A mouse dry eye model induced by topical administration of the air pollutant particulate matter 10

2017 ◽  
Vol 96 ◽  
pp. 524-534 ◽  
Author(s):  
Juan Li ◽  
Gang Tan ◽  
Xiaoyan Ding ◽  
Yahong Wang ◽  
Anhua Wu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Topical Administration ◽  
Air Pollutant ◽  
Eye Model

scholarly journals Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Su Jeong Song ◽  
Soo-Wang Hyun ◽  
Tae Gu Lee ◽  
Bongkyun Park ◽  
Kyuhyung Jo ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Topical Administration ◽  
Air Pollutant ◽  
Dry Eye Syndrome ◽  
Protective Effects ◽  
Corneal Epithelial ◽  
Liriope Platyphylla ◽  
Ocular System

Particulate matter (PM) is a type of air pollutant that poses a risk to human health. In the ocular system, PM causes or aggravates dry eye syndrome (DES) by damaging the corneal and conjunctival epithelia. Liriope platyphylla has been used traditionally as an expectorant, antitussive agent, and tonic in Korea. However, the effects of Liriope platyphylla extract (LPE) on PM-induced ocular damage have not been elucidated. In this study, we evaluated the in vivo protective effect of LPE against PM-induced DES in rats. Topical administration of LPE attenuated the PM-induced decrease in tear volume and reduced corneal epithelial irregularity and damage. LPE also protected against PM-induced disruption of the corneal mucin-4 layer and reduction in the conjunctival goblet cell density. These findings suggest that LPE has protective effects against PM-induced DES.

scholarly journals Air pollutant particulate matter 2.5 induces dry eye syndrome in mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Gang Tan ◽  
Juan Li ◽  
Qichen Yang ◽  
Anhua Wu ◽  
Dong-Yi Qu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Dry Eye ◽  
Air Pollutant ◽  
Dry Eye Syndrome ◽  
Particulate Matter 2.5

Vicious Cycle of Economic Growth, Pm2.5 and COVID-19 Case of G7 Countries

2020 ◽  
Author(s):  
Rıdvan Karacan
Keyword(s):  
Economic Growth ◽  
Air Pollution ◽  
Particulate Matter ◽  
Fossil Fuels ◽  
Fine Particulate Matter ◽  
Panel Cointegration ◽  
Air Pollutant ◽  
Population Exposure ◽  
Causality Analysis ◽  
G7 Countries

<p>Today, production is carried out depending on fossil fuels. Fossil fuels pollute the air as they contain high levels of carbon. Many studies have been carried out on the economic costs of air pollution. However, in the present study, unlike the former ones, economic growth's relationship with the COVID-19 virus in addition to air pollution was examined. The COVID-19 virus, which was initially reported in Wuhan, China in December 2019 and affected the whole world, has caused many cases and deaths. Researchers have been going on studying how the virus is transmitted. Some of these studies suggest that the number of virus-related cases increases in regions with a high level of air pollution. Based on this fact, it is thought that air pollution will increase the number of COVID-19 cases in G7 Countries where industrial production is widespread. Therefore, the negative aspects of economic growth, which currently depends on fossil fuels, is tried to be revealed. The research was carried out for the period between 2000-2019. Panel cointegration test and panel causality analysis were used for the empirical analysis. Particulate matter known as PM2.5[1] was used as an indicator of air pollution. Consequently, a positive long-term relationship has been identified between PM2.5 and economic growth. This relationship also affects the number of COVID-19 cases.</p><p><br></p><p><br></p><p>[1] "Fine particulate matter (PM2.5) is an air pollutant that poses the greatest risk to health globally, affecting more people than any other pollutant (WHO, 2018). Chronic exposure to PM2.5 considerably increases the risk of respiratory and cardiovascular diseases in particular (WHO, 2018). For these reasons, population exposure to (outdoor or ambient) PM2.5 has been identified as an OECD Green Growth headline indicator" (OECD.Stat).</p>

scholarly journals Effect of persimmon leaves (Diospyros kaki) on goblet cell density and inflammation in experimental dry eye model

