scholarly journals Prevalence of Cognitive Impairment and Its Predictors among HIV/AIDS Patients on Antiretroviral Therapy in Jimma University Medical Center, Southwest Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Getachew Yideg Yitbarek ◽  
Andualem Mossie Ayana ◽  
Moyeta Bariso Gare ◽  
Gashaw Garedew Woldeamanuel
Keyword(s):  
Cognitive Impairment ◽  
Antiretroviral Therapy ◽  
Medical Center ◽  
Clinical Stage ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Cross Sectional ◽  
Face To Face ◽  
Khat Chewing ◽  
Jimma University

Background. Cognitive impairment among human immunodeficiency virus (HIV) infected patients can lead to treatment nonadherence, faster progression of the illness, disability, and bed ridden state if we fail to detect it early. However, there is scarcity of previous published studies in Ethiopia on the assessment of cognitive impairment among HIV-positive patients. Hence, this study aimed to determine the prevalence and associated factors of cognitive impairment among HIV-positive patients receiving antiretroviral therapy (ART) at Jimma University Medical Center, Ethiopia. Methods. Hospital-based cross-sectional study was conducted among 328 HIV-positive patients attending Jimma University Medical Center, Ethiopia. Data were collected from a face-to-face interview and review of medical records using semistructured questionnaire. Validated International HIV Dementia Scale (IHDS) was used to screen for cognitive impairment. Data was analyzed using SPSS version 20. Results. A total of 328 (191 females and 137 males) HIV-positive patients were included in the study with a response rate of 97.04%. The prevalence of cognitive impairment among HIV-positive patients was 35.7%. Factors significantly associated with cognitive impairment were age group of 41−64 years (adjusted odds ratio [AOR] = 3.1, 95% confidence interval [CI] (1.3, 7.4)], plasma HIV-1 RNA load between 1.7log10 and 3log10 copies/ml [AOR = 2.2, 95% CI (1.1,4.3)] and ≥ 3log10 copies/ml [AOR = 7.5, 95% CI (2.6, 21.5)], khat chewing [AOR = 4.4, 95% CI (2.3, 8.3)], and clinical stage III of the disease [AOR = 5.6, 95% CI (1.7, 19.2)]. Conclusion. Despite the use of ART, the burden of cognitive impairment among HIV patients was high. Older age, khat chewing, advanced stage of the disease, and higher viral load were the independent factors associated with cognitive impairment. Thus, continuous screening of cognitive impairment, identification of the possible risk factors, and proper management strategy should be designed.

scholarly journals A High Prevalence Rate of a Positive Screen for Cognitive Impairment in Patients With Human Immunodeficiency Virus Attending an Irish Clinic

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Patricia H. McNamara ◽  
Robert Coen ◽  
Janice Redmond ◽  
Colin P. Doherty ◽  
Colm Bergin
Keyword(s):  
Human Immunodeficiency Virus ◽  
Cognitive Impairment ◽  
Large Scale ◽  
Screening Program ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Study Cohort ◽  
Cross Sectional ◽  
Positive Screen ◽  
Immunodeficiency Virus

Abstract Background Human immunodeficiency virus (HIV)-associated neurocognitive disorders occurs in 20%–50% of HIV-positive patients. We undertook this study to assess the prevalence of a positive screen for cognitive impairment in the clinic population at our institution and to demonstrate the feasibility of implementing a screening program in routine clinical encounters. Methods This was a cross-sectional study, and patients were recruited prospectively between December 2010 and February 2013. Inclusion criteria were as follows: patients were HIV positive, over the age of 18, capable of giving informed consent, and had sufficient ability to communicate in English. Patients were screened for cognitive impairment using the Brief Neurocognitive Screen. Results A total of 604 patients were recruited, and 51.5% had a positive screen for cognitive impairment. The majority of the study cohort were male (78.8%), mean age was 40.9 (standard deviation, 10.2) years, 70.9% were Irish, the most common mode of transmission was men who have sex with men (49.3%), 83% were on antiretroviral therapy, and 88.7% were virally suppressed. Logistic regression showed that the main factors predictive of a positive screen for cognitive impairment were the endorsement of cognitive symptoms (P = .024), being born in Africa (P < .000001), the use of benzodiazepines (P = .00341), being unemployed (P = .008), and consumption of more than 40 units of alcohol weekly (P = .035). There was a positive screen for depression in 9.1% and a positive screen for anxiety in 24.5%. Conclusions The study highlights the necessity for a structured, prospective, large-scale screening program for cognitive impairment across countries with limited resources and demonstrates the feasibility of easily implementing this with minimal training.

