scholarly journals Determination of Inorganic Elements in the Rhizome of Paris polyphylla Smith Var. chinensis (Franch.) Hara by Using Inductively Coupled Plasma Mass Spectrometry

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Tiezhu Chen ◽  
Juan Lin ◽  
Jun Yang ◽  
Yina Tang ◽  
Chunmei Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Inorganic Elements ◽  
Cultivation Conditions ◽  
Limit Of Quantification ◽  
Inductively Coupled ◽  
Paris Polyphylla ◽  
Validation Parameters ◽  
Plasma Mass Spectrometry

The objective of this study was to investigate the concentrations of inorganic elements in the rhizome of Paris polyphylla Smith var. chinensis (Franch.) Hara of different planting years and cultivation conditions. Twenty-five inorganic elements including Al, As, B, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, P, Pb, Se, Sr, Ti, V, and Zn in the rhizome were determined by using inductively coupled plasma mass spectrometry (ICP-MS). The analytical method was validated by measuring several parameters including linearity, correlation coefficient, limit of detection (LOD), limit of quantification (LOQ), and recovery. The linear working ranges were three, 0–300 μg/L, 0–500 μg/L, and 0–1000 μg/L, and the correlation coefficients (r) values were higher than 0.998. LOD varied from 0.001 μg/L (Be) to 11.957 μg/L (P), and LOQ varied from 0.003 μg/L (Be) to 35.870 μg/L (P). The recoveries spanned from 95.2 (Co) to 105.3% (Pb). Validation parameters showed the possibility of using whole of the sample preparation procedures used in this study. Based on the determined results, it is indicated that the toxic elements As, Cd, and Pb had no ingestion risk. The planting years and cultivation conditions had significant effects on the concentrations of inorganic elements of P. polyphylla var. chinensis. The concentrations of inorganic elements in cultivated samples were different from those in wild samples. The results can provide useful theoretical basis for the quality control and rational use of P. polyphylla var. chinensis.

scholarly journals Development and Validation of an Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Method for Quantitative Analysis of Platinum in Plasma, Urine, and Tissues

2016 ◽  
Vol 70 (9) ◽  
pp. 1529-1536 ◽  
Author(s):  
Ti Zhang ◽  
Shuang Cai ◽  
Wai Chee Forrest ◽  
Eva Mohr ◽  
Qiuhong Yang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Reaction System ◽  
Chemotherapeutic Agents ◽  
Limit Of Quantification ◽  
Rat Urine ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Validation Parameters ◽  
Plasma Mass Spectrometry

Cisplatin, a platinum chemotherapeutic, is one of the most commonly used chemotherapeutic agents for many solid tumors. In this work, we developed and validated an inductively coupled plasma mass spectrometry (ICP-MS) method for quantitative determination of platinum levels in rat urine, plasma, and tissue matrices including liver, brain, lungs, kidney, muscle, heart, spleen, bladder, and lymph nodes. The tissues were processed using a microwave accelerated reaction system (MARS) system prior to analysis on an Agilent 7500 ICP-MS. According to the Food and Drug Administration guidance for industry, bioanalytical validation parameters of the method, such as selectivity, accuracy, precision, recovery, and stability were evaluated in rat biological samples. Our data suggested that the method was selective for platinum without interferences caused by other presenting elements, and the lower limit of quantification was 0.5 ppb. The accuracy and precision of the method were within 15% variation and the recoveries of platinum for all tissue matrices examined were determined to be 85–115% of the theoretical values. The stability of the platinum-containing solutions, including calibration standards, stock solutions, and processed samples in rat biological matrices was investigated. Results indicated that the samples were stable after three cycles of freeze–thaw and for up to three months.

scholarly journals Simultaneous Analysis of Cadmium, Lead, Mercury, and Arsenic Content in Foodstuffs of Animal Origin by Inductively Coupled Plasma/Mass Spectrometry after Closed Vessel Microwave Digestion: Method Validation

2005 ◽  
Vol 88 (6) ◽  
pp. 1811-1821 ◽  
Author(s):  
Laurent Noël ◽  
Vincent Dufailly ◽  
Nadège Lemahieu ◽  
Christelle Vastel ◽  
Thierry Guérin
Keyword(s):  
Mass Spectrometry ◽  
Method Validation ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Microwave Digestion ◽  
Animal Origin ◽  
Closed Vessel ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Abstract A method validation of the total analysis of cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg) in foodstuffs by inductively coupled plasma/mass spectrometry (ICP/MS) after closed vessel microwave digestion is presented. Due to the lack of reference method for ICP/MS techniques in food and, based on the project of the European Committee of Normalization (CEN/TC 275/WG 10), the Agence Française de Normalisation (AFNOR) guidelines NF V03–110 were used for the evaluation of this method based on 2 steps, sample preparation and multielement detection. Several criteria considered as compulsory (linearity, specificity, precision under repeatability conditions, and trueness) have been estimated and discussed, in addition to intermediate precision reproducibility, the limit of detection, and the limit of quantification. Furthermore, a comparison with in-house methods using electrothermal atomic absorption was performed using an external proficiency testing scheme and food samples. The results indicated that this method could be used in the laboratory for the routine determination of these 4 cumulative toxic metals in foodstuffs with acceptable analytical performance.

