scholarly journals Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Shan-shan Su ◽  
Guo-qi Zheng ◽  
Ya-gang Liu ◽  
Yue-feng Chen ◽  
Zhao-wei Song ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Liver Involvement ◽  
Review Of Literature ◽  
Malignant Peritoneal Mesothelioma ◽  
Single Institution ◽  
Hepatic Involvement ◽  
Computed Tomography Images ◽  
History Of

Malignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological features of 5 patients with malignant peritoneal mesothelioma and liver involvement were evaluated. The diagnosis was established by imaging and immune profiles of the tumours. A review of 8 cases with primary or invading malignant mesothelioma in liver is presented. All 5 mesothelioma cases were asbestos-related. CT images of malignant peritoneal mesothelioma with the liver involvement typically showed that the lesion grew inside the liver along the capsule and was possibly accompanied by capsule breakthrough and extrahepatic infiltration. The tumours exhibited a common epithelioid appearance in all 5 patients and most cases revealed positive Cal, CK, and MC with negative CEA and HeP. Different from our findings, the review of literature revealed that most malignant mesothelioma of liver was due to primary intrahepatic malignant mesothelioma. Finally, we concluded that the diagnosis of malignant peritoneal mesothelioma cases with liver invasion is reliably achieved by the history of asbestos exposure, the characteristic CT imaging, and immune profiles of the tumours.

scholarly journals Multidisciplinary Approach to Diagnosing and Managing a Case of Peritoneal Mesothelioma

2020 ◽  
pp. 68-83
Author(s):  
Jonathan Maw ◽  
Geoffrey Kelly ◽  
Miriam Enriquez ◽  
Ronak Gor ◽  
Pauline Germain
Keyword(s):  
Multidisciplinary Approach ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Review Of Literature ◽  
Malignant Peritoneal Mesothelioma ◽  
History Of

Peritoneal mesothelioma is a rare cause of a peritoneal mass in adults and can occur in malignant or benign forms. Compared to the pleural variant of mesothelioma, the peritoneal form is understudied due to the small number of reported cases. We present a case of an 84-year-old male with a history of asbestos exposure who initially presented for an aggravated hernia, was found to have an incidental mass on imaging, and ultimately was diagnosed with malignant peritoneal mesothelioma (MPM)1 likely related to prior asbestos exposure. This case study will provide a review of literature and discuss the role of imaging for MPM.

Malignant peritoneal mesothelioma in a 76-year-old woman with a history of asbestos fiber ingestion

2004 ◽  
Vol 14 (1) ◽  
pp. 162-165
Author(s):  
P. Van Kesteren ◽  
J. Bulten ◽  
C. Schijf ◽  
H. Boonstra ◽  
L. Massuger
Keyword(s):  
Electron Microscopy ◽  
Weight Loss ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Asbestos Fiber ◽  
Malignant Peritoneal Mesothelioma ◽  
Small Tumor ◽  
Contaminated Food ◽  
History Of ◽  
Omental Cake

We report on a woman with malignant mesothelioma of the peritoneum. This is the first report of a subject with this disease who revealed a history of asbestos ingestion by asbestos-contaminated food. She presented with episodes of sweating and fever, ascites, and weight loss. At laparotomy, small tumor deposits were noted on the peritoneum. The omental cake was removed, together with the uterus, ovaries, and tubes which were all macroscopically normal. The diagnosis was established by immunohistochemistry and electron microscopy. Postoperatively, her complaints of fever and sweating disappeared. She refused further chemotherapy. After questioning her for asbestos exposure, she told us that, years ago, she used to prepare vegetables for cooking in rain water collected from a roof made of asbestos.

scholarly journals Localized Biphasic Malignant Peritoneal Mesothelioma with Rhabdoid Features Involving the Liver: Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Dalal Hassan ◽  
Saverio Ligato
Keyword(s):  
Abdominal Wall ◽  
Surgical Resection ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
Microscopic Appearance ◽  
Lateral Abdominal Wall ◽  
Rare Tumors ◽  
History Of ◽  
Rhabdoid Features

