scholarly journals Effects of Omega-3 Polyunsaturated Fatty Acids on Cognitive Function after Splenectomy in Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yong Guo ◽  
Feng Ping ◽  
Yongmei Cao ◽  
Jiawei Shang ◽  
Junfeng Zhang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cognitive Function ◽  
Inflammatory Response ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Morris Water Maze ◽  
Water Maze ◽  
Control Group ◽  
Omega 3 ◽  
Tnf Α

Background. Postoperative cognitive dysfunction (POCD) is a common complication after abdominal surgery. Several studies have reported that POCD is related to neuroinflammation caused by surgery. Omega-3 polyunsaturated fatty acids (PUFAs) can effectively inhibit the systematic inflammatory response. So, we use fish oil to study the effect of fish oil on inflammation, immunity, and cognitive behavior after splenectomy in rats. Methods. 60 SD (Sprague-Dawley) rats were randomly divided into control group (group C, n = 20 ), surgery group (group S, n = 20 ), and omega-3 (fish oil) intervention group (group F, n = 20 ). Omega-3 PUFA was injected intraperitoneally from 3 days before operation to 7 days after operation in group F, and normal saline was injected simultaneously in group S. Rats in group S and group F received splenectomy under general anesthesia. Morris water maze behavioral evaluation was performed on the first, third, fifth, and seventh day after operation. The levels of IL-1β (interleukin-1β), IL-6 (interleukin-6), TNF-α (tumor necrosis factor-α), SOD (superoxide dismutase), and GSH-PX (glutathione peroxidase) were detected. Results. Serums IL-1β, IL-6, and TNF-α concentrations in group S and group F were higher than those in group C ( P < 0.01 ), while those inflammatory cytokines in group F were significantly lower than those in group S ( P < 0.01 ); serum GSH-PX levels in group F were higher than group S ( P < 0.01 ). The Morris water maze behavior test performance of group F was better than that of group S ( P < 0.05 ). Conclusion. Omega-3 PUFA can effectively improve postoperative inflammatory response, reduce the damage of antioxidant defense system, and improve postoperative cognitive function.

scholarly journals Nootropic and Adaptogenic Effect of Combined Use of Cortexin with Polyunsaturated Fatty Acids Concentrate under Experimental Dislipidemia

2019 ◽  
Vol 4 (1) ◽  
pp. 150-154
Author(s):  
Tatyana I. Sangadieva ◽  
Galina P. Lamazhapova ◽  
Erzhena V. Syngeeva
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Open Field ◽  
Morris Water Maze ◽  
Water Maze ◽  
Atherogenic Diet ◽  
Morris Water Maze Test ◽  
Omega 3 ◽  
Lipid Complex ◽  
Combined Use

Background.We studied the effect of combined application of omega-3 polyunsaturated fatty acid concentrate, based on seals fat, with parenteral administration of brain cortex polypeptide preparation on cognitive-research reactions and adaptation of rats under experimental hyperlipidemia. The composition of the myelin sheaths of neurons is represented by a protein-lipid complex, which is a part of the cell membrane, the imbalance of which leads to a number of neurological diseases.The aim of the study was to confirm experimentally that the combined use of drugs, based on essential polyunsaturated fatty acids and polypeptides, would influence more effectively on neurometabolic processes in neurons, compared to their application separately.Materials and methods.Wistar rats were used. They were on a special atherogenic diet to build the model of hypercholesterolemia. The pharmacological effects of drugs were evaluated in the Open Field and Morris Water Maze tests.Results.The study found that in rats, who received a combination of polyunsaturated fatty acids concentrate with Cortexin injections, and undergoing atherogenic diet, the overall motor activity increased significantly in the Open field test, at the same time the number of acts of defecation and grooming decreased. The Morris Water Maze test results indicated an increase in the level of spatial memory and orientation, which shows a high level of adaptability and adaptation to new conditions, a decrease in the level of anxiety.Conclusions.The results demonstrated a more pronounced and prolonged nootropic and adaptogenic action of the complex use in comparison with the use of the studied agents as monotherapy.

THE RELATIONSHIP OF OMEGA 3 POLYUNSATURATED FATTY ACIDS IN RED BLOOD CELL MEMBRANES WITH COGNITIVE FUNCTION AND BRAIN STRUCTURE: A REVIEW FOCUSSED ON ALZHEIMER’S DISEASE

2017 ◽  
pp. 1-7
Author(s):  
C. Hooper ◽  
P. De Souto Barreto ◽  
M. Pahor ◽  
M. Weiner ◽  
B. Vellas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Cognitive Function ◽  
Blood Cell ◽  
Polyunsaturated Fatty Acids ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Research Attention ◽  
Pufa Supplementation

Significant research attention has focussed on the identification of nutraceutical agents for the prevention of cognitive decline as a natural means of cognitive preservation in the elderly. There is some evidence for a reduction of brain omega 3 polyunsaturated fatty acids (n-3 PUFAs) in normal aging and in Alzheimer’s disease. n-3 PUFAs exhibit anti-inflammatory and anti-amyloidogenic properties as well as being able to reduce tau phosphorylation. Many observational studies have demonstrated a link between n-3 PUFAs and cognitive aging, and some, but not all, randomized controlled trials have demonstrated a benefit of n-3 PUFA supplementation on cognition, particularly in those subjects with mild cognitive impairment. The identification of a biomarker that reflects n-3 PUFA intake over time and consequent tissue levels is required. In this narrative review we discuss the evidence associating red blood cell membrane n-3 PUFAs with cognitive function and structural brain changes associated with Alzheimer’s disease. Key words: Docosahexaenoic acid, omega 3 polyunsaturated fatty aci

Enrichment of spreadable fats with polyunsaturated fatty acids omega-3 using fish oil

2001 ◽  
Vol 52 (6) ◽  
pp. 469-476 ◽  
Author(s):  
Wojciech Kolanowski ◽  
Franciszek Swiderski ◽  
Ewa Lis ◽  
Stanislaw Berger
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Omega 3

scholarly journals Successful high‐level accumulation of fish oil omega‐3 long‐chain polyunsaturated fatty acids in a transgenic oilseed crop

2013 ◽  
Vol 77 (2) ◽  
pp. 198-208 ◽  
Author(s):  
Noemi Ruiz‐Lopez ◽  
Richard P. Haslam ◽  
Johnathan A. Napier ◽  
Olga Sayanova
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Oilseed Crop ◽  
Omega 3 ◽  
High Level ◽  
Long Chain

Biomarkers of Fish Oil Omega-3 Polyunsaturated Fatty Acids Intake in Humans

2013 ◽  
Vol 29 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Veronica Silva ◽  
Rocco Barazzoni ◽  
Pierre Singer
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Omega 3
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