scholarly journals Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Su Jeong Song ◽  
Soo-Wang Hyun ◽  
Tae Gu Lee ◽  
Bongkyun Park ◽  
Kyuhyung Jo ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Topical Administration ◽  
Air Pollutant ◽  
Dry Eye Syndrome ◽  
Protective Effects ◽  
Corneal Epithelial ◽  
Liriope Platyphylla ◽  
Ocular System

Particulate matter (PM) is a type of air pollutant that poses a risk to human health. In the ocular system, PM causes or aggravates dry eye syndrome (DES) by damaging the corneal and conjunctival epithelia. Liriope platyphylla has been used traditionally as an expectorant, antitussive agent, and tonic in Korea. However, the effects of Liriope platyphylla extract (LPE) on PM-induced ocular damage have not been elucidated. In this study, we evaluated the in vivo protective effect of LPE against PM-induced DES in rats. Topical administration of LPE attenuated the PM-induced decrease in tear volume and reduced corneal epithelial irregularity and damage. LPE also protected against PM-induced disruption of the corneal mucin-4 layer and reduction in the conjunctival goblet cell density. These findings suggest that LPE has protective effects against PM-induced DES.

scholarly journals Air pollutant particulate matter 2.5 induces dry eye syndrome in mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Gang Tan ◽  
Juan Li ◽  
Qichen Yang ◽  
Anhua Wu ◽  
Dong-Yi Qu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Air Pollutant ◽  
Dry Eye Syndrome ◽  
Particulate Matter 2.5

A mouse dry eye model induced by topical administration of the air pollutant particulate matter 10

2017 ◽  
Vol 96 ◽  
pp. 524-534 ◽  
Author(s):  
Juan Li ◽  
Gang Tan ◽  
Xiaoyan Ding ◽  
Yahong Wang ◽  
Anhua Wu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Topical Administration ◽  
Air Pollutant ◽  
Eye Model

scholarly journals Corneal Epithelial Immune Dendritic Cell Alterations in Subtypes of Dry Eye Disease: A Pilot In Vivo Confocal Microscopic Study

2015 ◽  
Vol 56 (12) ◽  
pp. 7179 ◽  
Author(s):  
Ahmad Kheirkhah ◽  
Raheleh Rahimi Darabad ◽  
Andrea Cruzat ◽  
Amir Reza Hajrasouliha ◽  
Deborah Witkin ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Microscopic Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Cell Alterations ◽  
Confocal Microscopic Study

scholarly journals In Vivo Anti-Inflammation Potential of Aster koraiensis Extract for Dry Eye Syndrome by the Protection of Ocular Surface

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3245
Author(s):  
Sung-Chul Hong ◽  
Jung-Heun Ha ◽  
Jennifer K. Lee ◽  
Sang Hoon Jung ◽  
Jin-Chul Kim
Keyword(s):  
Animal Model ◽  
Er Stress ◽  
Dry Eye ◽  
Lacrimal Gland ◽  
Ocular Surface ◽  
Inflammatory Responses ◽  
Dry Eye Syndrome ◽  
Inhibitory Effects ◽  
Food Material

Dry eye syndrome (DES) is a corneal disease often characterized by an irritating, itching feeling in the eyes and light sensitivity. Inflammation and endoplasmic reticulum (ER) stress may play a crucial role in the pathogenesis of DES, although the underlying mechanism remains elusive. Aster koraiensis has been used traditionally as an edible herb in Korea. It has been reported to have wound-healing and inhibitory effects against insulin resistance and inflammation. Here, we examined the inhibitory effects of inflammation and ER stress by A. koraiensis extract (AKE) in animal model and human retinal pigmented epithelial (ARPE-19) cells. Oral administration of AKE mitigated DE symptoms, including reduced corneal epithelial thickness, increased the gap between lacrimal gland tissues in experimental animals and decreased tear production. It also inhibited inflammatory responses in the corneal epithelium and lacrimal gland. Consequently, the activation of NF-κB was attenuated by the suppression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Moreover, AKE treatment ameliorated TNF-α-inducible ocular inflammation and thapsigargin (Tg)-inducible ER stress in animal model and human retinal pigmented epithelial (ARPE-19) cells. These results prove that AKE prevents detrimental functional and histological remodeling on the ocular surface and in the lacrimal gland through inhibition of inflammation and ER stress, suggesting its potential as functional food material for improvement of DES.

