Plasma Levels of Vitamin E in Pregnant Women prior to the Development of Preeclampsia and Other Hypertensive Complications

The concentrations of tocopherols and carotenoids are lowered in umbilical cord blood plasma, which may have a negative effect on antioxidant protection in neonates. Smoking may adversely affect dietary intakes and plasma concentrations of carotenoids. The dietary intakes of vitamin E and beta-carotene were assessed in 66 pregnant women (31 smokers and 35 non-smokers) between 10 and 20 weeks gestation using a food frequency questionnaire. The concentrations of alpha-tocopherol and beta-carotene were measured in maternal plasma at the time of the dietary assessment, and in the matched umbilical cords of their newborn after delivery. In smoking and non-smoking mothers, the mean intakes of vitamin E (9.3 [SD 5] and 8.2 [SD 5] mgd–1) and beta-carotene (3464 [SD 1885] and 2977 [SD 1503] mugd–1) were not significantly different. The plasma concentrations of alpha-tocopherol (20.8 [SD 4] and 20.5 [SD 4] mumolL–1), the alpha-tocopherol to lipid ratios (3.2 [SD 0.8] and 3.5 [SD 0.8]) and the plasma concentrations of beta-carotene (0.22 [SD 0.1] and 0.22 [SD 0.1] mumolL–1) were not significantly different in smoking and non-smoking mothers. There were no significant differences in plasma alpha-tocopherol (7.4 [SD 2] and 7.3 [SD 2] mumolL–1), in alpha-tocopherol to lipid ratios (3.2 [SD 0.6] and 2.8 [SD 0.6]) or in beta-carotene concentrations (0.05 [SD 0.04] and 0.03 [SD 0.02] mumolL–1) in cords from newborns of smoking and non-smoking mothers. There was a significant correlation (r = 0.41, P = 0.015) between dietary intakes and plasma concentrations of beta-carotene in non-smoking mothers. However, this relationship was not significant in smoking mothers (r = 0.28, P = 0.12). There were no relationships between dietary intakes and plasma concentrations of tocopherol. These results indicate that smoking during pregnancy does not appear to affect the dietary intakes or plasma concentrations of alpha-tocopherol and beta-carotene in pregnant women or their babies. However, smoking does influence the relationship between dietary intakes and plasma levels of beta-carotene.

Download Full-text

Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP Trial): randomised placebo-controlled trial

Yearbook of Obstetrics Gynecology and Women s Health ◽

10.1016/s1090-798x(08)70061-4 ◽

2007 ◽

Vol 2007 ◽

pp. 80-82

Author(s):

S. Thung

Keyword(s):

At Risk ◽

Vitamin E ◽

Vitamin C ◽

Pregnant Women ◽

Controlled Trial

Download Full-text

Anti-Factor Xa Plasma Levels in Pregnant Women Receiving Low Molecular Weight Heparin Thromboprophylaxis

Obstetrics and Gynecology ◽

10.1097/aog.0b013e31819b3b38 ◽

2009 ◽

Vol 113 (3) ◽

pp. 740 ◽

Cited By ~ 2

Author(s):

Ingrid Pabinger ◽

Andreas Greinacher

Keyword(s):

Molecular Weight ◽

Pregnant Women ◽

Plasma Levels ◽

Low Molecular Weight Heparin ◽

Factor Xa ◽

Low Molecular Weight

Download Full-text

Reduced estriol and dehydroepiandrosterone sulphate plasma levels in methadone-addicted pregnant women

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/0028-2243(86)90106-1 ◽

1986 ◽

Vol 23 (1-2) ◽

pp. 67-73 ◽

Cited By ~ 19

Author(s):

F. Facchinetti ◽

G. Comitini ◽

F. Petraglia ◽

A. Volpe ◽

A.R. Genazzani

Keyword(s):

Pregnant Women ◽

Plasma Levels ◽

Dehydroepiandrosterone Sulphate

Download Full-text

Anti-factor Xa Plasma Levels in Pregnant Women Receiving Low Molecular Weight Heparin Thromboprophylaxis

Obstetrics and Gynecology ◽

10.1097/aog.0b013e31818638dc ◽

2008 ◽

Vol 112 (4) ◽

pp. 884-889 ◽

Cited By ~ 33

Author(s):

