scholarly journals Effect of Fluticasone propionate Aqueous Nasal Spray Treatment on Platelet Activating Factor and Eicosanoid Production By nasal Mucosa in Patients with A house Dust Mite Allergy

1994 ◽  
Vol 3 (5) ◽  
pp. 381-385 ◽  
Author(s):  
I. M. Garrelds ◽  
T. de Graaf-in 't Veld ◽  
A. P. H. Jansen ◽  
R. Gerth van Wijk ◽  
F. J. Zijlstra
Keyword(s):  
Fluticasone Propionate ◽  
Nasal Spray ◽  
Nasal Mucosa ◽  
House Dust ◽  
House Dust Mite ◽  
Platelet Activating Factor ◽  
House Dust Mites ◽  
Allergic Reactions ◽  
Dust Mite ◽  
Allergen Provocation

The relationship between the release of platelet activating factor (PAF), leukotriene C4/D4/EE(LTC4/D4/E4) and prostaglandin D2(PGD2) from nasal mucosain vivowas examined in 24 rhinitis patients allergic to the house dust mite (HDM). During a double blind placebo controlled cross-over study 200 μg fluticasone propionate aqueous nasal spray (FPANS) was administered twice daily for two weeks. In response to allergen provocation (100, 1 000, 10 000 Bu/ml) and during the 9.5 h after this challenge the nasal fluid was obtained by washing the nose with saline and the levels of PAF, LTC4/D4/E4and PGD2, as indicators of mediator release, were measured at the following time-points: baseline (t = − 1/2), allergen provocation with 10 000 Bu/ml (t = 0), 3.5 and 7.5 h (late phase). After allergen provocation the levels of the mediators increased in the nasal fluids of placebo treated patients (x-fold increase to baseline: PAF, 15; LTC4/D4/E4, 12; PGD2, 1.5). In fluids of patients treated with FPANS these levels tended to decrease. At the time of provocation the levels of PAF, LTC4/D4/E4and PGD2showed a significant correlation. The results indicate that these mediators can be used as markers of allergic reactions against house dust mites and that fluticasone propionate aqueous nasal spray tended to reduce the release of mediators of inflammation correlated with beneficial effects on clinical symptoms in this type of allergic reactions.

Acaricidal activities of traditional Chinese medicine against the house dust mite, Dermatophagoides farinae

Parasitology ◽  
2010 ◽  
Vol 137 (6) ◽  
pp. 975-983 ◽  
Author(s):  
HAI-QIANG WU ◽  
JING LI ◽  
ZHEN-DAN HE ◽  
ZHI-GANG LIU
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
House Dust ◽  
House Dust Mite ◽  
Petroleum Ether Extract ◽  
House Dust Mites ◽  
Dermatophagoides Farinae ◽  
Dust Mite

SUMMARYObjective. This paper assessed the potential of traditional Chinese medicine (TCM) preparations for using as environmentally acceptable and alternative commercial acaricides. Methods. 22 kinds of TCM, which contained abundant essential oils and showed insecticidal effects, were collected. Samples extracted with petroleum ether, ethyl acetate and methanol were tested against house dust mites Dermatophagoides farinae and their toxicity assessed. Results. The results showed that 3 TCM of Cinnamonum cassia, Eugenia caryophyllata and Pogostemon cablin have higher activity, and the parallel tests showed that the petroleum ether extract had higher activities (0·0046 mg/cm2, 0·005 mg/cm2 and 0·006 mg/cm2 respectively, 24 h, LD50) than the extracts of ethyl acetate and methanol. The acaricidal activity of the ethyl acetate extracts from C. cassia, P. cablin and Asarum sieboldii (0·00144 mg/cm2, 0·00347 mg/cm2 and 0·05521 mg/cm2 respectively, 24 h, LD50) were almost comparable to that of benzyl benzoate and dibutyl phthalate. However, the methanolic extracts of were less effective. Conclusions. This study shows the use of extracts with petroleum ether of C. cassia, P. cablin and E. caryophyllata as eco-friendly biodegradable agents for the control of the house dust mite.

