scholarly journals Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
D. Graterol ◽  
C. Mir ◽  
C. Garcia-Vaquero ◽  
I. Braña ◽  
A. N. Pardo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Low Frequency ◽  
Pure Tone Audiometry ◽  
High Frequency Hearing Loss ◽  
High Frequencies ◽  
Observational Cohort ◽  
Chemotherapeutic Treatment ◽  
Design And Methods ◽  
Determining Factor

Background. Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity. Objective. We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss. Study Design and Methods. This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined. Results. 40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor. Conclusions. Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.

Effect of mastoid drilling on hearing of the contralateral ear

2013 ◽  
Vol 127 (10) ◽  
pp. 952-956 ◽  
Author(s):  
A Goyal ◽  
P P Singh ◽  
A Vashishth
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Prospective Clinical Study ◽  
Distortion Product Otoacoustic Emission ◽  
High Frequencies ◽  
Distortion Product ◽  
Contralateral Ear

AbstractObjectives:This study aimed to: understand the effect that high intensity noise associated with drilling (during otological surgery) has on hearing in the contralateral ear; determine the nature of hearing loss, if any, by establishing whether it is temporary or persistent; and examine the association between hearing loss and various drill parameters.Methods:A prospective clinical study was carried out at a tertiary centre. Thirty patients with unilateral cholesteatoma and normal contralateral hearing were included. Patients were evaluated pre-operatively and for five days following surgery using high frequency pure tone audiometry, and low and high frequency transient evoked and distortion product otoacoustic emission testing.Results:The findings revealed statistically significant changes in distortion product otoacoustic emissions at high frequencies (p = 0.016), and in transient evoked otoacoustic emissions at both low and high frequencies (p = 0.035 and 0.021, respectively). There was a higher statistical association between otoacoustic emission changes and cutting burrs compared with diamond burrs.Conclusion:Drilling during mastoid surgery poses a threat to hearing in the contralateral ear due to noise and vibration conducted transcranially.

scholarly journals The Relevance of the High Frequency Audiometry in Tinnitus Patients with Normal Hearing in Conventional Pure-Tone Audiometry

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Veronika Vielsmeier ◽  
Astrid Lehner ◽  
Jürgen Strutz ◽  
Thomas Steffens ◽  
Peter M. Kreuzer ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Normal Hearing ◽  
High Frequency Hearing Loss ◽  
Additional Information ◽  
Tinnitus Severity ◽  
Hearing Thresholds ◽  
High Frequency Audiometry

Objective. The majority of tinnitus patients suffer from hearing loss. But a subgroup of tinnitus patients show normal hearing thresholds in the conventional pure-tone audiometry (125 Hz–8 kHz). Here we explored whether the results of the high frequency audiometry (>8 kHz) provide relevant additional information in tinnitus patients with normal conventional audiometry by comparing those with normal and pathological high frequency audiometry with respect to their demographic and clinical characteristics.Subjects and Methods. From the database of the Tinnitus Clinic at Regensburg we identified 75 patients with normal hearing thresholds in the conventional pure-tone audiometry. We contrasted these patients with normal and pathological high-frequency audiogram and compared them with respect to gender, age, tinnitus severity, pitch, laterality and duration, comorbid symptoms and triggers for tinnitus onset.Results. Patients with pathological high frequency audiometry were significantly older and had higher scores on the tinnitus questionnaires in comparison to patients with normal high frequency audiometry. Furthermore, there was an association of high frequency audiometry with the laterality of tinnitus.Conclusion. In tinnitus patients with normal pure-tone audiometry the high frequency audiometry provides useful additional information. The association between tinnitus laterality and asymmetry of the high frequency audiometry suggests a potential causal role for the high frequency hearing loss in tinnitus etiopathogenesis.

The Effects of High-Frequency Hearing Loss on Low-Frequency Components of the Click-Evoked Otoacoustic Emission

2003 ◽  
Vol 14 (09) ◽  
pp. 525-533 ◽  
Author(s):  
Owen D. Murnane ◽  
John K. Kelly
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Low Frequency ◽  
Otoacoustic Emission ◽  
Normal Hearing ◽  
Group Differences ◽  
Basal Region ◽  
Significant Group ◽  
High Frequency Hearing Loss ◽  
Frequency Components

