scholarly journals Autoimmune Limbic Encephalitis in a Patient with Acute Encephalopathy and Hyponatremia

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
K. A. Agarwal ◽  
M. Albertolle ◽  
M. Tiru
Keyword(s):  
Hospital Admissions ◽  
Limbic Encephalitis ◽  
Autoimmune Encephalitis ◽  
Developed Countries ◽  
Acute Encephalopathy ◽  
Neurological Outcomes ◽  
Common Clinical Presentation ◽  
Autoimmune Limbic Encephalitis ◽  
The Developed Countries ◽  
Mri Changes

Acute encephalopathy is a common clinical presentation for hospital admissions. Autoimmune encephalitis is a rare cause of encephalopathy which has increasingly been recognized over the last decade. The detection of various neuronal antibodies has helped diagnose these syndromes, but they have limited availability, mostly in the developed countries. We present a case of a middle-aged female presenting with memory impairment, gait disturbances, and hyponatremia. A clinical diagnosis of autoimmune limbic encephalitis was made based on faciobrachial dystonic seizures, SIADH, and MRI changes 10 days prior to autoantibody titer returned. Prompt treatment with steroids and intravenous immunoglobulin was started with improvement in her neurological symptoms. This case highlights the importance of considering autoimmune encephalitis syndromes in the differential diagnosis of patients with classical neurological presentations and prompt diagnosis and immunotherapy to improve neurological outcomes.

scholarly journals Use of intravenous immunoglobulin for the treatment of autoimmune encephalitis: audit of the NHS experience

JRSM Open ◽  
2018 ◽  
Vol 9 (9) ◽  
pp. 205427041879302 ◽  
Author(s):  
JA Kinsella ◽  
SR Irani ◽  
R Hollingsworth ◽  
D O’Shaughnessy ◽  
P Kane ◽  
...  
Keyword(s):  
Intravenous Immunoglobulin ◽  
Limbic Encephalitis ◽  
Tertiary Care ◽  
Case Series ◽  
Autoimmune Encephalitis ◽  
Symptomatic Treatment ◽  
Outcome Data ◽  
National Database ◽  
Retrospective Audit ◽  
Autoimmune Limbic Encephalitis

Objectives The treatments of limbic and other autoimmune encephalitis include immunosuppression, symptomatic treatment, and in the case of paraneoplastic syndromes, appropriate therapy for underlying neoplasms. When immunotherapy is considered, intravenous immunoglobulin is one option for treatment, either alone or in combination with corticosteroids. To date, however, evidence for the use of intravenous immunoglobulin in this context comes from case series/expert reviews as no controlled trials have been performed. We aimed to analyse the NHS England Database of intravenous immunoglobulin usage, which was designed to log use and guide procurement, to explore usage and therapeutic effect of intravenous immunoglobulin in autoimmune encephalitis in England. Design We conducted a retrospective audit and review of the NHS England Database on intravenous immunoglobulin use. Setting NHS England Database of intravenous immunoglobulin use which covers secondary and tertiary care prescribing and use of intravenous immunoglobulin for all patients in hospitals in England. Participants Hospital in-patients with confirmed or suspected autoimmune/limbic encephalitis between September 2010 and January 2017. Results A total of 625 patients who were 18 years of age or older were treated with intravenous immunoglobulin for autoimmune encephalitis, of whom 398 were determined as having 'highly likely' or 'definite' autoimmune/limbic encephalitis. Ninety-six percent were treated with a single course of intravenous immunoglobulin. The availability and accuracy of reporting of outcomes was very poor, with complete data only available in 27% of all cases. Conclusions This is the first review of data from this unique national database. Whilst there was evidence for clinical improvement in many cases of patients treated with intravenous immunoglobulin, the quality of outcome data was generally inadequate. Methods to improve quality, accuracy and completeness of reporting are crucial to maximise the potential value of this resource as an auditing tool.

scholarly journals Recurrent Anti-AMPA Receptor Limbic Encephalitis: A Case Report and Literature Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Yuanyuan Fang ◽  
Dengji Pan ◽  
Hao Huang
Keyword(s):  
Differential Diagnosis ◽  
Ampa Receptor ◽  
Magnetic Resonance Image ◽  
Limbic Encephalitis ◽  
Autoimmune Encephalitis ◽  
Imaging Findings ◽  
Rare Presentation ◽  
Important Differential Diagnosis ◽  
Autoimmune Limbic Encephalitis ◽  
Multiple Relapses

