scholarly journals The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Yuehui Zhang ◽  
Xiaozhu Guo ◽  
Shuting Ma ◽  
Haoyue Ma ◽  
Hang Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Polycystic Ovary Syndrome ◽  
Alternative Medicine ◽  
Traditional Medicine ◽  
Polycystic Ovary ◽  
World Health ◽  
Menstrual Disorders ◽  
Ovary Syndrome ◽  
The World ◽  
Complementary And Alternative

Polycystic ovary syndrome (PCOS) is a frequent gynecological female endocrinopathy, characterized by chronic anovulation, hyperandrogenism, and insulin resistance (IR). Menstrual disorders are one of the main clinical manifestations of PCOS. Other symptoms include hirsutism and/acne. At present, the treatment of PCOS with irregular menstruation is mainly based on oral contraceptives, but there are some side effects and adverse reactions. In recent years, more and more attention has been paid to the complementary and alternative medicine (CAM), which has been widely used in clinical practice. Modern Western medicine is called “conventional medicine” or “orthodox medicine,” and the complementary and alternative medicine is called “unconventional medicine” or “unorthodox medicine.” CAM includes traditional medicine and folk therapy around the world. Around 65–80% of world health management business is classified into traditional medicine by the World Health Organization, which is used as alternative medicine in Western countries. In our country, Chinese medicine, acupuncture, and other therapies are commonly used due to their significant efficacy and higher safety. Therefore, this review aims to summarize and evaluate the mechanisms and the effect of current complementary replacement therapy in the treatment of menstrual disorders caused by PCOS, so as to provide guidance for the following basic and clinical research.

scholarly journals The Effects of Traditional Chinese Medicine-Associated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-26
Author(s):  
Wenjuan Shen ◽  
Bao Jin ◽  
Yujia Pan ◽  
Yanhua Han ◽  
Tianjiao You ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Symptom Relief ◽  
Public Health Problem ◽  
Signs And Symptoms ◽  
Ovary Syndrome ◽  
The Impact ◽  
Complementary And Alternative

Polycystic ovary syndrome (PCOS) is a touchy clinical and public health problem worldwide, which adversely affects women’s health and health-related comorbidities for lifetime, and represents a tremendous burden for both the family of the patient and for society. According to the diagnostic criteria used and the population studied, the prevalence rate of PCOS is between 6% and 21%. However, current conventional modern medicines for PCOS are only moderately effective at controlling the signs and symptoms, while they are not thoroughly able to prevent complications. Therefore, many patients have turned to complementary and alternative medical (CAM) treatments. CAM use is wide spread among patients with PCOS, and more than 70% of patients use CAM at one point during their diseases. The patients’ primary motivations include dissatisfaction with available medications, perceive higher risk of drug side effects and crushing health burden and economic costs, desire for symptom relief, pursuit of shortening the course of disease, and the belief that CAM therapy is in accordance with the patients’ values and beliefs. At present, several CAM methods have been used in women with PCOS, which has achieved obvious effects. However, biologically plausible mechanisms of the action of traditional Chinese medicine- (TCM-) associated CAM for PCOS have not been systematically reviewed. This review briefly summarizes the current progress of the impact of herbal medicine on the outcomes of PCOS and introduces the mechanisms.

scholarly journals The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Li-Yan Jia ◽  
Jia-Xing Feng ◽  
Juan-Li Li ◽  
Fang-Yuan Liu ◽  
Liang-zhen Xie ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Polycystic Ovary ◽  
Diet Therapy ◽  
Specific Method ◽  
Childbearing Age ◽  
Ovary Syndrome ◽  
Reproductive Endocrine ◽  
Complementary And Alternative

