scholarly journals Intramucosal Carcinoma of the Appendix Arising from Traditional Serrated Adenoma

2015 ◽  
Vol 2015 ◽  
pp. 1-6
Author(s):  
Carlos Augusto Real Martinez ◽  
Júlia Cutovoi ◽  
Debora Helena Rossi ◽  
Luciana Rodrigues Meirelles ◽  
Maria de Lourdes Setsuko Ayrizono ◽  
...  
Keyword(s):  
Preoperative Diagnosis ◽  
Histopathological Examination ◽  
Screening Colonoscopy ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Intramucosal Adenocarcinoma ◽  
One Year ◽  
Risk Of Cancer ◽  
Laparoscopic Removal ◽  
Serrated Adenomas

Introduction. Serrated adenomas of the appendix are rare and usually found during appendectomy or autopsies. The preoperative diagnosis of these tumors is uncommon. This report describes a case of a sessile serrated adenoma located in the appendix diagnosed by a screening colonoscopy and successfully treated by laparoscopic removal.Presentation of Case. An 86-year-old woman underwent colonoscopy to investigate the cause of her diarrhea, weight loss, and anemia. During the colonoscopy, an expansive and vegetating mass of 1.5 cm in diameter was identified, protruding through the appendicular ostium with slightly lateral growth to the cecum. The patient was referred for laparoscopic surgical resection due to the location of the lesion, which did not allow its removal by colonoscopy. She underwent wedge removal of the cecum without complications and was discharged on the 4th postoperative day. Histopathological examination showed the presence of a sessile serrated adenoma with an intramucosal adenocarcinoma. The patient is currently well one year after surgery, without endoscopic signs of relapse.Conclusion. Despite serrated adenomas being a possibility rarely described in appendix it should be recognized and properly treated because it is presenting a higher risk of cancer.

scholarly journals Sessile serrated adenoma of the appendix: literature review and clinical cases

2020 ◽  
Vol 1 (10) ◽  
pp. 105-109
Author(s):  
L. M. Mikhaleva ◽  
R. A. Vandysheva ◽  
I. S. Kozlov ◽  
O. A. Vasyukova ◽  
K. Yu. Midiber ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Symptoms ◽  
Health Department ◽  
Endoscopic Examination ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
True Incidence ◽  
Moscow City ◽  
Serrated Adenomas ◽  
Clinical Cases

The article contains a literature review of clinical cases describing sessile serrated adenomas in the appendix from 1998 to 2018. Currently, it is still diffi cult to assess the true incidence of this pathology due to the fact that in most cases serrated adenomas are accidental fi ndings diagnosed after removing an inflamed appendix, since often, at small sizes, they do not cause clinical symptoms, do not bother patients and are inaccessible for endoscopic examination (if located behind its orifi ce). In addition, we present 2 clinical cases of sessile serrated adenoma of the appendix in patients who were admitted to the City Clinical Hospital No. 31 of the Moscow City Health Department in 2018 due to acute appendicitis, with a clinical and morphological characteristic, including a molecular genetics study.

scholarly journals Hyperplastic Polyp? Look Again... The Impact of the New Classification for Serrated Polyps

2014 ◽  
Vol 27 (3) ◽  
pp. 304 ◽  
Author(s):  
Catarina Fidalgo ◽  
Liliana Santos ◽  
Isadora Rosa ◽  
Ricardo Fonseca ◽  
Pedro Lage ◽  
...  
Keyword(s):  
World Health Organization ◽  
Colonic Polyps ◽  
World Health ◽  
Hyperplastic Polyps ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
World Health Organization Classification ◽  
Health Organization ◽  
The Impact ◽  
Serrated Adenomas

