scholarly journals Role of Serum Uric Acid as a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Soheila Manifar ◽  
Arezoo Rahimzamani ◽  
Mohammad Shirkhoda ◽  
Mohammad Nikkhah Ghamsari ◽  
Mahin Bakhshi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Case Control ◽  
Healthy Controls ◽  
Control Study

The antioxidant properties of uric acid may have a protective effect against the formation of oxygen radicals and subsequently against carcinogenicity. The present study aimed at evaluating the serum level of uric acid in patients with oral squamous cell carcinoma (OSCC) with different histopathological grades. In this descriptive-analytical, case-control study, patients with OSCC and healthy controls were selected and matched regarding age and gender. The serum samples were collected from patients (before radiotherapy and chemotherapy) and controls, and their serum uric acid levels were measured enzymatically. Data were analyzed using independent t-test and ANOVA at 0.05 level of significance. The mean serum uric acid level in OSCC patients (4.2±1.5 mg/dL) and healthy controls (4.38±1.22 mg/dL) was not significantly different (P=0.377). No significant association was noted between the histopathological grade of OSCC and mean serum uric acid (P=0.781). The serum uric acid level had a direct significant correlation with age in OSCC patients (P<0.001). The results of this study did not support the role of uric acid as a protective biomarker in OSCC. Further prospective studies are recommended to better elucidate the role of uric acid in the etiology of OSCC.

Serum uric acid level as a determinant of the metabolic syndrome: A case control study

2017 ◽  
Vol 11 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Satyendra Khichar ◽  
Shyama Choudhary ◽  
Veer Bahadur Singh ◽  
Priyanka Tater ◽  
R.V. Arvinda ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Case Control ◽  
The Metabolic Syndrome ◽  
Control Study

scholarly journals Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

2021 ◽  
Vol 19 (1) ◽  
pp. 50-54
Author(s):  
Aruna Sayami ◽  
Aatmaram Gupta ◽  
Narayan Gautam
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Acid Value ◽  
High Serum ◽  
Control Group ◽  
Control Study

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

scholarly journals Role of serum uric acid in ischemic stroke: A case-control study in Bangladesh

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0236747
Author(s):  
Mohammad Ibrahim Khalil ◽  
Marium Salwa ◽  
Sarmin Sultana ◽  
Mohammad Abdullah Al Mamun ◽  
Nilima Barman ◽  
...  
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

The Possible Impact of Hyperuricemia on Serum Soluble Receptor for Advanced Glycation end Products (sRAGE) Levels in Teenagers: A Case Control Study

2018 ◽  
Vol 24 (27) ◽  
pp. 3232-3239 ◽  
Author(s):  
Marta Lemiesz ◽  
Edyta Tenderenda-Banasiuk ◽  
Dorota Sosnowska ◽  
Agnieszka Rybi-Szumińska ◽  
Justyna Storonowicz ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Reference Group ◽  
Serum Uric Acid Level ◽  
Case Control ◽  
Advanced Glycation ◽  
Soluble Receptors ◽  
Glycation End Products ◽  
Control Study

Background: Dietary advanced glycation end products (AGEs) and their interactions with the soluble receptors for AGEs (RAGE) play a crucial role in the pathogenesis of cardiovascular diseases. Objective: This study was set out to assess, whether there was any association between serum sRAGE level and serum uric acid level in children with hyperuricemia. Methods: This case-control study involved 53 patients (12 girls, 41 boys) with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) aged (median [IQR]) (15.5 [13.5-15.5] years). Thirty-six healthy individuals with normal serum uric acid level were selected as a reference group. Additionally, the study group with hyperuricemia was divided into two groups: HU-HT (hypertensive n=25) and HU-NT (normotensive n=28) teenagers. The serum concentration of human sRAGE was measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: We found statistically significant differences in serum sRAGE levels between normotensive subjects with hyperuricemia (median [IQR]) (169.8 [148.3-231.1] pg/ml) and reference group (median [IQR]) (129 [107.4-175.3] pg/ml), p<0.01. Univariate analysis of the data revealed a positive correlation between serum sRAGE and serum uric acid in the study group (r=0.306, p<0.05). Conclusion: Our data showed that serum soluble receptors for AGEs are increased in teenagers with hyperuricemia. In contrast, neither hypertension nor increased BMI had a significant influence on serum sRAGE concentration. Further studies are needed to discover the possible mechanism on the influence of uric acid on sRAGE levels and to assess its possible clinical significance.

Serum Uric Acid Levels in Relation to Atrial Fibrillation: A Case-Control Study

2021 ◽  
Vol 28 ◽  
Author(s):  
Xia Zhong ◽  
Huachen Jiao ◽  
Dongsheng Zhao ◽  
Jing Teng
Keyword(s):  
Atrial Fibrillation ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

The role of human papillomavirus in head and neck squamous cell carcinoma: A case control study on a southern Chinese population

2015 ◽  
Vol 88 (5) ◽  
pp. 877-887 ◽  
Author(s):  
Josette S.Y. Chor ◽  
Alexander C. Vlantis ◽  
Tam-Lin Chow ◽  
Siu-Chung Fung ◽  
Fiona Y.H. Ng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Southern Chinese ◽  
Control Study
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