scholarly journals In Vitro Antimicrobial Activity Evaluation of a Novel Fitostimoline® Plus Spray Formulation

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Maria Domenica Falciglia ◽  
Roberta Palladino ◽  
Barbara Maglione ◽  
Giulia Schiavo
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Standard Of Care ◽  
Microbial Infection ◽  
In Vitro Antimicrobial Activity ◽  
Disk Diffusion Assay ◽  
Spray Formulation ◽  
Carrier Test ◽  
And Control

Wound contaminants are the main cause of healing delay and infection in both chronic and acute wounds; for this reason, the microbial infection management in wound healing is one of the most important components for an effective standard of care. The wound contaminants are most likely to originate from the environment and from the surrounding skin lesion, and to date, the most frequent bacteria isolated are Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. In order to counteract and control these contaminants, the standard care includes topical antiseptic agents. The most commonly used include iodine-releasing agents (e.g., povidone-iodine), hydrogen peroxide, and polyhexanide. This study aims to investigate the in vitro antibacterial activity of a novel topical spray (Fitostimoline® Plus spray) based on 0.1% polyhexanide and Rigenase® against S. aureus, P. aeruginosa, K. pneumoniae, and the combination of S. aureus and K. pneumoniae. The in vitro antimicrobial activity of Fitostimoline® Plus spray was evaluated by the agar disk diffusion assay, quantitative suspension test, and quantitative carrier test, demonstrating that Fitostimoline® Plus spray is able to kill 99.9% bacteria. These results support the microbiological characterization of Fitostimoline® Plus spray confirming the antibacterial activity of polyhexanide (PHMB).

Scapania nemorea liverwort extracts: Investigation on volatile compounds, in vitro antimicrobial activity and control of Saccharomyces cerevisiae in fruit juice

LWT ◽  
2014 ◽  
Vol 55 (2) ◽  
pp. 452-458 ◽  
Author(s):  
Danka Bukvicki ◽  
Davide Gottardi ◽  
Amit Kumar Tyagi ◽  
Milan Veljic ◽  
Petar D. Marin ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Antimicrobial Activity ◽  
Volatile Compounds ◽  
Fruit Juice ◽  
In Vitro Antimicrobial Activity ◽  
And Control

scholarly journals Maclura tinctoria Extracts: In Vitro Antibacterial Activity against Aeromonas hydrophila and Sedative Effect in Rhamdia quelen

Fishes ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 25
Author(s):  
Luana da Costa Pires ◽  
Patricia Rodrigues ◽  
Quelen Iane Garlet ◽  
Luisa Barichello Barbosa ◽  
Bibiana Petri da Silveira ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Phenolic Compounds ◽  
Pathogenic Bacteria ◽  
Sedative Effect ◽  
In Vitro Antimicrobial Activity ◽  
Normal Behavior ◽  
In Vitro Antibacterial Activity ◽  
Light Sedation

Maclura tinctoria is a tree species native from Brazil and rich in phenolic compounds. Since plant antibacterial activity is highly associated with phenolic compound concentration, we aim to evaluate the in vitro antimicrobial activity of different extracts against fish pathogenic bacteria. In addition, some phenolic compounds have central depressant effects and can be useful in aquaculture due to possible sedative and/or anesthetic effects. Four M. tinctoria extracts were extracted separately with ethanol; leaves (LE), bark (BE), heartwood (HE), and the sapwood (SE). In vitro antimicrobial activity was tested against Aeromonas strains at concentrations of 6400 to 3.125 μg/mL. The sedative effect was evaluated for 24 h with 30 and 100 mg/L concentrations. Chemical composition was analyzed by HPLC-DAD-MS. The HE extract had the best MIC (400 µg/mL) and MBC (800 µg/mL) compared to the LE, BE, and SE extracts. LE extract induced deep sedation and the BE, SE, and HE extracts induced light sedation. Additionally, BE, SE, and HE induced a normal behavior without side effects. Polyphenolic compounds with antimicrobial activity and sedative effects were identified mainly in HE. Thus, HE extract is safe and can be used as a sedative for silver catfish.

Oxidation studies on β-lactam antibiotics: In-vitro antimicrobial activity of the oxidized products of 3-heteroarylthiomethyl-ceph-3-ems

1991 ◽  
Vol 56 (11) ◽  
pp. 2362-2372 ◽  
Author(s):  
Rajeshwar Singh ◽  
Maya P. Singh ◽  
Ronald G. Micetich
Keyword(s):  
Hydrogen Peroxide ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Acetic Acid ◽  
Side Chain ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
In Vitro Antimicrobial Activity ◽  
Oxidized Products

Various products from the oxidation of 3-heteroarylthiomethyl-ceph-3-ems using m-chloroperbenzoic acid (m-CPBA) and hydrogen peroxide in acetic acid in varying stoichiometric ratios have been isolated, identified and their in vitro antimicrobial activity determined. The oxidized compounds with the 2-aminothiazol-4-yl-(Z)-2-methoxyiminoacetamido side chain showed better antibacterial activity against various Gram negative bacteria compared to the unoxidized compounds.