scholarly journals Method Validation for Determination of Thallium by Inductively Coupled Plasma Mass Spectrometry and Monitoring of Various Foods in South Korea

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6729
Author(s):  
Yeon-hee Kim ◽  
Wook-jin Ra ◽  
Solyi Cho ◽  
Shinai Choi ◽  
Bokyung Soh ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Food Groups ◽  
Rare Element ◽  
Animal Products ◽  
Inductively Coupled ◽  
South Korean ◽  
Plasma Mass Spectrometry ◽  
Korean Market

Thallium (Tl) is a rare element and one of the most harmful metals. This study validated an analytical method for determining Tl in foods by inductively coupled plasma mass spectrometry (ICP-MS) based on food matrices and calories. For six representative foods, the method’s correlation coefficient (R2) was above 0.999, and the method limit of detection (MLOD) was 0.0070–0.0498 μg kg−1, with accuracy ranging from 82.06% to 119.81% and precision within 10%. We investigated 304 various foods in the South Korean market, including agricultural, fishery, livestock, and processed foods. Tl above the MLOD level was detected in 148 samples and was less than 10 μg kg−1 in 98% of the samples. Comparing the Tl concentrations among food groups revealed that fisheries and animal products had higher Tl contents than cereals and vegetables. Tl exposure via food intake did not exceed the health guidance level.

Using ICP-MS to Detect Inorganic Elements in Organic Materials: A New Tool to Identify Mordants or Dyes on Ancient Textiles

2004 ◽  
Vol 852 ◽  
Author(s):  
Laure Dussubieux ◽  
Mary W. Ballard
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Organic Materials ◽  
Organic Dye ◽  
Inorganic Elements ◽  
Metallic Elements ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Inorganic Constituents

ABSTRACTThe feasibility of determining metallic elements used as mordants or dyes with inorganic constituents was tested using inductively coupled plasma – mass spectrometry (ICP-MS). For this purpose, modern, historic and archaeological samples were investigated. Mordants containing copper, iron, tin, aluminium or uranium were successfully identified as well as an organic dye with a substitutional bromine.

Determination of Heavy Metals in Rhizomes of Alpinia galanga by Inductively Coupled Plasma Mass Spectrometry

2011 ◽  
Vol 486 ◽  
pp. 143-146 ◽  
Author(s):  
Chutima Limmatvapirat ◽  
Thawatchai Phaechamud ◽  
Juree Charoenteeraboon
Keyword(s):  
Mass Spectrometry ◽  
Heavy Metals ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Acid Digestion ◽  
Alpinia Galanga ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Galangal (Alpinia galanga(Linn.) Swartz.) is a popular spice in Thailand. Heavy metals, deriving from environmental pollution, might be contaminated in galangal rhizomes. Inductively coupled plasma mass spectrometry (ICP-MS) was a new and fast technique for ultratrace elemental analysis. The aim of this study was to validate a method for the determination of aluminium (Al), arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), mercury (Hg), manganese (Mn), nickel (Ni), lead (Pb), and zinc (Zn) in galangal rhizomes according to the European standards (EU) using nitric acid digestion followed by ICP-MS. The parameters evaluated in the validation were recovery, repeatability and within-laboratory reproducibility, limit of detection (LOD), and limit of quantification (LOQ). This method was used to analyze the concentrations of 11 heavy metals in 15 samples of galangal rhizomes collected in Nakhon Pathom province. The metal concentrations varied considerably in the different sample sources. The concentration of heavy metals in the galangal samples arranged in increasing order was Hg < Cd < As < Cr < Pb < Ni < Cu < Zn < Fe < Mn < Al. An acid digestion and ICP-MS method was applicable to determination of 11 heavy metals in galangal rhizomes, based on the recovery analysis, cost, and time taken

scholarly journals Determination of mercury species in seafood by liquid chrom tography - inductively coupled plasma mass spectrometry (LC-ICP-MS)

2019 ◽  
Vol 2 (4) ◽  
pp. 33-41
Author(s):  
Hieu Pham Cong ◽  
Chien Dinh Viet ◽  
Ri Nguyen Van ◽  
Anh Huong Nguyen Thi ◽  
Hong Hao Le Thi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Limit Of Detection ◽  
Mercury Species ◽  
Standard Samples ◽  
Inductively Coupled ◽  
Performance Requirements ◽  
Icp Ms ◽  
Limit Of Quantitation ◽  
Plasma Mass Spectrometry

Liquid chromatography hyphenated with inductively coupled plasma mass spectrometry (LC&shy;ICP&shy;MS) was investigated to simultaneously determine three mercury species (mercury methyl mercury and ethyl mercury) in seafood samples. Important parameters such as organic solvents, flow rate of the mobile phase, 2&shy;mercaptoethanol concentration, extraction time and temperature were optimized. The method was validated in term of the limit of detection, limit of quantitation, repeatability, and recovery meeting the AOAC performance requirements. The method has also been validated based on the analysis of certified standard samples DORM&shy;4, then applied to determine three mercury species in 30 seafood samples. Results showed that the content of mercury species was below the maximum limit according to the QCVN 8&shy;2 : 2011/BYT.

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