Within-Person Variability as a Dynamic Measure of Late-Life Development: New Methodologies and Future Directions

Gerontology ◽  
2004 ◽  
Vol 50 (4) ◽  
pp. 255-258 ◽  
Author(s):  
Kaarin J. Anstey
Keyword(s):  
Late Life ◽  
Future Directions ◽  
New Methodologies

Methods and approaches to examining the interface of late-life depression and dementia

2020 ◽  
pp. 267-276
Author(s):  
Mirjam I Geerlings
Keyword(s):  
Study Design ◽  
Late Life ◽  
Prodromal Symptom ◽  
Exact Nature ◽  
Late Life Depression ◽  
Future Directions ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Depressive Episodes ◽  
Pituitary Adrenal Axis

Late-life depression increases the risk of dementia. The exact nature of this relationship is not clear, however. Late-life depression may be a causal factor in the development of dementia, but is may also be a preclinical or prodromal symptom of dementia. This chapter reviews the approaches used to examine the interface between depression and dementia, and reviews existing evidence for the two main hypotheses to explain this relationship: the neurotoxicity hypothesis stating that dysregulation of the hypothalamic-pituitary-adrenal axis resulting from repeated depressive episodes has neurotoxic effects on the hippocampus, and the vascular hypothesis stating that depression precedes dementia through small vessel ischaemic changes in mood-regulating brain areas. It then discusses a number of methodological issues and limitations of existing studies relating to study design, and definition and measurement of late-life depression, and proposes future directions for research.

The Case for a Psychological Perspective on Late-Onset Psychosis

1997 ◽  
Vol 31 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Anne Hassett
Keyword(s):  
Old Age ◽  
Psychotic Disorders ◽  
Late Onset ◽  
Late Life ◽  
Personality Factors ◽  
Elderly Persons ◽  
Developmental Studies ◽  
Vulnerability Factors ◽  
Future Directions ◽  
Self Image

Objective:A conceptual framework is proposed for studying late-onset psychotic disorders. This incorporates developmental and psychological perspectives to complement the biological focus of most recent studies in this area. Method:Studies of late-onset psychosis that focus on the specificity of neuroimaging abnormalities, family history and sensory deficits were reviewed. Aspects of the developmental and personality literature were then examined with the goal of ascertaining their relevance for the emergence of psychosis in late life. Possible future directions incorporating biological and psychological approaches are proposed. Results:The biological abnormalities identified in studies of late-onset psychosis lack the specificity to stand alone as aetiological factors. Neuroimaging changes and sensory impairment are commonly found in study subjects; however, they also occur in elderly persons without psychiatric illness as well as in those with other late-onset psychiatric disorders. Perhaps it is more appropriate to regard these changes as conferring a vulnerability to psychosis in old age, but symptoms do not develop unless other risk factors, either longstanding or ageing-related, are also present. Developmental studies of late life that have used Erikson's concept of a final lifestage crisis of achieving ‘ego-integrity’, suggest that personality style may be influential in determining the negotiation of this last maturational task. Failure to do so results in ‘despair’, fragmentation of self-image and paranoid fears. To date, there has been little investigation of the relevance of these developmental and personality factors for the emergence of psychosis in old age. Conclusions:If we are to advance our understanding of late-onset psychotic disorders, research in this area needs to move beyond the elusive search for specific biological markers. A model of causation that integrates the longitudinal perspective of lifestage tasks with personality and biological vulnerability factors provides a broad framework which protects against premature foreclosure on aetiological determinants.

scholarly journals Proteomics-Based Methodologies for the Detection and Quantification of Seafood Allergens

Foods ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 1134
Author(s):  
Mónica Carrera ◽  
Manuel Pazos ◽  
María Gasset
Keyword(s):  
Detection Methods ◽  
Future Directions ◽  
Comprehensive Review ◽  
Fast Detection ◽  
The World ◽  
Allergen Sources ◽  
New Methodologies ◽  
And Control ◽  
Fish And Shellfish ◽  
Detection And Quantification

Seafood is considered one of the main food allergen sources by the European Food Safety Authority (EFSA). It comprises several distinct groups of edible aquatic animals, including fish and shellfish, such as crustacean and mollusks. Recently, the EFSA recognized the high risk of food allergy over the world and established the necessity of developing new methodologies for its control. Consequently, accurate, sensitive, and fast detection methods for seafood allergy control and detection in food products are highly recommended. In this work, we present a comprehensive review of the applications of the proteomics methodologies for the detection and quantification of seafood allergens. For this purpose, two consecutive proteomics strategies (discovery and targeted proteomics) that are applied to the study and control of seafood allergies are reviewed in detail. In addition, future directions and new perspectives are also provided.

