scholarly journals Peritoneal (Paraovarian) Malignant Mesothelioma

Medicinus ◽  
2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Erna Kristiani ◽  
Stephanie Marisca
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Strong Association ◽  
Uncommon Disease ◽  
Microscopic Features ◽  
Adenocarcinoma Of The Ovary ◽  
History Of ◽  
Desmoplastic Stroma ◽  
Mitotic Figures ◽  
Columnar Cells

<p>Peritoneal Malignant Mesothelioma (PMM) is uncommon disease, but increasing in frequency nowadays. This highly aggressive malignancy occurs most commonly in older men and has a strong association with asbestos exposure. It manifests most often as diffuse sheet-like or nodular thickening of the peritoneal surfaces, but it may occasionally be a localized mass. The very large variations of its clinical features and its histological appearance mimicking adenocarcinoma make this tumor is difficult to diagnose.<br />We report a case of PMM that previously diagnose as adenocarcinoma of the ovary. A 29 year-old female came to gynecology clinic with para-ovarian mass. She had no history of asbestos exposure. The mass was oval 9x6x6 cm in size, whitish and firm. Microscopic features showed papillary dense structure with desmoplastic stroma, covered by a layer of cuboidal to columnar cells. The cells with mild pleomorphism and hyperchromatic nuclei, mitotic figures were minimal. The immunohistochemistry tests revealed positive for D2-40, Calretinin, CK8 and CK 18, weakly positive for Inhibin and EMA, and negative for CEA and AFP. Patient had been received chemotherapy, there were no metastasis.</p>

Malignant Mesothelioma of Spermatic Cord in an Elderly Man With a History of Asbestos Exposure

Urology ◽  
2016 ◽  
Vol 87 ◽  
pp. e1-e3 ◽  
Author(s):  
Antonio D'Antonio ◽  
Federica Mastella ◽  
Angelo Colucci ◽  
Gianmarco Silvestre
Keyword(s):  
Malignant Mesothelioma ◽  
Spermatic Cord ◽  
Asbestos Exposure ◽  
History Of

Malignant peritoneal mesothelioma in a 76-year-old woman with a history of asbestos fiber ingestion

2004 ◽  
Vol 14 (1) ◽  
pp. 162-165
Author(s):  
P. Van Kesteren ◽  
J. Bulten ◽  
C. Schijf ◽  
H. Boonstra ◽  
L. Massuger
Keyword(s):  
Electron Microscopy ◽  
Weight Loss ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Asbestos Fiber ◽  
Malignant Peritoneal Mesothelioma ◽  
Small Tumor ◽  
Contaminated Food ◽  
History Of ◽  
Omental Cake

We report on a woman with malignant mesothelioma of the peritoneum. This is the first report of a subject with this disease who revealed a history of asbestos ingestion by asbestos-contaminated food. She presented with episodes of sweating and fever, ascites, and weight loss. At laparotomy, small tumor deposits were noted on the peritoneum. The omental cake was removed, together with the uterus, ovaries, and tubes which were all macroscopically normal. The diagnosis was established by immunohistochemistry and electron microscopy. Postoperatively, her complaints of fever and sweating disappeared. She refused further chemotherapy. After questioning her for asbestos exposure, she told us that, years ago, she used to prepare vegetables for cooking in rain water collected from a roof made of asbestos.

Differentiation of malignant mesothelioma from adenocarcinoma

1993 ◽  
Vol 51 ◽  
pp. 312-313
Author(s):  
John Garancis ◽  
John Cafaro ◽  
Anthony Cafaro ◽  
Raymond Venezia
Keyword(s):  
Malignant Mesothelioma ◽  
Clinical Course ◽  
Wide Spectrum ◽  
Asbestos Exposure ◽  
Distant Metastases ◽  
Etiologic Agent ◽  
Parietal Pleura ◽  
Metastatic Adenocarcinoma ◽  
Microscopic Appearance ◽  
History Of

Malignant mesothelioma (MM) is a rare tumor arising predominantly from either the visceral or parietal pleura or peritoneal surfaces. It primarily effects individuals between 45 and 75 years. of age and asbestos is felt to be the single most important etiologic agent. Studies suggest that the incidence of MM is increasing perhaps at a rate of as high as 13% per year. The diagnosis of MM can be difficult and is often complicated by the tumors similarity to metastatic adenocarcinoma, both in it's microscopic appearance and to some extent clinical course.In this particular study the immunohistochemical properties of 22 malignant mesotheliomas (20 pleural and two peritoneal) are compared with 20 pulmonary adenocarcinomas. Each tissue was examined using monoclonal antibodies to wide-spectrum cytokeratin, CEA, Leu-M1 and B72.3. Extensive asbestos exposure was identified in all but 1 of the mesothelioma cases. The cases of peritoneal MM were found to have a history of chrysctile exposure only (Fig.1). Distant metastases were present in four cases of MM.