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is a relatively rare anti-neuronal surface antigen autoimmune encephalitis (LE). We described a case of a 47-year-old Chinese man having anti-AMPA receptor limbic encephalitis initially presented with cognitive decline, undetectable antibodies, and normal imaging findings in magnetic resonance image (MRI) and then developed into typical autoimmune limbic encephalitis a few months later with a course of multiple relapses. In addition, we found progressive brain atrophy in our case, which was a rare presentation of LE. This report also summarized the characteristics of nine reported cases of anti-AMPA receptor limbic encephalitis with relapse up to date. This case highlighted that autoimmune limbic encephalitis is an important differential diagnosis for patients with typical symptoms even when the MRI and antibodies are normal, and more attention should be paid to the relapse of anti-AMPA receptor encephalitis.

scholarly journals Atypical Association of Autoimmune Limbic Encephalitis with Anti-NMDA Receptor Antibodies in a Young Male Patient: Clinical, Imaging, and Neuropsychological Characteristics

2021 ◽  
pp. 541-548
Author(s):  
José Alberto Choreño-Parra ◽  
Tania de la Rosa-Arredondo ◽  
André Garibay-Gracián ◽  
Ingrid Montes de Oca-Vargas ◽  
Deyanira Capi-Casillas ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Limbic Encephalitis ◽  
Psychiatric Symptoms ◽  
Brain Mri ◽  
Clinical Manifestations ◽  
Memory Loss ◽  
Autoimmune Encephalitis ◽  
Young Male ◽  
Autoimmune Limbic Encephalitis ◽  
Receptor Antibodies

The spectrum of autoimmune encephalitis (AE) encompasses several entities characterized by a variable frequency of psychiatric symptoms, cognitive dysfunction, focal deficits, and seizures. Although patients with AE can be categorized in specific syndromes, overlapping manifestations are also common. Furthermore, atypical correlations between clinical phenotypes and autoantibody profiles could occur in rare cases. Here, we report the rare case of a young adult man attending due to new-onset seizures and a history of memory loss, autonomic disturbances, headache, behavioral changes, and visual and olfactory hallucinations. The patient was subjected to a complete diagnostic approach that included a comprehensive laboratory workup, neuropsychological testing, electroencephalogram, cerebrospinal fluid (CSF) analysis, brain MRI, and positron emission tomography/computed tomography scan that revealed a functional and structural compromise of the bilateral medial temporal lobes. Together with the clinical manifestations of the patient, these findings were compatible with the diagnosis of autoimmune limbic encephalitis (ALE). Strikingly, further analysis of the CSF showed autoantibodies against the N-methyl-D-aspartate (NMDA) receptor. We found very few cases of the co-occurrence of anti-NMDA receptor antibodies and nonparaneoplastic ALE in the literature, especially in male patients. Our report exemplifies the complicated differential diagnosis of ALE and adds clinical information of the association with anti-NMDA receptor antibodies.

How to Assure Stable Development in Unstable Financial Environment?

2007 ◽  
pp. 4-26 ◽  
Author(s):  
M. Ershov
Keyword(s):  
Stock Market ◽  
Developed Countries ◽  
Market Liquidity ◽  
Market Mechanisms ◽  
Russian Economy ◽  
The Developed Countries ◽  
Russian Stock Market ◽  
Stable Development ◽  
Financial Environment

Growing involvement of Russian economy in international economic sphere increases the role of external risks. Financial problems which the developed countries are encountered with today result in volatility of Russian stock market, liquidity problems for banks, unstable prices. These factors in total may put longer-term prospects of economic growth in jeopardy. Monetary, foreign exchange and stock market mechanisms become the centerpiece of economic policy approaches which should provide for stable development in the shaky environment.

The Reproduction Vector of the Russian Economy: 1999-2007

2008 ◽  
pp. 94-109 ◽  
Author(s):  
D. Sorokin
Keyword(s):  
Economic Policy ◽  
Human Capital ◽  
Growth Rates ◽  
Developed Countries ◽  
Gdp Per Capita ◽  
Real Sector ◽  
Russian Economy ◽  
Per Capita ◽  
The Developed Countries

The problem of the Russian economy’s growth rates is considered in the article in the context of Russia’s backwardness regarding GDP per capita in comparison with the developed countries. The author stresses the urgency of modernization of the real sector of the economy and the recovery of the country’s human capital. For reaching these goals short- or mid-term programs are not sufficient. Economic policy needs a long-term (15-20 years) strategy, otherwise Russia will be condemned to economic inertia and multiplying structural disproportions.

