scholarly journals A Case of John Cunningham Virus Induced Rhombencephalitis after Rituximab Therapy for Idiopathic Thrombocytopenic Purpura

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Silpita Katragadda ◽  
Varshaa Koneru ◽  
Genevieve Devany ◽  
Aaron S. DeWitt ◽  
Vasudev H. Tati
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Granule Cell ◽  
Jc Virus ◽  
Thrombocytopenic Purpura ◽  
Case Presentation ◽  
John Cunningham Virus ◽  
Polymerase Chain ◽  
Magnetic Resonance Imaging Mri ◽  
High Degree ◽  
Granule Cell Neuronopathy

Background. John Cunningham virus (JCV) is known to cause progressive multifocal leukoencephalopathy (PML) in immuno-compromised patients due to lytic infection of oligodendrocytes and astrocytes. Rarely, it may also present as granule cell neuronopathy (GCN), leading to degeneration of cerebellar granule cell neurons. It is described in patients with underlying conditions or medication contributing to immune compromise. Case Presentation. A 73-year-old man presented with ataxia and difficulty in speech which began 3 months after initiation of treatment for idiopathic thrombocytopenic purpura with rituximab. Neurological examination was significant for torsional nystagmus, motor aphasia, right-sided dysmetria, and dysdiadochokinesia with gait ataxia. Magnetic resonance imaging (MRI) showed right cerebellar lesion and cerebrospinal fluid (CSF) polymerase chain reaction (PCR) was positive for JC virus. Conclusion. The diagnosis of JC virus-related cerebellar disease can be missed, due to the subacute to chronic onset and challenges in detection. Clinicians should have a high degree of suspicion for development of these symptoms, even a few months after initiation of immune-modulatory therapy because the progression and outcomes can be disastrous.

scholarly journals JC Virus Granule Cell Neuronopathy and Lymphoma

2018 ◽  
Vol 5 (6) ◽  
Author(s):  
Alexis Demas ◽  
Omar Bennani ◽  
Anne Vandendriessche ◽  
Laurence Hellouin de Menibus ◽  
Vincent Langlois ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Cerebrospinal Fluid ◽  
Granule Cell ◽  
Opportunistic Infections ◽  
Jc Virus ◽  
Immunocompromised Patient ◽  
Chain Reaction ◽  
Progressive Cerebellar Ataxia ◽  
Polymerase Chain ◽  
Granule Cell Neuronopathy

Abstract Neurological opportunistic infections are going to increase. Clinicians should be aware of the neurological spectrum of JC virus manifestations, including granule cell neuronopathy. Detection of JC virus DNA by polymerase chain reaction in cerebrospinal fluid should be realized in the assessment of a progressive cerebellar ataxia in an immunocompromised patient.

What lies beneath the tent? JC-virus cerebellar granule cell neuronopathy complicating sarcoidosis

2009 ◽  
Vol 16 (8) ◽  
pp. 1091-1092 ◽  
Author(s):  
Ron Granot ◽  
Richard Lawrence ◽  
Michael Barnett ◽  
Lynette Masters ◽  
Michael Rodriguez ◽  
...  
Keyword(s):  
Granule Cell ◽  
Jc Virus ◽  
Cerebellar Granule Cell ◽  
Cerebellar Granule ◽  
Granule Cell Neuronopathy

scholarly journals JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

2016 ◽  
Vol 23 (1) ◽  
pp. 141-146 ◽  
Author(s):  
David N. Soleimani-Meigooni ◽  
Katherine E. Schwetye ◽  
Maria Reyes Angeles ◽  
Caroline F. Ryschkewitsch ◽  
Eugene O. Major ◽  
...  
Keyword(s):  
Granule Cell ◽  
Jc Virus ◽  
Interleukin 7 ◽  
Granule Cell Neuronopathy

HIV-Associated JC Virus-Granule-Cell Neuronopathy (JCV-GCN) with the Hot-Cross-Bun Sign

2015 ◽  
Vol 06 (09) ◽  
Author(s):  
Antoine Moulignier ◽  
Julie Bottero Julien Savatovsky ◽  
Jennifer Aboab Pierre-Marie Girard
Keyword(s):  
Granule Cell ◽  
Jc Virus ◽  
Granule Cell Neuronopathy

Concentrations of Thrombopoietin in Bone Marrow in Normal Subjects and in Patients With Idiopathic Thrombocytopenic Purpura, Aplastic Anemia, and Essential Thrombocythemia Correlate With Its mRNA Expression of Bone Marrow Stromal Cells

Blood ◽  
1998 ◽  
Vol 92 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Yasuo Hirayama ◽  
Sumio Sakamaki ◽  
Takuya Matsunaga ◽  
Takashi Kuga ◽  
Hiroyuki Kuroda ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Aplastic Anemia ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Essential Thrombocythemia ◽  
Stromal Cells ◽  
Detection System ◽  
Normal Subjects ◽  
Normal Range ◽  
Thrombocytopenic Purpura ◽  
Polymerase Chain

