scholarly journals Hearing loss among children with sickle cell anaemia in Uganda

2019 ◽  
Vol 5 (4) ◽  
pp. 840
Author(s):  
Nzanzu Kikuhe ◽  
Heather Hume ◽  
Emily Kakande ◽  
Justine Namwagala
Keyword(s):  
Hearing Loss ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Motor Deficit ◽  
Control Group ◽  
High Frequency Hearing Loss ◽  
High Frequencies ◽  
Structured Questionnaire

<p class="abstract"><strong>Background:</strong> A case control was carried out to study the prevalence, the pattern and associated factors of hearing loss among Ugandan children with sickle cell anaemia.</p><p class="abstract"><strong>Methods:</strong> One hundred and thirty-two children known sickle cell and one hundred thirty aged matched non-SCA controls were recruited after medical ethics committee approval and informed consent. Two obtain information on socio-demographic characteristics, history, and examination of the participants, a structured questionnaire was administered. Pure tone audiometry (PTA) was used to assess the hearing in a sound-treated room.  </p><p class="abstract"><strong>Results:</strong> Twenty-two of the children had hearing impairment compared to 6 controls. Prevalence of hearing loss found among children with SCA was 17% but in the control group the prevalence found was 5%. Sensorineural hearing loss (SNHL) affected 39%, conductive (CHL) 25% and mixed (MHL) 14% among cases compared to CHL 7%, SNHL 7% and MHL 7% among the controls. The hearing loss varied from mild to moderate (95%). All sickle cell children had high-frequency hearing loss. There was a statistically significant association of hearing loss and neurologic motor deficit.</p><p class="abstract"><strong>Conclusions:</strong> Sickle patients are at risk of developing hearing loss as the study demonstrated a difference in hearing threshold in children living with sickle cell anaemia and the controls. High frequencies were more affected. The neurologic motor deficit was highly associated with hearing loss among patients with SCA compared to controls.</p>

scholarly journals HEARING EVALUATION OF NIGERIAN PRISON INMATES: A CROSS-SECTIONAL SURVEY

2020 ◽  
Vol 14 (2) ◽  
pp. 106-114
Author(s):  
Abdullahi Musa Kirfi ◽  
◽  
Mohammed Bello Fufore ◽  
Garba Mohammed Mainasara ◽  
Abdulrazak Ajiya ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Pure Tone ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Control Group ◽  
Prison Inmates ◽  
Impaired Hearing ◽  
Cross Sectional ◽  
The Mean ◽  
The Right

Background: Prisoners, due to confinement are isolated from contact with the society and access to many of the facilities, including medical care. This study aimed to evaluate the hearing threshold of inmates of Kaduna convict prison. Method: It was a cross-sectional study of prison inmates at the Kaduna convict prison between April 2017 and February 2019. Ethical approvals were obtained from relevant bodies and all consented inmates aged 18 – 55years in the Kaduna convict prison were enrolled. Equal number of control matched for age and gender were enrolled from the communities in Kaduna North Local Government Area. Data were collated using a structured questionnaire. A diagnostic Pure Tone Audiometry was performed to assess their hearing threshold. Statistical Package for Social Sciences (SPSS) version 20.0 was used for analysis. Results: Four hundred and thirty inmates and equal number of control group were enrolled. The mean age for the inmates and controls were 30.2±7.5 and 30.4±8.02 years respectively. There were 383 males and 47 females in both groups. Among the 860 ears of the inmates, 238(27.7%) ears had hearing loss while in the control group, 95/ (11.1%) ears had impaired hearing. Conductive hearing loss was the commonest among the inmates 111(46.6%) while sensorineural was commoner among the controls 57(60.0%). The mean pure tone average among the inmates was 25.6±11.3dBHL and 26.1±11.2dBHL on the right and left ears respectively while in the control group, it was 18.4±7.8dBHL on the right and 17.9±7.9dBHL on the left. Conclusion: This study revealed that hearing loss was more prevalent among prison inmates than the general population. In majority of the inmates, the hearing loss was mild, conductive and mostly affecting all the frequencies.