Quantitation of house dust mites and house dust mite allergens in the microenvironment of dogs

2003 ◽  
Vol 64 (10) ◽  
pp. 1301-1309 ◽  
Author(s):  
Amy Randall ◽  
Andrew Hillier ◽  
Lynette K. Cole ◽  
Kenneth W. Kwochka ◽  
Glen Needham ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
House Dust Mites ◽  
Dust Mites ◽  
Dust Mite

scholarly journals Investigation on risk factors of adult allergic rhinitis in China

2021 ◽  
Author(s):  
Guo Hong ◽  
Zhou Yibo ◽  
Li Fengxia ◽  
Liu Ming Ping ◽  
Cao Yong
Keyword(s):  
Risk Factors ◽  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Air Pressure ◽  
House Dust Mites ◽  
Control Group ◽  
Observation Group ◽  
Dust Mites ◽  
Dust Mite

Abstract OBJECTIVE: To investigate the risk factors associated with allergic rhinitis in adults. METHODS: Using the 1:1 matching principle, 1096 cases of allergic rhinitis patients aged 18-65 years were selected as the observation group, and another group of healthy medical checkups were selected as the control group, and the data related to allergic rhinitis were collected by allergen testing and questionnaire survey, and univariate and multifactorial analyses were performed respectively. RESULTS: The univariate analysis showed that allergic rhinitis may be related to temperature changes, dryness and humidity, air pressure, wind speed, seasonal changes and exposure to allergens such as dust mites and house dust mites. After allergen testing of all patients in the observation group, it was found that dust mite and house dust mite were the highest percentage of allergens, accounting for 40.51%, indicating that environmental factors play a decisive role in allergic rhinitis. Multi-factor analysis showed that exposure to dust mites, house dust mites, Penicillium punctatum, Streptomyces crossatus and Aspergillus fumigatus were independent risk factors for allergic rhinitis when it was humid, when it was cold, when it was windy and when the air pressure was low. CONCLUSION: The epidemiological status of allergic rhinitis in adults in China was initially understood, and the main allergens were house dust mite and dust mite, which provided scientific epidemiological information for the standardized prevention and treatment of allergic rhinitis in this region.

scholarly journals High Dust Mite specific Immunoglobulin E (sIgE): a Promising Indicator of Allergic Rhinitis to Asthma

2020 ◽  
Author(s):  
Rui Tang ◽  
Xiaohong Lyu ◽  
Yuelun Zhang ◽  
Shi Chen ◽  
Hong Li
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Immunoglobulin E ◽  
House Dust Mites ◽  
Kaplan Meier ◽  
Sige Level ◽  
Specific Immunoglobulin E ◽  
Dust Mite ◽  
Specific Immunoglobulin

Abstract Background: House dust mites are the most prevalent allergens in patients with asthma and/or rhinitis in China. Cross-sectional data in 2009 have shown that allergic rhinitis often preceded or occurred at the same time as asthma in patients which was used to investigate the association of serum specific immunoglobulin E (sIgE) levels to house dust mite with the onset of asthma in patients with allergic rhinitis. Methods: 321 patients with allergic rhinitis were face-to-face interviewed and underwent sIgE tests to house dust mite. The temporal sequence of allergic rhinitis and asthma was documented. Univariate analysis, multinomial logistic regression, and Kaplan-Meier survival analysis were performed. Results: Of the 321 participants, 213 (66.4%) had asthma, which occurred after or simultaneously with rhinitis, and 108 (33.6%) suffered from allergic rhinitis only. After controlling basic parameters, factors correlated to sIgE, and essential factors considered by clinical allergists, the risk of developing asthma always increased with the levels of sIgE to house dust mite in all four models (p < 0.01). In Kaplan–Meier analysis, in the first ten years with allergy rhinitis, a high sIgE level represented a high probability of the coexistence of allergic rhinitis and asthma (p < 0.01). For house dust mite sIgE level 5-6, 5 years Rhinitis-Asthma Conversion Rate (RACR) had reached almost 70%. Conclusion: High-level house dust mite sIgE can exist as an indicator of rhinitis to asthma. It provides a theoretical basis for early intervention in patients with high sIgE levels in order to prevent asthma. This assessment and intervention should be performed at the early stage of rhinitis.

scholarly journals Do Other Components of Bedding Dust Affect Sensitisation to House Dust Mites?

