scholarly journals Stability of a Discrete-Time Pathogen Infection Model with Adaptive Immune Response

2020 ◽  
Vol 2020 ◽  
pp. 1-26
Author(s):  
M. A. Alshaikh ◽  
A. M. Elaiw
Keyword(s):  
Global Stability ◽  
Discrete Time ◽  
Adaptive Immune Response ◽  
Steady States ◽  
Infection Model ◽  
Continuous Time Model ◽  
Time Model ◽  
Adaptive Immune ◽  
Existence And Stability ◽  
Infected Cells

This paper studies the global stability of a discrete-time pathogen dynamic model with both cell-mediated and antibody immune responses. Both latently and actively infected cells are incorporated into the model. We discretize the continuous-time model by using the nonstandard finite difference (NSFD) method. We establish that NSFD preserves the nonnegativity and boundedness of the solutions of the model. We derive four threshold parameters which govern the existence and stability of the steady states. We establish by using the Lyapunov method, the global stability of the five steady states of the model. We illustrate our theoretical results by using numerical simulations.

scholarly journals Analysis of an HTLV/HIV dual infection model with diffusion

2021 ◽  
Vol 18 (6) ◽  
pp. 9430-9473
Author(s):  
A. M. Elaiw ◽  
◽  
N. H. AlShamrani ◽  
◽  
Keyword(s):  
Lyapunov Functions ◽  
Global Solutions ◽  
Dual Infection ◽  
Steady States ◽  
Infection Model ◽  
Well Posedness ◽  
Pde Model ◽  
Existence And Stability ◽  
Infected Cells ◽  
Theoretical Results

<abstract><p>In the literature, several HTLV-I and HIV single infections models with spatial dependence have been developed and analyzed. However, modeling HTLV/HIV dual infection with diffusion has not been studied. In this work we derive and investigate a PDE model that describes the dynamics of HTLV/HIV dual infection taking into account the mobility of viruses and cells. The model includes the effect of Cytotoxic T lymphocytes (CTLs) immunity. Although HTLV-I and HIV primarily target the same host, CD$ 4^{+} $T cells, via infected-to-cell (ITC) contact, however the HIV can also be transmitted through free-to-cell (FTC) contact. Moreover, HTLV-I has a vertical transmission through mitosis of active HTLV-infected cells. The well-posedness of solutions, including the existence of global solutions and the boundedness, is justified. We derive eight threshold parameters which govern the existence and stability of the eight steady states of the model. We study the global stability of all steady states based on the construction of suitable Lyapunov functions and usage of Lyapunov-LaSalle asymptotic stability theorem. Lastly, numerical simulations are carried out in order to verify the validity of our theoretical results.</p></abstract>

scholarly journals A Discrete-TimeGeo/G/1 Retrial Queue with Two Different Types of Vacations

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Feng Zhang ◽  
Zhifeng Zhu
Keyword(s):  
Discrete Time ◽  
Queueing System ◽  
Retrial Queue ◽  
System Size ◽  
Stochastic Decomposition ◽  
Continuous Time Model ◽  
Time Model ◽  
Different Types ◽  
Number Of Customers ◽  
The Relationship

We analyze a discrete-timeGeo/G/1 retrial queue with two different types of vacations and general retrial times. Two different types of vacation policies are investigated in this model, one of which is nonexhaustive urgent vacation during serving and the other is normal exhaustive vacation. For this model, we give the steady-state analysis for the considered queueing system. Firstly, we obtain the generating functions of the number of customers in our model. Then, we obtain the closed-form expressions of some performance measures and also give a stochastic decomposition result for the system size. Moreover, the relationship between this discrete-time model and the corresponding continuous-time model is also investigated. Finally, some numerical results are provided to illustrate the effect of nonexhaustive urgent vacation on some performance characteristics of the system.

scholarly journals Global Properties of Latent Virus Dynamics Models with Immune Impairment and Two Routes of Infection