The function of bone marrow (BM) stromal thrombopoietin (TPO) in megakaryopoiesis remains unknown. In the present study we attempted to clarify the pathophysiological implications of stromal TPO in normal subjects (NS) and in patients with idiopathic thrombocytopenic purpura (ITP), aplastic anemia (AA), and essential thrombocythemia (ET) by measuring TPO concentrations in BM and peripheral blood (PB) and by estimating the levels of stromal TPO mRNA with TaqMan fluorescence-based post–reverse transcription-polymerase chain reaction product detection system. The results showed that TPO concentrations in PB were significantly elevated in patients with ITP (34.9 ± 11.7 pg/mL) and AA (364.1 ± 153.5 pg/mL) but within normal range in patients with ET (each 20.0 and 22.1; NS, 22.1 ± 8.2 pg/mL). In all subjects, the TPO concentrations in BM correlated well with the PB levels, and the former were consistently higher than the latter. The concentrations of TPO in BM also correlated with the levels of TPO mRNA in stromal cells. Furthermore, expression levels of TPO mRNA clearly correlated with megakaryocyte counts in NS and patients with ITP, indicating that stromal TPO actually enhances megakaryopoiesis. Thus, our results in the present study indicate that TPO from BM stromal cells is considered to play an essential role for megakaryopoiesis under various patho-physiological conditions.

scholarly journals Splenic Primary Follicular Lymphoma With Idiopathic Thrombocytopenic Purpura: Report of a Case

2018 ◽  
Vol 103 (7-8) ◽  
pp. 366-370
Author(s):  
Ryoga Hamura ◽  
Hiroaki Shiba ◽  
Yoshihiro Shirai ◽  
Kenei Furukawa ◽  
Takashi Horiuchi ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Fluorescent In Situ Hybridization ◽  
Rare Condition ◽  
Oral Prednisolone ◽  
High Dose ◽  
Histologic Diagnosis ◽  
Thrombocytopenic Purpura ◽  
Case Presentation

Introduction: Primary splenic lymphoma is a rare condition that accounts for approximately 1% of non-Hodgkin's lymphoma. No primary splenic follicular lymphoma with idiopathic thrombocytopenic purpura (ITP) has been reported in the literature. Case presentation: A 41-year-old man was diagnosed with idiopathic thrombocytopenic purpura (ITP), and received steroid maintenance treatment with oral prednisolone 13 mg/d for 6 years. However, the platelet counts were 20 × 103 /μL or less. Abdominal enhanced computer tomography (CT) revealed splenomegaly. He underwent laparoscopic splenectomy after preoperative high-dose immunoglobulin preparation (30 mg/d intravenously for 5 days) which were effective in the improvement of platelets count (130 × 103 /μL). The histologic diagnosis was B cell type follicular lymphoma of the spleen. Fluorescent in situ hybridization (FISH) revealed a t(14; 18)(q32; q21) translocation, which supported the diagnosis of primary follicular lymphoma of the spleen. After the operation, the patient showed satisfactory recovery, and was discharged on postoperative day 7. He remains well with the platelet count of more than 200 × 103 / μl without medication. We herein report such a case. Conclusion: To the best of our knowledge, this is the first reported case of splenic primary follicular lymphoma with ITP.

JC Virus Granule Cell Neuronopathy in a Child With CD40 Ligand Deficiency

2007 ◽  
Vol 36 (3) ◽  
pp. 186-189 ◽  
Author(s):  
Jonathan H. Hecht ◽  
Orit A. Glenn ◽  
Diane W. Wara ◽  
Yvonne W. Wu
Keyword(s):  
Granule Cell ◽  
Jc Virus ◽  
Cd40 Ligand ◽  
Granule Cell Neuronopathy

scholarly journals JC Virus Granule Cell Neuronopathy as AIDS-Presenting Illness

2018 ◽  
Vol 45 (4) ◽  
pp. 466-469 ◽  
Author(s):  
Simon Grandjean Lapierre ◽  
Xin Dang ◽  
Danielle Gilbert ◽  
Sylvie Lauzier ◽  
Igor J. Koralnik ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Progressive Multifocal Leukoencephalopathy ◽  
Granule Cell ◽  
Demyelinating Disease ◽  
Jc Virus ◽  
Clinical Manifestations ◽  
Immunodeficiency Virus ◽  
Granule Cell Neuronopathy

AbstractJC virus is the etiological agent of progressive multifocal leukoencephalopathy, a white matter demyelinating disease that mostly affects immunocompromised patients. JC virus can also infect neurons and meningeal cells and cause encephalitis, meningitis and granule cell neuronopathy. We report a patient with JC virus granule cell neuronopathy, without concomitant progressive multifocal leukoencephalopathy, presenting as inaugural acquired immune deficiency syndrome-related illness. This patient’s human immunodeficiency virus infection remained undiagnosed for several months after neurological symptoms onset. We review JC virus pathophysiology, clinical manifestations, treatment and prognosis, and emphasize the importance of considering human immunodeficiency virus infection and related opportunistic infections in the differential diagnosis of new-onset isolated cerebellar disease.

scholarly journals JC virus granule cell neuronopathy onset two months after chemotherapy for low-grade lymphoma

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Kathryn B. Holroyd ◽  
Elias S. Sotirchos ◽  
Scott R. DeBoer ◽  
Kelly A. Mills ◽  
Scott D. Newsome
Keyword(s):  
Granule Cell ◽  
Jc Virus ◽  
Low Grade ◽  
Granule Cell Neuronopathy
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