scholarly journals A Case of Endometrial Carcinosarcoma Containing Sertoliform Endometrioid Carcinoma Component

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Satoru Munakata ◽  
Hanae Kushibiki ◽  
Taishi Akimoto ◽  
Tsuyoshi Yamashita ◽  
Norihiko Shimoyama
Keyword(s):  
Clear Cell ◽  
Uterine Cavity ◽  
Myometrial Invasion ◽  
Positive Staining ◽  
Endometrioid Carcinoma ◽  
Sarcomatous Component ◽  
Cytoplasmic Staining ◽  
First Case ◽  
Gross Examination ◽  
Solid Area

Carcinosarcomas (CSs) of the endometrium have admixture of malignant epithelial and mesenchymal components. The carcinomatous component exhibit endometrioid, serous, or clear cell differentiation, or are undifferentiated. CSs are considered homologous or heterologous according to the type of sarcomatous component. Sertoliform endometrioid carcinomas (SECs) of the endometrium which comprise a rare subtype of endometrial cancer, typically occur in the ovary. SECs as a carcinomatous component of CS of the endometrium have not been reported. Here, we report an endometrial carcinosarcoma that contains an SEC component. An 88-year-old female presented to a clinic with atypical genital bleeding. She was referred to our hospital and underwent total hysterectomy, bilateral adnexectomy and partial omentectomy due to endometrial carcinoma. Gross examination revealed a polypoid mass in the uterine cavity with massive myometrial invasion. Histologically, the tumor was a high-grade endometrioid carcinoma. In addition to an ordinary conventional endometrioid carcinoma, approximately 30% of the area exhibited sex cord-like pattern and contained small hollow tubules, anastomosing cords and trabeculae, and tightly packed nests. Immunohistochemically, the SEC component showed diffuse p53 staining. Sex cord-like area, especially the solid area, showed positive staining for EMA, vimentin, α-inhibin, CD99, calretinin, p53, CD56, synaptophysin, and chromogranin A, which is a staining pattern similar to that previously reported SEC of the endometrium. Diminished membranous and positive cytoplasmic staining for β-catenin was observed. This is the first case report of an endometrial carcinosarcoma containing an SEC component. SECs of the endometrium might exhibit sex cord-like differentiation in contrast to SECs of the ovary, which do not exhibit sex cord differentiation.

scholarly journals To study the relationship of parity and laterality with different ovarian lesions

2021 ◽  
Vol 6 (2) ◽  
pp. 135-137
Author(s):  
Dupinder Kaur ◽  
Pooja Agarwal
Keyword(s):  
Observational Study ◽  
Outer Surface ◽  
Neoplastic Lesions ◽  
Relationship Of ◽  
The Relationship ◽  
Cut Surface ◽  
Gross Examination ◽  
Solid Area

The present study is based on histomorphological evaluation in 107 cases of Ovarian neoplastic and non-neoplastic lesions received. The gross specimens received were fixed in 10 percent formalin for 24 hours. Gross examination was done carefully examining the outer surface and on-cut surface of ovary, looking for any cyst with its content and type of fluid filled inside, any solid area, papillary projections and growth. Observational study.Among 69 non neoplastic lesions, right sided cases found in 34 (49.4%), and left sided lesion found in 22 cases (31.8%). 13 cases (18.8%) of non neoplastic lesions are observed to be bilateral. Like non neoplastic lesions, neoplastic lesions are also found more common on right side (55%) than left (35%), while bilaterality is found in 10% of the cases. The results of present study are comparable to other series of studies regarding occurrence with respect to age, bilaterality, gross features and microscopy. Both non neoplastic and neoplastic lesions were more common in right side. 18% of non neoplastic and 11% of neoplastic lesions were found to be bilateral.

scholarly journals Defective Autophagy in MPN Were Predominantly Detected in Megakaryocytes in Philadelphia Negative (Ph -) Myeloproliferative Neoplasm

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 5386-5386
Author(s):  
Jen-Chin Wang ◽  
Guanfang Shi ◽  
Karan Josan ◽  
Preethi Ramachandran ◽  
Vladimir Gotlieb ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Western Blot ◽  
Cell Signaling ◽  
Mononuclear Cells ◽  
Myeloproliferative Neoplasm ◽  
Beclin 1 ◽  
Positive Staining ◽  
Rt Pcr ◽  
Peripheral Blood Mononuclear ◽  
Cytoplasmic Staining

We previously reported that autophagy was defective in classical Philadelphia negative (Ph -) Myeloproliferative Neoplasm (MPN) by demonstrating increased p62, decreased Beclin-1 by RT-PCR and Western Blot (WB) methods and decreased LC3-II by WB (ASH annual meeting poster 2018) in peripheral blood mononuclear cells. Now, we further performed immunohistochemical staining of these autophagy markers on the bone marrow biopsy specimens. Methods: Formalin-fixed and paraffin-embedded bone marrow samples were stained with primary antibodies against Beclin-1 (mouse monoclonal, Millipore), LC3B (rabbit monoclonal, Cell Signaling Technology), and p62 (mouse monoclonal, Cell Signaling Technology). The tissue sections were analyzed using VENTANA BenchMark Ultra System (Ventana Medical Systems, Inc.) according to the manufacturer's protocol. Patients who were studied included 12 essential thrombocythemia (ET), 10 polycythemia (PV), and 5 myelofibrosis (MF) (including 1 post-ET MF and 1 post-PV MF). Scoring was given based on the degree of cytoplasmic staining. Score 1 included weak cytoplasmic stain, score 2 included moderate cytoplasmic stain and score 3 was given for strong cytoplasmic staining . Results: 1) As shown in Fig1, the predominant cells which stained positive including p62, Beclin-1 , or LC3 B were mostly found on the megakaryoctes, although very few of other cell types were found to have positive staining as well 2) As shown in Table 1, the immunostaining results were in general correlated to the RT-PCR , or western blot findings that a defective autophagy was demonstrated in MPN patients with combined finding of a stronger staining in p62,and weak staining in Beclin-1 and LC3B. Conclusion: We have demonstrated defective autophagy in these Ph (-) MPN, by immunostaining of the bone marrow specimens, and demonstrating positivity for defective autophagy predominantly in megakaryocytes. Since megakaryocytes are the most important cells involved in the pathogenesis of MPN, we propose that defective autophagy in megakaryocytes play an important role in the pathogenesis of these diseases. Disclosures Wang: Incyt: Research Funding.

