scholarly journals Low-Intensity Exercise Routine for a Long Period of Time Prevents Osteosarcopenic Obesity in Sedentary Old Female Rats, by Decreasing Inflammation and Oxidative Stress and Increasing GDF-11

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Beatriz Mena-Montes ◽  
David Hernández-Álvarez ◽  
Gibrán Pedraza-Vázquez ◽  
Rafael Toledo-Pérez ◽  
Raúl Librado-Osorio ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Older Adults ◽  
Low Intensity ◽  
Long Period ◽  
Exercise Routine ◽  
Osteosarcopenic Obesity ◽  
Low Intensity Exercise ◽  
And Oxidative Stress

The loss of skeletal muscle mass and strength is known as sarcopenia; it is characterized as a progressive and generalized muscle disorder associated with aging. This deterioration can seriously compromise the elderly’s health and reduce their quality of life. In addition to age, there are other factors that induce muscle mass loss, among which are sedentary lifestyle, chronic diseases, inflammation, and obesity. In recent years, a new clinical condition has been observed in older adults that affects their physical capacities and quality of life, which is known as osteosarcopenic obesity (OSO). Osteoporosis, sarcopenia, and obesity coexist in this condition. Physical exercise and nutritional management are the most widely used interventions for the treatment and prevention of sarcopenia. However, in older adults, physical exercise and protein intake do not have the same outcomes observed in younger people. Here, we used a low-intensity exercise routine for a long period of time (LIERLT) in order to delay the OSO appearance related to sedentarism and aging in female Wistar rats. The LIERLT routine consisted of walking at 15 m/min for 30 min, five days a week for 20 months. To evaluate the effects of the LIERLT routine, body composition was determined using DXA-scan, additionally, biochemical parameters, inflammatory profile, oxidative protein damage, redox state, and serum concentration of GDF-11 at different ages were evaluated (4, 8, 12, 18, 22, and 24 months). Our results show that the LIERLT routine delays OSO phenotype in old 24-month-old rats, in a mechanism involving the decrease in the inflammatory state and oxidative stress. GDF-11 was evaluated as a protein related to muscle repair and regeneration; interestingly, rats that perform the LIERLT increased their GDF-11 levels.

scholarly journals Early programmes of high and low intensity exercise and quality of life after acute myocardial infarction.

BMJ ◽  
1993 ◽  
Vol 307 (6914) ◽  
pp. 1244-1247 ◽  
Author(s):  
M C Worcester ◽  
D L Hare ◽  
R G Oliver ◽  
M A Reid ◽  
A J Goble
Keyword(s):  
Quality Of Life ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Low Intensity ◽  
Low Intensity Exercise

Combined Low-Intensity Exercise and Ascorbic Acid Attenuates Kainic Acid-Induced Seizure and Oxidative Stress in Mice

2015 ◽  
Vol 41 (5) ◽  
pp. 1035-1041 ◽  
Author(s):  
Hee-jae Kim ◽  
Wook Song ◽  
Eun Hee Jin ◽  
Jongkyu Kim ◽  
Yoonseok Chun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Kainic Acid ◽  
Low Intensity ◽  
Low Intensity Exercise ◽  
And Oxidative Stress

scholarly journals Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation

2020 ◽  
Vol 12 (4) ◽  
pp. 384-389
Author(s):  
Ardian Rizal ◽  
Ferry Sandra ◽  
Muhamad Rizki Fadlan ◽  
Djanggan Sargowo
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Blood Plasma ◽  
Ganoderma Lucidum ◽  
Atrial Remodelling ◽  
Post Test ◽  
Anti Inflammatory ◽  
And Oxidative Stress

BACKGROUND: Atrial fibrillation (AF) could be triggered by inflammation and oxidative stress. Ganoderma lucidum has an active substance in the form of β-glucan that can reduce inflammatory process and oxidative stress in rats. The objective of this study was to evaluate the effect of Ganoderma lucidum polysaccharide peptide (GLPP) in paroxysmal AF subjects with parameters of anti-inflammatory antioxidant, electrocardiography and health-related quality of life (HRQoL).METHODS: A randomized closed-label clinical trial with pre- and post-test design was conducted. After AF subjects selection, the subjects were randomized, interviewed and veni-punctured to isolate blood plasma. AF Subjects were then treated with placebo or GLPP for 90 days. Post-test blood plasma was collected on the following day after the 90th day. Then anti-inflammatory and antioxidant parameters were measured. After that, echocardiographic and HRQoL assessments were performed.RESULTS: A total of 38 subjects, 11 males and 27 females, completed the study with no significant changes in diets, physical activities, or medications. Comparing to control, the 90-days GLPP-treated subject characteristics were significant difference in systolic blood pressure, heart rate, malondialdehyde, high-sensitivity C-reactive protein, tumor necrosis factor-a, interleukin (IL)-1b, IL-6, primary (P)-wave dispersion, P-max, physical functioning, limitation to physical health, energy/fatigue, pain, and physical limitation.CONCLUSION: GLPP has several potential effects in AF subjects, including anti-inflammatory, antioxidant, and atrial remodelling, so that HRQoL of AF subjects could be improved. Hence, GLPP could suggested as a potential supplementing agent for AF management.KEYWORDS: atrial fibrillation, Ganoderma lucidum, inflammation, antioxidant, atrial remodelling, quality of life

Low Intensity Aerobic Exercise and Oxidative Stress Markers in Older Adults

2014 ◽  
Vol 22 (4) ◽  
pp. 536-542 ◽  
Author(s):  
Mohamed A. Bouzid ◽  
Omar Hammouda ◽  
Régis Matran ◽  
Sophie Robin ◽  
Claudine Fabre
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Aerobic Exercise ◽  
Oxidative Stress Markers ◽  
Physically Active ◽  
Low Intensity ◽  
Stress Markers ◽  
Before And After ◽  
And Oxidative Stress ◽  
Sedentary Subjects

This comparative study examined the effects of regular low intensity aerobic exercise on oxidative stress markers in older adults. The study was carried out on 15 sedentary subjects (age: 65.1 ± 3.5 years) versus 18 subjects performing fitness exercises (age: 65.8 ± 3.3 years). Before and after an incremental exercise test, oxidative stress markers were assessed. Superoxide dismutase was higher at rest and at the recovery for the physically active subjects compared with sedentary subjects (p < .05). At recovery, glutathione peroxidase and α -Tocopherol increased significantly above the resting values only in the active group (p < .05). Malondialdehyde had increased in both groups (p < .01), associated with a higher level in the sedentary group (p < .05) at the recovery. These data suggest that low intensity aerobic exercise may be useful to prevent the decline of antioxidants linked with aging.

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