived, but are also verified through the direct measurement of images on micrographs. However, the samples commonly used for this purpose are specifically optimized for the measurement of instrument resolution and are most often not typical of the sample used in practical applications.SEM RESOLUTION. Some instruments resolve better than others either due to engineering design or other reasons. There is no definitively accurate definition of how to quantify instrument resolution and its measurement in the SEM.

Dasein, personeidad, intersubjetividad y persona-núcleo. El sujeto relacional después de Heidegger, en Zubiri, Apel y Polo. Dasein, Personhood, Inter-subjectivity and Nucleus-Person. The Relational Subject after Heidegger, in Zubiri, Apel and Polo

2017 ◽  
Author(s):  
Carlos Ortiz de Landázuri
Keyword(s):  
Heuristic Strategies ◽  
Accurate Definition ◽  
Being There ◽  
Definition Of

Heidegger, Zubiri, Apel y Polo habrían propuesto una definición más correcta de las respectivas nociones de sujeto relacional humano, a saber: “Dasein” o “ser-ahí”; “personeidad” o “esencia abierta”; “intersubjetividad” o “la llamada por parte de los entes a diversos interlocutores”; y, finalmente, “persona-núcleo” o “agente mediador entre los entes y el ser”. Se pretendía así evitar una vuelta a las paradojas del “sujeto transcendental” en Kant, del “yo absoluto” en Hegel o del “sujeto fenomenológico” en Husserl. Sin embargo en cada caso se siguieron estrategias heurísticas específicamente distintas a la hora de conceptualizar dicho sujeto relacional: Heidegger propuso una superación de la noción de “sujeto fenomenológico” en Husserl; Zubiri, en cambio, defendería una recuperación de la noción de “sujeto fenomenológico” en Husserl; por su parte, Apel propondría una reformulación semióticamente transformada del “Dasein” heideggeriano; finalmente, Polo propondría una reformulación gnoseológica de la noción de “Dasein” heideggeriano.Heidegger, Zubiri, Apel, and Polo have proposed a more accurate definition of the respective notions of human relational subject: “Dasein” or “being-there”; “Personhood” or “open essence”; “inter-subjectivity” or “entities’ appeal to diverse interlocutors”; and, finally, “nucleus-person” or “mediator between entities and being”. The aim is to avoid a return to Kant’s transcendental subject paradoxes and Hegel’s “absolute I” or Husserl´s “fenomenological subject”. But in each case specifically different heuristic strategies were followed when conceptualizing said relational subject: Heidegger proposed overcoming the notion of “phenomenological subject” in Husserl; Zubiri, however, defend the recovery of the notion of “phenomenological subject” in Husserl; meanwhile, Apel propose a transformed semiotically reformulation of Heidegger’s “Dasein”; finally, Polo propose a reformulation of the epistemological notion of Heidegger’s “Dasein”.

scholarly journals Advancing UK Regulatory Science Strategy in the Context of Global Regulation: a Stakeholder Survey

2021 ◽  
Author(s):  
Samantha Cruz Rivera ◽  
Barbara Torlinska ◽  
Eliot Marston ◽  
Alastair K. Denniston ◽  
Kathy Oliver ◽  
...  
Keyword(s):  
Pay For Performance ◽  
Regulatory Science ◽  
International Strategy ◽  
Free Text ◽  
The European Union ◽  
Accurate Definition ◽  
Definition Of ◽  
Healthcare Innovation ◽  
The Uk ◽  
Medium Enterprises

Abstract Background The UK’s transition from the European Union creates both an urgent need and key opportunity for the UK and its global collaborators to consider new approaches to the regulation of emerging technologies, underpinned by regulatory science. This survey aimed to identify the most accurate definition of regulatory science, to define strategic areas of the regulation of healthcare innovation which can be informed through regulatory science and to explore the training and infrastructure needed to advance UK and international regulatory science. Methods A survey was distributed to UK healthcare professionals, academics, patients, health technology assessment agencies, ethicists and trade associations, as well as international regulators, pharmaceutical companies and small or medium enterprises which have expertise in regulatory science and in developing or applying regulation in healthcare. Subsequently, a descriptive quantitative analyses of survey results and directed thematic analysis of free-text comments were applied. Results Priority areas for UK regulatory science identified by 145 participants included the following: flexibility: the capability of regulations to adapt to novel products and target patient outcomes; co-development: collaboration across sectors, e.g. patients, manufacturers, regulators, and educators working together to develop appropriate training for novel product deployment; responsiveness: the preparation of frameworks which enable timely innovation required by emerging events; speed: the rate at which new products can reach the market; reimbursement: developing effective tools to track and evaluate outcomes for “pay for performance” products; and education and professional development. Conclusions The UK has a time-critical opportunity to establish its national and international strategy for regulatory science leadership by harnessing broader academic input, developing strategic cross-sector collaborations, incorporating patients’ experiences and perspectives, and investing in a skilled workforce.