2019 ◽  
Vol 8 (2) ◽  
pp. 16
Author(s):  
Aeshah A. Raezah ◽  
Ahmed M. Elaiw ◽  
Badria S. Alofi
Keyword(s):  
Global Stability ◽  
Lyapunov Method ◽  
Incidence Rates ◽  
Steady States ◽  
Global Properties ◽  
Infection Models ◽  
Latently Infected ◽  
Immune Impairment ◽  
Infected Cells ◽  
Dynamics Models

This paper studies the global stability of viral infection models with CTL immune impairment. We incorporate both productively and latently infected cells. The models integrate two routes of transmission, cell-to-cell and virus-to-cell. In the second model, saturated virus–cell and cell–cell incidence rates are considered. The basic reproduction number is derived and two steady states are calculated. We first establish the nonnegativity and boundedness of the solutions of the system, then we investigate the global stability of the steady states. We utilize the Lyapunov method to prove the global stability of the two steady states. We support our theorems by numerical simulations.

scholarly journals Predicting IBNYR Events and Delays II. Discrete Time

1990 ◽  
Vol 20 (1) ◽  
pp. 93-111 ◽  
Author(s):  
William S. Jewell
Keyword(s):  
Discrete Time ◽  
Continuous Time ◽  
Bayesian Method ◽  
Predictive Accuracy ◽  
Random Delay ◽  
Continuous Time Model ◽  
Practical Situation ◽  
Time Model ◽  
Numerical Example ◽  
Exposure Interval

AbstractAn IBNYR event is one that occurs randomly during some fixed exposure interval and incurs a random delay before it is reported. A previous paper developed a continuous-time model of the IBNYR process in which both the Poisson rate at which events occur and the parameters of the delay distribution are unknown random quantities; a full-distributional Bayesian method was then developed to predict the number of unreported events. Using a numerical example, the success of this approach was shown to depend upon whether or not the occurrence dates were available in addition to the reporting dates. This paper considers the more usual practical situation in which only discretized epoch information is available; this leads to a loss of predictive accuracy, which is investigated by considering various levels of quantization for the same numerical example.

scholarly journals Global Stability of Humoral Immunity HIV Infection Models with Chronically Infected Cells and Discrete Delays

2015 ◽  
Vol 2015 ◽  
pp. 1-25
Author(s):  
A. M. Elaiw ◽  
N. A. Alghamdi
Keyword(s):  
Hiv Infection ◽  
Global Stability ◽  
Incidence Rate ◽  
Sufficient Conditions ◽  
Humoral Immune ◽  
Infection Models ◽  
Existence And Stability ◽  
Discrete Delays ◽  
Infected Cells ◽  
Theoretical Results

We study the global stability of three HIV infection models with humoral immune response. We consider two types of infected cells: the first type is the short-lived infected cells and the second one is the long-lived chronically infected cells. In the three HIV infection models, we modeled the incidence rate by bilinear, saturation, and general forms. The models take into account two types of discrete-time delays to describe the time between the virus entering into an uninfected CD4+T cell and the emission of new active viruses. The existence and stability of all equilibria are completely established by two bifurcation parameters,R0andR1. The global asymptotic stability of the steady states has been proven using Lyapunov method. In case of the general incidence rate, we have presented a set of sufficient conditions which guarantee the global stability of model. We have presented an example and performed numerical simulations to confirm our theoretical results.

scholarly journals Global Properties of a General Latent Pathogen Dynamics Model with Delayed Pathogenic and Cellular Infections

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
A. M. Elaiw ◽  
A. A. Almatrafi ◽  
A. D. Hobiny ◽  
K. Hattaf
Keyword(s):  
Global Stability ◽  
Infection Model ◽  
Global Dynamics ◽  
Dynamics Model ◽  
Pathogen Dynamics ◽  
Global Properties ◽  
Latently Infected ◽  
Infected Cells ◽  
Theoretical Results ◽  
Pathogenic Infection

This paper studies the global dynamics of a general pathogenic infection model with two ways of infections. The effect of antibody immune response is analyzed. We incorporate three discrete time delays and both latently infected cells and actively infected cells. The infection rate and production and clearance/death rates of the cells and pathogens are given by general functions. We determine two threshold parameters to investigate the global stability of three equilibria. We use Lyapunov method to establish the global stability. We support our theoretical results by numerical simulations.

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