scholarly journals A rare case of synchronous right ovarian clear cell carcinoma and an incidental left ovarian endometrioid carcinoma with immunohistochemical study

2014 ◽  
Vol 5 (2) ◽  
pp. 91
Author(s):  
SiddhiG. S. Khandeparkar ◽  
SanjayD Deshmukh ◽  
HemantS Lekawale ◽  
Amit Bhoge ◽  
AnsariTabassum Parveen Maqbool Ahmed
Keyword(s):  
Cell Carcinoma ◽  
Rare Case ◽  
Clear Cell ◽  
Immunohistochemical Study ◽  
Clear Cell Carcinoma ◽  
Endometrioid Carcinoma ◽  
Ovarian Clear Cell Carcinoma

Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization

2019 ◽  
Vol 46 (7) ◽  
Author(s):  
Takahiro Kiyohara ◽  
Takako Shijimaya ◽  
Mari Miyamoto ◽  
Naoko Nagano ◽  
Sei Nakamaru ◽  
...  
Keyword(s):  
Clear Cell ◽  
First Case ◽  
String Of Pearls

scholarly journals PD-L1/PD-1 Expression in Endometrial Clear Cell Carcinoma: A Potential Surrogate Marker for Clinical Trials

2019 ◽  
Vol 28 (1) ◽  
pp. 31-37
Author(s):  
Cao Jin ◽  
Sean Hacking ◽  
Sharon Liang ◽  
Mansoor Nasim
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Surrogate Marker ◽  
Myometrial Invasion ◽  
Lymphocyte Infiltration ◽  
Pathological Features ◽  
Napsin A ◽  
Programmed Death ◽  
Clinical And Pathological Features

Background. Endometrial clear cell carcinoma (ECCC) represents a rare subtype of endometrial cancer. Recently, immunotherapeutic drugs targeting programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) was associated with improved survival in several types of cancer (especially in patients with mismatch-repair (MMR)-deficient status). The aim of this study is to evaluate the correlation between the PD-L1/PD-1 axis and clinical and pathological features in strictly defined ECCC diagnosed at our institution. Design. Review of ECCC (diagnosed in the period of 2000 to 2017) identified 23 cases (n = 23) in our institution. The cases were reviewed by 2 gynecological pathologists. Estrogen receptor, progesterone receptor, napsin A, p16, and p53 were also performed so that only pure CCC cases were included. PD-L1 (SP142), PD-1, and MMR antibodies were performed. PD-L1 and PD-1 were scored in both the tumor and the peritumoral lymphocyte infiltration. Clinical and pathological features were recorded to correlate with the expression of the 2 markers. Results. Among the 23 cases, 20 cases were qualified for pure CCC by histology and immunohistochemistry patterns. Regarding PD-1 expression, 6/20 (30%) patients had positive expression in peritumoral lymphocyte infiltration. While 3/20 (15%) cases had PD-L1 either tumoral or peritumoral lymphocytes expression. Loss of MMR expression was present in 1 (5%) of 20 patients. PD-1 and/or PD-L1 expression cases tended to have deeper myometrial invasion and higher stage at presentation. Conclusions. Our results are suggestive of the roles of both PD-1 and PD-L1 in ECCCs as useful therapeutic biomarkers for immunotherapy.

Progression from Nodular to Lymphangitic Subcutaneous Metastasis from Clear Cell Endometrial Carcinoma: Ct Findings

1998 ◽  
Vol 84 (3) ◽  
pp. 387-390 ◽  
Author(s):  
Alfredo La Fianza ◽  
Lorenzo Preda ◽  
Enrico Maria Di Maggio ◽  
Paolo Pedrazzoli ◽  
Saverio Tateo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Diagnostic Imaging ◽  
Endometrial Carcinoma ◽  
Clear Cell ◽  
Imaging Techniques ◽  
Genital System ◽  
Frequent Type ◽  
First Case ◽  
Subcutaneous Metastases ◽  
Diagnostic Imaging Techniques

Subcutaneous metastases from clear cell endometrial carcinoma are an uncommon event and tumor implantations are rarely found with diagnostic imaging techniques. The nodular form is the most frequent type of subcutaneous metastasis from genital system tumors, even though plaque-like and infiltrative forms have also been reported. We report the first case of subcutaneous metastasis from clear cell endometrial carcinoma whose progression from the early nodular to the lymphangitic infiltrative form was studied with computed tomography (CT). Differential diagnostic problems are discussed.

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