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Kyung-A Kim ◽  
Chung Hyun Lee ◽  
Tae Kyeom Kang ◽  
Sung Jae Yang ◽  
Chang Yong Lee ◽  
...  
Keyword(s):  
Cell Density ◽  
Dry Eye ◽  
Goblet Cell ◽  
Diospyros Kaki ◽  
Eye Model ◽  
Goblet Cell Density

scholarly journals Knowledge, Attitude, and Practice of Dry Eye Treatment by Institutional Chinese Physicians in Singapore

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Wanwen Lan ◽  
Sze Yee Lee ◽  
Man Xin Lee ◽  
Louis Tong
Keyword(s):  
Dry Eye ◽  
Public Awareness ◽  
Topical Administration ◽  
Treatment Session ◽  
Eye Drops ◽  
Public Health Burden ◽  
Attitude And Practice ◽  
Eye Acupuncture ◽  
Chinese Physicians ◽  
Knowledge Attitude And Practice

Dry eye is a common health problem worldwide, causing significant discomfort and inconvenience to sufferers. The conventional treatment of dry eye via topical administration of eye drops is deemed palliative and unsatisfactory to many. Traditional Chinese medicine (TCM) has shown some promise in dry eye treatment; however, the extent of its use and acceptance is uncertain. We evaluated the knowledge, attitude, and practice of institutional TCM practitioners in the treatment of dry eye in Singapore. A questionnaire was generated to address the study aims and sent to TCM practitioners listed in the Singapore TCM practitioners’ board database. About three quarters of respondents thought that dry eye was not severe enough to be a public health burden but most thought that TCM was effective in the treatment of dry eye. Acupuncture and herbal medicine were most commonly used TCM modalities in dry eye treatment, and a single TCM treatment session would be charged S$20–50 by the practitioner. The majority of surveyed institutional TCM practitioners in Singapore believe that TCM is relevant in dry eye treatment. Public awareness should be raised regarding the availability of TCM as alternative medicine for dry eye.

scholarly journals Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis

2016 ◽  
Vol 310 (11) ◽  
pp. H1423-H1438 ◽  
Author(s):  
Petra Haberzettl ◽  
James P. McCracken ◽  
Aruni Bhatnagar ◽  
Daniel J. Conklin
Keyword(s):  
Insulin Resistance ◽  
Bone Marrow ◽  
Particulate Matter ◽  
Insulin Sensitivity ◽  
Ambient Air ◽  
Air Pollutant ◽  
Ambient Air Pollution ◽  
Endothelial Progenitor ◽  
Insulin Sensitizer ◽  
Circulating Levels

Exposure to fine particular matter (PM2.5) increases the risk of developing cardiovascular disease and Type 2 diabetes. Because blood vessels are sensitive targets of air pollutant exposure, we examined the effects of concentrated ambient PM2.5 (CAP) on vascular insulin sensitivity and circulating levels of endothelial progenitor cells (EPCs), which reflect cardiovascular health. We found that CAP exposure for 9 days decreased insulin-stimulated Akt phosphorylation in the aorta of mice maintained on control diet. This change was accompanied by the induction of IL-1β and increases in the abundance of cleaved IL-18 and p10 subunit of Casp-1, consistent with the activation of the inflammasome pathway. CAP exposure also suppressed circulating levels of EPCs (Flk-1+/Sca-1+ cells), while enhancing the bone marrow abundance of these cells. Although similar changes in vascular insulin signaling and EPC levels were observed in mice fed high-fat diet, CAP exposure did not exacerbate diet-induced changes in vascular insulin resistance or EPC homeostasis. Treatment with an insulin sensitizer, metformin or rosiglitazone, prevented CAP-induced vascular insulin resistance and NF-κB and inflammasome activation and restored peripheral blood and bone marrow EPC levels. These findings suggest that PM2.5 exposure induces diet-independent vascular insulin resistance and inflammation and prevents EPC mobilization, and that this EPC mobilization defect could be mediated by vascular insulin resistance. Impaired vascular insulin sensitivity may be an important mechanism underlying PM2.5-induced vascular injury, and pharmacological sensitization to insulin action could potentially prevent deficits in vascular repair and mitigate vascular inflammation due to exposure to elevated levels of ambient air pollution. Listen to this article's corresponding podcast at http://ajpheart.podbean.com/e/particulate-matter-induced-vascular-insulin-resistance/ .