As a reproductive endocrine disease, polycystic ovary syndrome (PCOS) has influenced billions of women during childbearing age worldwide. Owing to its complex etiology and ambiguous pathogenesis, there is still not a specific method to cure it. Clinical treatments, such as hormone therapy and surgical treatment, have side effects. Therefore, it is essential and urgent to seek alternative treatment to solve these problems. The satisfactory efficacy of complementary and alternative medicine (CAM), such as traditional Chinese medicine (TCM), immunotherapy, medicinal foods, vitamin therapy, diet therapy, psychotherapy, spa, and oxygen therapy, in treating PCOS, has aroused an increasing number of medical workers’ concern and gradually become the mainstream. This paper reviews the application of CAM in the treatment of PCOS, especially from the perspective of TCM. Meanwhile, the limitations of the literature about CAM in the treatment of PCOS are mentioned and analyzed as well.

scholarly journals A comparison of the efficacy and safety of complementary and alternative therapies for polycystic ovary syndrome A protocol for network meta-analysis

2021 ◽  
Author(s):  
Jing Pan ◽  
Shan Xiang ◽  
Shuangqian Dong ◽  
Xiuyun Qin ◽  
Jianwei Zhang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Alternative Therapies ◽  
World Health ◽  
Cochrane Library ◽  
Ovary Syndrome ◽  
Medicine Research ◽  
Complementary And Alternative Therapies ◽  
Complementary And Alternative

Abstract Background: With the increase in the incidence of Polycystic Ovary Syndrome (PCOS) over the years, restoring ovulation function has become one of the important contents of reproductive medicine research today. PCOS affects reproductive ability and harms physical and mental health. Studies show both complementary and alternative therapies to be effective in treating PCOS. However, the consistency of the conclusion is still inadequated. In view of this, we will develop a research to evaluate the effectiveness and safety of complementary and alternative therapies for PCOS. We therefore carry on a study protocol for a proposed network meta-analysis (NMA) and systematic review on PCOS.Methods: The following electronic bibliographic database will be searched: PubMed, Chinese National Knowledge Infrastructure (CNKI), VIP database, Wanfang database, The Cochrane Library, EMBASE and Web of Science from inception till 31 December2020. A search at the World Health Organization (WHO) International Clinical Trials Registry Platform will also be done. Two researchers will independently screen literature, extract data and assess the risk of bias of included studies. Analysis will be performed on included studies using the NMA technique. Data will be analyzed using ADDIS 1.16.8 and STATA 15.0.Results: This work will evaluate the safety and effectiveness of alternative and complementary therapies used in the treatment of PCOS.Conclusion: The results of this study will provide reliable evidence for clinicians in the field to build on for best practices in effective interventions (complementary and alternative therapies) for PCOS.

scholarly journals Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Coptis chinensis Franchin Polycystic Ovary Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Jian Xiong Ma ◽  
Miaoyong Ye ◽  
Ke Ma ◽  
Kang Zhou ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Polycystic Ovary Syndrome ◽  
Signaling Pathways ◽  
Polycystic Ovary ◽  
Interaction Network ◽  
Network Pharmacology ◽  
Bioactive Components ◽  
Coptis Chinensis ◽  
Ovary Syndrome

