Abstract 3252: TAK-981: A first in class SUMO inhibitor in Phase 1 trials that promotes dendritic cell activation, antigen-presentation, and T cell priming

2019 ◽  
Author(s):  
Mithun Khattar ◽  
Keli Song ◽  
Stephen Grossman ◽  
Kristina Xega ◽  
Xingyue He ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Cell Activation ◽  
Phase 1 ◽  
Dendritic Cell Activation ◽  
Phase 1 Trials ◽  
T Cell Priming ◽  
Activation Antigen

scholarly journals Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses

2017 ◽  
Vol 1 (9) ◽  
pp. 557-568 ◽  
Author(s):  
Maria Dolores Lopez Robles ◽  
Annaick Pallier ◽  
Virginie Huchet ◽  
Laetitia Le Texier ◽  
Severine Remy ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Surface ◽  
Human Blood ◽  
Cell Activation ◽  
Inhibitory Receptor ◽  
Dendritic Cell Activation ◽  
Key Points ◽  
T Cell Priming

Key PointsCLEC-1 is restricted to CD16− myeloid DCs in human blood and acts as an inhibitory receptor to restrain downstream Th17 activation. CLEC-1–deficient rats highlight an in vivo function for CLEC-1 in preventing excessive T-cell priming and effector Th responses.

scholarly journals Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation

2007 ◽  
Vol 104 (39) ◽  
pp. 15460-15465 ◽  
Author(s):  
R. Obst ◽  
H.-M. van Santen ◽  
R. Melamed ◽  
A. O. Kamphorst ◽  
C. Benoist ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Cell Response ◽  
Cell Activation ◽  
T Cell Response ◽  
Dendritic Cell Activation

Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes

Biomaterials ◽  
2012 ◽  
Vol 33 (26) ◽  
pp. 6211-6219 ◽  
Author(s):  
Evan A. Scott ◽  
Armando Stano ◽  
Morgane Gillard ◽  
Alexandra C. Maio-Liu ◽  
Melody A. Swartz ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
T Cell Priming

scholarly journals Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection

2015 ◽  
Vol 9 (1) ◽  
pp. 24-37 ◽  
Author(s):  
S M Dillon ◽  
E J Lee ◽  
C V Kotter ◽  
G L Austin ◽  
S Gianella ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Dendritic Cell Activation ◽  
Hiv 1

scholarly journals Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression

2020 ◽  
Vol Volume 15 ◽  
pp. 6579-6592
Author(s):  
Ross Darling ◽  
Sujata Senapati ◽  
John Christiansen ◽  
Luman Liu ◽  
Amanda E Ramer-Tait ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Tumor Progression ◽  
Cell Activation ◽  
T Cell Memory ◽  
Dendritic Cell Activation ◽  
Cell Memory
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