scholarly journals Analysis of an HTLV/HIV dual infection model with diffusion

2021 ◽  
Vol 18 (6) ◽  
pp. 9430-9473
Author(s):  
A. M. Elaiw ◽  
◽  
N. H. AlShamrani ◽  
◽  
Keyword(s):  
Lyapunov Functions ◽  
Global Solutions ◽  
Dual Infection ◽  
Steady States ◽  
Infection Model ◽  
Well Posedness ◽  
Pde Model ◽  
Existence And Stability ◽  
Infected Cells ◽  
Theoretical Results

<abstract><p>In the literature, several HTLV-I and HIV single infections models with spatial dependence have been developed and analyzed. However, modeling HTLV/HIV dual infection with diffusion has not been studied. In this work we derive and investigate a PDE model that describes the dynamics of HTLV/HIV dual infection taking into account the mobility of viruses and cells. The model includes the effect of Cytotoxic T lymphocytes (CTLs) immunity. Although HTLV-I and HIV primarily target the same host, CD$ 4^{+} $T cells, via infected-to-cell (ITC) contact, however the HIV can also be transmitted through free-to-cell (FTC) contact. Moreover, HTLV-I has a vertical transmission through mitosis of active HTLV-infected cells. The well-posedness of solutions, including the existence of global solutions and the boundedness, is justified. We derive eight threshold parameters which govern the existence and stability of the eight steady states of the model. We study the global stability of all steady states based on the construction of suitable Lyapunov functions and usage of Lyapunov-LaSalle asymptotic stability theorem. Lastly, numerical simulations are carried out in order to verify the validity of our theoretical results.</p></abstract>

scholarly journals HTLV/HIV Dual Infection: Modeling and Analysis

Mathematics ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 51
Author(s):  
Ahmed M. Elaiw ◽  
Noura H. AlShamrani
Keyword(s):  
Asymptotic Stability ◽  
Dual Infection ◽  
Steady States ◽  
Single Infection ◽  
Infection Model ◽  
Type I ◽  
Modeling And Analysis ◽  
Specific Ctls ◽  
Infected Cells ◽  
The Impact

Human T-lymphotropic virus type I (HTLV-I) and human immunodeficiency virus (HIV) are two famous retroviruses that share similarities in their genomic organization, and differ in their life cycle as well. It is known that HTLV-I and HIV have in common a way of transmission via direct contact with certain body fluids related to infected patients. Thus, it is not surprising that a single-infected person with one of these viruses can be dually infected with the other virus. In the literature, many researchers have devoted significant efforts for modeling and analysis of HTLV or HIV single infection. However, the dynamics of HTLV/HIV dual infection has not been formulated. In the present paper, we formulate an HTLV/HIV dual infection model. The model includes the impact of the Cytotoxic T lymphocyte (CTLs) immune response, which is important to control the dual infection. The model describes the interaction between uninfected CD4+T cells, HIV-infected cells, HTLV-infected cells, free HIV particles, HIV-specific CTLs, and HTLV-specific CTLs. We establish that the solutions of the model are non-negative and bounded. We calculate all steady states of the model and deduce the threshold parameters which determine the existence and stability of the steady states. We prove the global asymptotic stability of all steady states by utilizing the Lyapunov function and Lyapunov–LaSalle asymptotic stability theorem. We solve the system numerically to illustrate the our main results. In addition, we compared between the dynamics of single and dual infections.

scholarly journals Global Dynamics of Secondary DENV Infection with Diffusion

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
A. M. Elaiw ◽  
A. S. Alofi
Keyword(s):  
Global Solutions ◽  
Denv Infection ◽  
Nonlinear Pdes ◽  
Target Cells ◽  
Global Dynamics ◽  
Spatial Mobility ◽  
Existence And Stability ◽  
Infected Cells ◽  
In The Beginning ◽  
Theoretical Results

During the past eras, many mathematicians have paid their attentions to model the dynamics of dengue virus (DENV) infection but without taking into account the mobility of the cells and DENV particles. In this study, we develop and investigate a partial differential equations (PDEs) model that describes the dynamics of secondary DENV infection taking into account the spatial mobility of DENV particles and cells. The model includes five nonlinear PDEs describing the interaction among the target cells, DENV-infected cells, DENV particles, heterologous antibodies, and homologous antibodies. In the beginning, the well-posedness of solutions, including the existence of global solutions and the boundedness, is justified. We derive three threshold parameters which govern the existence and stability of the four equilibria of the model. We study the global stability of all equilibria based on the construction of suitable Lyapunov functions and usage of Lyapunov–LaSalle’s invariance principle (LLIP). Last, numerical simulations are carried out in order to verify the validity of our theoretical results.

scholarly journals Stability of a Discrete-Time Pathogen Infection Model with Adaptive Immune Response