THE ANTIBACTERIAL ACTIVITY OF SELECTED PHARMACOLOGICAL AGENTS

1965 ◽  
Vol 11 (4) ◽  
pp. 637-640
Author(s):  
Alfred A. Richtarik ◽  
Klaus Lindemulder ◽  
B. De Boer
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antimicrobial Effect ◽  
Pharmacological Agents ◽  
Phenoxymethyl Penicillin ◽  
In Vitro Antimicrobial Activity ◽  
Phage Types ◽  
Bacteriostatic Action

The in vitro antimicrobial activity of selected pharmacological agents was studied against five strains of staphylococci (phage types 7 US, 54, 71, 80, 81). At the concentrations used (maximal 0.125 μg/ml) chlorothiazide, acetazolamide, FeCl3, SnCl2, stilbamine urea, quinacrine, antimony Na thioglycollate, antimony thioglycollamide, and sulfisoxazole were found to have no antimicrobial effect against these strains of staphylococci, whereas HgCl2, AgNO3, meralluride sodium, stilbamidine, pentamidine, and propamidine did show activity. When effective agents were combined with potassium phenoxymethyl penicillin, the bacteriostatic action of the antibiotic was inhibited in some cases and markedly potentiated in others. Consideration should be given to the possible incorporation of effective agents into the structure of synthetic antibiotics as a means of combating resistant staphylococci.

scholarly journals Synthesis and antimicrobial activity of azepine and thiepine derivatives

2015 ◽  
Vol 80 (7) ◽  
pp. 839-852 ◽  
Author(s):  
Nina Bozinovic ◽  
Irena Novakovic ◽  
Sladjana Kostic-Rajacic ◽  
Igor Opsenica ◽  
Bogdan Solaja
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antibacterial And Antifungal Activity ◽  
In Vitro Antimicrobial Activity ◽  
Antibacterial And Antifungal ◽  
Weak Antibacterial Activity

A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The 5H-pyridobenzazepine derivatives showed better antibacterial and antifungal activity than corresponding 5H-dipyridoazepine analogs. Among the synthesized azepines, derivative 8 displayed potent activity against tested bacteria (MIC = 39-78 ?g/mL), while azepine 12 showed promising antifungal activity (MIC = 156-313 ?g/mL). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.

Chemical Composition and in-vitro antimicrobial screening of leaf essential oil of Plectranthus gerardianus Benth., and isolation of the major constituent of oil

2020 ◽  
Vol 10 ◽  
Author(s):  
Navadha Bhatt ◽  
Navabha Joshi ◽  
Kapil Ghai ◽  
Om Prakash
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Major Constituent ◽  
In Vitro Antimicrobial Activity ◽  
Gram Positive Bacteria ◽  
Medicinal Value ◽  
Leaf Essential Oil ◽  
Plant Families ◽  
Total Oil

Background: The Lamiaceae (Labiatae) is one of the most diverse and widespread plant families’ in terms of ethno medicine and its medicinal value is based on the volatile oils concentration. This family is important for flavour, fragrance and medicinal properties. Manyplants belonging to this family have indigenous value. Method: The essential oil of Plectranthus gerardianusBenth. (Lamiaceae), was analysed by GC and GC-MS analysis, while the major component was isolated and conformed by NMR spectroscopy. Result: The oil was found to be rich in oxygenated monoterpenes, which contribute around 62% of the total oil. The major components identified were fenchone (22.90%) and carvenone oxide (16.75%), besides other mono and sesquiterpenoids. The in-vitro antimicrobial activity of essential oil was tested against three gram negative bacteria viz. Pasteurellamultocida, Escherichia coli, and Salmonella enterica, two gram positive bacteria viz. Staphylococcus aureus and Bacillus subtilis and two fungi viz. Candida albicans and Aspergillusflavus. The antimicrobial activity of the oil was also compared to the antimicrobial activity of leaf essential oil of another Himalayan plant viz. Nepetacoerulescens. Conclusion: The oil showed in-vitro antimicrobial activity against all the microbial strains and can lessen the ever-growing demand of potentially hazardous antibiotics for treatment.

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