Clinical Picture of Self-Inflicted Skin Lesions

Dermatomyositis is a disease from the group of diffuse connective tissue diseases mainly affecting the cross-striated and smooth muscles. The leading disorders in the clinical picture of dermatomyositis are movement disorders, which are often regarded to as a manifestation of acute inflammatory demyelinating polyneuropathy. Also skin lesions in the form of erythema and edema are characteristic, in the absence of these manifestations the term «polymyositis» is used. The disease proceeds with the development of severe neurological symptoms, and is dangerous because of complications which can lead to patient’s death. The article contains a description of cases of two female patients with the initial diagnosis of «Guillain-Barre syndrome». The analysis of the clinical picture, paraclinical studies, features of the disease course in patients was performed, and it enables differential diagnosis between acute/chronic inflammatory demyelinating polyneuropathy and dermatomyositiss at early stages of the disease.

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Differential diagnosis of rosacea

Russian Journal of Skin and Venereal Diseases ◽

10.17816/dv2020150-56 ◽

2020 ◽

Vol 23 (1) ◽

pp. 50-56

Author(s):

Vsevolod G. Akimov ◽

L. S. Kruglova

Keyword(s):

Differential Diagnosis ◽

Clinical Picture ◽

Clinical Signs ◽

Diagnostic Errors ◽

Skin Lesions ◽

Facial Skin ◽

Skin Erythema

The clinical picture of rosacea, including facial skin erythema, telangiectasia, and popular, and pustular elements, is similar to other dermatoses, thereby causing difficulties in the differential diagnosis. Original photos and descriptions of the clinical signs that distinguish these diseases from rosacea are provided. Therefore, the possibility of rare skin lesions that are sometimes mistaken for a more frequent pathology should be considered to avoid diagnostic errors.

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Sarcoid-like lesions in paracoccidioidomycosis: immunological factors*

Anais Brasileiros de Dermatologia ◽

10.1590/s0365-05962013000100017 ◽

2013 ◽

Vol 88 (1) ◽

pp. 113-116 ◽

Cited By ~ 7

Author(s):

Vanessa Lucília Silveira de Medeiros ◽

Lúcia Arruda

Keyword(s):

Immune Response ◽

Clinical Picture ◽

Clinical Presentation ◽

Skin Lesions ◽

Host Immunity ◽

Spontaneous Cure ◽

Long Time ◽

Immunological Factors ◽

Different Levels ◽

Active Disease

The clinical presentation of paracoccidioidomycosis is spectral. Spontaneous cure, state of latency or active disease with different levels of severity can occur after the hematogenous dissemination. The morphology and number of skin lesions will depend on the interaction of host immunity, which is specific and individual, and fungus virulence. Some individuals have natural good immunity, which added to the low virulence of the fungus maintain the presence of well-marked granulomas with no microorganism and negative serology for a long time, making the diagnosis a challenge. Factors inherent to the fungus, however, may modulate the immune response and modify the clinical picture over the time. We present a sarcoidosis-like clinical presentation and discuss the immunological factors involved.

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Relationship between type of skin lesions and nailfold capillaroscopy pattern in mixed connective tissue disease

Clinical Rheumatology ◽

10.1007/s10067-021-05717-4 ◽

2021 ◽

Author(s):

Anna Felis-Giemza ◽

Sylwia Ornowska ◽

Ewa Haładyj ◽

Zenobia Czuszyńska ◽

Marzena Olesińska

Keyword(s):

Systemic Lupus Erythematosus ◽

Systemic Sclerosis ◽

Connective Tissue ◽

Connective Tissue Disease ◽

Lupus Erythematosus ◽

Clinical Picture ◽

Mixed Connective Tissue Disease ◽

Skin Lesions ◽

Systemic Lupus ◽

Skin Changes

Abstract Introduction Mixed connective tissue disease (MCTD) is a rare disease with clinical picture consisted of multiple organ manifestations, including skin changes resembling systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or dermatomyositis (DM). On the background of these manifestations are microvascular changes — alteration of endothelial function and impairment of endothelial progenitor cell. Nailfold capillaroscopy (NFC) is a simple, non-invasive technique for investigating microvascular involvement in rheumatic diseases. Objectives To describe the relationship between type of skin lesions and NFC pattern in MCTD patients. Methods We analyzed the clinical picture and NFC patterns in 79 patients with MCTD. The NFC changes were classified into Normal, “Early,” “Active,” and “Late” scleroderma-like patterns (SD-like pattern) based on Cutolo classification. In all patients, subjective and physical examinations were carried out, specifically the occurrence of skin lesions in the course of MCTD was assessed (systemic sclerosis-like (Ssc-like), systemic lupus erythematosus-like (SLE-like), dermatomysitis-like (DM-like)). Results Skin changes were present in 64 (81%) patients, involving 43 (54%) SLE-like, 48 (61%) SSc-like, and 4 (5.1%) DM-like. NFC changes were observed in a total of 55 (69.6 %) patients with predominance of the “Early” pattern — 41 (51.9 %) patients. According to skin change phenotypes, NFC changes were observed in 31 (72%) patients with SLE-like and in 32 (66.7%) patients with SSc-like skin phenotypes. The “early” pattern predominated in both group. Conclusions We did not find any correlation between NFC pattern and the type skin changes. Key Points• The study did not show a correlation between the presence and absence of skin lesions and NFC pattern.• Scleroderma-like patterns were found in over 60% of patients with mixed connective tissue disease.• The “early” pattern is dominant regardless of the occurrence or absence of skin lesions in patients with MCTD.• Skin lesions, regardless of their type (SLE or SSc), do not correlate with type of lesion found in the NFC examination.

