scholarly journals Efficacy and Safety of Shexiang Baoxin Pill for Coronary Heart Disease after Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Jingjing Wei ◽  
Shanshan Liu ◽  
Xinlu Wang ◽  
Bin Li ◽  
Lijie Qiao ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Inflammatory Mediators ◽  
Blood Lipid ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
Shexiang Baoxin Pill ◽  
Lipid Index

Objective. Shexiang Baoxin Pill (SBP) is a licensed Chinese herbal pharmaceutical that has been widely accustomed to treat coronary heart disease (CHD) after percutaneous coronary intervention (PCI). This study points to systematically assess the efficacy and security of the combination of SBP with conventional western medicine in the treatment of CHD after PCI. Methods. Databases including PubMed, the Cochrane Library, Web of Science, Embase, CNKI, Wanfang, VIP, and SINOMED were searched to collect RCTs on SBP in CHD after PCI before July 2021. Review Manager 5.3 was used to analyze the data. The Cochrane Collaboration Bias Risk Tool is used to assess the quality of methods. Results. A total of 19 eligible trials of 2022 patients with CHD after PCI were finally included. The results of the aggregate evidence showed that, compared with routine western medicine treatment alone, the combination of SBP with conventional treatment trial groups could significantly reduce the incidence of major adverse cardiac events (MACE) of the patients (RR = 0.38, 95% CI (0.29, 0.51), P < 0.00001 ). SBP also significantly enhanced left ventricular ejection fraction (LVEF) (MD = 4.00, 95% CI (3.42, 4.58), P < 0.00001 ) and lessened N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels (MD = −167.18, 95% CI (−174.80, −159.57), P < 0.00001 ). In addition, the inflammatory mediators and blood lipid index in the experimental group after the combined therapy were also mediated ( P < 0.05 ). Moreover, SBP did not increase the incidence of adverse reactions during treatment. The results of subgroup analysis illustrated that the length of the intervention course might be the source of the heterogeneity of NT-pro-BNP and hs-CRP. Conclusion. SBP could demonstrate a beneficial role in patients with CHD after PCI of reducing the incidence of MACE and improving LVEF, NT-pro-BNP, inflammatory mediators, and blood lipid index. However, limited by the quantity and quality of eligible studies, the above conclusions required more standardized, rigorous, high-quality clinical trials to verify further.

scholarly journals The Efficacy and Safety of Compound Danshen Dripping Pill Combined with Percutaneous Coronary Intervention for Coronary Heart Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Cailan Li ◽  
Qian Li ◽  
Jiamin Xu ◽  
Wenzhen Wu ◽  
Yuling Wu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Endothelial Function ◽  
Adverse Reactions ◽  
Blood Lipid ◽  
Coronary Intervention ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Percutaneous Coronary

Objective. Compound Danshen dripping pill (CDDP) is a well-known Chinese patent medicine, which is commonly used for the treatment of coronary heart disease (CHD) in China. This study is aimed at systematically assessing the clinical efficacy of CDDP for CHD patients. Methods. Eight databases were retrieved for eligible research studies from the founding date to April 20, 2020. Risk ratio (RR) was used to assess major adverse cardiac events (MACE) and adverse reactions, and mean difference (MD) was adopted to evaluate the hemorheology and blood lipid indexes, vascular endothelial function, cardiac function, and inflammation. Result. Twenty randomized controlled trials involving 2574 participants with CHD were included. The results indicated that, compared with percutaneous coronary intervention (PCI) alone, the combination of CDDP with PCI treatment remarkably reduced MACE (RR = 0.53, 95% confidence interval (CI) (0.44, 0.65), P < 0.00001 ). Moreover, hemorheology and blood lipid parameters and inflammatory mediators of CHD patients were also dramatically mitigated after the combined therapy P < 0.01 . In addition, vascular endothelial function and cardiac function were prominently improved by this combination P < 0.001 . However, there was no significant difference in adverse reactions between the two groups P > 0.05 . Conclusion. Evidence from the meta-analysis demonstrated that CDDP combined with PCI treatment prominently reduced the incidence of MACE, improved cardiovascular functions, and inhibited inflammation in CHD patients. Therefore, CDDP combined with PCI treatment could be an effective and safe therapeutic method for CHD patients.

scholarly journals The Relationship Between Self Care and Quality of Life Among Coronary Heart Disease Patient After Receiving Percutaneous Coronary Intervention: A Systematic Review

2021 ◽  
pp. 155-171
Author(s):  
. Herdiman ◽  
Heri Harsono
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Self Care ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
The Relationship