Click-evoked otoacoustic emission (CEOAE) input/output (I/O) functions were measured in ears with normal hearing and in ears with sensorineural hearing loss above 2000 Hz. The low- to midfrequency CEOAEs obtained from the ears with high-frequency hearing loss were significantly reduced in level compared to the CEOAEs obtained from the ears with normal hearing even though there were no significant group differences in the 250–2000 Hz pure-tone thresholds. The findings are discussed within the context of two hypotheses that explain the low- to midfrequency reduction in transient-evoked otoacoustic emission (TEOAE) magnitude: (1) subclinical damage to the more apical regions of the cochlea not detected by behavioral audiometry, or (2) trauma to the basal region of the cochlea that affects the generation of low-frequency emissions. It is proposed that localized damage at basal cochlear sites affects the generation of low- to midfrequency CEOAE energy.

scholarly journals Hearing loss among children with sickle cell anaemia in Uganda

2019 ◽  
Vol 5 (4) ◽  
pp. 840
Author(s):  
Nzanzu Kikuhe ◽  
Heather Hume ◽  
Emily Kakande ◽  
Justine Namwagala
Keyword(s):  
Hearing Loss ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Motor Deficit ◽  
Control Group ◽  
High Frequency Hearing Loss ◽  
High Frequencies ◽  
Structured Questionnaire

<p class="abstract"><strong>Background:</strong> A case control was carried out to study the prevalence, the pattern and associated factors of hearing loss among Ugandan children with sickle cell anaemia.</p><p class="abstract"><strong>Methods:</strong> One hundred and thirty-two children known sickle cell and one hundred thirty aged matched non-SCA controls were recruited after medical ethics committee approval and informed consent. Two obtain information on socio-demographic characteristics, history, and examination of the participants, a structured questionnaire was administered. Pure tone audiometry (PTA) was used to assess the hearing in a sound-treated room.  </p><p class="abstract"><strong>Results:</strong> Twenty-two of the children had hearing impairment compared to 6 controls. Prevalence of hearing loss found among children with SCA was 17% but in the control group the prevalence found was 5%. Sensorineural hearing loss (SNHL) affected 39%, conductive (CHL) 25% and mixed (MHL) 14% among cases compared to CHL 7%, SNHL 7% and MHL 7% among the controls. The hearing loss varied from mild to moderate (95%). All sickle cell children had high-frequency hearing loss. There was a statistically significant association of hearing loss and neurologic motor deficit.</p><p class="abstract"><strong>Conclusions:</strong> Sickle patients are at risk of developing hearing loss as the study demonstrated a difference in hearing threshold in children living with sickle cell anaemia and the controls. High frequencies were more affected. The neurologic motor deficit was highly associated with hearing loss among patients with SCA compared to controls.</p>

scholarly journals Reduction in high-frequency hearing loss following technical modifications to microvascular decompression for hemifacial spasm

2015 ◽  
Vol 123 (4) ◽  
pp. 1059-1064 ◽  
Author(s):  
Parthasarathy Thirumala ◽  
Andrew M. Frederickson ◽  
Jeffrey Balzer ◽  
Donald Crammond ◽  
Miguel E. Habeych ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hemifacial Spasm ◽  
Microvascular Decompression ◽  
High Frequency ◽  
Auditory Evoked Potentials ◽  
Pure Tone Audiometry ◽  
Brainstem Auditory Evoked Potentials ◽  
Vestibulocochlear Nerve ◽  
High Frequency Hearing Loss ◽  
Technical Modifications

OBJECT Microvascular decompression is a safe and effective procedure to treat hemifacial spasm, but the operation poses some risk to the patient’s hearing. While severe sensorineural hearing loss across all frequencies occurs at a low rate in experienced hands, a recent study suggests that as many as one-half of patients who undergo this procedure may experience ipsilateral high-frequency hearing loss (HFHL), and as many as one-quarter may experience contralateral HFHL. While it has been suggested that drill-related noise may account for this finding, this study was designed to examine the effect of a number of techniques designed to protect the vestibulocochlear nerve from operative manipulation on the incidence of HFHL. METHODS Pure-tone audiometry was performed both preoperatively and postoperatively on 67 patients who underwent microvascular decompression for hemifacial spasm during the study period. A change of greater than 10 dB at either 4 kHz or 8 kHz was considered to be HFHL. Additionally, the authors analyzed intraoperative brainstem auditory evoked potentials from this patient cohort. RESULTS The incidence of ipsilateral HFHL in this cohort was 7.4%, while the incidence of contralateral HFHL was 4.5%. One patient (1.5%; also included in the HFHL group) experienced an ipsilateral nonserviceable hearing loss. CONCLUSIONS The reduced incidence of HFHL in this study suggests that technical modifications including performing the procedure without the use of fixed retraction may greatly reduce, but not eliminate, the occurrence of HFHL following microvascular decompression for hemifacial spasm.