Management Science and Marketing Management

1985 ◽  
Vol 49 (2) ◽  
pp. 93-105 ◽  
Author(s):  
A. Charnes ◽  
W. W. Cooper ◽  
D. B. Learner ◽  
F. Y. Phillips
Keyword(s):  
Marketing Research ◽  
Management Science ◽  
Marketing Management ◽  
Future Directions ◽  
Future Potential ◽  
New Methodologies

In interactions with management, management science and marketing research have produced new methodologies and methodological (as distinguished from substantive) theories. Data developments and identification and structuring of new problems have also been important. Future directions are suggested for these kinds of activities, evaluated relative to other alternatives and examined in terms of past accomplishment and future potential.

Future Directions for Research on Late-Life Suicide

1995 ◽  
Vol 7 (2) ◽  
pp. 357-360
Author(s):  
Eric D. Caine ◽  
Barry D. Lebowitz
Keyword(s):  
Late Life ◽  
Future Directions ◽  
Left Behind

Suicide is an action that calls for explanation. Many who kill themselves leave written words behind, attempting to explain, but many others do not. For those outside the experience, there remains a need to understand. Self-inflicted death may make sense occasionally, however painful it may be to those left behind. Most often, it is called a tragedy, death before one's time.

scholarly journals The Terebelliformia-Recent Developments and Future Directions

Diversity ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 60 ◽  
Author(s):  
Pat Hutchings ◽  
Orlemir Carrerette ◽  
João M. M. Nogueira ◽  
Stephane Hourdez ◽  
Nicolas Lavesque
Keyword(s):  
Deep Sea ◽  
Current Knowledge ◽  
Knowledge Gaps ◽  
Future Directions ◽  
Large Group ◽  
Deposit Feeders ◽  
Species Complexes ◽  
Recent Developments ◽  
Biogeographic Regions ◽  
New Methodologies

Terebelliformia comprises a large group of sedentary polychaetes which live from the intertidal to the deep sea. The majority live in tubes and are selective deposit feeders. This study synthesises the current knowledge of this group, including their distribution, in the different biogeographic regions. We highlight the new methodologies being used to describe them and the resolution of species complexes occurring in the group. The main aim of this review is to highlight the knowledge gaps and to stimulate research in those directions, which will allow for knowledge of their distribution and abundances to be used by ecologists and managers.

scholarly journals Proteomics-based Methodologies for the Detection and Quantification of Seafood Allergens

2020 ◽  
Author(s):  
Mónica Carrera ◽  
Manuel Pazos ◽  
María Gasset
Keyword(s):  
Detection Methods ◽  
Future Directions ◽  
Comprehensive Review ◽  
Fast Detection ◽  
The World ◽  
Allergen Sources ◽  
New Methodologies ◽  
And Control ◽  
Fish And Shellfish ◽  
Detection And Quantification

Seafood is considered one of the main food allergen sources by the European Food Safety Authority (EFSA). It comprises several distinct groups of edible aquatic animals including fish and shellfish such as crustacean and mollusks. Recently the EFSA recognized the high risk of food allergy over the world and established the necessity of developing new methodologies for its control. Consequently, accurate, sensitive and fast detection methods for seafood allergy control and detection in food products are highly recommendable. In this work, we present a comprehensive review of the applications of the proteomics methodologies for the detection and quantification of seafood allergens. For that, two consecutive proteomics strategies (Discovery and Targeted Proteomics) applied for the study and control of seafood allergy are reviewed in detail. In addition, future directions and new perspectives were also provided.

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