Cervical cytologic abnormalities and negative colposcopy: histologic assessment

1994 ◽  
Vol 4 (5) ◽  
pp. 348-351 ◽  
Author(s):  
R. Chenoy ◽  
S. Manohar ◽  
C. W.E. Redman ◽  
D. M. Luesley
Keyword(s):  
Cervical Cytology ◽  
Histologic Diagnosis ◽  
Abnormal Cervical Cytology ◽  
Accurate Definition ◽  
Cone Biopsy ◽  
Histologic Evaluation ◽  
Simple Regression Analysis ◽  
Definition Of ◽  
Cytologic Abnormalities ◽  
Intraepithelial Lesions

Colposcopic assessment may be normal in the presence of severe or persistent minor cytologic abnormality. To assess the significance of negative satisfactory colposcopy in patients with abnormal cervical smears, a retrospective review was carried out on 1170 patients who had undergone out-patient loop diathermy excision for abnormal cervical cytology. Of these, 69 patients were treated for abnormal cervical cytology, despite normal colposcopic findings. Cytologic abnormalities ranged from persistent borderline changes to severe dyskariosis. Histologic assessment of the excision specimens revealed cervical intraepithalial neoplasia (CIN) in 43 (62.3%) cases, of which high-grade CIN accounted for 24 (34.8%) cases. There was good correlation between cytologic and histologic diagnosis. Simple regression analysis showedr= 0.46,P< 0.0001. The cytologic abnormality was highly predictive of the corresponding histologic diagnosis. This analysis has shown that significant intraepithelial lesions may exist despite negative colposcopic examination and highlights the need for histologic evaluation in such cases. In these circumstances, loop cone biopsy permits accurate definition of lesion severity, avoids potential undertreatment of significant lesions and causes less morbidity than conventional cone biopsy.

Theism and Hypertheism

1943 ◽  
Vol 36 (1) ◽  
pp. 63-81
Author(s):  
John Laird
Keyword(s):  
Accurate Definition ◽  
Definition Of

Theists, I suppose, are persons who believe in “God's” existence. Atheists are persons who deny the same.Such statements may be suitable, and even adequate, for many proper purposes. In several contexts it is silly or malicious to interrogate them closely. Even in theology, which is, or should be, some kind of science, they may have, and they do have, their use and their propriety. For many theological purposes, however (and also for some others) they are far too vague. It may be wrong, no doubt, to tell a theologian that he must either produce an accurate definition of what he means by “God” or be forever shamed.

Role of magnetic resonance ventriculography in multiloculated hydrocephalus

2013 ◽  
Vol 11 (6) ◽  
pp. 697-703 ◽  
Author(s):  
Gurpreet S. Gandhoke ◽  
Paolo Frassanito ◽  
Nagesh Chandra ◽  
Bal K. Ojha ◽  
Anoop Singh
Keyword(s):  
Magnetic Resonance ◽  
Endoscopic Treatment ◽  
Ventricular System ◽  
Third Ventriculostomy ◽  
Csf Flow ◽  
Reliable Technique ◽  
Accurate Definition ◽  
Multiloculated Hydrocephalus ◽  
Definition Of ◽  
Complex Cases

Object In this paper the authors' goal was to investigate the clinical usefulness of Gd-enhanced MR ventriculography (MRV) in pediatric patients affected by multiloculated hydrocephalus. Methods Eighteen patients (11 boys and 7 girls, age range 2–14 months) with a diagnosis of multiloculated hydrocephalus were included in the study. After injection of gadodiamide (0.02–0.04 mmol) into the lateral ventricle by tapping the anterior fontanel, sagittal, coronal, and axial T1-weighted MR images were acquired. The location of the septations and the sites of obstruction of CSF flow were assessed. Postoperative MRV was obtained to confirm the results of endoscopic treatment in most complex cases. Results No adverse events were observed after injection of contrast medium into the ventricular system. Preoperative MRV accurately defined the exact morphology of septae and ventricular walls in all cases. In 1 case the diagnosis of multiloculated hydrocephalus was ruled out. Sites of obstruction of CSF flow within the ventricular system were also well established. In 4 cases the multiple compartments were proven to intercommunicate. Postoperative MRV was useful in assessing the functional status of third ventriculostomy, aqueductoplasty, and other endoscopic fenestrations. Conclusions Magnetic resonance ventriculography is a safe, effective, and reliable technique. The accurate definition of the anatomy of the ventricles and the site of obstruction in multiloculated hydrocephalus can help to plan the most appropriate treatment and minimize the number of procedures. Although MRV is also useful during postoperative follow-up to determine the results of endoscopic treatment, it should be limited to particularly complex cases, due to its invasiveness.