2020 ◽  
Vol 2020 ◽  
pp. 1-26
Author(s):  
M. A. Alshaikh ◽  
A. M. Elaiw
Keyword(s):  
Global Stability ◽  
Discrete Time ◽  
Adaptive Immune Response ◽  
Steady States ◽  
Infection Model ◽  
Continuous Time Model ◽  
Time Model ◽  
Adaptive Immune ◽  
Existence And Stability ◽  
Infected Cells

This paper studies the global stability of a discrete-time pathogen dynamic model with both cell-mediated and antibody immune responses. Both latently and actively infected cells are incorporated into the model. We discretize the continuous-time model by using the nonstandard finite difference (NSFD) method. We establish that NSFD preserves the nonnegativity and boundedness of the solutions of the model. We derive four threshold parameters which govern the existence and stability of the steady states. We establish by using the Lyapunov method, the global stability of the five steady states of the model. We illustrate our theoretical results by using numerical simulations.

scholarly journals Global Stability of Humoral Immunity HIV Infection Models with Chronically Infected Cells and Discrete Delays

2015 ◽  
Vol 2015 ◽  
pp. 1-25
Author(s):  
A. M. Elaiw ◽  
N. A. Alghamdi
Keyword(s):  
Hiv Infection ◽  
Global Stability ◽  
Incidence Rate ◽  
Sufficient Conditions ◽  
Humoral Immune ◽  
Infection Models ◽  
Existence And Stability ◽  
Discrete Delays ◽  
Infected Cells ◽  
Theoretical Results

We study the global stability of three HIV infection models with humoral immune response. We consider two types of infected cells: the first type is the short-lived infected cells and the second one is the long-lived chronically infected cells. In the three HIV infection models, we modeled the incidence rate by bilinear, saturation, and general forms. The models take into account two types of discrete-time delays to describe the time between the virus entering into an uninfected CD4+T cell and the emission of new active viruses. The existence and stability of all equilibria are completely established by two bifurcation parameters,R0andR1. The global asymptotic stability of the steady states has been proven using Lyapunov method. In case of the general incidence rate, we have presented a set of sufficient conditions which guarantee the global stability of model. We have presented an example and performed numerical simulations to confirm our theoretical results.

scholarly journals Dynamics of Mosquito Population Models with Spatial Diffusion

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Urbain Traoré
Keyword(s):  
Numerical Simulations ◽  
Reaction Diffusion ◽  
Population Models ◽  
Steady States ◽  
Mosquito Population ◽  
Spatial Diffusion ◽  
Well Posedness ◽  
Interactive Dynamics ◽  
The Stability ◽  
Theoretical Results

In this paper, we study some reaction-diffusion models of interactive dynamics of the wild and sterile mosquitoes. The well-posedness of the concerned model is proved. The stability of the steady states is discussed. Numerical simulations are presented to illustrate our theoretical results.

scholarly journals Global Properties of a General Latent Pathogen Dynamics Model with Delayed Pathogenic and Cellular Infections

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
A. M. Elaiw ◽  
A. A. Almatrafi ◽  
A. D. Hobiny ◽  
K. Hattaf
Keyword(s):  
Global Stability ◽  
Infection Model ◽  
Global Dynamics ◽  
Dynamics Model ◽  
Pathogen Dynamics ◽  
Global Properties ◽  
Latently Infected ◽  
Infected Cells ◽  
Theoretical Results ◽  
Pathogenic Infection

This paper studies the global dynamics of a general pathogenic infection model with two ways of infections. The effect of antibody immune response is analyzed. We incorporate three discrete time delays and both latently infected cells and actively infected cells. The infection rate and production and clearance/death rates of the cells and pathogens are given by general functions. We determine two threshold parameters to investigate the global stability of three equilibria. We use Lyapunov method to establish the global stability. We support our theoretical results by numerical simulations.

ANALYSIS OF A STOCHASTIC HBV INFECTION MODEL WITH NONLINEAR INCIDENCE RATE

2019 ◽  
Vol 27 (03) ◽  
pp. 399-421 ◽  
Author(s):  
HONGWEN HUI ◽  
LIN-FEI NIE
Keyword(s):  
Numerical Simulations ◽  
Deterministic Model ◽  
Sufficient Conditions ◽  
Stochastic Perturbation ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Infection Model ◽  
Exponentially Stable ◽  
Infected Cells ◽  
Theoretical Results

Considering that environmental factors, diet, subconscious mind and other uncertainties play an important role in the process of delaying and treating diseases, we propose, in this paper, an amended Hepatitis B virus (HBV) model with stochastic perturbation, and investigate the longtime dynamics of this stochastic model. First, if the basic reproductive number of the corresponding deterministic model is less than 1, some sufficient conditions for almost surely exponentially stable in the sense of the infected cells and free virus are established, and the stationary probability density function of the uninfected sell is also obtained. Further, some sufficient conditions for the existence of the stationary distribution are obtained for the basic reproductive number more than 1. In addition, oscillatory behaviors of this model about the equilibrium of the corresponding deterministic model are discussed. Finally, numerical simulations demonstrate the main theoretical results and show stochastic virus model has more dynamic behaviors relative to its corresponding deterministic model. Theoretical results and numerical simulations imply that the intensity and “type (divided into positive and negative)” of white noise play very important roles in the treatment of infectious disease, which can make the disease more and more repetitive and unpredictable. Of course, comfortable environment, reasonable diet, optimistic mood and other positive uncertainty factors have active effects on the treatment and delaying of diseases, but not the converse.

