scholarly journals A Retrospective Analysis of Colorectal Serrated Lesions from 2005 to 2014 in a Single Center: Importance of the Establishment of Diagnostic Patterns

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Priscilla S. P. Oliveira ◽  
Rita B. Carvalho ◽  
Daniela O. Magro ◽  
Michel G. Camargo ◽  
Carlos A. R. Martinez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Analysis ◽  
Histopathological Examination ◽  
Morphological Characterization ◽  
Histological Diagnosis ◽  
Single Center ◽  
Serrated Adenoma ◽  
Serrated Lesions ◽  
Patient’S History ◽  
Serrated Adenomas

Background. Serrated colorectal lesions are increasingly recognized as an important process in the development of colorectal cancer. Endoscopic and histological diagnosis may be difficult, and knowledge of the serrated lesions is important for the establishment of strategies for treating colorectal lesions. We aimed to analyze serrated lesions diagnosed at a single center and evaluate if there was an increase in their identification over the years. Design and Setting. A retrospective analysis of colonoscopy reports was performed at a specialized center from 2005 to 2014. Methods. Colonoscopy reports about any resected endoscopic lesions were reviewed and subjected to histological diagnosis from 2005 to 2014. Then, serrated lesions were evaluated based on morphological characterization, location, size, occurrence of synchronous lesions, and the patient’s history of colorectal cancer and polyps. Results. A total of 2126 colonoscopy examination reports were reviewed, and 3494 lesions were analyzed. On histopathological examination, 1089 (31.2%) were classified as hyperplastic polyps, 22 (0.6%) as sessile serrated adenomas, and 21 (0.6%) as traditional serrated adenomas. There was an increase in the number of cases of sessile and traditional serrated adenomas diagnosed after 2010. Before 2010, two cases of sessile serrated adenomas and seven cases of traditional serrated adenomas were diagnosed; after 2010, 20 cases of sessile serrated adenoma and 14 cases of traditional serrated adenomas were diagnosed. Conclusion. There was an increase in the diagnosis of sessile serrated adenomas over the years, which can be attributed to better accuracy in colonoscopy and histological classification.

Risk stratification for colorectal cancer in individuals with subtypes of serrated polyps

Gut ◽  
2021 ◽  
pp. gutjnl-2021-324301
Author(s):  
Dan Li ◽  
Amanda R Doherty ◽  
Menaka Raju ◽  
Liyan Liu ◽  
Nan Ye Lei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Community Based ◽  
Kaiser Permanente ◽  
Serrated Polyps ◽  
Increased Risk ◽  
Synchronous Adenoma ◽  
Serrated Lesions ◽  
Serrated Adenomas ◽  
Control Study

ObjectiveThe longitudinal risk of colorectal cancer (CRC) associated with subtypes of serrated polyps (SPs) remains incompletely understood.DesignThis community-based, case–control study included 317 178 Kaiser Permanente Northern California members who underwent their first colonoscopy during 2006–2016. Nested within this population, we identified 695 cases of CRC and 3475 CRC-free controls (matched 5:1 to cases for age, sex and year of colonoscopy). Two expert pathologists reviewed the tissue slides of all SPs identified on the first colonoscopy and reclassified them to sessile serrated lesions (SSLs), hyperplastic polyps (HPs) and traditional serrated adenomas. SPs with borderline characteristics of SSLs but insufficient to make a definitive diagnosis were categorised as unspecified SPs. The association with development of CRC was assessed using multivariable logistic regression.ResultsCompared with individuals with no polyp, the adjusted ORs (aORs) for SSL alone or with synchronous adenoma were 2.9 (95% CI: 1.8 to 4.8) and 4.4 (95% CI: 2.7 to 7.2), respectively. The aORs for SSL with dysplasia, large proximal SSL,and small proximal SSL were 10.3 (95% CI: 2.1 to 50.3), 12.8 (95% CI: 3.5 to 46.9) and 1.9 (95% CI: 0.8 to 4.7), respectively. Proximal unspecified SP also conferred an increased risk (aOR: 5.8, 95% CI: 2.2 to 15.2). Women with SSL were associated with higher risk (aOR: 4.4; 95% CI: 2.3 to 8.2) than men (aOR: 1.7; 95% CI: 0.8 to 3.8).ConclusionIncreased risk of CRC was observed in individuals with SSLs, particularly large proximal ones or with dysplasia, supporting close endoscopic surveillance. Proximal unspecified SPs were also associated with increased risk of CRC and should be managed as SSLs.