<p><span style="font-family: Times New Roman; font-size: small;"><strong>Introduction:</strong> The World Health Organization reviewed the classification for serrated colonic polyps in 2010. A new entity, sessile serrated adenoma, was included with two variants: with and without cytological dysplasia. This lesion’s malignant potential has been recognized and according to the new classification, many polyps may be reclassified. The impact of this change is yet to be assessed.<br /><strong>Objective:</strong> Analyze the proportion of lesions that were reclassified according to the new World Health Organization classification and the variables that influenced it.<br /><strong>Material and Methods:</strong> Every patient with at least one sessile serrated adenoma diagnosed in a 5 year period was included. All polyps (regardless of type) resected during the study period were reviewed. Data concerning polyp’s characteristics and patient variables were collected. Forty consecutive patients were included [13 female, mean age at 1st sessile serrated adenoma -59 yrs (34-80)].<br /><strong>Results:</strong> Were reviewed 247 polyps: hyperplastic - 42%; conventional adenomas - 29%; sessile serrated adenoma - 24%; serrated adenomas - 5%. Sixty-three polyps were reclassified: 43 hyperplastic, 12 serrated adenomas, 7 sessile serrated adenoma and 1 conventional adenoma with low grade dysplasia. Reclassification was significantly greater for hyperplastic polyps when compared with the other subtypes. Forty-three of one hundred and four (41%) hyperplastic polyps were reclassified all as sessile serrated adenoma. In these polyps the probability of reclassification was independent from polyp location but was greater if polyp size ≥ 5 mm.<br /><strong>Discussion: </strong>This is a single center, rectrospective study. The fact that it was done in an Oncology Referral Institution with a Family Risk Clinic may have influenced the results. Nevertheless the impressive reclassification rate for Hyperplastic Polyps and the fact that they were reclassified mainly as Serrated Adenomas makes these results relevant to daily practice.<br /><strong>Conclusion:</strong> Our results suggest that, according to the new World Health Organization classification for serrated colonic polyps, a considerable proportion of hyperplastic polyps will be reclassified. The serrated pathway of colorectal carcinogenesis has probably been underestimated and at-risk patients may have been under inappropriate surveillance.<br /><strong>Keywords: </strong>Colonic Neoplasms/diagnosis; Colonic Polyps/classification; World Health Organization; Neoplasm Grading.</span></p>

scholarly journals Frequency of coexistent carcinoma in sessile serrated adenoma/polyps and traditional serrated adenomas removed by endoscopic resection

2016 ◽  
Vol 04 (04) ◽  
pp. E451-E458 ◽  
Author(s):  
Hirotsugu Saiki ◽  
Tsutomu Nishida ◽  
Masashi Yamamoto ◽  
Shiro Hayashi ◽  
Hiromi Shimakoshi ◽  
...  
Keyword(s):  
Endoscopic Resection ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Serrated Adenomas

scholarly journals Histopathological Audit of 373 Nononcological Hysterectomies in a Teaching Hospital

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Kanwardeep Kaur Tiwana ◽  
Sarita Nibhoria ◽  
Tanvi Monga ◽  
Richa Phutela
Keyword(s):  
Preoperative Diagnosis ◽  
Health Care Services ◽  
Histopathological Examination ◽  
Treatment Modalities ◽  
Common Finding ◽  
Kappa Statistics ◽  
Histopathological Diagnosis ◽  
Care Services ◽  
One Year

Hysterectomy, the most common gynecological surgery, provides a definitive cure to various diseases like DUB (dysfunctional uterine bleeding), leiomyoma, adenomyosis, chronic pelvic pain, prolapse, and malignancy. However, with advent of effective medical and conservative treatment modalities for nononcological causes it is now posing question mark on justification of hysterectomy. Therefore, an audit is required to assess the correlation between preoperative diagnosis and histopathological examination of specimen for justification of the procedure. In this study over period of one year (April 2013 to March 2014) 373 hysterectomies specimens were received in the department of pathology for nononcological causes. The age of patients ranged from 22 to 85 years with mean 45±9.2 years. All cases were divided into five categories on the basis of age and audit was done. In this study the most common finding was leiomyoma (43.7%) followed by adenomyosis (19.3%). Almost 50% of hysterectomies causes were justified as preoperative diagnosis matched with histopathology. Cohen kappa statistics were used to measure agreement between preoperative and postoperative histopathological diagnosis which was found to be fair with κ value being 0.36. This study highlights that regular audit of surgeries can help improve quality of health care services and provide safe conservative option to patients.

Histopathology of Serrated Adenoma, Its Variants, and Differentiation From Conventional Adenomatous and Hyperplastic Polyps

2007 ◽  
Vol 131 (3) ◽  
pp. 440-445
Author(s):  
Shuan C. Li ◽  
Lawrence Burgart
Keyword(s):  
Cancer Progression ◽  
Hyperplastic Polyp ◽  
Routine Practice ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Comparable Rate ◽  
Traditional Serrated Adenoma ◽  
Gastrointestinal Pathology ◽  
Conventional Adenoma ◽  
Serrated Adenomas

Abstract Context.—Serrated adenomas can be morphologically subdivided into traditional and sessile types. They are thought to have a comparable rate of cancer progression like conventional adenomas, but they potentially have a faster rate of growth through methylation pathway(s). They share similar morphologic features with both the conventional adenoma and the hyperplastic polyp in a fashion that is different from a mixed adenoma and a hyperplastic polyp. Objective.—To describe the histopathologic features of traditional serrated adenoma and sessile serrated adenoma and their comparison with traditional adenomas and hyperplastic polyp. Data Sources.—Relevant articles in peer-review journals and the authors' working experience as practicing surgical pathologists with a specific interest in gastrointestinal pathology. Conclusions.—Both types of serrated adenomas, traditional serrated adenoma and sessile serrated adenoma, are morphologically distinct, clinically important entities, and they can be diagnosed accurately in routine practice.