Background. Polycystic ovary syndrome (PCOS) causes low fertility in females. Coptis chinensis (C. chinensis) is used to clear heat and dampness, purify fire, and detoxify in traditional Chinese medicine (TCM). Although C. chinensis has demonstrated efficacy against PCOS in clinical practice, there are no available data regarding the bioactive components of C. chinensis, their targets, and molecular mechanisms underlying their effects. Methods and Results. Network pharmacology was used to analyze the bioactive components of C. chinensis, their targets, and signaling pathways underlying their effects. The TCM systems pharmacology database and analysis platform (TCMSP) was used to screen 14 effective active ingredients and 218 targets of C. chinensis. The GeneCards, OMIM, and PharmGkb databases were used to screen 3517 disease targets for PCOS, and 102 common targets of drugs and diseases were screened using R Cytoscape that was utilized to build a drug-active ingredient-disease target interaction network, and the STRING platform was utilized to construct a common target protein-protein interaction network, including 102 nodes and 221 edges. Key targets of C. chinensis for the treatment of PCOS included JUN, MAPK, IL6, CXCL8, FOS, and IL1B. A total of 123 gene ontology (GO) terms and 129 pathways were acquired by GO and KEGG enrichment analyses. The AGEs/RAGE, TNF, IL-17, MAPK, and HIF-1 signaling pathways were closely related to PCOS and may be the core pathways involved in PCOS. Schrodinger software was used to evaluate the interaction between active components and their targets and explore binding modes. Furthermore, based on the prediction of network pharmacology study, a mouse model of PCOS was established to evaluate the curative role and underlying mechanisms of C. chinensis. The results showed that C. chinensis treatment reversed histopathological damage of the ovary and also ameliorated the mRNA and protein expression levels of the predicted hub targets (MAPK1, CXCL8, IL-6, and IL-1β). These results indicated that WZYZP has a protective effect on spermatogenesis disorder, suggesting that it could be an alternative choice for male infertility therapy. Conclusions. This preliminary study verified the basic pharmacological effects and mechanisms of C. chinensis, a TCM, in the treatment of PCOS. These results indicate that the therapeutic effects of C. chinensis on PCOS may be achieved by regulating the expression of inflammatory factors. This study provides new insights for the systematic exploration of the mechanism of traditional Chinese medicine.

MENSTRUAL DISORDERS AND ANDROGEN-RELATED TRAITS IN YOUNG WOMEN WITH TYPE 1 DIABETES MELLITUS: A CLINICAL STUDY

2020 ◽  
Vol 26 (11) ◽  
pp. 1269-1276
Author(s):  
Stavroula A. Paschou ◽  
Andromachi Vryonidou ◽  
Marina Melissourgou ◽  
Ioanna Kosteria ◽  
Dimitrios G. Goulis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Young Women ◽  
Polycystic Ovary ◽  
Menstrual Disorders ◽  
Ovary Syndrome ◽  
Pcos Group

Objective: To investigate possible causes of menstrual disorders and androgen-related traits in young women with type 1 diabetes mellitus (T1DM). Methods: Fifty-three women with T1DM (duration 8.0 ± 5.6 years), 41 women with (polycystic ovary syndrome) PCOS, and 51 controls matched for age (19.4 ± 4.3 years vs. 21.2 ± 2.7 years vs. 20.8 ± 3.1 years; P>.05) and body mass index (BMI) (22.2 ± 2.7 kg/m2 vs. 21.9 ± 2.0 kg/m2 vs. 21.4 ± 1.9 kg/m2; P>.05) were prospectively recruited. Results: Two women (3.8%) in the T1DM group had not experienced menarche (at 15.5 and 16.6 years); of the rest, 23.5% had oligomenorrhea, 32.1% hirsutism, and 45.3% had acne. The age at menarche was delayed in the T1DM group compared to controls (12.7 ± 1.3 vs. 12.0 ± 1.0 years; P = .004), while no difference was observed with the polycystic ovary syndrome (PCOS) group (12.4 ± 1.2 years). There were no differences in total testosterone (0.43 ± 0.14 ng/mL vs. 0.39 ± 0.14 ng/mL; P>.05), dehydroepiandrosterone sulfate (DHEA-S) (269 ± 112 μg/dL vs. 238 ± 106 μg/dL; P>.05) or Δ4-androstenedione (2.4 ± 1.3 ng/mL vs. 1.9 ± 0.5 ng/mL; P>.05) concentrations between T1DM and controls. However, patients with T1DM had lower sex hormone binding globulin (SHBG) concentrations than controls (61 ± 17 nmol/L vs. 83 ± 18.1 nmol/L; P = .001), which were even lower in the PCOS group (39.5 ± 12.9 nmol/L; P = .001 compared with T1DM). The free androgen index (FAI) was higher in the PCOS group compared with both other groups (T1DM vs. PCOS vs. controls: 2.53 ± 0.54 vs. 7.88 ± 1.21 vs. 1.6 ± 0.68; P<.001). FAI was higher in patients with T1DM compared to controls as well ( P = .038). There was no difference in DHEA-S concentrations between T1DM and PCOS patients (269 ± 112 μg/dL vs. 297 ± 100 μg/dL; P>.05). Conclusion: Menstrual disorders and androgen-related traits in young women with T1DM may be attributed to an increase in androgen bioavailability due to decreased SHBG concentrations. Abbreviations: Δ4A = Δ4-androstenedione; BMI = body mass index; CI = confidence interval; CV = coefficient of variation; DHEA-S = dehydroepiandrosterone sulfate; FAI = free androgen index; HbA1c = glycated hemoglobin; PCOS = polycystic ovary syndrome; RIA = radioimmunoassay; SHBG = sex hormone binding globulin; T1DM = type 1 diabetes mellitus