scholarly journals Intramucosal Carcinoma of the Appendix Arising from Traditional Serrated Adenoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Carlos Augusto Real Martinez ◽  
Júlia Cutovoi ◽  
Debora Helena Rossi ◽  
Luciana Rodrigues Meirelles ◽  
Maria de Lourdes Setsuko Ayrizono ◽  
...  
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Screening Colonoscopy ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Intramucosal Adenocarcinoma ◽  
One Year ◽  
Risk Of Cancer ◽  
Laparoscopic Removal ◽  
Serrated Adenomas

Introduction. Serrated adenomas of the appendix are rare and usually found during appendectomy or autopsies. The preoperative diagnosis of these tumors is uncommon. This report describes a case of a sessile serrated adenoma located in the appendix diagnosed by a screening colonoscopy and successfully treated by laparoscopic removal.Presentation of Case. An 86-year-old woman underwent colonoscopy to investigate the cause of her diarrhea, weight loss, and anemia. During the colonoscopy, an expansive and vegetating mass of 1.5 cm in diameter was identified, protruding through the appendicular ostium with slightly lateral growth to the cecum. The patient was referred for laparoscopic surgical resection due to the location of the lesion, which did not allow its removal by colonoscopy. She underwent wedge removal of the cecum without complications and was discharged on the 4th postoperative day. Histopathological examination showed the presence of a sessile serrated adenoma with an intramucosal adenocarcinoma. The patient is currently well one year after surgery, without endoscopic signs of relapse.Conclusion. Despite serrated adenomas being a possibility rarely described in appendix it should be recognized and properly treated because it is presenting a higher risk of cancer.

Serrated and Non-Serrated Precursor Lesions of Colorectal Cancer

2014 ◽  
Vol 33 (1) ◽  
pp. 28-37 ◽  
Author(s):  
Cord Langner
Keyword(s):  
Colorectal Cancer ◽  
Cpg Island ◽  
Aberrant Crypt Foci ◽  
Neoplastic Progression ◽  
Precursor Lesions ◽  
Adenomatous Polyposis ◽  
Cpg Island Methylator Phenotype ◽  
Serrated Adenoma ◽  
Serrated Lesions ◽  
Methylator Phenotype

Although often viewed as a single disease, colorectal cancer more accurately represents a family of diseases with different precursor lesions. Conventional (tubular, tubulovillous and villous) adenomas are the most common neoplastic lesions occurring in the large intestine. They have adenomatous polyposis coli (APC) mutations and arise from dysplastic aberrant crypt foci, initially as polyclonal lesions. In sporadic tumours, neoplastic progression follows the traditional pathway (chromosomal instability pathway), resulting in CpG island methylator phenotype (CIMP)-negative, microsatellite-stable (MSS), BRAF and KRAS wild-type cancers. Germline mutations in the APC gene lead to familial adenomatous polyposis. Conventional adenomas are also the precursors of Lynch syndrome-associated microsatellite-instable (MSI-high) cancers. Sessile serrated adenoma/polyp (SSA/P) is the principal precursor lesion of the serrated pathway, in which BRAF mutation can lead to colorectal cancer with MSI-high CIMP-high or MSS CIMP-high phenotype. SSA/Ps have been associated with synchronous and metachronous invasive adenocarcinomas as well as so-called interval carcinomas. Serrated polyposis is rare but most likely underdiagnosed. Affected individuals bear an increased but unspecified risk for the development of colorectal cancer; close endoscopic surveillance is warranted. Traditional serrated adenomas (TSAs) are much less common than the other serrated lesions. Cancers originating from TSAs may show KRAS mutation with a CIMP-high MSS phenotype.

scholarly journals Microwave ablation for colorectal cancer metastasis to the liver: a single-center retrospective analysis

2021 ◽  
Vol 12 (4) ◽  
pp. 1454-1469
Author(s):  
Emily A. Knott ◽  
Timothy J. Ziemlewicz ◽  
Sam J. Lubner ◽  
John F. Swietlik ◽  
Sharon M. Weber ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Analysis ◽  
Microwave Ablation ◽  
Cancer Metastasis ◽  
Single Center ◽  
Colorectal Cancer Metastasis

scholarly journals Laparoscopic Colorectomy for Colorectal Cancer: Retrospective Analysis of 889 Patients in a Single Center

2012 ◽  
Vol 227 (3) ◽  
pp. 171-177 ◽  
Author(s):  
Liesheng Lu ◽  
Donglei Zhou ◽  
Xun Jian ◽  
Jianzhong Deng ◽  
Ping Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Analysis ◽  
Single Center ◽  
Laparoscopic Colorectomy
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