ISRN Allergy ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Claire Smith ◽  
Thorsten Stanley ◽  
Julian Crane ◽  
Robert Siebers
Keyword(s):  
Patch Test ◽  
House Dust ◽  
House Dust Mite ◽  
House Dust Mites ◽  
Dust Mites ◽  
Prick Test ◽  
Significant Difference ◽  
Dust Mite ◽  
Der P 1 ◽  
Asymptomatic Subjects

Bedding dust is a mixture of many components, of which the house dust mite (HDM) allergen, Der p 1, is the most allergenic. There has been little work to investigate the effect of other bedding dust components on HDM sensitisation. The objective of the study was to determine the effect of endotoxin in bedding dust on the allergic response in HDM-sensitised individuals. Twenty-nine house dust mite-sensitised adults were skin prick and allergen patch tested against a sterile solution of their own bedding dust and against a solution containing the same concentration of Der p 1 as the bedding solution for comparison. There was no significant difference in wheal size between the diluted house dust mite solution and the bedding dust in spite of their high levels of endotoxin. Symptomatic subjects had larger, but not statistically significant, responses to commercial house dust mite solution than asymptomatic subjects. Allergen patch test responses were negative in 22/29 of subjects using either bedding dust solutions or comparable diluted house dust mite solutions. An individual's own bedding dust does not appear to contain factors that enhance skin prick test or atopy patch test responses to house dust mites.

scholarly journals Parental Perspectives on the Implementation of House Dust Mite Avoidance Measures for Children with House Dust Mite Sensitization

2021 ◽  
Vol 19 (3) ◽  
pp. 125-135
Author(s):  
Pınar Gür Çetinkaya ◽  
Elif Soyak Aytekin ◽  
Ayşegül Akarsu ◽  
Ümit Murat Şahiner ◽  
Bülent Enis Şekerel ◽  
...  
Keyword(s):  
High School ◽  
Middle School ◽  
House Dust ◽  
House Dust Mite ◽  
Allergic Diseases ◽  
House Dust Mites ◽  
Dust Mite ◽  
Associate's Degree ◽  
Education Status ◽  
Avoidance Measures

ABSTRACTObjective: The avoidance of house dust mite (HDM) is crucial in the management of HDM allergies. We aimed to demonstrate the implementation and perspective of the parents whose children had HDM allergy/sensitization to HDM avoidance measures. Materials and Methods: Parents of the patients with HDM sensitization were interviewed via telephone questionnaires.Results: One hundred and three patients with asthma (73.8%), allergic rhinitis (AR) (77.7%) and/or atopic dermatitis (AD) (29.1%) aged four to 18 years were included in the study. Seventy-one patients had multiple allergic diseases (68.9%). Of the parents, 39.8% fully adhered to HDM avoidance measures, and their education status was as follows: 41.5% illiterate/elementary/middle school, 31.7% high school, and 26.8% associate’s degree/university. In addition, 32.2% of the mothers who were partially adherent (n=62) were illiterate or had graduated from elementary/middle school, 33.9% had graduated from high school, and 33.9% had an associate’s degree or had graduated from university. Forty-one (39.8%) mothers were working, and most of them (61%) had graduated from university or had an associate’s degree. Nearly half of the mothers who were partially adherent to HDM measures were working (n=32). In the multivariate analysis, the risk factors for partial adherence to measures was to be a working mother [OR:4.072, 95%CI: 1.350-12.882, p=0.013] and to have the belief that the measures were useless [OR:4.886, 95%CI: 1.499-15.923, p=0.008]. However, no relationship was shown between adherence to the measures and the severity of AR or AD, asthma control status and having multiple allergic diseases.Conclusion: Full adherence to HDM avoidance measures was considerably dependent on the mothers’ working status and belief in the ineffectiveness of the measures whereas there was no relationship to the severity of allergic diseases. This study also revealed how the education status of the mothers affected the adherence to allergen avoidance measures in real life.Keywords: Children, Dermatophagoides pteronyssinus,Dermatophagoides farinae, house dust mites, avoidance measures, parents, pediatrics, questionnaire

Comparison of bronchial and nasal allergen provocation in children and adolescents with bronchial asthma and house dust mite sensitization

2019 ◽  
Vol 31 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Anna Fischl ◽  
Jonas Eckrich ◽  
Vanessa Passlack ◽  
Sara-Kristin Klenke ◽  
Desiree Hartmann ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Bronchial Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Allergen Provocation
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