scholarly journals Topical administration of Esculetin as a potential therapy for experimental dry eye syndrome

Eye ◽  
2017 ◽  
Vol 31 (12) ◽  
pp. 1724-1732 ◽  
Author(s):  
D Jiang ◽  
X Liu ◽  
J Hu
Keyword(s):  
Dry Eye ◽  
Topical Administration ◽  
Dry Eye Syndrome

scholarly journals Achyranthis radix Extract Improves Urban Particulate Matter-Induced Dry Eye Disease

2019 ◽  
Vol 16 (18) ◽  
pp. 3229 ◽  
Author(s):  
Tae Gu Lee ◽  
Soo-Wang Hyun ◽  
Kyuhyung Jo ◽  
Bongkyun Park ◽  
Ik Soo Lee ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Water Extract ◽  
Dry Eye Disease ◽  
Hot Water ◽  
Eye Disease ◽  
Corneal Epithelial ◽  
Urban Particulate Matter ◽  
Eye Health ◽  
Induced Apoptosis

Dry eye disease (DED) is a multifactorial inflammatory disease that severely impairs patients’ quality of life. Particulate matter comprises a harmful mixture of particles less than 10 μm in size, which on contact with the eye, causes inflammation in the cornea/conjunctival epithelium, threatening eye health and triggering the onset of DED. Achyranthis radix is an ingredient of traditional medicine generally used for treating osteoporosis, trauma, and thrombosis in Asian countries. However, the effect of Achyranthis radix on eye health has not been elucidated. In this study, we evaluate the protective effect of Achyranthis radix hot water extract (ARE) in a rat model of urban particulate matter (UPM)-induced DED. UPM with or without ARE were topically administered on both eyes thrice daily for 10 days. ARE induced tear secretion and improved corneal irregularity. Additionally, ARE treatment protected the corneal epithelial cells from UPM-induced apoptosis. It also restored rMuc4 expression in the cornea and increased goblet cell density in the conjunctiva. These results are suggestive of the potential of ARE as a topical therapeutic agent for treating DED.

scholarly journals New application for assessment of dry eye syndrome induced by particulate matter exposure

2020 ◽  
Vol 205 ◽  
pp. 111125
Author(s):  
Su Jeong Song ◽  
Soo-Wang Hyun ◽  
Tae Gu Lee ◽  
Bongkyun Park ◽  
Kyuhyung Jo ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Dry Eye Syndrome ◽  
Particulate Matter Exposure

scholarly journals Prediction Model for Dry Eye Syndrome Incidence Rate Using Air Pollutants and Meteorological Factors in South Korea: Analysis of Sub-Region Deviations

2020 ◽  
Vol 17 (14) ◽  
pp. 4969
Author(s):  
Jong-Sang Youn ◽  
Jeong-Won Seo ◽  
Wonjun Park ◽  
SeJoon Park ◽  
Ki-Joon Jeon
Keyword(s):  
South Korea ◽  
Prediction Model ◽  
Incidence Rate ◽  
Dry Eye ◽  
Air Pollutants ◽  
Metropolitan Areas ◽  
Meteorological Factors ◽  
Air Pollutant ◽  
Dry Eye Syndrome ◽  
Population Rate

Here, we develop a dry eye syndrome (DES) incidence rate prediction model using air pollutants (PM10, NO2, SO2, O3, and CO), meteorological factors (temperature, humidity, and wind speed), population rate, and clinical data for South Korea. The prediction model is well fitted to the incidence rate (R2 = 0.9443 and 0.9388, p < 2.2 × 10−16). To analyze regional deviations, we classify outpatient data, air pollutant, and meteorological factors in 16 administrative districts (seven metropolitan areas and nine states). Our results confirm NO2 and relative humidity are the factors impacting regional deviations in the prediction model.

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