scholarly journals Impact of Sleep Disturbances on the Quality of Life Among Schizophrenic Out-patients of Jimma University Medical Center, Southwest Ethiopia: Hospital Based Cross-sectional Study

2020 ◽  
Vol 13 (1) ◽  
pp. 684-691
Author(s):  
Aman Dule ◽  
Mustefa Mohammedhussein ◽  
Mohammedamin Hajure
Keyword(s):  
Quality Of Life ◽  
Sleep Disturbances ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Southwest Ethiopia ◽  
Schizophrenic Patients ◽  
Jimma University

Aim: Current study was aimed to assess the impacts of sleep disturbances on patient’s quality of life. Background: Schizophrenia is a syndrome, which affects sleep. Up to 80% of schizophrenic patients complain of sleep disturbances which affect the quality of life Objectives: To assess the association of sleep disturbances and quality of life and other contributing factors among schizophrenic patients on follow-up treatment at Jimma University Southwest Ethiopia. Methods: A cross-sectional study with a consecutive sampling of 411 out-patients at Jimma University medical center was employed from April 21-June 20, 2019. Sleep disturbances and the quality of life were assessed by Pittsburgh sleep quality index and WHOQOL-BREF, respectively. Epi data version 3.1 and SPSS version 23.0 software was used. Chi-square and independent samples t-test were used for association and P-value < 0.05 was considered for statistical significance. Results: Most participants had sleep disturbances and the mean score of positive scale on PANSS was higher for patients with sleep disturbances. About one-fourth of the patients had very good subjective sleep quality and > 85% of sleep efficiency was reported by 139 participants. More than half (51.1%) of the subjects had used sleep medication and the majority (64.7%) of them were reported daytime dysfunctions in the past month. The social domain (M±SD=3.92±2.51, t=8.46, p= <0.001, eta2=0.15) and overall WHOQOL (M±SD=57.60±16.87, t=9.24, p= < 0.001, eta2= 0.17) score had a large difference of means and about 15% and 17% of the variance in sleep disturbance have been explained. Conclusion: Generally, the finding of the current study was in agreement with most of the previous studies and sleep disturbances respectively moderate to significant effects on the patient’s quality of life.

scholarly journals Comorbidity of HIV, hypertension, and diabetes and associated factors among people receiving antiretroviral therapy in Bahir Dar city, Ethiopia

2020 ◽  
Vol 10 ◽  
pp. 2235042X1989931
Author(s):  
Zenebework Getahun ◽  
Muluken Azage ◽  
Taye Abuhay ◽  
Fantu Abebe
Keyword(s):  
Antiretroviral Therapy ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Noncommunicable Diseases ◽  
Hiv Positive ◽  
Bahir Dar ◽  
Second Line ◽  
Double Burden ◽  
Cross Sectional ◽  
Hiv Positive Adults