Efficacy of Hyperbaric Oxygen on Idiopathic Sudden Sensorineural Hearing Loss and Its Correlation with Treatment Course: Prospective Clinical Research

2021 ◽  
pp. 1-7
Author(s):  
Chao Huang ◽  
Ge Tan ◽  
Jing Xiao ◽  
Guihua Wang
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hyperbaric Oxygen ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Related Factors ◽  
Group B

<b><i>Objectives:</i></b> This study was conducted to explore the effectiveness of hyperbaric oxygen (HBO) in the treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) and recommend the appropriate course of treatment. <b><i>Methods:</i></b> 102 patients (105 diseased ears) with ISSNHL were recruited from the Department of Neurology and Otorhinolaryngology, West China Fourth Hospital, Sichuan University, between January 2018 and September 2020. Of them, 45 patients (group A) received intravenous steroid (IVS), and the remaining patients (group B) received IVS and HBO therapy (HBOT). Pure-tone audiometry (PTA) was performed twice at baseline and 10 days after treatment. Patients in group B were subdivided into group 1 (≤10 sessions) and group 2 (&#x3e;11 sessions) to verify the correlation between the efficacy and course of HBOT, at the follow-up endpoint, the PTA was performed again. The multivariate logistical regression model was used to analyze the related factors of prognosis. <b><i>Results:</i></b> Compared with the control group, significantly larger hearing gains and better hearing recovery rate were observed in the IVS + HBOT group (<i>p</i> &#x3c; 0.05). The time of treatment and course of HBOT were significantly correlated with the hearing threshold after treatment (<i>p</i> &#x3c; 0.05) and had no significant relationship with tinnitus and age (<i>p</i> &#x3e; 0.05). <b><i>Conclusion:</i></b> HBOT + IVS is an effective method for ISSNHL, especially for the recovery of low-frequency hearing and initial hearing levels of severe and profound. Tinnitus is the most common concomitant symptom of ISSNHL, and prolonging the course of HBOT did not significantly improve it. Initiating HBOT within 7 days for 10–25 sessions of treatment was more beneficial.

scholarly journals Association between Ocular Pseudoexfoliation and Sensorineural Hearing Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nandini Vijaya Singham ◽  
Mimiwati Zahari ◽  
Mohammadreza Peyman ◽  
Narayanan Prepageran ◽  
Visvaraja Subrayan
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
The Body ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Speech Comprehension ◽  
Hearing Thresholds ◽  
Significant Difference

Background. Our study aimed to investigate an association between ocular pseudoexfoliation (PXF) and sensorineural hearing loss (SNHL) and to compare them with age and sex matched controls without pseudoexfoliation.Method. This was a case-control study of 123 patients which included 68 cases with PXF (at least one eye) and 55 controls without pseudoexfoliation. Pure-tone audiometry (PTA) was done for these patients at sound frequencies taken as important for speech comprehension, that is, 250 Hertz (Hz), 500 Hz, 1000 Hz, and 2000 Hz.Results. There were 41 patients with pseudoexfoliation syndrome (PXE) and 27 with pseudoexfoliative glaucoma (PXEG). The majority of patients with hearing loss (60%;n=51) were PXF patients and the remaining 40%(n=34)were controls. Below average hearing thresholds were significantly higher in the pseudoexfoliation group compared to the control group (P=0.01; odds ratio (OR), 3.00; 95% confidence interval (CI), 1.25–7.19). However, there was no significant difference in the mean hearing threshold levels between the three groups (PXE, PXEG, and controls) in either ear (ANOVA, right ear:P=0.46and left earP=0.36).Conclusion. Our study found an association between PXF and SNHL, confirming that PXF can involve organs in the body other than the eye.

scholarly journals Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
D. Graterol ◽  
C. Mir ◽  
C. Garcia-Vaquero ◽  
I. Braña ◽  
A. N. Pardo ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Low Frequency ◽  
Pure Tone Audiometry ◽  
High Frequency Hearing Loss ◽  
High Frequencies ◽  
Observational Cohort ◽  
Chemotherapeutic Treatment ◽  
Design And Methods ◽  
Determining Factor

Background. Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity. Objective. We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss. Study Design and Methods. This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined. Results. 40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor. Conclusions. Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.