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The Clinical Picture: A woman with ulcerating, painful skin lesions

Cleveland Clinic Journal of Medicine ◽

10.3949/ccjm.75.6.414 ◽

2008 ◽

Vol 75 (6) ◽

pp. 414-422

Author(s):

M. P. PILIANG ◽

J. K. STOLLER

Keyword(s):

Clinical Picture ◽

Skin Lesions

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A case of canine epitheliotropic lymphoma (mycosis fungoides)

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.15459 ◽

2018 ◽

Vol 52 (4) ◽

pp. 286

Author(s):

M. N. SARIDOMICHELAKIS (Μ. Ν. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ) ◽

C. K. KOUTINAS (X.K. ΚΟΥΤΙΝΑΣ) ◽

A. F. KOUTINAS (Α. Φ. ΚΟΥΤΙΝΑΣ)

Keyword(s):

Mycosis Fungoides ◽

Combination Chemotherapy ◽

Clinical Picture ◽

Initial Treatment ◽

Lymphocytic Infiltration ◽

Skin Lesions ◽

Substantial Improvement ◽

Short Period ◽

History Of ◽

Pruritic Skin

The clinical picture, diagnosis and treatment of a dog with epitheliotropic lymphoma are presented. The dog (male, mongrel, 13-year old) was admitted to our Clinic with a 5-month history of non-pruritic skin lesions. At clinical examination a multifocal to diffuse exfoliative erythrodermia was the most striking finding. Diagnosis of epitheliotropic lymphoma was based on cutaneous histopathology, revealing a dense dermal and epidermal lymphocytic infiltration and Pautrie microabcess formation. Initial treatment with isotretinoin had a poor impact on skin lesions that progressed to the macular stage. On the contrary, combination chemotherapy with Lasparaginase and isotretinoin resulted in substantial improvement. The animal died, following a short period of depression and inappetance, 15 months after the first appearance of skin lesions and 10 months after diagnosis.

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TUBEROUS SKLEROSIS PADA ANAK

JURNAL BIOMEDIK (JBM) ◽

10.35790/jbm.7.3.2015.10444 ◽

2015 ◽

Vol 7 (3) ◽

Author(s):

Sandra Ayamiseba ◽

Pieter L. Suling

Keyword(s):

