A comparison of the efficacy and safety of complementary and alternative therapies for polycystic ovary syndrome A protocol for network meta-analysis
Abstract Background: With the increase in the incidence of Polycystic Ovary Syndrome (PCOS) over the years, restoring ovulation function has become one of the important contents of reproductive medicine research today. PCOS affects reproductive ability and harms physical and mental health. Studies show both complementary and alternative therapies to be effective in treating PCOS. However, the consistency of the conclusion is still inadequated. In view of this, we will develop a research to evaluate the effectiveness and safety of complementary and alternative therapies for PCOS. We therefore carry on a study protocol for a proposed network meta-analysis (NMA) and systematic review on PCOS.Methods: The following electronic bibliographic database will be searched: PubMed, Chinese National Knowledge Infrastructure (CNKI), VIP database, Wanfang database, The Cochrane Library, EMBASE and Web of Science from inception till 31 December2020. A search at the World Health Organization (WHO) International Clinical Trials Registry Platform will also be done. Two researchers will independently screen literature, extract data and assess the risk of bias of included studies. Analysis will be performed on included studies using the NMA technique. Data will be analyzed using ADDIS 1.16.8 and STATA 15.0.Results: This work will evaluate the safety and effectiveness of alternative and complementary therapies used in the treatment of PCOS.Conclusion: The results of this study will provide reliable evidence for clinicians in the field to build on for best practices in effective interventions (complementary and alternative therapies) for PCOS.