Hearing threshold in patients with diabetes mellitus

1989 ◽  
Vol 103 (2) ◽  
pp. 164-168 ◽  
Author(s):  
M. Kurien ◽  
K. Thomas ◽  
T. S. Bhanu
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Metabolic Diseases ◽  
Age Groups ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Diabetic Patients ◽  
High Frequency Hearing Loss ◽  
Patients With Diabetes ◽  
Significant High Frequency

AbstractHearing threshold of 30 diabetic patients and 30 healthy controls attending the medical outpatient department were determined using pure tone audiometry (Arphi Digital 900). All subjects were less than 50 years old. Subjects with otological and other metabolic diseases were excluded from the study. The patients were categorized into groups according to age, duration of disease, complications and control of diabetes. These observations were compared with those from the control subjects using appropriate statistical methods.It was found that diabetics had a poorer hearing threshold than the non-diabetics; all age groups with diabetes showed a significant high frequency hearing loss, as compared to the control population; poorly controlled and complicated diabetics have significant, high frequency hearing loss as compared to those who were well controlled and uncomplicated; there was no relationship between duration of the diabetes and the level of hearing loss.

scholarly journals Sensorineural Hearing Loss in Rheumatoid Arthritis

2021 ◽  
Vol 11 (12) ◽  
pp. 79-82
Author(s):  
Shelja Deswal ◽  
Jyoti Yadav ◽  
Mridul Yadav
Keyword(s):  
Rheumatoid Arthritis ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Sensorineural Hearing ◽  
Unknown Etiology ◽  
Control Group ◽  
Multisystem Disease ◽  
Organ Systems

Introduction: Rheumatoid arthritis (RA) is a chronic multisystem disease of unknown etiology is characterized by persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution. RA is well known to affect many organ systems, including the auditory system and can involve the incudomalleolar and incudostapedial joints altering the ossicular mechanics in response to static air pressure modifications. Objective: This study evaluates the degree of sensorineural hearing loss in patients with rheumatoid arthritis (RA) Material and Methods: This study was conducted in the Department of Physiology in collaboration with departments of Medicine and ENT Pt. B.D. Sharma PGIMS, Rohtak. 25 rheumatoid arthritis female patients with disease duration of more than five years as per 1987 criteria of American college of rheumatology were included in the study to study the effect of rheumatoid arthritis on hearing. 25 healthy volunteer females were included in control group. Audiological evaluation was based on pure tone audiometry. Results: We observed a high incidence of hearing loss in rheumatoid arthritis patients as compared to corresponding age and sex matched controls. Nine RA (36%) cases, were having hearing threshold more than 25 dB. Of the total of 36% patients having hearing loss 24% patients had sensorineural hearing loss. Bilateral hearing loss was seen in 8% of cases. Conclusion: Based on our study it can be postulated that patients with RA are at higher risk of hearing impairment. Key words: Rheumatoid arthritis, hearing, sensorineural, audiometry.

scholarly journals Pure tone hearing threshold of patients with cleft palate anomaly in Kaduna, Nigeria

2018 ◽  
Vol 4 (2) ◽  
pp. 330 ◽  
Author(s):  
Emmanuel Musa ◽  
Aliyu Mohammed Kodiya ◽  
Abdullahi Musa Kirfi ◽  
Onyekwere George B. Nwaorgu
Keyword(s):  
Hearing Loss ◽  
Cleft Palate ◽  
Pure Tone ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Statistical Significance ◽  
Hearing Threshold ◽  
Pure Tone Audiometry ◽  
Controlled Study ◽  
Control Group