Background: People living with human immunodeficiency virus (HIV) are facing an increased burden of noncommunicable diseases (NCDs) comorbidity. There is, however, paucity of information on the magnitude of HIV-NCDs comorbidity, its associated factors, and how the health system is responding to the double burden in Ethiopia. Objective: To determine the magnitude of comorbidity between HIV and hypertension or diabetes and associated factors among HIV-positive adults receiving antiretroviral therapy (ART) in Bahir Dar city, Ethiopia. Methods: A facility-based cross-sectional study was conducted among 560 randomly selected HIV-positive adults taking ART. Data were collected using a structured questionnaire and analyzed using SPSS version 23. Descriptive statistics were used to describe the data. A logistic regression model was fit to identify associated factors with comorbidity of HIV and NCDs. Results: The magnitude of comorbidity was 19.6% (95% confidence interval (CI): 16.0–23.0). Being older (55 and above years) adjusted odds ratio (AOR: 8.5; 95% CI: 3.2–15.1), taking second-line ART regimen containing tenofovir (AOR: 2.7; 95% CI: 1.3–5.6), and increased body mass index (BMI) ≥25 (AOR: 2.7; 95% CI: 1.2–6.5) were the factors associated with comorbidity. Participants reported that they were not managed in an integrated and coordinated manner. Conclusions: The magnitude of comorbidity among adults was high in the study area. Being older, second-line ART regimen and high BMI ≥25 increased the odds of having NCDs among HIV-positive adults. Targeted screening for the incidences of NCDs, addressing modifiable risk factors, and providing integrated care would help to improve the quality of life comorbid patients.

Prevalence of neurocognitive impairment and its associated factors among patients with HIV in Indonesia

2020 ◽  
Vol 16 (6) ◽  
pp. 258-264
Author(s):  
Linlin Lindayani ◽  
Diwa Agus Sudrajat ◽  
Chanti Melnawati ◽  
Dian Anggarini
Keyword(s):  
Cognitive Impairment ◽  
Associated Factors ◽  
High School Graduates ◽  
Cross Sectional Study ◽  
Neurocognitive Impairment ◽  
Hiv Positive ◽  
Study Participation ◽  
Cross Sectional ◽  
The Mean ◽  
Living With Hiv

Background: Patients with HIV are susceptable to developing HIV-associated neurocognitive disorder (HAND). However, few studies have explored the prevalence of neurocognitive impairment and its associated factors among patients with HIV in Indonesia. Aims: This study aimed to explore the prevalence of neurocognitive impairment in patients with HIV in Indonesia. Methods: A cross-sectional study was conducted among patients with HIV in West Java, Indonesia. Patients were eligible for study participation if they were HIV-positive and were aged over 20 years. The International HIV Dementia Scale (IHDS) was used to measure probable HIV–related dementia. Descriptive categorisations and statistics, using mean scores, standard deviation (SD) calculations or frequency rates, were applied to participant characteristics and major variables. Findings: There were a total 150 participants in this study. The mean age was 38.09 years (SD=3.99); 74% were male; 80.7% were high school graduates. The mean of CD4 counts was 493.3 (SD=139.8), and all participants had been living with HIV for more than 9 years (SD=3.84). The mean of total scores using the IHDS was 10.2 (SD=1.58), and 49.30% of patients with HIV were reported to have cognitive impairment. There was an increased prevalence of cognitive impairment among males with a higher BMI and higher systolic blood pressure Conclusions: Nearly half of patients with HIV in Indonesia are at high risk of cognitive impairment, as measured by IHSD. Health professionals caring for patients with HIV may consider routine neurocognitive impairment screenings during clinical visits to address this risk.

scholarly journals HUBUNGAN PENGETAHUAN, STIGMA DAN EFEK PENGOBATAN DENGAN KEPATUHAN ORANG DENGAN HIV DAN AIDS (ODHA) TERHADAP TERAPI ANTIRETROVIRAL (ARV) DI KOTA KENDARI

