scholarly journals Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ligia Rios ◽  
Liliana Vásquez ◽  
Mónica Oscanoa ◽  
Iván Maza ◽  
Jenny Gerónimo
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Solid Tumors ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Paternal Age ◽  
Parental Age ◽  
Advanced Paternal Age ◽  
Control Study

Background. The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies. In this study, we examine a possible link between parental age and childhood solid tumors. Methods. We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru. Odd ratio was used to compare categories of advancing maternal and paternal age with and without adjusting for possible confounding factors were calculated. Results. The risk of childhood retinoblastoma was significantly higher among children of mothers aged> 35 years (adjusted OR 1.21; 95% CI, 1.09-6.08) and fathers aged> 35 years (OR 1.17; 1.01-16.33). A significant trend with increasing mother's age (p = 0.037) and father's age (p = 0.005) was found. There were more risks to development of non-Hodgkin's lymphoma (p = 0.047) and gonadal germ cell tumors (p = 0.04) for advanced paternal age. There was a strong protective effect of increasing parity on risk of solid tumors in children (p=0.0015). Conclusion. Our results suggest that advanced parental age is associated with the risk for the development of retinoblastoma. Advanced paternal age increases the risk of non-Hodgkin lymphoma and gonadal germ cell tumor. The higher the order of birth of the children, the less the chance of developing any neoplasm.

scholarly journals Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016

2021 ◽  
Author(s):  
Clinton Hall ◽  
Johnni Hansen ◽  
Jørn Olsen ◽  
Di He ◽  
Ondine S. von Ehrenstein ◽  
...  
Keyword(s):  
Germ Cell ◽  
Maternal Employment ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Social Contact ◽  
Case Control ◽  
Yolk Sac ◽  
Parental Occupation ◽  
Yolk Sac Tumors ◽  
Control Study

Abstract Purpose To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Results Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). Conclusion Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.

Case-control study of male germ cell tumors nested in a cohort of car-manufacturing workers: Findings from the occupational history

2010 ◽  
Vol 53 (10) ◽  
pp. 1006-1018 ◽  
Author(s):  
Ingo Langner ◽  
Nils Schmeißer ◽  
Birte Mester ◽  
Thomas Behrens ◽  
Andrea Gottlieb ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Male Germ Cell ◽  
Occupational History ◽  
Control Study

The Inter-Regional, Epidemiological Study of Childhood Cancer (IRESCC): case-control study in children with germ cell tumours

1986 ◽  
Vol 7 (5) ◽  
pp. 717-722 ◽  
Author(s):  
H.E. Johnston ◽  
J.R. Mann ◽  
J. Williams ◽  
J.A.H. Waterhouse ◽  
J.M. Birch ◽  
...  
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Epidemiological Study ◽  
Case Control Study ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Control Study

Molecular markers in extragonadal germ cell tumors (EGCTs): A matched-case control study

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 9700-9700
Author(s):  
M. Nikolaou ◽  
C. Valavanis ◽  
I. Lekka ◽  
G. Aravantinos ◽  
G. Fountzilas ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Germ Cell ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Extragonadal Germ Cell Tumors ◽  
Control Study

scholarly journals Parental Age and the Risk of Autism Spectrum Disorder in Oman

2021 ◽  
Author(s):  
Watfa Al-Mamari ◽  
Ahmed Babiker Idris ◽  
Aala' Abdul Rahman Al-Zadjali ◽  
Saquib Jalees ◽  
Sathiya Murthi ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Odds Ratio ◽  
Maternal Age ◽  
Case Control Study ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Paternal Age ◽  
Parental Age ◽  
Control Study

Objective: This study aimed at evaluating advanced parental age as a risk factor for Autism Spectrum Disorder (ASD) in an Omani cohort. Methods: Case-control study of 278 ASD cases compared with 722 sex-matched controls retrieved from the electronic records of the Developmental Paediatric Clinic, Sultan Qaboos University Hospital (SQUH) between January 2015 and June 2016. Results: ASD cases (76.6% male) were mostly diagnosed between 3-4 years of age, with more than 50% of them originating from Muscat and Batinah governorates. Compared to controls, mothers from the case group had significantly higher educational level (post-secondary education versus high school/no formal education (odds-ratio (OR)=1.62; 95% C.I. 1.20-2.19). In a multivariate logistic regression, the odds ratio of maternal age as a risk for ASD increased dramatically with advancing age category (using age<25 as a reference, OR was 3.39, 6.12, 7.86 and 13.13 for age categories 25-29, 30-34, 35-39, and ≥40 years, respectively). The ORs of advancing paternal age as a risk for ASD were also statistically significant (using age<30 as referent, OR was 2.20, 2.36, and 3.12 for age categories 30-34, 35-39 and 40-44 years); however, there was a drop in the effect with paternal age ≥ 45 years (OR=1.42; 95% C.I .64-3.15). Conclusion: Both maternal and paternal increased age were associated with a higher risk of ASD; however, the association was more pronounced and more consistent with advanced maternal age compared to paternal age. Keywords: Autism; parental age; case-control study

