Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa

Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important regulatory functions in innate immunity. There are no studies showing extraskeletal changes associated with hypovitaminosis D3 in eating disorders.Methods.We have analyzed the blood of 18 patients affected by anorexia nervosa and bulimia nervosa collected over a 15-month period. We performed a panel of chemical and clinical analyses: the assay of vitamin D3, the immunoblotting of vitamin D receptor and peroxisome proliferator-activated receptor gamma, and the genotyping of 5-hydroxytryptamine transporter linked polymorphic region.Results.We choose 18 patients with a normal blood test profile such as thyroid hormones, hepatic and renal parameters, triglycerides, proteins, vitamin B12, and folic acid. Among these emerged the case of a woman with long-term anorexia nervosa and the case of a woman with long-term bulimia nervosa both complicated by anxiety and depression, severe hypovitaminosis D3, decrease of vitamin D receptor, leukopenia, and 5-hydroxytryptamine transporter linked polymorphic region short allele.Conclusion.The results induce hypothesising that the severe hypovitaminosis D3 might be responsible for the lack of the inflammatory response and the depressive symptoms in patients with long-term eating disorders.

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Eighteen-year trajectories of depressive symptoms in mothers with a lifetime eating disorder: findings from the ALSPAC cohort

The British Journal of Psychiatry ◽

10.1192/bjp.2019.89 ◽

2019 ◽

Vol 216 (2) ◽

pp. 90-96 ◽

Cited By ~ 1

Author(s):

Yu Wei Chua ◽

Gemma Lewis ◽

Abigail Easter ◽

Glyn Lewis ◽

Francesca Solmi

Keyword(s):

Eating Disorders ◽

Body Image ◽

Anorexia Nervosa ◽

Depressive Symptoms ◽

Bulimia Nervosa ◽

Growth Curves ◽

Sensitivity Analyses ◽

Continuous Measure ◽

In Pregnancy

BackgroundTwo longitudinal studies have shown that depressive symptoms in women with eating disorders might improve in the antenatal and early postnatal periods. No study has followed up women beyond 8 months postnatal.AimsTo investigate long-term trajectories of depressive symptoms in mothers with lifetime self-reported eating disorders.MethodUsing data from the Avon Longitudinal Study of Parents and Children and multilevel growth curves we modelled trajectories of depressive symptoms from the 18th week of pregnancy to 18 years postnatal in women with lifetime self-reported anorexia nervosa, bulimia nervosa or both anorexia and bulimia nervosa. As sensitivity analyses we also investigated these trajectories using quintiles of a continuous measure of body image in pregnancy.ResultsOf the 9276 women in our main sample, 126 (1.4%) reported a lifetime diagnosis of anorexia nervosa, 153 (1.6%) of bulimia nervosa and 60 (0.6%) of both anorexia and bulimia nervosa. Women with lifetime eating disorders had greater depressive symptoms scores than women with no eating disorders, before and after adjustment for confounders (anorexia nervosa: 2.10, 95% CI 1.36–2.83; bulimia nervosa: 2.28, 95% CI: 1.61–2.94, both anorexia and bulimia nervosa: 2.86, 95% CI 1.81–3.90). We also observed a dose–response association between greater body image and eating concerns in pregnancy and more severe trajectories of depressive symptoms, even after adjusting for lifetime eating disorders which also remained independently associated with greater depressive symptoms.ConclusionsWomen with eating disorders experience persistently greater depressive symptoms across the life-course. More training for practitioners and midwives on how to recognise eating disorders in pregnancy could help to identify depressive symptoms and reduce the long-term burden of disease resulting from this comorbidity.

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Inhibition of peroxisome proliferator-activated receptor α signaling by vitamin D receptor

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2003.10.131 ◽

2003 ◽

Vol 312 (2) ◽

pp. 513-519 ◽

Cited By ~ 14

Author(s):

Takahiro Sakuma ◽

Takahide Miyamoto ◽

Wei Jiang ◽

Tomoko Kakizawa ◽

Shin-ich Nishio ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor

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Coactivation of the Human Vitamin D Receptor by the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 α

Molecular Pharmacology ◽

10.1124/mol.105.012708 ◽

2005 ◽

Vol 68 (2) ◽

pp. 511-517 ◽

Cited By ~ 29

Author(s):

Rajesh S. Savkur ◽

Kelli S. Bramlett ◽

Keith R. Stayrook ◽

Sunil Nagpal ◽

Thomas P. Burris

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor

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Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARγ) and vitamin D receptor (VDR) in lean male mice offspring

European Journal of Nutrition ◽

10.1007/s00394-016-1359-x ◽

2016 ◽

Vol 57 (2) ◽

pp. 723-730 ◽

Cited By ~ 10

Author(s):

Anthony M. Belenchia ◽

Karen L. Jones ◽

Matthew Will ◽

David Q. Beversdorf ◽

Victoria Vieira-Potter ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D Receptor ◽

Peroxisome Proliferator ◽

Male Mice ◽

Peroxisome Proliferator Activated Receptor ◽

Maternal Vitamin

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Increased Body Mass Index but Not Common Vitamin D Receptor, Peroxisome Proliferator–Activated Receptor γ, or Cytokine Polymorphisms Confers Predisposition to Posttransplant Diabetes

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2011-0160-oa ◽

2011 ◽

Vol 135 (12) ◽

pp. 1581-1584 ◽

Cited By ~ 2

Author(s):

Ping Wang ◽

Elissa Hudspeth

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Vitamin D Receptor ◽

Solid Organ Transplantation ◽

Significant Risk ◽

Peroxisome Proliferator ◽

Solid Organ ◽

Peroxisome Proliferator Activated Receptor

Context.—Posttransplant diabetes mellitus (PTDM) is a major complication after solid organ transplantation. The use of corticosteroids and calcineurin inhibitors, especially tacrolimus, are significant risk factors. However, it is not clear what genetic factors modify the risk. Evidence suggests vitamin D deficiency, perturbed glucose homeostasis, and increased inflammation all play roles in the development of diabetes. Objective.—To investigate whether common vitamin D receptor (VDR), cytokine, and peroxisome proliferator–activated receptor γ (PPARγ) polymorphisms are correlated with the development of PTDM. Design.—DNA was isolated from the peripheral blood of 51 kidney transplant recipients with PTDM and 72 patients without diabetes pretransplant or posttransplant at the time of follow-up. The genotypes for 5 polymorphisms, 1 each in VDR, PPARγ, INFγ, TGFβ1, and TNF, were determined using direct sequencing. Age, sex, number of acute rejection episodes, follow-up length, ethnicity, body mass index, and the frequency of alleles and genotypes for each polymorphism were compared between the 2 groups. Results.—Body mass index was the only factor that was statistically different between the 2 groups (P = .001). The frequency of different alleles and genotypes for each of the 5 polymorphisms did not differ between the 2 groups. Conclusions.—These results indicate that increased body mass index is a significant risk factor for the development of PTDM. However, none of the genetic polymorphisms studied confer predisposition to PTDM with the current sample size.

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