Introduction. Localized malignant mesotheliomas, defined as sharply circumscribed tumors of the serosal membrane with the microscopic appearance of diffuse malignant mesothelioma, are rare tumors; their behavior and prognosis are uncertain. Intrahepatic mesotheliomas are postulated to arise from mesothelial cells of Glisson’s capsule. Case Presentation. A 69-year-old female with no history of asbestos exposure presented with a one-month history of increasing abdominal pain associated with constitutional symptoms. Computerized Tomography (CT) scan of the abdomen and pelvis revealed a sizable soft tissue mass within the right paracolic gutter, abutting the inferior hepatic margin, the lateral abdominal wall, and descending colon. Ultrasound-guided biopsy of the mass suggested a poorly differentiated hepatocellular carcinoma. There was no disease elsewhere on PET scan. Surgical resection of the mass was performed. Pathological assessment suggested the tumor to be arising from the liver with invasion of the liver, abdominal wall musculature, and the adventitial surface of the ascending colon. A final diagnosis of localized biphasic malignant peritoneal mesothelioma with rhabdoid features was rendered based on morphology and the result of immunohistochemical studies. The abdominal wall margin was positive. The patient progressed over the course of 6 months despite receiving adjuvant chemotherapy and immunotherapy with metastases and a decline in performance status and was transitioned to hospice. Conclusion. Localized malignant peritoneal mesotheliomas are rare tumors that may present clinically as a liver mass and simulate primary hepatic or secondary tumors. Definitive diagnosis is obtained by surgical resection in most cases. The clinical outcome is variable with most cases having a poor outcome.

scholarly journals Advances in diffuse malignant peritoneal mesothelioma

2011 ◽  
pp. 53-64
Author(s):  
Tristan D. Yan ◽  
Raffit Hassan ◽  
Laura Welch ◽  
Paul H. Sugarbaker
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Combined Treatment ◽  
Medical Science ◽  
Great Majority ◽  
Terminal Condition ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
The Past ◽  
Diffuse Malignant Peritoneal Mesothelioma

Malignant mesothelioma is a highly aggressive neoplasm. The incidence of malignant mesothelioma is increasing worldwide. Diffuse malignant peritoneal mesothelioma (DMPM) represents one-fourth of all mesotheliomas. Association of asbestos exposure with DMPM has been observed, especially in males. A great majority of patients present with abdominal pain and distension, caused by accumulation of tumors and ascitic fluid. In the past, DMPM was considered a pre-terminal condition; therefore attracted little attention. Patients invariably died from their disease within a year. Recently, several prospective trials have demonstrated median survival of 40 to 90 months and 5-year survival of 30% to 60% after the combined treatment using cytoreductive surgery and perioperative intraperitoneal chemotherapy. This improvement in survival has prompted new searches into the medical science related to DMPM, a disease previously ignored as uninteresting. This review article focuses on the key advances in the epidemiology, diagnosis, staging, treatments and prognosis of DMPM that have occurred in the past decade.

scholarly journals Malignant peritoneal mesothelioma

KYAMC Journal ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 40-42
Author(s):  
Sayeed Bin Sharif
Keyword(s):  
Early Diagnosis ◽  
Rare Disease ◽  
Incidence Rate ◽  
Malignant Mesothelioma ◽  
Poor Prognosis ◽  
Standard Treatment ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
Aggressive Tumor ◽  
Reported Data

Malignant mesothelioma is one of the rare disease. It is an aggressive tumor arising from the mesothelial lining of the pleura or peritoneum. In our country there is no reported data or known incidence rate. It has an association with exposure to asbestos and usually has a poor prognosis. Early diagnosis and establishment of a standard treatment for malignant peritoneal mesothelioma is difficult. We report on a case of malignant peritoneal mesothelioma in a 59-year-old man with huge abdominal swelling, ascites and respiratory distress.KYAMC Journal Vol. 8, No.-2, Jan 2018, Page 40-42

Malignant Peritoneal Mesothelioma in a Hemodialysis Patient with Familial Mediterranean Fever: A Case Report and Literature Review

2008 ◽  
Vol 53 (4) ◽  
pp. 1-3
Author(s):  
E Sengul ◽  
K Yildiz ◽  
Y Topcu ◽  
A Yilmaz
Keyword(s):  
Case Report ◽  
Familial Mediterranean Fever ◽  
Literature Review ◽  
Medical Literature ◽  
Hemodialysis Patient ◽  
Peritoneal Mesothelioma ◽  
Rare Tumor ◽  
Malignant Peritoneal Mesothelioma ◽  
History Of ◽  
Mediterranean Fever

Malignant mesothelioma is a rare tumor. The most common localization of mesothelioma is pleura. It rarely arises from the peritoneum. It has been suggested that familial Mediterranean fever (FMF) may cause the development of peritoneal mesothelioma. We describe a case of malignant peritoneal mesothelioma in a hemodialysis patient with FMF. The patient was a 56 year old female. A history of FMF was present since her childhood. She did not use colchicine and suffered from recurrent ascites. To the best of our knowledge, this is the seventh case of FMF diagnosed as having malignant peritoneal mesothelioma in the medical literature.