scholarly journals Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Aurélie M. N. Danjou ◽  
Olivia Pérol ◽  
Astrid Coste ◽  
Elodie Faure ◽  
Rémi Béranger ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Germ Cell Tumors ◽  
Developed Countries ◽  
Case Control ◽  
Testicular Germ Cell ◽  
Increased Risk ◽  
Domestic Use ◽  
Control Study

Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development. Methods We conducted a case-control study of 304 TGCT cases, aged 18–45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants’ mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son’s birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results Prevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80–2.01) or herbicides (OR = 1.15, CI = 0.67–2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04–2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26–4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06–5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12–3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype. Conclusions Although recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.

scholarly journals Is Advanced Paternal Age associated with Fetal Growth and Adverse Neonatal Outcomes? A Case-Control Study

2011 ◽  
Vol 2 (3) ◽  
pp. 109-113
Author(s):  
Tarakeswari Surapaneni ◽  
Manisha Dudlani
Keyword(s):  
Pregnant Women ◽  
Fetal Growth ◽  
Gestational Age ◽  
Case Control Study ◽  
Case Control ◽  
Neonatal Outcomes ◽  
Paternal Age ◽  
Advanced Paternal Age ◽  
Adverse Neonatal Outcomes ◽  
Control Study

ABSTRACT Aim To determine associations of advanced paternal age with fetal growth and adverse neonatal outcomes. Methods A hospital-based unmatched case-control study with random selection of controls. Fetal growth was determined by serial ultrasound measurements and growth was classified at birth by a neonatalogist based on the Lubchenco charts. Advanced paternal age was explored using two cutoffs (35 and 40 years). Likelihood ratios, unadjusted and adjusted odds ratios and the 95% confidence intervals around point estimates are presented. Results The study covered 218 pregnant women that included 137 (63.72%) pregnant women who delivered a live AGA/LGA baby and 78 (36.28%) pregnant women who delivered a live small for gestational age baby and 45 (20.64%) fathers with advanced paternal age based on a cutoff of ≥ 40 years and 73 (33.49%) fathers with advanced paternal age based on a age cutoff ≥ 35 years. Although advanced paternal age (both ≥ 35 and ≥ 40 years) was protective for small for gestational age babies in a bivariate analysis, the association was not significant in a multivariate regression model that adjusted for maternal age, parity, diabetes and gestational age at delivery. Advanced paternal age (both ≥ 35 and ≥ 40 years) did not show a clinically meaningful positive or negative likelihood ratio with other adverse neonatal outcomes. Conclusion Paternal age does not seem to be associated with fetal growth or adverse neonatal outcomes; however, a prospective cohort study is necessary to provide further evidence after controlling for potential confounders.

Factors associated with non-epithelial ovarian cancer among Mexican women: A matched case-control study

2003 ◽  
Vol 13 (6) ◽  
pp. 756-763
Author(s):  
L. M. Sanchez-Zamorano ◽  
E. Salazar-Martinez ◽  
P. Escudero-De Los Rios ◽  
G. Gonzalez-Lira ◽  
L. Flores-Luna ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Epithelial Ovarian Cancer ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Full Term ◽  
Mexican Women ◽  
Factors Associated ◽  
Control Study

The purpose of this study was to identify risk factors associated with the development of non-epithelial ovarian cancer in Mexican women. A case-control study was carried out on women registered with the Mexican Institute of Social Security in Mexico City over a period of two years (1995–97). Twenty-eight new cases were recruited from the Gynecology and Obstetrics Hospital no. 4, “Luis Castelazo Ayala”, and were matched by age with 84 controls selected randomly. Eighteen (64.3%) cases of germ cell tumors and 10 (35.7%) stromal sex cord tumors were found. The number of full term pregnancies was associated inversely to development of stromal sex cord tumors with lower risk in women with more than three full term pregnancies (odds ratio, 0.02: 95% confidence interval, 0.001–0.56) compared to nulliparous women. No associations were found respecting to germ cell tumors. Parity was inversely associated to development of stromal sex cord tumors, probably as a result of the endocrine system's influence on the ovaries. The development of germ cell tumors could be associated to factors not evaluated in this study.

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