2020 ◽  
Vol 6 (1) ◽  
pp. 10-15
Author(s):  
Suharjuniatin Habibi ◽  
Timbul Supodo ◽  
Sunarsih
Keyword(s):  
Antiretroviral Therapy ◽  
Treatment Effect ◽  
Cross Sectional Study ◽  
Hiv And Aids ◽  
Hiv Positive ◽  
Chi Square ◽  
Cross Sectional ◽  
Knowledge Variable ◽  
Chi Square Test ◽  
Relationship Of

The spread of HIV and AIDS around the world, including Indonesia is growing very rapidly. HIV prevalence in Southeast Sulawesi continues to increase, while HIV patients who are still undergoing antiretroviral therapy (ARV) are not in line with the HIV epidemic. There are several constraints in improving the people’s commitment to undergo ARV.This study aims to determine the relationship of the knowledge, stigma and the effect of treatment on the commitment of AIDS and HIV-Positive people to undergo antiretroviral therapy (ARV) in Kendari. This study is cross-sectional study. The population is those who suffer from HIV and AIDS in Kendari  with a sample of 48 HIV-positive people. Sampling was done by simple random sampling.The result indicates that based on the chi-square test on knowledge variable, X2 count <X2 table (4.375> 3.841). The stigma results of chi-square test value of X2 count> X2 table (19.139> 3.841). And the treatment effect result of the chi-square test value of X2 count> X2 table (22.275> 3.841). The conclusion is there is relationship between, knowledge, stigma, treatment effect on the commitment of AIDS and HIV-Positive people to undergo the antiretroviral therapy (ARV) in Kendari.   Keywords : side effect, stigma, antiretroviral therapy

scholarly journals Pulmonary Function Tests and Their Associated Factors in HIV-infected Patients at Jimma Medical Center; Ethiopia: A Comparative Cross-Sectional Study

2021 ◽  
Author(s):  
Muluken Teshome ◽  
Teshome Gobena ◽  
Misganaw Asmamaw ◽  
Elias Mulat
Keyword(s):  
Pulmonary Function ◽  
Medical Center ◽  
Pulmonary Function Tests ◽  
Cross Sectional Study ◽  
Hiv Positive ◽  
Duration Of Treatment ◽  
Cross Sectional ◽  
Retroviral Infection ◽  
Function Test ◽  
History Of

Abstract BackgroundHIV-infected persons have a greater risk of developing respiratory disorders. Poor socio-economic status, High viral load, low CD4 counts, and anti-retroviral therapy are linked with the problems. Despite its high prevalence the association between retroviral infection and pulmonary function status as well as their associated factors has not yet well established in resource-scarce countries in general and study setting in particularMethodsA comparative cross-sectional study was conducted from September 24 to October 15 of 2020 at Jimma Medical Center among HIV-positive patients and matched control group. Data were collected using a pretested structured questionnaire administered via face-to-face interview. The collected data included Socio-demographic, respiratory, retroviral infection, and substance use related. Pulmonary function tests were also conducted using SP10 spirometer. Collected data were entered and analyzed using SPSS version 26. Independent t-test and multiple linear regressions were carried out to identify factors independently associated with the pulmonary function status of the study participants while controlling for potential confounders.ResultsOne hundred ninety two HIV-positive patients and matched control individuals participated in the study. A mean pulmonary function test parameters among HIV-infected participants were FVC (l) (2.957±0.792, p0.006), FEV (l) (2.289±0.593, p<0.001), and PEFR (l) (4.258±2.039, p<0.001) with a significant declined in the group. Respiratory symptom, history of pulmonary TB, duration of living with RVI, duration of treatment, and current CD4 cell count were significant predictors of pulmonary function test indices(p<0.05) in HIV infected respondents.ConclusionA significant reduction in mean pulmonary function parameters were observed among HIV-positive participants in comparison to non-RVI participants. A strong association was observed between pulmonary function status of HIV-infected patients and current CD4 count, duration of living with RVI, duration of treatment, and history of PTB. Therefore, due consideration in screening, diagnosing, and managing noninfectious lung diseases should be given by health professionals while treating HIV-infected patients.

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