A Synthetic Strategy for Conjugation of Paromomycin to Cell-Penetrating Tat(48-60) for Delivery and Visualization into Leishmania Parasites
Keyword(s):
A successful approach to deliver paromomycin, a poorly absorbed aminoglycoside antibiotic, to parasite cells is reported, based on selective protection of amino and hydroxyl groups followed by conjugation to a fluorolabeled, PEG-functionalized cell-penetrating Tat(48-60) peptide. The resulting construct is efficiently internalized into Leishmania cells, evidencing the fitness of cell-penetrating peptides as vectors for efficiently transporting low-bioavailability drugs into cells.
2010 ◽
Vol 17
(11)
◽
pp. 1313-1327
◽
2013 ◽
Vol 19
(16)
◽
pp. 2963-2969
◽
2014 ◽
Vol 15
(3)
◽
pp. 192-199
◽
Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System
2014 ◽
Vol 15
(3)
◽
pp. 220-230
◽
2019 ◽
Vol 15
(3)
◽
pp. 206-211
◽