A Review of the Gut-Uterine Axis in Persian Medicine Literature: Implications in Polycystic Ovary Syndrome

2020 ◽  
Author(s):  
Ayeh Naghizadeh ◽  
Mohammad Ali Zareian ◽  
Maliheh Tabarrai
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Holistic Approach ◽  
Mutual Relationship ◽  
Menstrual Disorders ◽  
Reproductive Systems ◽  
Ovary Syndrome ◽  
Disease States ◽  
Persian Medicine ◽  
Digestive Disorders

Persian medicine (PM) takes a holistic approach towards diagnosis and management of disease states, focusing on the connections between body systems and organs. Menstrual disorders are of utmost importance in women, as they may lead to dysfunctions in other body systems. Deeming a mutual relationship between the gastrointestinal and female reproductive systems, PM physicians believed in a gut-uterine axis to exist. Ehtebas-e Tams (ET), meaning menstrual retention, is not an exception, being accompanied by gastrointestinal morbidities including digestive disorders, nausea, heartburn, food craving and pica, reduced appetite, abdominal pain, and bloody diarrhea. Considering polycystic ovary syndrome (PCOS) as an instance of ET, we searched studies to investigate these correlations. While a number of the mentioned ET symptoms were confirmed by contemporary studies, others had not been investigated widely and are yet to be elucidated. Conducting studies to clarify such correlations has implications in improved diagnosis and novel modes of treatment.

scholarly journals Auricular points acupressure for insulin resistance in overweight/obese women with polycystic ovary syndrome: protocol for a randomised controlled pilot trial

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e027498 ◽  
Author(s):  
Yan Li ◽  
Lihui Hou ◽  
Yingji Wang ◽  
Liangzhen Xie ◽  
Meiwei Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chinese Medicine ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Pilot Trial ◽  
Intervention Group ◽  
Well Being ◽  
Control Group ◽  
Model Assessment ◽  
Ovary Syndrome

IntroductionApproximately 5%–20% of reproductive women suffer from polycystic ovary syndrome (PCOS). Auricular points acupressure (AA) may serve as alternative management for PCOS for its benefits in both physical and psychological well-being. However, the effects of AA for insulin resistance (IR) in overweight/obese PCOS women have not been confirmed.Methods and analysisThe present study is designed as a randomised, placebo-controlled pilot trial to evaluate the effectiveness and safety of AA in treating IR in women with PCOS. A total of 60 eligible PCOS subjects will be randomised into an intervention group (AA group) and a control group (sham AA group) in a ratio of 1:1. Magnetic beads will be taped to the auricular points by the same senior acupuncture specialist from the First Affiliated Hospital, Heilongjiang University of Chinese Medicine. The treatment will last for 12 weeks. Primary outcome measure will be changes in homeostasis model assessment of IR between baseline and after 3 months of AA/sham AA treatment. Secondary outcomes include hormonal profile, weight, waist/hip circumference, body mass index, blood pressure, Ferriman-Gallwey score, acne and the assessment of health-related quality of life. Outcome measures are collected at baseline and the end of treatment visit.Ethics and disseminationThe protocol has been approved by the ethics committee of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine (HZYLLKY201800301). Written informed consent will be obtained from all participants. The results will be disseminated through peer-reviewed journals for publications.Trial registration numberNCT03546595; Pre-results.

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