Abstract A2-03: Hotspot mutation in breast benign biopsy associated with subsequent progression to malignant breast cancer

We herein present a rare case of breast fibromatosis, the contrast-enhanced ultrasonography (CEUS) findings of which we believe have never been described. The high similarity between the clinical and imaging manifestations of breast cancer makes its differential diagnosis difficult. In this report, we describe the CEUS findings of a less common type of fibromatosis, discuss the potential value of CEUS to differentiate it from malignant breast lesions, and briefly review the literature.

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Blood levels of Polycyclic Aromatic Hydrocarbons in Women with Benign and Malignant Breast Lesions: A case-control study

Asian Journal of Medical Sciences ◽

10.3126/ajms.v1i2.2924 ◽

2011 ◽

Vol 1 (2) ◽

pp. 80-86 ◽

Cited By ~ 2

Author(s):

Vipul K Singh ◽

M Anand ◽

D Rawtani ◽

Uday P Singh ◽

DK Patel ◽

...

Keyword(s):

Breast Cancer ◽

Polycyclic Aromatic Hydrocarbons ◽

Aromatic Hydrocarbons ◽

Case Control Study ◽

Case Control ◽

Breast Lesions ◽

Total Pahs ◽

Polycyclic Aromatic ◽

Malignant Breast ◽

Control Study

Objective: As part of our program to investigate the possible role of environmental pollutants in the incidence of breast cancer in India, we conducted for the first time a hospital based case-control study where blood polycyclic aromatic hydrocarbons (PAHs) levels were determined in women suffering from benign and malignant breast lesions, and compared with those of disease free controls drawn from similar socioeconomic environment residing in and around New Delhi, India. Material & Methods: Anthracene, phenanthrene, fluoranthene, naphthalene, pyrene, benzo (a) pyrene, benzo (k) fluoranthene and dibenzo (a,h) anthracene were determined by HPLC-FD. Results: Level of total PAHs in control, benign and malignant groups (30 numbers in each) were 142.05 ± 50.84, 185.99 ± 61.97 and 200.74 ± 55.05 μg / L respectively. Mean levels of naphthalene, phenanthrene, pyrene and benzo (k) fluoranthene were higher in both malignant and benign groups than in control but the difference was not statistically significant. Of the total PAHs, 3–ringed compounds were found much higher (89%) in controls than in benign (52%) and malignant groups (54%). However, the percentage sum of 2, 4 and 5-ringed PAHs were much higher in malignant (46%) and benign (48%) groups when compared with those of controls (11%). Conclusion: Results of the present study indicate that higher levels of PAHs (especially non-carcinogenic), though statistically non-significant, were present in cases with benign and malignant breast lesions than in those of controls. Key Words: Polycyclic Aromatic Hydrocarbons; Breast cancer; Benign lesions; HPLC-FD DOI: 10.3126/ajms.v1i2.2924Asian Journal of Medical Sciences 1 (2010) 80-86

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Qualitative Diagnosis of Solid Breast Mass by Blood Flow in Solid Breast Mass Based on Color Doppler Ultrasound

Journal of Medical Imaging and Health Informatics ◽

10.1166/jmihi.2021.3682 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1608-1615

Author(s):

Ding Zuopeng ◽

Liu Weiyong ◽

Hu Chunmei ◽

Wang Tao ◽

Wang Mingming

Keyword(s):

