scholarly journals The Association between Helicobacter pylori Infection and Glycated Hemoglobin A in Diabetes: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jinhu Chen ◽  
Yuling Xing ◽  
Liying Zhao ◽  
Huijuan Ma
Keyword(s):  
Helicobacter Pylori ◽  
Publication Bias ◽  
Subgroup Analysis ◽  
Glycated Hemoglobin ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Helicobacter Pylori Infection ◽  
Sensitivity Analyses ◽  
Hemoglobin A ◽  
Glycated Hemoglobin A

Background.The association between Helicobacter pylori infection and glycated hemoglobin A has been confirmed in many studies, but these conclusions are still contradictory and controversial. Therefore, we conducted a meta-analysis to resolve the problem of inconsistent results in diabetes.Methods. A comprehensive search was conducted on related researches published in PubMed, Embase, and China Academic Journal Full-text Database (CNKI) from the inception of each database to April 2019. Fixed or random effects model was used to pool the weighted mean difference with 95% confidence interval from individual studies. Subgroup and sensitivity analyses were also performed. Publication bias was estimated by funnel plot, Egger’s test, and fail-safe numbers.Results. 35 studies with 4,401 participants with diabetes were included in the meta-analysis. Glycated hemoglobin A levels were elevated in patients with Helicobacter pylori infection compared with patients without Helicobacter pylori infection (WMD=0.50, 95% CI: 0.28-0.72,p<0.001). In subgroup analysis by the subtype of diabetes, there was a correlation between Helicobacter pylori infection and elevated glycated hemoglobin A in type 1 diabetes (I2=74%,p<0.001,WMD=0.46, 95% CI: 0.12-0.80), and in type 2 diabetes (I2=90%,p<0.001,WMD=0.59, 95% CI: 0.28-0.90,p<0.001). In subgroup analysis by the study design, there was a correlation in cross-sectional study (I2=89%,p<0.001,WMD=0.42, 95% CI: 0.16-0.69,p≤0.003) and in case-control study (I2=83%,p<0.001,WMD=0.39, 95% CI: 0.14-0.64,p≤0.003). By different methods for detecting Helicobacter pylori, there was a correlation in the biopsy group (I2=83%,p<0.001,WMD=0.6, 95% CI: 0.11-1.09,p≤0.03) and in other groups of test methods (I2=87%,p<0.001,WMD=0.37, 95% CI: 0.17-0.56,p<0.001). Sensitivity analysis showed that our results were reliable, and no evidence of substantial publication bias was detected.Conclusion. The meta-analysis might indicate a correlation between Helicobacter pylori infection and glycated hemoglobin A levels in diabetes.

Helicobacter pylori infection and the risk of colorectal cancer: A meta-analysis of epidemiologic evidence.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 408-408 ◽  
Author(s):  
Basile M. Njei ◽  
Ivo C. Ditah ◽  
Juliet Appiah ◽  
Raxitkumar Jinjuvadia ◽  
John W. Birk
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Publication Bias ◽  
Study Design ◽  
Subgroup Analysis ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Helicobacter Pylori Infection ◽  
Quality Data ◽  
Current Evidence

408 Background: The association between Helicobacter pylori infection (HPI) and gastric cancer is well known, but it is unclear whether HPI is also a risk factor for colorectal cancer. Several epidemiological studies on the latter association have yielded conflicting results. The aim of this study is to summarize available evidence on the association between HPI and CRC, evaluating its magnitude and direction in a meta-analysis. Methods: Two reviewers independently conducted a systemic search on Medline, OvidSP and PubMed databases from January 1980 to July 2011 for studies on the association between HPI and CRC. The reference lists of eligible studies were next reviewed for additional studies on the subject. Firstly, a combined analysis including all studies was done. Next, subgroup analysis by study design and country of study (USA Vs Europe Vs Asia) were also performed. All analyses were done using the random effects model. Publication bias was assessed using the Begg’s and Egger’s tests and visual inspection of funnel plot. All analyses were performed using STATA 11. Results: Sixteen studies (14 retrospective and 2 prospective) including 12,892 participants were included in the analysis. Overall, HP was associated with a 49% significantly higher risk of CRC (OR 1.49, 95% CI: 1.22-1.82; P < 0.001). By study design, the association persisted only among the retrospective studies with a pooled OR of 1.43 (95% CI: 1.31-1.56, P = 0.004). The subgroup analysis by study region showed significant associations in Europe (OR 1.35, 95% CI 1.09-1.66) and Asia (RR 1.43, 95% CI 1.29-1.58). Though there was a 17% higher risk noted among studies done in the USA, this was not statistically significant. There was no evidence of publication bias in all the analyses. Conclusions: Current evidence on the association between H. pylori infection and CRC remains inconclusive. The absence of any association among the prospective studies (with less risk of bias) suggests that the association seen among the retrospective studies could be due to residual confounding. Better quality data is required before a conclusive statement on the association between HPI and CRC can be made.