scholarly journals Global Dynamics of a Stochastic Viral Infection Model with Latently Infected Cells

2021 ◽  
Vol 11 (21) ◽  
pp. 10484
Author(s):  
Chinnathambi Rajivganthi ◽  
Fathalla A. Rihan
Keyword(s):  
Viral Infection ◽  
Global Solutions ◽  
Infection Model ◽  
Global Dynamics ◽  
Large Intensity ◽  
Ergodic Distribution ◽  
Latently Infected ◽  
Infected Cells ◽  
White Noises ◽  
Viral Infection Model

In this paper, we study the global dynamics of a stochastic viral infection model with humoral immunity and Holling type II response functions. The existence and uniqueness of non-negative global solutions are derived. Stationary ergodic distribution of positive solutions is investigated. The solution fluctuates around the equilibrium of the deterministic case, resulting in the disease persisting stochastically. The extinction conditions are also determined. To verify the accuracy of the results, numerical simulations were carried out using the Euler–Maruyama scheme. White noise’s intensity plays a key role in treating viral infectious diseases. The small intensity of white noises can maintain the existence of a stationary distribution, while the large intensity of white noises is beneficial to the extinction of the virus.

scholarly journals Nonlinear Spatiotemporal Viral Infection Model with CTL Immunity: Mathematical Analysis

Mathematics ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 52
Author(s):  
Jaouad Danane ◽  
Karam Allali ◽  
Léon Matar Tine ◽  
Vitaly Volpert
Keyword(s):  
Nonlinear Differential Equations ◽  
Infection Model ◽  
Viral Dynamics ◽  
Spatial Mobility ◽  
Latently Infected ◽  
Infected Cells ◽  
Cellular Immune ◽  
Viral Infection Model ◽  
Theoretical Results ◽  
Positivity And Boundedness

A mathematical model describing viral dynamics in the presence of the latently infected cells and the cytotoxic T-lymphocytes cells (CTL), taking into consideration the spatial mobility of free viruses, is presented and studied. The model includes five nonlinear differential equations describing the interaction among the uninfected cells, the latently infected cells, the actively infected cells, the free viruses, and the cellular immune response. First, we establish the existence, positivity, and boundedness for the suggested diffusion model. Moreover, we prove the global stability of each steady state by constructing some suitable Lyapunov functionals. Finally, we validated our theoretical results by numerical simulations for each case.

Modeling and stability analysis of HIV/HTLV-I co-infection

2021 ◽  
pp. 2150030
Author(s):  
A. M. Elaiw ◽  
N. H. AlShamrani
Keyword(s):  
T Cells ◽  
Infection Model ◽  
Type I ◽  
Infected Person ◽  
T Lymphotropic Virus ◽  
Specific Ctls ◽  
Immunodeficiency Virus ◽  
Existence And Stability ◽  
Infected Cells ◽  
The Impact

Human immunodeficiency virus (HIV) and human T-lymphotropic virus type I (HTLV-I) are two retroviruses that infect the susceptible CD[Formula: see text]T cells. It is known that HIV and HTLV-I have in common a way of transmission through direct contact with certain body fluids related to infected individuals. Therefore, it is not surprising that a mono-infected person with one of these viruses can be co-infected with the other virus. In the literature, a great number of mathematical models has been presented to describe the within-host dynamics of HIV or HTLV-I mono-infection. However, the within-host dynamics of HIV/HTLV-I co-infection has not been modeled. In this paper, we develop a new within-host HIV/HTLV-I co-infection model. The model includes the impact of Cytotoxic T lymphocytes (CTLs) immune response, which is important to control the progression of viral co-infection. The model describes the interaction between susceptible CD[Formula: see text]T cells, silent HIV-infected cells, active HIV-infected cells, silent HTLV-infected cells, Tax-expressing HTLV-infected cells, free HIV particles, HIV-specific CTLs and HTLV-specific CTLs. We first show the nonnegativity and boundedness of the model’s solutions and then we calculate all possible equilibria. We derive the threshold parameters which govern the existence and stability of all equilibria of the model. We prove the global asymptotic stability of all equilibria by utilizing Lyapunov function and LaSalle’s invariance principle. We have presented numerical simulations to illustrate the effectiveness of our main results. In addition, we discuss the effect of HTLV-I infection on the HIV-infected patients and vice versa.

Sign in / Sign up

Export Citation Format

Share Document