Breast Cancer ◽

Blood Flow ◽

Differential Diagnosis ◽

Color Doppler ◽

Flow Characteristics ◽

Flow Distribution ◽

Color Doppler Ultrasound ◽

Blood Flow Distribution ◽

Breast Masses ◽

Malignant Breast

The incidence of breast cancer ranks first among female malignant tumor. With the increase of the sensitivity of color Doppler ultrasound blood flow, the blood flow distribution in and around the tumor can be clearly displayed, and the analysis of hemodynamic parameters is provided, which provides convenience for the study of tumor blood flow characteristics. Studies have shown that tumor cells can secrete a substance called angiogenesis factor, which makes the tumor site form a rich vascular network to promote tumor growth and metastasis. The tumor has many new blood vessels, abnormal structure, thin wall, lack of muscle layer, and is prone to form arteriovenous rash. These characteristics provide a pathological basis for color Doppler flow imaging (CDFI) for the diagnosis of breast cancer. This article discusses the role of two-dimensional sonographic features in the differential diagnosis of benign and malignant breast masses, CDFI was used to study the blood flow distribution and hemodynamic characteristics in benign and malignant breast masses; explore the value of blood flow characteristics and blood flow parameters in the differential diagnosis of breast masses. The experimental results show that the detection rate of blood flow signals and the classification of blood flow signals in the malignant group are higher than those in the benign group, mainly level II and III blood flow, and the irregular branched blood flow is more common, especially when the tumor appears penetrating blood flow supports the diagnosis of malignancy. PSV, RI and PI have a certain differential meaning in the diagnosis of benign and malignant breast masses. PSV, RI and PI of malignant masses are higher than benign masses. For tumors without obvious necrosis, the larger the tumor diameter, the richer the blood flow and the higher the blood flow grade is. The malignant tumors have more blood flow than the benign ones.

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Logistic Regression and Artificial Neural Network: A Comparative Study in Diagnosing Breast Cancer

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.01094 ◽

2021 ◽

pp. 6330-6334

Author(s):

W. Abdul Hameed ◽

Anuradha D. ◽

Kaspar S.

Keyword(s):

Breast Cancer ◽

Neural Network ◽

Artificial Neural Network ◽

Logistic Regression ◽

Breast Tumor ◽

Diagnostic Performance ◽

Malignant Breast Tumor ◽

Malignant Breast ◽

Artificial Neural ◽

Artificial Neural Network Ann

Breast tumor is a common problem in gynecology. A reliable test for preoperative discrimination between benign and malignant breast tumor is highly helpful for clinicians in culling the malignant cells through felicitous treatment for patients. This paper is carried out to generate and estimate both logistic regression technique and Artificial Neural Network (ANN) technique to predict the malignancy of breast tumor, utilizing Wisconsin Diagnosis Breast Cancer Database (WDBC). Our aim in this Paper is: (i) to compare the diagnostic performance of both methods in distinguishing between malignant and benign patterns, (ii) to truncate the number of benign cases sent for biopsy utilizing the best model as an auxiliary implement, and (iii) to authenticate the capability of each model to recognize incipient cases as an expert system.

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Expression analisis of the ITSN2 and TKS5 mRNA isoforms in human malignant breast tumors

Visnik ukrains'kogo tovaristva genetikiv i selekcioneriv ◽

10.7124/visnyk.utgis.16.1.899 ◽

2018 ◽

Vol 16 (1) ◽

pp. 20-27

Author(s):

S. V. Kropyvko ◽

L. O. Tsyba ◽

O. V. Novokhatska ◽

L. A. Syvak ◽

T. Ye. Tarasenko ◽

...

Keyword(s):

Breast Cancer ◽

Expression Analysis ◽

Rna Isolation ◽

Breast Tumors ◽

Quantitative Real Time Pcr ◽

Mrna Isoforms ◽

Extensive Experience ◽

Great Progress ◽

Malignant Breast ◽

The Many

Aim. Despite the great progress in cancer treating, the breast cancer remains lethal in 15 % cases. Regardless of the many years of research and extensive experience in the treatment of this type of cancer, one of the main problems in diagnosis and therapy is its high clinical and genetic heterogeneity. Thereby the identification of markers for personalized treatment of patients is still an actual issue. Methods. Collection of clinical material, RNA isolation, and expression analysis of ITSN2 and TKS5 isoforms using quantitative real time PCR with fluorescence-labeled probes. Results. We have found that ITSN2-S expression is reliably reduced in HER2/neu-positive tumors with poor prognosis. There were no significant differences in the expression of ITSN2-L and TKS5-L in the analyzed samples. Conclusions. These studies have demonstrated the possible use of ITSN2 short isoform (ITSN2-S) as a prognostic marker for breast cancer. Keywords: breast cancer, ITSN2, TKS5, expression analysis.

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