Mental Retardation ◽

Tuberous Sclerosis ◽

Diagnostic Criteria ◽

Clinical Picture ◽

Autosomal Dominant ◽

Histopathological Examination ◽

Skin Lesions ◽

Systemic Involvement ◽

The Us ◽

Dominant Disease

Abstract: Tuberous sclerosis (TS) is an autosomal dominant disease associated with mutation of one of two different genes, TSC1 or TSC2. The typical clinical picture of TS cases is skin lesions, mental retardation, and epilepsy. According to the consensus of TS alliance, the US National Tuberous Sclerosis Association, in July 1998, the diagnostic criteria of TS are based on major and minor symptoms: two major symptoms, or one major and two minor symptoms. The management of the skin disorders such as angiofibroma with a cosmetic purpose can be done by using electrocauterization, dermabrasion, and excision. The prognosis depends on the systemic involvement. We reported a case of a male, aged 7 years, with 2 major symptoms of TS: facial angiofibroma that spreaded to his neck and back, and hypomelanotic macula on his back. The histopathological examination showed subepithelial keratosis associated with fibrocollagen tissue and teleangiectasis in the stroma, atrophy of sebacceous glands, without any malignancy. Conclusion: In this case, the diagnosis of tuberous sclerosis was based on anamnesis, clinical picture (two major symptoms), and histopathological examination. Electrocauterization could not be performed because the patient was incooperative. The prognosis was quo ad vitam, quo ad functionam, quo ad sanationam: dubia.Keywords: tuberous sclerosis, multiple hyperpigmented noduleAbstrak: Tuberous sklerosis (TS) merupakan suatu penyakit autosomal dominan yang dihubungkan dengan mutasi satu dari dua gen yang berbeda, yaitu TSC1 atau TSC2. Gambaran klinis yang khas pada kasus ini ialah lesi kulit, retardasi mental, dan epilepsi. Berdasarkan konsensus aliansi US National Tuberous Sclerosis Association pada Juli 1998 dirumuskan kriteria diagnostik berdasarkan adanya gejala mayor dan minor, yaitu dua gejala mayor; atau satu gejala mayor dan dua gejala minor. Prinsip pengobatan untuk kelainan kulit berupa angiofibroma dengan tujuan kosmetik yaitu dengan elektrokauter, dermabrasi, dan eksisi. Prognosis tergantung pada keterlibatan sistemik. Pada kasus ini ditemukan 2 gejala mayor yaitu angiofibroma pada wajah yang menyebar ke leher dan punggung serta makula hipomelanotik pada punggung. Pemeriksaan histopatologik jaringan menunjukkan hiperkeratosis subepitelial di lapisan epidermis. Tampak stroma jaringan ikat fibrokolagen dengan pelebaran pembuluh darah kapiler, kelenjar sebaseus atrofi, dan tidak didapatkan tanda-tanda keganasan. Simpulan: Pada kasus ini, diagnosis TS ditegakkan berdasarkan anamnesis, gambaran klinis (2 gejala mayor), dan pemeriksaan histopatologik. Penatalaksanaan dengan elektrokauter tidak dapat dilakukan karena pasien tidak kooperatif. Prognosis tergantung gejala klinis, quo ad vitam, quo ad functionam, quo ad sanationam: dubia.Kata kunci: tuberous sklerosis, nodul hiperpigmentasi multipel

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The Dermatological Manifestations in the Coronavirus Infection COVID-19

The Russian Archives of Internal Medicine ◽

10.20514/2226-6704-2020-10-6-422-429 ◽

2020 ◽

Vol 10 (6) ◽

pp. 422-429

Author(s):

A. S. Dvornikov ◽

A. A. Silin ◽

T. A. Gaydina ◽

V. N. Larina ◽

P. A. Skripkina ◽

...

Keyword(s):

Drug Treatment ◽

Clinical Picture ◽

Viral Infections ◽

Skin Lesions ◽

The Novel ◽

Skin Manifestations ◽

Depth Analysis ◽

Vesicular Rash ◽

Coronavirus Infection ◽

Novel Coronavirus

The variety of dermatological manifestations in patients with the novel coronavirus infection COVID-19, the incidence of which depends on concomitant pathology and the characteristics of drug treatment, and their characteristics are similar to those that occur with conventional viral infections is discussed. At the present time it is proposed to distinguish several groups depending on the cause and mechanism of development: angiitis of the skin; papulo-squamous rash and pink lichen; measles rash and infectious erythema; papulo-vesicular rash; toxidermia; urticarial eruptions and artifical lesions. The variety of the clinical picture of the skin manifestations of coronavirus infection requires in-depth analysis in order to interpret correctly the skin lesions and other infectious exanthema and dermatoses in patients with COVID-19.

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Terra Firma Forme Dermatosis – a Report of two Cases and a Review of the Literature

Serbian Journal of Dermatology and Venerology ◽

10.2478/sjdv-2018-0019 ◽

2018 ◽

Vol 10 (4) ◽

pp. 129-132 ◽

Cited By ~ 1

Author(s):

Katarina Runtić ◽

Sonja Prćić ◽

Milana Ivkov Simić ◽

Zorica Gajinov ◽

Anica Radulović ◽

...

Keyword(s):

Ethyl Alcohol ◽

Clinical Picture ◽

Diagnostic Tests ◽

Isopropyl Alcohol ◽

Skin Lesions ◽

Review Of The Literature ◽

Terra Firma ◽

Pediatric Practice ◽

Benign Nature

Abstract Terra firma-forme dermatosis (TFFD) or Duncan’s dirty dermatosis is a bizarre, acquired, and idiopathic dermatosis. It is characterized by its asymptomatic, yellowish, or brownish dirt-like lesions, resistant to usual washing with soap and water, but disappearing when rubbed with 70% ethyl alcohol or isopropyl alcohol. Swabbing with alcohol is both diagnostic and therapeutic means for this disorder. We present two boys, aged 14 and 11, with asymptomatic brownish, dirt-like lesions on the chest and forearms, respectively. Skin lesions were continuously present for more than a month. Both of the patients had usual hygiene habits. The diagnosis of TFFD was confirmed by rubbing with 70% ethyl alcohol which led to disappearance of the lesions. TFFD often causes much concern in patients and parents of affected children. Since its clinical picture is similar to some other dermatoses, the disease can be misdiagnosed. Therefore, it is important to recognize this dermatosis in dermatological and pediatric practice in order to explain the benign nature of the disease to patients and to avoid unnecessary diagnostic tests.

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