Synchronous Pulmonary Carcinoma and Pleural Diffuse Malignant Mesothelioma

2006 ◽  
Vol 130 (5) ◽  
pp. 721-724
Author(s):  
Timothy Craig Allen ◽  
Cesar Moran
Keyword(s):  
Malignant Mesothelioma ◽  
English Language ◽  
Asbestos Exposure ◽  
Smoking History ◽  
Pulmonary Carcinoma ◽  
Average Survival ◽  
History Of ◽  
Patient’S History ◽  
Pleural Involvement ◽  
Diffuse Malignant Mesothelioma

Abstract Synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma is rare. Cases from the archives of 2 large referral centers were reviewed to identify cases of synchronously occurring pulmonary carcinoma and pleural diffuse malignant mesothelioma. Three cases of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma were identified from more than 16 000 pleuropulmonary cases and were reviewed for demographic, clinical, radiographic, histologic, and immunohistochemical findings. The patients were men who were 63, 67, and 77 years old. Two had positive smoking histories; the smoking history of the other patient is unknown. One patient had a positive history of asbestos exposure; one patient had no history of asbestos exposure; and one patient's history of asbestos exposure is unknown. The patients underwent surgery for treatment of adenocarcinoma that was diagnosed preoperatively. Two of the adenocarcinomas were of a predominantly bronchioloalveolar pattern. No diffuse malignant mesothelioma was identified preoperatively. Diffuse malignant mesothelioma was suspected on the basis of pleural involvement by tumor with histology differing from that of the adenocarcinoma. Tumor immunostaining supported the diagnoses. The average survival after diagnosis was 6 weeks or less. In summary, the paucity of cases at 2 large referral centers and the paucity of cases reported in the English language literature highlights the rarity of synchronous pulmonary carcinoma and pleural diffuse malignant mesothelioma. These synchronous neoplasms occur in patients who have risk factors for both neoplasms independently. Length of survival following diagnosis is bleak.

scholarly journals Malignant Peritoneum Mesothelioma with Hepatic Involvement: A Single Institution Experience in 5 Patients and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Shan-shan Su ◽  
Guo-qi Zheng ◽  
Ya-gang Liu ◽  
Yue-feng Chen ◽  
Zhao-wei Song ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Peritoneal Mesothelioma ◽  
Liver Involvement ◽  
Review Of Literature ◽  
Malignant Peritoneal Mesothelioma ◽  
Single Institution ◽  
Hepatic Involvement ◽  
Computed Tomography Images ◽  
History Of

Malignant peritoneal mesothelioma with invasion of the liver is an invariably fatal disease. We aimed to clarify the characteristics of malignant peritoneal mesothelioma cases with liver involvement. The clinical presentation, computed tomography images, and immunohistochemical and histopathological features of 5 patients with malignant peritoneal mesothelioma and liver involvement were evaluated. The diagnosis was established by imaging and immune profiles of the tumours. A review of 8 cases with primary or invading malignant mesothelioma in liver is presented. All 5 mesothelioma cases were asbestos-related. CT images of malignant peritoneal mesothelioma with the liver involvement typically showed that the lesion grew inside the liver along the capsule and was possibly accompanied by capsule breakthrough and extrahepatic infiltration. The tumours exhibited a common epithelioid appearance in all 5 patients and most cases revealed positive Cal, CK, and MC with negative CEA and HeP. Different from our findings, the review of literature revealed that most malignant mesothelioma of liver was due to primary intrahepatic malignant mesothelioma. Finally, we concluded that the diagnosis of malignant peritoneal mesothelioma cases with liver invasion is reliably achieved by the history of asbestos exposure, the characteristic CT imaging, and immune profiles of the tumours.

scholarly journals Malignant Mesothelioma of the Tunica Vaginalis Testis—A Malignancy Associated With Asbestos Exposure and Trauma: A Case Report and Literature Review

2019 ◽  
Vol 7 ◽  
pp. 232470961982733 ◽  
Author(s):  
AAM A. Baqui ◽  
Nicholas A. Boire ◽  
Tajruba T. Baqui ◽  
Dhanan J. Etwaru
Keyword(s):  
Case Report ◽  
Occupational Exposure ◽  
Literature Review ◽  
Malignant Mesothelioma ◽  
Unusual Case ◽  
Surgical Intervention ◽  
Asbestos Exposure ◽  
Tunica Vaginalis ◽  
Tunica Vaginalis Testis ◽  
History Of