Coronary Heart Disease is a chronic disease with the highest morbidity and mortality rates in the world. Management is needed in the form of self-care management as a core element for CHD patients in order to improve the quality of life. Until now, there has been no comprehensive summary regarding self-care and quality of life for CHD patients with stents attached. This study aims to summarize research studies that link self-care and QOL in CHD patients after receiving Percutaneous coronary intervention. Systematic review using three databases (PubMed, ScienDirect, Google Scholar) for previous studies published in the last 10 years (2010–2020). The Joana Bright Institute format and PRISMA guidelines were used to assess the quality of studies and assist in the selection of articles. Data was extracted and summarized by the author using data extraction tools from JBI. Five articles from 2,729 studies were included. The results show inconsistency, namely three studies have a significant relationship and two studies have an insignificant relationship. All questionnaire domains used in the five articles state that the self-care domain of smoking cessation and exercise are correlated with the QOL domain of physical function, body pain, vitality, mental health, symptom domains and satisfaction. Only three articles reported the strength of the relationship (r = 0.117–0.64) and two articles didn’t report the strength of the relationship. By knowing self-care and QOL of CHD patients after receiving PCI, it’s hoped that the hospital can better understand and provide promotive/preventive education related to self-care management so that the patient’s QOL increases significantly.   Keywords: Self-care, quality of life, Coronary Heart Disease, Percutaneous Coronary Intervention, Systematic Review

Kualitas Hidup Pasien Pascaintervensi Koroner Perkutan

1970 ◽  
Vol 2 (1) ◽  
Author(s):  
Remita Ully Hutagalung ◽  
F Sri Susilaningsih ◽  
Ai Mardiyah
Keyword(s):  
Quality Of Life ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
College Education ◽  
Coronary Intervention ◽  
Health Condition ◽  
Cross Sectional ◽  
Percutaneous Coronary ◽  
Environment Domain

Penyakit jantung koroner adalah penyakit yang dapat mengancam kehidupan seseorang. Pelaksanaan tindakan non bedah intervensi koroner perkutan pasien masih memiliki risiko terjadinya serangan berulang, stenosis dan ancaman kematian. Tujuan penelitian ini adalah mengidentifikasi kualitas hidup pasien pascatindakan intervensi koroner perkutan. Desain penelitian ini adalah potong lintang. Pengambilan sampel secara consecutive samplingdidapatkan 50 responden yaitu pasien yang sedang kontrol pascaintervensi coroner per kutan di Poliklinik Spesialis Jantung RSUP Dr. Hasan Sadikin Bandung, penelitian ini dilakukan pada 1-14 November 2013. Kualitas hidup diukur dengan instrumen WHOQOL-BREFdengan empat domain kualitas hidup yaitu domain fisik, psikologis, sosial, dan lingkungan. Analisis menggunakan statistik deskripsi. Hasil penelitian menunjukkan bahwa responden memiliki kualitas hidup baik sebesar 50%. Perawat memiliki peran dalam membantu pasien mencapai kualitas hidup yang optimal, diantaranya melalui peningkatan efikasi diri pasien melalui pendampingan dan pemberian informasi dalam usaha mencapai kualitas hidup.Kata kunci:Intervensi koroner perkutan, kualitas hidup, WHOQOL-BREF AbstractCoronary heart disease is a disease that can threaten person’s life, and can lead to the change of the quality of life. This coronary heart disease can be solved with non-surgical called percutaneous coronary intervention. This action will be normalized the quality of perfusion in the coronary arteries, which would certainly have an impact on the quality of life of patients. The research objective was to observe the patient of quality of life after treatment on intervention percutaneous coronary. The research design was cross sectional. There were 50 respondents taken by consecutive sampling. Data were collected in outpatient room in RSUP Dr. Hasan Sadikin Bandung, who have came with treatment routine schedule after percutaneous coronary intervention during November 1st–14th 2013. The questionnaire use WHOQOL-BREF format with 26 questions that consisting of 4 domains of quality of life: physical domain, psychological domain, social domain, and environment domain. Majority of patients were male (74 %), with the range of age mostly 56-66 years ( 34 % ), married ( 96 % ), college education was the highest ( 66 % ), the majority had not a primary job like as housewife , retired, student, etc. ( 26 % ). Data were collected using the questionnaire WHOQOL – BREF. The result have shown that rates of quality of life was good ( 50 % ) and health condition after percutaneous coronary intervention neither satisfied nor dissatisfied ( 44 % ). Nurses have a role in helping patients achieve optimal quality of life like giving information to patient correctlyKey words: Percutaneous coronary intervention, quality of life, WHOQOL – BREF