Malignant Mesothelioma of Spermatic Cord in an Elderly Man With a History of Asbestos Exposure

Urology ◽  
2016 ◽  
Vol 87 ◽  
pp. e1-e3 ◽  
Author(s):  
Antonio D'Antonio ◽  
Federica Mastella ◽  
Angelo Colucci ◽  
Gianmarco Silvestre
Keyword(s):  
Malignant Mesothelioma ◽  
Spermatic Cord ◽  
Asbestos Exposure ◽  
History Of

scholarly journals Malignant Peritoneal Mesothelioma: Clinicopathological Characteristics of Two Cases

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Mustafa Cem Algın ◽  
Faik Yaylak ◽  
Zülfü Bayhan ◽  
Figen Aslan ◽  
Nilüfer Araz Bayhan
Keyword(s):  
Abdominal Pain ◽  
Asbestos Exposure ◽  
Final Diagnosis ◽  
Clinicopathological Characteristics ◽  
Clinical Findings ◽  
Peritoneal Mesothelioma ◽  
Abdominal Masses ◽  
History Of ◽  
The Right ◽  
Specific Symptoms

Introduction. Peritoneal mesothelioma is a rare tumor, presenting difficulties in diagnosis and treatment. Peritoneum is the second most common area of the mesothelioma after pleura, and even synchronous pleural and peritoneal mesotheliomas are observed in 30–45% of all cases. The diagnosis may be difficult due to lack of specific symptoms and clinical findings. In addition, a delay in the diagnosis is not rare especially in the absence of previous asbestos exposure. Here we report two cases of malignant peritoneal mesotheliomas. The diagnostic and therapeutic approaches for these rare neoplasms are discussed.Case Presentation. The cases were two men (one aged 54 years old and the other 40 years old). Prolonged abdominal pain and swelling were the primary presentation symptoms and findings. The mesotheliomas were developed in the right upper quadrant of abdomen in both of the cases. Both cases were treated with surgical resection. Final diagnosis were possible with histological and immunohistochemical documentation of tumor characteristics, which were consistent with dictating a mesothelial origin. No history of asbestos exposure was reported.Conclusion. Peritoneal mesotheliomas are rare clinical entities. However, patients with prolonged abdominal pain and abdominal masses should be considered to have atypical pathologies such as peritoneal mesotheliomas.

scholarly journals Peritoneal (Paraovarian) Malignant Mesothelioma

Medicinus ◽  
2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Erna Kristiani ◽  
Stephanie Marisca
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Strong Association ◽  
Uncommon Disease ◽  
Microscopic Features ◽  
Adenocarcinoma Of The Ovary ◽  
History Of ◽  
Desmoplastic Stroma ◽  
Mitotic Figures ◽  
Columnar Cells

<p>Peritoneal Malignant Mesothelioma (PMM) is uncommon disease, but increasing in frequency nowadays. This highly aggressive malignancy occurs most commonly in older men and has a strong association with asbestos exposure. It manifests most often as diffuse sheet-like or nodular thickening of the peritoneal surfaces, but it may occasionally be a localized mass. The very large variations of its clinical features and its histological appearance mimicking adenocarcinoma make this tumor is difficult to diagnose.<br />We report a case of PMM that previously diagnose as adenocarcinoma of the ovary. A 29 year-old female came to gynecology clinic with para-ovarian mass. She had no history of asbestos exposure. The mass was oval 9x6x6 cm in size, whitish and firm. Microscopic features showed papillary dense structure with desmoplastic stroma, covered by a layer of cuboidal to columnar cells. The cells with mild pleomorphism and hyperchromatic nuclei, mitotic figures were minimal. The immunohistochemistry tests revealed positive for D2-40, Calretinin, CK8 and CK 18, weakly positive for Inhibin and EMA, and negative for CEA and AFP. Patient had been received chemotherapy, there were no metastasis.</p>

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