scholarly journals The incidence of high-frequency hearing loss after microvascular decompression for trigeminal neuralgia, glossopharyngeal neuralgia, or geniculate neuralgia

2015 ◽  
Vol 123 (6) ◽  
pp. 1500-1506 ◽  
Author(s):  
Parthasarathy Thirumala ◽  
Kristin Meigh ◽  
Navya Dasyam ◽  
Preethi Shankar ◽  
Kanika R. K. Sarma ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Trigeminal Neuralgia ◽  
Microvascular Decompression ◽  
High Frequency ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Contralateral Side ◽  
Glossopharyngeal Neuralgia ◽  
Ipsilateral Side ◽  
High Frequency Hearing Loss

OBJECT The primary aim of this study was to evaluate the incidence and discuss the pathogenesis of high-frequency hearing loss (HFHL) after microvascular decompression (MVD) for trigeminal neuralgia (TGN), glossopharyngeal neuralgia (GPN), or geniculate neuralgia (GN). METHODS The authors analyzed preoperative and postoperative audiogram data and brainstem auditory evoked potentials (BAEPs) from 93 patients with TGN, 6 patients with GPN, and 8 patients with GN who underwent MVD. Differences in pure tone audiometry > 10 dB at frequencies of 0.25, 0.5, 1, 2, 4, and 8 kHz were calculated preoperatively and postoperatively for both the ipsilateral and the contralateral sides. Intraoperative monitoring records were analyzed and compared with the incidence of HFHL, which was defined as a change in pure tone audiometry > 10 dB at frequencies of 4 and 8 kHz. RESULTS The incidence of HFHL was 30.84% on the side ipsilateral to the surgery and 20.56% on the contralateral side. Of the 47 patients with HFHL, 20 had conductive hearing loss, and 2 experienced nonserviceable hearing loss after the surgery. The incidences of HFHL on the ipsilateral side at 4 and 8 kHz were 17.76% and 25.23%, respectively, and 8.41% and 15.89%, respectively, on the contralateral side. As the audiometric frequency increased, the number of patients with hearing loss increased. No significant postoperative difference was found between patients with and without HFHL in intraoperative BAEP waveforms. Sex, age, and affected side were not associated with an increase in the incidence of hearing loss. CONCLUSIONS High-frequency hearing loss occurred after MVD for TGN, GPN, or GN, and the greatest incidence occurred on the ipsilateral side. This hearing loss may be a result of drill-induced noise and/or transient loss of cerebrospinal fluid during the course of the procedure. Changes in intraoperative BAEP waveforms were not useful in predicting HFHL after MVD. Repeated postoperative audiological examinations may be useful in assessing the prognosis of HFHL.

scholarly journals Noise Induced Hearing Loss

AAOHN Journal ◽  
1998 ◽  
Vol 46 (2) ◽  
pp. 67-75 ◽  
Author(s):  
Oi Saeng Hong ◽  
Shu-Pi C. Chen ◽  
Karen M. Conrad
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Low Frequency ◽  
Full Time ◽  
Cross Sectional ◽  
Hearing Conservation ◽  
High Frequency Hearing Loss ◽  
Significant Difference ◽  
Record Review ◽  
Continuous Use

The purposes of this study of airport workers were to a) determine the prevalence and symptoms of hearing loss, and b) identify compliance in using hearing protective devices (HPDs) and its relationship with hearing loss. This cross sectional epidemiological study was conducted with 255 noise exposed and 195 non-noise exposed, full time, male workers at a large metropolitan airport in Seoul, Korea. The three measures used were the self administered Occupational Hearing Questionnaire (OHQ), an audiological assessment, and a record review of baseline hearing and noise levels of locations in which the employee worked. The results showed a significant difference in prevalence of hearing loss (more than 25dB) between the noise and the non-noise exposed groups ( p < .05). About 60.8% of noise exposed workers reported continuous use of the HPDs. The continuous HPD users had significantly lower rates of hearing loss than the occasional users or non-users. The major symptom for workers with low frequency hearing loss was trouble in communication, whereas tinnitus and fullness in the ear were the most common symptoms for the workers with high frequency hearing loss. The airport workers exposed to excessive noise had a great deal of high frequency hearing loss. The degree of hearing loss present reinforces the need for aggressive hearing conservation programs among airport workers exposed to noise.