Power Generation for India with Higher Efficiency

2018 ◽  
Vol 6 (7) ◽  
pp. 267
Author(s):  
Umeshkannan P ◽  
Muthurajan KG
Keyword(s):  
Power Generation ◽  
Objective Function ◽  
Fossil Fuels ◽  
Programming Model ◽  
Developed Countries ◽  
Power Requirement ◽  
Average Efficiency ◽  
Potential Demand ◽  
The Developed Countries ◽  
Developed Nations

The developed countries are consuming more amount of energy in all forms including electricity continuously with advanced technologies.  Developing  nation’s  energy usage trend rises quickly but very less in comparison with their population and  their  method of generating power is not  seems  to  be  as  advanced  as  developed  nations. The   objective   function   of   this   linear   programming model is to maximize the average efficiency of power generation inIndia for 2020 by giving preference to energy efficient technologies. This model is subjected to various constraints like potential, demand, running cost and Hydrogen / Carbon ratio, isolated load, emission and already installed capacities. Tora package is used to solve this linear program. Coal,  Gas,  Hydro  and  Nuclear  sources can are  supply around 87 %  of  power  requirement .  It’s concluded that we can produce power  at  overall  efficiency  of  37%  while  meeting  a  huge demand  of  13,00,000  GWh  of  electricity.  The objective function shows the scenario of highaverage efficiency with presence of 9% renewables. Maximum value   is   restricted   by   low   renewable   source’s efficiencies, emission constraints on fossil fuels and cost restriction on some of efficient technologies. This    model    shows    that    maximum    18%    of    total requirement   can   be   met   by   renewable itself which reduces average efficiency to 35.8%.   Improving technologies  of  renewable  sources  and  necessary  capacity addition  to  them in  regular  interval  will  enhance  their  role and existence against fossil fuels in future. The work involves conceptualizing, modeling, gathering information for data’s to be used in model for problem solving and presenting different scenarios for same objective.

International Economic Assistance in the 1970's — A Critique of Partners in Development (Review Article)

1970 ◽  
Vol 10 (4) ◽  
pp. 469-490
Author(s):  
Nurul Islam
Keyword(s):  
Developing Countries ◽  
Foreign Aid ◽  
International Aid ◽  
Developed Countries ◽  
Armed Conflicts ◽  
Economic Assistance ◽  
Self Help ◽  
Service Charge ◽  
The Developed Countries ◽  
Defence Expenditure

Foreign economic aid is at the cross-roads. There is an atmosphere of gloom and disenchantment surrounding international aid in both the developed and developing countries — more so in the former than in the latter. Doubts have grown in the developed countries, especially among the conservatives in these countries, as to the effectiveness of aid in promoting economic development, the wastes and inefficiency involved in the use of aid, the adequacy of self-help on the part of the recipient countries in husbanding and mobilising their own resources for development and the dangers of getting involved, through ex¬tensive foreign-aid operations, in military or diplomatic conflicts. The waning of confidence on the part of the donors in the rationale of foreign aid has been accentuated by an increasing concern with their domestic problems as well as by the occurrence of armed conflicts among the poor, aid-recipient countries strengthened by substantial defence expenditure that diverts resources away from development. The disenchantment on the part of the recipient countries is, on the other hand, associated with the inadequacy of aid, the stop-go nature of its flow in many cases, and the intrusion of noneconomic considerations governing the allocation of aid amongst the recipient countries. There is a reaction in the developing countries against the dependence, political and eco¬nomic, which heavy reliance on foreign aid generates. The threat of the in¬creasing burden of debt-service charge haunts the developing world and brings them back to the donors for renewed assistance and/or debt rescheduling.

PENGARUH INFRASTRUKTUR SECARA SPASIAL TERHADAP KONVERGENSI PERTUMBUHAN EKONOMI DI INDONESIA

INFO ARTHA ◽  
2017 ◽  
Vol 1 ◽  
pp. 17-28
Author(s):  
Anisa Fahmi
Keyword(s):  
Economic Growth ◽  
Regional Economics ◽  
Developed Countries ◽  
Road Infrastructure ◽  
Long Run ◽  
Catch Up ◽  
The Developed Countries ◽  
Positive Effect ◽  
Neoclassical Growth Theory

Motivated by inter-regional disparities condition that occurs persistently, this study examines the Indonesian economy in the long run in order to know whether it tends to converge or diverge. This convergence is based on the Solow Neoclassical growth theory assuming the existence of diminishing returns to capital so that when the developed countries reach steady state conditions, developing countries will continuously grow up to 'catch-up' with developed countries. Based on regional economics perspective, each region can not be treated as a stand-alone unit,therefore, this study also focuses on the influence of spatial dependency and infrastructure. Economical and political situations of a region will influence policy in that region which will also have an impact to the neighboring regions. The estimation results of spatial cross-regressive model using fixed effect method consistently confirmed that the Indonesian economy in the long term will likely converge with a speed of 8.08 percent per year. Other findings are road infrastructure has a positive effect on economic growth and investment and road infrastructure are spatially showed a positive effect on economic growth. In other words, the investment and infrastructure of a region does not only affect the economic growth of that region but also to the economy of the contiguous regions. 

Sign in / Sign up

Export Citation Format

Share Document