The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score

Angiology ◽  
2021 ◽  
pp. 000331972110155
Author(s):  
Xiaogang Liu ◽  
Peng Zhang ◽  
Jing Zhang ◽  
Xue Zhang ◽  
Shicheng Yang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
High Risk ◽  
Risk Groups ◽  
Coronary Intervention ◽  
Preventive Effect ◽  
Moderate Risk ◽  
Contrast Induced Nephropathy ◽  
Percutaneous Coronary

The Mehran risk score (MRS) was used to classify patients with coronary heart disease and evaluate the preventive effect of alprostadil on contrast-induced nephropathy (CIN) after percutaneous coronary intervention. The patients (n = 1146) were randomized into an alprostadil and control group and then divided into 3 groups on the basis of the MRS: low-risk, moderate-risk, and high-risk groups. The primary end point was the occurrence of CIN (alprostadil + hydration vs simple hydration treatment); secondary end points included serum creatinine, blood urea nitrogen, creatinine clearance rate, cystatin C, interleukin-6, C-reactive protein, proteinuria, and differences in the incidence of major adverse events. In the low-risk, moderate-risk, and high-risk groups, the incidence of CIN in the control and alprostadil group was 2.9 versus 2.6% ( P = .832), 11.4 versus 4.9% ( P = .030), 19.1 versus 7.7% ( P = .041), respectively. Multivariate logistic regression analysis showed that alprostadil treatment was a favorable protective factor for moderate-risk and high-risk CIN patients (OR = 0.343, 95% CI: 0.124-0.951, P = .040). Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CIN by alprostadil may be related to an anti-inflammatory effect.

scholarly journals Total and Cause-Specific Mortality After Percutaneous Coronary Intervention: Observations From the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease Registry

CJC Open ◽  
2019 ◽  
Vol 1 (4) ◽  
pp. 182-189
Author(s):  
Dat T. Tran ◽  
Walid Barake ◽  
Diane Galbraith ◽  
Colleen Norris ◽  
Merril L. Knudtson ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Outcome Assessment ◽  
Coronary Intervention ◽  
Disease Registry ◽  
Percutaneous Coronary ◽  
Specific Mortality

scholarly journals EFFECTIVENESS OF TICAGRELOR COMPARED TO CLOPIDOGREL IN REDUCING THE RISK OF MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY HEART DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTION

2017 ◽  
Vol 9 (9) ◽  
pp. 178 ◽  
Author(s):  
Hendra Wana Nur’amin ◽  
Iwan Dwiprahasto ◽  
Erna Kristin
Keyword(s):  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Coronary Intervention ◽  
Population Based ◽  
Major Adverse Cardiovascular Events ◽  
Repeat Revascularization ◽  
Percutaneous Coronary

Objective: Antiplatelet therapy is recommended in patients with coronary heart disease (CHD) who had the percutaneous coronary intervention (PCI) procedure to reduce major adverse cardiovascular events (MACE). There has been a lack of population-based studies that showed the superior effectiveness of ticagrelor over clopidogrel and similar studies have not been conducted in Indonesia yet. The aim of the study was to investigate the effectiveness of ticagrelor compared to clopidogrel in reducing the risk of MACE in patients with CHD after PCI.Methods: A retrospective cohort study with 1-year follow-up was conducted. 361 patients consisted of 111 patients with ticagrelor exposure and 250 patients with clopidogrel exposure. The primary outcome was MACE, defined as a composite of repeat revascularization, myocardial infarction, or all-cause death. The association between antiplatelet exposure and the MACE was analyzed with Cox proportional hazard regression, adjusted for sex, age, comorbid, PCI procedures and concomitant therapy.Results: MACE occurred in 22.7% of the subjects. Clopidogrel had a significantly higher risk of MACE compared with ticagrelor (28.8%, vs 9.0%, hazard ratio (HR): 1.96 (95% CI 1.01 to 3.81, p=0.047). There were no significant differences in risk of repeat revascularization (20.40% vs 5.40%, HR: 2.32, 95% CI 0.99 to 5.42, p = 0.05), myocardial infarction (11.60% vs 3.60%, HR: 2.08, 95% CI, 0.73 to 5.93, p = 0.17), and death (1.60% vs 1.80%, HR: 0.77, 95% CI, 0.14 to 4.25, p = 0.77).Conclusion: Clopidogrel had a higher risk of MACE compared to clopidogrel in patients with CHD after PCI, but there were no significant differences in the risk of repeat revascularization, myocardial infarction, and all-cause death. 

scholarly journals Role of depression in secondary prevention of Chinese coronary heart disease patients receiving percutaneous coronary intervention

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0187016 ◽  
Author(s):  
Can Feng ◽  
Tao Ji ◽  
Yu Liu ◽  
Danfeng Chen ◽  
Jia Dai ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Secondary Prevention ◽  
Coronary Intervention ◽  
Percutaneous Coronary
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