Nathan S. Fox ◽

S Katherine Laughon ◽

Samuel D. Bender ◽

Daniel H. Saltzman ◽

Andrei Rebarber

Keyword(s):

Molecular Weight ◽

Pregnant Women ◽

Plasma Levels ◽

Low Molecular Weight Heparin ◽

Factor Xa ◽

Low Molecular Weight

Download Full-text

Maternal plasma fetuin-A levels in fetal growth restriction: A case-control study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v17i7.4860 ◽

2019 ◽

Author(s):

Mujde Can Ibano ◽

Cem Yasar Sanhal ◽

Seval Ozgu-Erdinc ◽

Aykan Yucel

Keyword(s):

Pregnant Women ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Plasma Levels ◽

Case Control Study ◽

Maternal Plasma ◽

Case Control ◽

Growth Restriction ◽

Fetuin A ◽

Control Study

Background: Higher Fetuin-A (FA) concentrations were found to be associated with obesity and there is an interest to the relation between maternal FA and pregnancy outcomes. Objective: In this study, our aim was to evaluate the association of maternal plasma levels of FA with fetal growth restriction (FGR). Materials and Methods: 41 pregnant women with FGR and 40 controls were recruited in this case-control study between July and November 2015. At the diagnosis of FGR, venous blood samples (10 cc) were obtained for FA analysis. Results: Maternal plasma FA levels were significantly higher in fetal growth-restricted pregnant women compared with controls (19.3 ± 3.0 ng/ml vs 25.9 ± 6.8 ng/ml, p = 0.001). Area under receiver operating characteristic curve analysis of FA in FGR was 0.815 (95% confidence interval (CI): 0.718-0.912, p < 0.001). The maternal FA levels with values more than 22.5 ng/ml had a sensitivity of about 73.17% (95% CI: 56.79- 85.25) and a specificity of about 82.5% (95% CI: 66.64-92.11) with positive and negative predictive values of about 81.08% (95% CI: 64.29-91.45) and 75% (95% CI: 59.35-86.30), respectively. Therefore, the diagnostic accuracy was obtained about 77.78%. Conclusion: The results of this study show higher maternal plasma levels of FA in FGR. Further studies are needed in order to demonstrate the long-term effects of FA in pregnancies complicated with FGR and early prediction of FGR.

Download Full-text

Comparison of the Antioxidant Nutrient Profile among Normal Pregnant Women and Women having Pregnancy Induced Hypertension

Pakistan Journal of Public Health ◽

10.32413/pjph.v10i4.388 ◽

2021 ◽

Vol 10 (4) ◽

pp. 246-251

Author(s):

Kausar Aamir ◽

Arfa Azhar ◽

Fatima Abid ◽

Shamaila Khalid ◽

Fiza Ali Khan

Keyword(s):

Vitamin E ◽

Pregnant Women ◽

Cell Damage ◽

Alpha Tocopherol ◽

Control Group ◽

P Value ◽

Pregnancy Induced Hypertension ◽

Nutrient Profile ◽

Induced Hypertension ◽

Mild Hypertensive

Background: Preeclampsia is a multifactorial disorder comprising many organs. Oxidative stress (OS) has been intensely linked to its occurrence. Vitamin E, a lipophilic chain breaking antioxidant has been proved to suppress the OS. Present study was designed to investigate antioxidant nutrient profile in patients with different grades of pregnancy induced hypertension (PIH) and to compare them with normal pregnant controls. Methods: The study group comprised 110 patients divided in three groups as Group A (n=40) Normotensive patients, Group B (n=40) Mild hypertensive, Group C (n=30) Severe hypertensive. Vitamin A, B-Carotene, serum alpha tocopherol (vitamin E) and vitamin C levels were analysed. Results: Serum alpha tocopherol (vitamin E) was significantly low in severe and mild cases (0.32±0.00 mg/dl, 0.74±0.03 mg/dl respectively), when compared with normal pregnant women levels (0.78±0.040). All other nutrients were also found to be in reduced quantity for Group C when compared to control group (P value <0.001). Conclusion: It was therefore concluded that in patients with risk of preeclampsia (PE) adequate antioxidant nutrients may have a role in cessation of free radical-mediated cell disturbances, and thereby protecting against endothelial cell damage, which is the key factor in PE development.

Download Full-text