scholarly journals A Retrospective Analysis of Colorectal Serrated Lesions from 2005 to 2014 in a Single Center: Importance of the Establishment of Diagnostic Patterns

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Priscilla S. P. Oliveira ◽  
Rita B. Carvalho ◽  
Daniela O. Magro ◽  
Michel G. Camargo ◽  
Carlos A. R. Martinez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Retrospective Analysis ◽  
Histopathological Examination ◽  
Morphological Characterization ◽  
Histological Diagnosis ◽  
Single Center ◽  
Serrated Adenoma ◽  
Serrated Lesions ◽  
Patient’S History ◽  
Serrated Adenomas

Background. Serrated colorectal lesions are increasingly recognized as an important process in the development of colorectal cancer. Endoscopic and histological diagnosis may be difficult, and knowledge of the serrated lesions is important for the establishment of strategies for treating colorectal lesions. We aimed to analyze serrated lesions diagnosed at a single center and evaluate if there was an increase in their identification over the years. Design and Setting. A retrospective analysis of colonoscopy reports was performed at a specialized center from 2005 to 2014. Methods. Colonoscopy reports about any resected endoscopic lesions were reviewed and subjected to histological diagnosis from 2005 to 2014. Then, serrated lesions were evaluated based on morphological characterization, location, size, occurrence of synchronous lesions, and the patient’s history of colorectal cancer and polyps. Results. A total of 2126 colonoscopy examination reports were reviewed, and 3494 lesions were analyzed. On histopathological examination, 1089 (31.2%) were classified as hyperplastic polyps, 22 (0.6%) as sessile serrated adenomas, and 21 (0.6%) as traditional serrated adenomas. There was an increase in the number of cases of sessile and traditional serrated adenomas diagnosed after 2010. Before 2010, two cases of sessile serrated adenomas and seven cases of traditional serrated adenomas were diagnosed; after 2010, 20 cases of sessile serrated adenoma and 14 cases of traditional serrated adenomas were diagnosed. Conclusion. There was an increase in the diagnosis of sessile serrated adenomas over the years, which can be attributed to better accuracy in colonoscopy and histological classification.

Anatomic Distribution of Sessile Serrated Adenoma/Polyp With and Without Cytologic Dysplasia

2015 ◽  
Vol 139 (3) ◽  
pp. 388-393 ◽  
Author(s):  
Juliana F. Yang ◽  
Shou-Jiang Tang ◽  
Richard H. Lash ◽  
Ruonan Wu ◽  
Qinghua Yang
Keyword(s):  
Distal Colon ◽  
Proximal Colon ◽  
Published Data ◽  
Low Grade ◽  
Ascending Colon ◽  
Sessile Serrated Adenoma ◽  
Serrated Adenoma ◽  
Anatomic Distribution ◽  
Low Prevalence ◽  
Serrated Adenomas

Context Sessile serrated adenomas/polyps (SSA/Ps) have been increasingly studied during the last 10 years. However, their detailed anatomic distribution pattern has not been studied, especially given newer (broader) criteria for the diagnosis. Objectives To characterize the anatomic distribution of SSA/P with and without cytologic dysplasia and to assess the demographics of these patients in a nationwide database. Design We retrospectively analyzed the database of Miraca Life Sciences Research Institute for a 1-year period. Patients with a diagnosis of SSA/P, SSA/P with low-grade cytologic dysplasia (SSA/P-LGD), SSA/P with high-grade cytologic dysplasia (SSA/P-HGD), or SSA/P with adenocarcinoma (SSA/P-ACA) were retrieved, and patients' age, sex, and specific anatomic location were analyzed. Results A total of 11 201 patients were identified, of which 10 646 (95.0%) had SSA/P, 514 (4.6%) had SSA/P-LGD, 39 (0.35%) had SSA/P-HGD, and 2 (0.018%) had SSA/P-ACA. All SSA/Ps and more advanced lesions were significantly more common in the proximal colon—SSA/P (61.2%), SSA/P-LGD (61.2%), SSA/P-HGD (80%), and SSA/P-ACA (100%)—than in either the transverse (18.8%, 17.8%, 10.0%, and 0%, respectively) or the distal (19.9%, 21.0%, 10.0%, and 0%, respectively) colon, P &lt; .001. Sessile serrated adenoma/polyp with cytologic dysplasia was most commonly found in the ascending colon (LGD, 31.6%) and cecum (HGD, 37.5%). Advanced SSA/Ps were disproportionally more common among older women. Conclusions Sessile serrated adenomas/polyps with and without cytologic dysplasia and carcinoma are predominantly found in the cecum and ascending colon, whereas there is low prevalence in both the transverse and distal colon. Confirmation of previously published data regarding demographics of advanced lesions among a different cohort and including newer (broader) criteria suggests these criteria are valid.

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