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Hearing loss is common in people with isolated cleft palate (ICP) or cleft lip and palate (CLP). There is renewed hope for surgical repair for people with cleft deformity in Nigeria today due to serious commitment in offering them free surgeries by Smile Train and other non-governmental organizations. While effort at corrective surgery is very commendable, the need for proper diagnosis and management of hearing loss among the cleft population cannot be overemphasized. The aim of this study was to assess the pure tone hearing threshold of patients with cleft palate anomaly at Smile Train Centre Kaduna, Nigeria. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">This was a prospective cross-sectional case controlled study to assess the pure tone hearing threshold of consecutive adults and children not less than 5 years of age with repaired or unrepaired cleft lip and cleft palate attending Etomie Smile Train Centre in Kaduna, Nigeria compared with a control group of non-cleft volunteers matched for age and sex. Ethical clearance and informed consent were obtained. History, ear examination and pure tone audiometry were performed. Data collected were analyzed using SPSS version 16. Simple statistical parameters, Chi - Square and paired-samples T-test were used as appropriate. The level of statistical significance was set at p&lt;­­0.05.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">The prevalence of hearing loss was 59.4% in patients with CLP and ICP and 12% among the control group. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">There is high prevalence of conductive hearing loss among patients with cleft palate anomaly at Etomie Smile Train Centre Kaduna.</span></p>

Effect of mastoid drilling on hearing of the contralateral ear

2013 ◽  
Vol 127 (10) ◽  
pp. 952-956 ◽  
Author(s):  
A Goyal ◽  
P P Singh ◽  
A Vashishth
Keyword(s):  
Hearing Loss ◽  
High Frequency ◽  
Otoacoustic Emissions ◽  
Pure Tone Audiometry ◽  
Otoacoustic Emission ◽  
Prospective Clinical Study ◽  
Distortion Product Otoacoustic Emission ◽  
High Frequencies ◽  
Distortion Product ◽  
Contralateral Ear

AbstractObjectives:This study aimed to: understand the effect that high intensity noise associated with drilling (during otological surgery) has on hearing in the contralateral ear; determine the nature of hearing loss, if any, by establishing whether it is temporary or persistent; and examine the association between hearing loss and various drill parameters.Methods:A prospective clinical study was carried out at a tertiary centre. Thirty patients with unilateral cholesteatoma and normal contralateral hearing were included. Patients were evaluated pre-operatively and for five days following surgery using high frequency pure tone audiometry, and low and high frequency transient evoked and distortion product otoacoustic emission testing.Results:The findings revealed statistically significant changes in distortion product otoacoustic emissions at high frequencies (p = 0.016), and in transient evoked otoacoustic emissions at both low and high frequencies (p = 0.035 and 0.021, respectively). There was a higher statistical association between otoacoustic emission changes and cutting burrs compared with diamond burrs.Conclusion:Drilling during mastoid surgery poses a threat to hearing in the contralateral ear due to noise and vibration conducted transcranially.

scholarly journals Growth and puberty in a prospective cohort of patients with sickle-cell anaemia: an assessment over ten years abstract

2017 ◽  
Vol 27 (1) ◽  
pp. 91 ◽  
Author(s):  
Ingrid Cristiane Pereira Gomes ◽  
Hugo Nivaldo Melo ◽  
Suyaluane Italla Amana Melo ◽  
Nelmo Vasconcelos de Menezes ◽  
Tulio Vinicius Paes Dantas ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Pubertal Development ◽  
Hereditary Diseases ◽  
Control Group ◽  
Age At Menarche ◽  
Prospective Longitudinal Study ◽  
Cellular Expression ◽  
Z Scores ◽  
Prospective Longitudinal