Information System for the Initiation and Competitive Selection of Participatory Projects

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Marina Tsurkan ◽  
◽  
David Mamagulashvili
Keyword(s):  
Information Technologies ◽  
Selection Procedure ◽  
Project Managers ◽  
Data Management System ◽  
It Use ◽  
Accurate Definition ◽  
Government Project ◽  
The Government ◽  
Definition Of ◽  
Selection Of

The relevance of the article is caused by the necessity to use information technologies and digital methods during the selection and launch of regional participatory projects. The objective of the paper is to develop technical task pattern for PIMS of LISP projects with the emphasis on launching models and appropriate selection procedure for participatory projects that are to obtain the interbudgetary transfer in the form of grant. The article gives more accurate definition of the term «participatory project» in the area under study. The study demonstrates the best examples of IT use during the launch and selection of regional participatory projects. The paper sets out the key requirements to the participatory projects data management system. The results of the study are practically relevant for the government, project managers and scientists, engaged in digital economics and management.

Role of magnetic resonance imaging in prediction of chondrosarcoma of bone grade

2021 ◽  
pp. 21-24
Author(s):  
A. V. Fedorova ◽  
N. V. Kochergina ◽  
A. B. Bludov ◽  
I. V. Boulycheva ◽  
E. A. Sushentsov ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diagnostic Value ◽  
Low Grade ◽  
High Grade ◽  
Resonance Imaging ◽  
Accurate Definition ◽  
Definition Of ◽  
Decisive Rule

Purpose. Determining the diagnostic value of magnetic resonance imaging in the accurate definition of chondrosarcoma of bone grade at the pre-surgery examination. Material and methods. We analyzed examination data (magnetic resonance imaging with no contrast enhancement) of 70 patients with chondrosarcoma (35 patients with low-grade chondrosarcoma and 35 patients with high grade chondrosarcoma). Informative weighted coefficients were determined separately for ‘learning’ and ‘examination’ samples. On the basis of weighted coefficients, the decisive rule was created for differentiation between low-grade and high-grade chondrosarcoma. Results. The sensitivity of the method was 87.0%, specificity was 95.6%, total correct classification was 91.03%. Conclusion. Magnetic resonance imaging is a highly informative method for prediction of chondrosarcoma grade at the pre-surgery examination.

Approximation and the point of flicker-noise formation

2021 ◽  
Author(s):  
A.S. Matsaev
Keyword(s):  
Spectral Density ◽  
Flicker Noise ◽  
Electronic Devices ◽  
Electrical Circuit ◽  
Maximum Magnitude ◽  
Noise Characteristics ◽  
Exponential Increase ◽  
Accurate Definition ◽  
Definition Of ◽  
Flat Section

The article refers to the field of research of noise fluctuations or flicker noise in electronic amplifiers and is devoted to the exact definition of the magnitude and shape of the spectral density of flicker-noise. The 1/f approximation of flicker noise is analyzed and the problem of its non-constructiveness in analyzing the noise characteristics of electronic amplifiers is shown. To eliminate this problem, the mechanism of physical formation of the envelope, a form of spectral density flicker-noise is defined. The physics of flicker-noise is detailed by accurate definition of the place of its formation. An accurate definition of the maximum difference of the amplifier flickernoise on the flat section of noise characteristics is given, using an explanation of the physics of flicker noise. The mechanism and conditions of the exponential increase of flicker noise and its subsequent exponential desire for maximum magnitude are explained. A simple physical approximation is given to determine the processes of forming the envelope form of the spectral density of flickernoise. The physical understanding of the formation of spectral density of flicker-noise tension in the internal structure of the transistor with the participation of external circuits of the amplifier electrical circuit is detailed. The results of the study will help developers to solve many problems of building electronic devices and optimizing their characteristics at a qualitatively new level.

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