In this article, we report an unusual case of a malignant mesothelioma of the testis, presenting as hydrocele. The patient has a known medical history of trauma and occupational exposure to asbestos. The clinical features of this injury are discussed together with its immunohistochemistry. Surgical intervention is discussed due to the nature of this pathology.

scholarly journals Malignant Mesothelioma Mimicking Invasive Mammary Carcinoma in a Male Breast

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Mohamed Mokhtar Desouki ◽  
Daniel Jerad Long
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Malignant Mesothelioma ◽  
Asbestos Exposure ◽  
Lobular Carcinoma ◽  
Strong Association ◽  
Final Diagnosis ◽  
Pleural Mesothelioma ◽  
Invasive Mammary Carcinoma ◽  
Pleomorphic Lobular Carcinoma ◽  
The Right

Malignant mesothelioma is an uncommon tumor with strong association with asbestos exposure. Few cases of malignant pleural mesothelioma metastatic to the female breast have been reported. Herein, we presented, for the first time, a case of locally infiltrating malignant pleural mesothelioma forming a mass in the breast of a male as the first pathologically confirmed manifestation of the disease. Breast ultrasound revealed an irregular mass in the right breast which involves the pectoralis muscle. Breast core biopsy revealed a proliferation of neoplastic epithelioid cells mimicking an infiltrating pleomorphic lobular carcinoma. IHC studies showed the cells to be positive for calretinin, CK5/6, WT1, and CK7. The cells were negative for MOC-31, BerEp4, ER, and PR. A final diagnosis of malignant mesothelioma, epithelioid type, was rendered. This case demonstrates the importance of considering a broad differential diagnosis in the setting of atypical presentation with application of a panel of IHC markers.

Factor V Leiden Is Associated with Repeated and Recurrent Unexplained Fetal Losses

1997 ◽  
Vol 77 (05) ◽  
pp. 0822-0824 ◽  
Author(s):  
Elvira Grandone ◽  
Maurizio Margaglione ◽  
Donatella Colaizzo ◽  
Marina d'Addedda ◽  
Giuseppe Cappucci ◽  
...  
Keyword(s):  
Protein C ◽  
Strong Association ◽  
Activated Protein C ◽  
Fetal Loss ◽  
Factor V Leiden ◽  
Factor V ◽  
Significant Difference ◽  
History Of ◽  
Fv Leiden ◽  
Caucasian Women

SummaryActivated protein C resistance (APCR) is responsible for most cases of familial thrombosis. The factor V missense mutation Arg506>Gln (FV Leiden) has been recognized as the commonest cause of this condition. Recently, it has been suggested that APCR is associated with second trimester fetal loss. We investigated the distribution of FV Leiden in a sample (n = 43) of Caucasian women with a history of two or more unexplained fetal losses. A group (n = 118) of parous women with uneventful pregnancies from the same ethnical background served as control. We found the mutation in 7 cases (16.28%) and 5 controls (4.24%; p = 0.011). A statistically significant difference between women with only early fetal loss vs those with late events (p = 0.04) was observed. Our data demonstrate a strong association between FV Leiden and fetal loss. Furthermore, they indicate that late events are more common in these patients.

scholarly journals Thymoma in an aged backyard Leghorn chicken, with reviews of a database and literature

2021 ◽  
Vol 33 (2) ◽  
pp. 336-339
Author(s):  
Julia Blakey ◽  
Carmen Jerry ◽  
Ana da Silva ◽  
Simone Stoute
Keyword(s):  
Soft Tissue Mass ◽  
Animal Health ◽  
Postmortem Examination ◽  
Cervical Region ◽  
Laboratory System ◽  
Unexpected Death ◽  
Tissue Mass ◽  
Microscopic Features ◽  
History Of ◽  
Backyard Chickens

A 7-y-old backyard Leghorn chicken ( Gallus domesticus) was submitted to the California Animal Health and Food Safety Laboratory System (CAHFS)–Turlock branch for postmortem examination, with a history of unexpected death. At postmortem examination, a hemorrhagic soft tissue mass was observed in the cervical region. Microscopically, a densely cellular neoplasm of polygonal epithelial cells and small lymphocytes was observed. The microscopic features of the neoplasm in combination with positive immunohistochemistry for pancytokeratin and CD3 were used to classify the lesion as a thymoma. Thymoma was diagnosed in only 5 birds submitted to CAHFS from 1990 to 2019. Thymoma has been described only rarely in birds, and is an unusual diagnosis in backyard chickens.

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