Introduction: Hereditary haemoglobinopathies are the most common group of monogenic hereditary diseases in the world. Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. Objective: The evaluation of the growth pattern and pubertal development of a group of patients with sickle-cell anaemia (SCA) from childhood to adulthood. Method: Thirty patients with SCA between the ages of 10 and 23 years were evaluated in a prospective longitudinal study at three points in time (Te1: 2005; Te2: 2010 and Te3: 2015) and compared with controls. Anthropometric, pubertal and hormonal evaluations were carried out. Age- and gender-specific Z-scores for weight, height and BMI (body mass index) were calculated according to the reference growth standards. Results: Thirty patients with SCA (mean age = 13.93 years) were evaluated at Te1 and 26 patients (mean age = 25.08 years) at Te3. The SCA group lower showed Z-scores for weight (p = 0.0002), height (p = 0.0184) and BMI (p = 0.0011) than the control group at Te1. At Te3, there was no difference in height, but weight (p = <0.0001) and BMI (p = <0.0001) were lower in the SCA group. Men showed greater weight commitment than women at the three study times (Te1: p = 0.0340, Te2: p = 0.0426 and Te3: p = 0.0387) and lower BMI in Te3 (p = 0.0155) in the SCA group. There was a significant increase in weight when comparing Te1 with Te3 (p = 0.0009) and in height when comparing Te1 with Te2 (p = 0.0292) and with Te3 (p = 0.0003) in the SCA group. There was a significant increase in weight when comparing Te1 and Te3 (p = 0.0009) and in height when comparing Te1 and Te2 (p = 0.0292) and Te3 (p = 0.0003) in the SCA group. At Te1, 14 cases and 2 controls were prepubertal. Bone age was delayed in 12 patients. Age at menarche was delayed and lower in the SCA group (mean = 15 years). Five patients had gestated, but no patient had experienced fatherhood. At Te1, TSH levels were higher (p = 0.0080) and T3 levels were lower (p = 0.0020) in the SCA group. At Te3, LH and FSH levels were higher in men with SCA (p = 0.0014; p; 0.0002). IGF-I levels were lower in cases both at Te1 (p = 0.0002) and at Te3 (p = 0.0032). Conclusions: Patients with SCA showed growth impairment and pubertal delay compared with healthy controls. However, albeit belatedly, they reached normal sexual maturation and height in adulthood. Women with SCA showed no fertility problems. The findings highlight the need to investigate the intention of paternity and fertility among men with SCA.

Bilateral profound sudden sensorineural hearing loss presenting a diagnostic conundrum in a child with sickle cell anaemia

2008 ◽  
Vol 123 (7) ◽  
pp. 811-816 ◽  
Author(s):  
A D Mace ◽  
M S Ferguson ◽  
M Offer ◽  
K Ghufoor ◽  
M J Wareing
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Sensorineural Hearing Loss ◽  
Sickle Cell ◽  
Cochlear Implantation ◽  
World Literature ◽  
Sickle Cell Anaemia ◽  
Early Recognition ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

AbstractObjective:To present the first published case of a child with bilateral profound sudden sensorineural hearing loss found in association with sickle cell anaemia, and to demonstrate the importance of early recognition, investigation and empirical treatment of sudden sensorineural hearing loss.Method:Case report and review of world literature.Case report:The authors present the case of a seven-year-old child with known sickle cell anaemia, who presented with bilateral profound sensorineural hearing loss developing over a period of five days. There was a history of ophthalmological disease in the preceding weeks, and inflammatory markers were raised. The differential diagnosis included a vaso-occlusive or inflammatory aetiology such as Cogan's syndrome, and treatment for both was instigated. Hearing thresholds did not recover, and the patient underwent cochlear implantation 12 weeks later.Conclusion:Sudden sensorineural hearing loss has a variable aetiology and is rare in children. Immediate treatment for all possible aetiologies is essential, along with targeted investigations and early referral for cochlear implantation if no recovery is demonstrated.

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