scholarly journals Prevalence difference of Helicobacter pylori infection between Tibetan and Han ethnics: A meta-analysis on epidemiologic studies

2019 ◽  
Author(s):  
Dan Bai ◽  
Kai Liu ◽  
An-Mo Wang ◽  
Si-Yu Duan ◽  
Wei-Han Zhang ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Gastrointestinal Symptoms ◽  
Northwest China ◽  
Epidemiologic Studies ◽  
Sensitivity Analyses ◽  
Human Gastric Cancer ◽  
Northwestern Region ◽  
Meta Analyses

Abstract Background Helicobacter pylori (Hp) appears worldwide prevalent as a primary carcinogenic pathogen of human gastric cancer. China is a multi-ethnic country, and the prevalence of Hp infection may be diverse among ethnics. This meta-analysis was conducted to compare the prevalence of Hp infection between Tibetan and Han ethnics.Methods The databases, PubMed, Web of Science, Blackwell Journals, CNKI, and Wanfang were searched. Those studies which reported the prevalence of Hp infection between Tibetans and Hans in China were eligible. There were no limitation to Hp detection method, publication language, and observation period. RevMan 5.3 and Stata 12.0 softwares were used for heterogeneity tests and meta-analyses. Meanwhile, subgroup analysis, sensitivity analysis and publication bias evaluation were performed where applicable.Results Totally, 11 studies with 3,826 Tibetans and 19,787 Hans were analyzed. The pooled prevalence of Hp infection were 62.2% and 55.3% among Tibetans and Hans, respectively. Tibetans had higher risk of Hp infection than Hans (OR=1.38, 95% CI 1.05-1.80). In subgroup analysis, those Tibetans with upper gastrointestinal symptoms (OR=1.51, 95% CI 1.06-2.16), inhabiting in Tibet (OR=1.51, 95% CI 1.22-1.87), or in Northwestern region (OR=1.15, 95% CI 1.00-1.31) had significantly higher risk of Hp infection. Additionally, in recent ten years, Hans appeared a decreased risk of Hp infection (OR=1.81, 95% CI 1.42-2.30). Heterogeneity was common, while sensitivity analyses showed partially inconsistent results against main findings.Conclusions This study demonstrated the higher prevalence of Hp infection in Tibetans compared with Hans, especially in recent years, or in the Tibet and the northwest China, as well as symptomatic Tibetans. It suggests tailored strategy and robustness need further consider for Hp screening and eradication among Tibetans.Trial registration: The present systematic review and meta-analysis was registered in the PROSPERO International Prospective Register of Systematic Reviews supported by the National Institute for Health Research of the National Health Service (NHS), UK (registration number: CRD42019121192).

scholarly journals Risk of dementia in gout and hyperuricaemia: a meta-analysis of cohort studies

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e041680
Author(s):  
Shu-Yue Pan ◽  
Rui-Juan Cheng ◽  
Zi-Jing Xia ◽  
Qiu-Ping Zhang ◽  
Yi Liu
Keyword(s):  
Cohort Studies ◽  
Quality Assessment ◽  
Publication Bias ◽  
Data Extraction ◽  
Meta Analysis ◽  
Sensitivity Analyses ◽  
Cochrane Library ◽  
Crystal Formation ◽  
Medical Subject Headings ◽  
Eligibility Criteria

ObjectivesGout, characterised by hyperuricaemia with monosodium urate crystal formation and inflammation, is the most common inflammatory arthritis in adults. Recent studies have found that elevated uric acid levels are related to the occurrence of dementia. We conducted a study to investigate the association between dementia and gout or hyperuricaemia.DesignSystematic review and meta-analysis of cohort studies.Data sourcesStudies were screened from inception to 28 June 2019 by searching Medline, Embase and the Cochrane Library databases.Eligibility criteriaCohort studies comparing the risk of dementia in patients with gout and hyperuricaemia versus non-gout and non-hyperuricaemia controls were enrolled.Data extraction and analysisTwo reviewers separately selected studies and extracted data using the Medical Subject Headings without restriction on languages or countries. The adjusted HRs were pooled using the DerSimonian and Laird random effects model. Sensitivity analyses were conducted to evaluate the stability of the results. Publication bias was evaluated using Egger’s and Begg’s tests. Quality assessment was performed according to the Newcastle-Ottawa Scale.ResultsFour cohort studies that met the inclusion criteria were included in our meta-analysis. We found that gout and hyperuricaemia did not increase the risk of dementia, with a pooled HR of 0.94 (95% CI 0.69 to 1.28), but might decrease the risk of Alzheimer’s disease (AD), with a pooled HR of 0.78 (95% CI 0.64 to 0.95). There was little evidence of publication bias. Quality assessment of the included studies was high (range: 6–8 points).ConclusionsOur study shows that gout and hyperuricaemia do not increase the risk of dementia. However, gout and hyperuricaemia might have a protective effect against AD. Due to the limited number of research articles, more investigations are needed to demonstrate the potential relationship between dementia and gout or hyperuricaemia.

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