The Sensitivity of Adolescent School-Based Hearing Screens Is Significantly Improved by Adding High Frequencies

2016 ◽  
Vol 32 (6) ◽  
pp. 416-422 ◽  
Author(s):  
Deepa L. Sekhar ◽  
Thomas R. Zalewski ◽  
Jessica S. Beiler ◽  
Beth Czarnecki ◽  
Ashley L. Barr ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Confidence Interval ◽  
Gold Standard ◽  
High Frequency ◽  
State School ◽  
High Frequency Hearing Loss ◽  
High Frequencies ◽  
School Based ◽  
Hazardous Noise ◽  
Sensitivity Specificity

High frequency hearing loss (HFHL), often related to hazardous noise, affects one in six U.S. adolescents. Yet, only 20 states include school-based hearing screens for adolescents. Only six states test multiple high frequencies. Study objectives were to (1) compare the sensitivity of state school-based hearing screens for adolescents to gold standard sound-treated booth testing and (2) consider the effect of adding multiple high frequencies and two-step screening on sensitivity/specificity. Of 134 eleventh-grade participants (2013–2014), 43 of the 134 (32%) did not pass sound-treated booth testing, and 27 of the 43 (63%) had HFHL. Sensitivity/specificity of the most common protocol (1,000, 2,000, 4,000 Hz at 20 dB HL) for these hearing losses was 25.6% (95% confidence interval [CI] = [13.5, 41.2]) and 85.7% (95% CI [76.8, 92.2]), respectively. A protocol including 500, 1,000, 2,000, 4,000, 6,000 Hz at 20 dB HL significantly improved sensitivity to 76.7% (95% CI [61.4, 88.2]), p < .001. Two-step screening maintained specificity (84.6%, 95% CI [75.5, 91.3]). Adolescent school-based hearing screen sensitivity improves with high frequencies.

Potential Benefits of an Integrated Electric-Acoustic Sound Processor with Children: A Preliminary Report

2017 ◽  
Vol 28 (02) ◽  
pp. 127-140 ◽  
Author(s):  
Jace Wolfe ◽  
Sara Neumann ◽  
Erin Schafer ◽  
Megan Marsh ◽  
Mark Wood ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Speech Recognition ◽  
Real World ◽  
High Frequency ◽  
Low Frequency ◽  
High Frequency Hearing Loss ◽  
Sentence Recognition ◽  
Acoustic Hearing ◽  
Potential Benefits ◽  
Sound Processor

Background: A number of published studies have demonstrated the benefits of electric-acoustic stimulation (EAS) over conventional electric stimulation for adults with functional low-frequency acoustic hearing and severe-to-profound high-frequency hearing loss. These benefits potentially include better speech recognition in quiet and in noise, better localization, improvements in sound quality, better music appreciation and aptitude, and better pitch recognition. There is, however, a paucity of published reports describing the potential benefits and limitations of EAS for children with functional low-frequency acoustic hearing and severe-to-profound high-frequency hearing loss. Purpose: The objective of this study was to explore the potential benefits of EAS for children. Research Design: A repeated measures design was used to evaluate performance differences obtained with EAS stimulation versus acoustic- and electric-only stimulation. Study Sample: Seven users of Cochlear Nucleus Hybrid, Nucleus 24 Freedom, CI512, and CI422 implants were included in the study. Data Collection and Analysis: Sentence recognition (assayed using the pediatric version of the AzBio sentence recognition test) was evaluated in quiet and at three fixed signal-to-noise ratios (SNR) (0, +5, and +10 dB). Functional hearing performance was also evaluated with the use of questionnaires, including the comparative version of the Speech, Spatial, and Qualities, the Listening Inventory for Education Revised, and the Children’s Home Inventory for Listening Difficulties. Results: Speech recognition in noise was typically better with EAS compared to participants’ performance with acoustic- and electric-only stimulation, particularly when evaluated at the less favorable SNR. Additionally, in real-world situations, children generally preferred to use EAS compared to electric-only stimulation. Also, the participants’ classroom teachers observed better hearing performance in the classroom with the use of EAS. Conclusions: Use of EAS provided better speech recognition in quiet and in noise when compared to performance obtained with use of acoustic- and electric-only stimulation, and children responded favorably to the use of EAS implemented in an integrated sound processor for real-world use.

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