scholarly journals Regional Energy, CO2, and Economic and Air Quality Index Performances in China: A Meta-Frontier Approach

Energies ◽  
2018 ◽  
Vol 11 (8) ◽  
pp. 2119 ◽  
Author(s):  
Ying Li ◽  
Yung-Ho Chiu ◽  
Liang Lu
Keyword(s):  
Particulate Matter ◽  
Energy Consumption ◽  
Air Quality ◽  
Quality Index ◽  
Air Pollutant ◽  
Air Quality Index ◽  
Significant Difference ◽  
Desirable Output ◽  
Reduce Emissions ◽  
Carbon Dioxide Co2

Rapid economic development has resulted in a significant increase in energy consumption and pollution such as carbon dioxide (CO2), particulate matter (PM2.5), particulate matter 10 (PM10), SO2, and NO2 emissions, which can cause cardiovascular and respiratory diseases. Therefore, to ensure a sustainable future, it is essential to improve economic efficiency and reduce emissions. Using a Meta-frontier Non-radial Directional Distance Function model, this study took energy consumption, the labor force, and fixed asset investments as the inputs, Gross domestic product (GDP) as the desirable output, and CO2 and the Air Quality Index (AQI) scores as the undesirable outputs to assess energy efficiency and air pollutant index efficiency scores in China from 2013–2016 and to identify the areas in which improvements was necessary. It was found that there was a large gap between the western and eastern cities in China. A comparison of the CO2 and AQI in 31 Chinese cities showed a significant difference in the CO2 emissions and AQI efficiency scores, with the lower scoring cities being mainly concentrated in China’s western region. It was therefore concluded that China needs to pay greater attention to the differences in the economic levels, stages of social development, and energy structures in the western cities when developing appropriately focused improvement plans.

scholarly journals Assessment of PM10 in Aurangabad City of Central India

2016 ◽  
Vol 5 (2) ◽  
pp. 61-74 ◽  
Author(s):  
Geetanjali Kaushik ◽  
Arvind Chel ◽  
Sangeeta Shinde ◽  
Ashish Gadekar
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Tall Buildings ◽  
Central India ◽  
Air Pollutant ◽  
Traffic Density ◽  
High Pollution ◽  
High Concentrations ◽  
The City

Almost 670 million people comprising 54.5% of our population reside in regions that do not meet the Indian NAAQS for fine particulate matter. Numerous studies have revealed a consistent correlation for particulate matter concentration with health than any other air pollutant. Aurangabad city a rapidly growing city with population of 1.5 million is home to five major industrial areas, the city is also known for its historical monuments which might also be adversely affected from air pollution. Therefore, this research aims at estimating PM10 concentrations at several locations across Aurangabad. The concentration of PM10 was highest at the Railway Station followed by Waluj (an industrial zone) and City chowk is the centre of the city which has high population, tall buildings, few open spaces which causes high congestion and does not allow the particulates to disperse. Other locations with high concentrations of PM are Mill corner, Harsul T-point, Kranti Chowk, Seven Hill, TV centre and Beed Bye pass. All these locations have narrow roads, high traffic density, poor road condition with pot holes and few crossing points which cause congestion and vehicle idling which are responsible for high pollution. Therefore, it is evident that air pollution is a serious issue in the city which may be further aggravated if it is not brought under control. Hence, strategies have to be adopted for combating the menace of air pollution.INTERNATIONAL JOURNAL OF ENVIRONMENTVolume-5, Issue-2, March-May 2016, Page :61-74

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