scholarly journals Sarcoid-like lesions in paracoccidioidomycosis: immunological factors*

2013 ◽  
Vol 88 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Vanessa Lucília Silveira de Medeiros ◽  
Lúcia Arruda
Keyword(s):  
Immune Response ◽  
Clinical Picture ◽  
Clinical Presentation ◽  
Skin Lesions ◽  
Host Immunity ◽  
Spontaneous Cure ◽  
Long Time ◽  
Immunological Factors ◽  
Different Levels ◽  
Active Disease

The clinical presentation of paracoccidioidomycosis is spectral. Spontaneous cure, state of latency or active disease with different levels of severity can occur after the hematogenous dissemination. The morphology and number of skin lesions will depend on the interaction of host immunity, which is specific and individual, and fungus virulence. Some individuals have natural good immunity, which added to the low virulence of the fungus maintain the presence of well-marked granulomas with no microorganism and negative serology for a long time, making the diagnosis a challenge. Factors inherent to the fungus, however, may modulate the immune response and modify the clinical picture over the time. We present a sarcoidosis-like clinical presentation and discuss the immunological factors involved.

scholarly journals Clinically Amyopathic Dermatomyositis Caused by a Tattoo

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Bing Han ◽  
Qiang Guo
Keyword(s):  
Immune Response ◽  
Case Report ◽  
Interstitial Lung Disease ◽  
Laboratory Test ◽  
Clinical Presentation ◽  
Unknown Origin ◽  
Skin Lesions ◽  
Amyopathic Dermatomyositis ◽  
Clinically Amyopathic Dermatomyositis ◽  
Left Chest

Introduction. Clinically amyopathic dermatomyositis (CADM) is a rare disease with unknown origin. It is characterized by the specific skin lesions of dermatomyositis (DM) without clinical or laboratory evidence of myopathy. Previous studies indicated that tattoo may induce immune response. Case Report. A 22-year-old male who tattooed butterfly on the left chest with blue and red ink. Then, he gradually had typical Gottron rash and interstitial lung disease (ILD) without weakness of the muscle. The clinical presentation and laboratory test represent the diagnosis of CADM. According to the history, CADM was induced by the tattoo five months before admission. Discussion. We first reported the CADM induced by a tattoo. However, further studies are still needed to approach the specific substances within the tattoo that trigger immune response.

scholarly journals Dermoscopy’s Contribution for the Diagnosis of Folliculotropic Mycosis Fungoides.

2021 ◽  
Vol 6 (1) ◽  
pp. 01-04
Author(s):  
Gustavo Moreira Amorim ◽  
Ingrid Reuwsaat Paul ◽  
Bruna Molozzi ◽  
Elisa Rohsig Dannebrock ◽  
Timotio Volnei Dorn ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Medical Literature ◽  
Clinical Presentation ◽  
Skin Lesions ◽  
Definitive Diagnosis ◽  
Dermatological Examination ◽  
Long Time

Folliculotropic mycosis fungoides (FMF) is one of the three recognized variants of mycosis fungoides. FMF predominates in men over 50 years old. Often it takes a long time for the definitive diagnosis after the onset of skin lesions. Dermoscopy today represents almost an extension of the clinical dermatological examination, with its application being expanded day after day in medical literature. The authors demonstrate the dermoscopic findings recently described in the context of FMF (follicular accentuation / white halo around the follicles), in a case of typical clinical presentation, with a diagnosis confirmed by the clinical-dermatological correlation.

scholarly journals Helminth-induced immune response: A new perspective for the treatment of Multiple Sclerosis

2021 ◽  
Author(s):  
Karla Viana Rezende ◽  
Ayrton Senna do Brasil Amaral Alves ◽  
Juliana Carollyne Amorim ◽  
Maria Inês Vaz de Oliveira ◽  
Maria Paula Banhara Rodrigues ◽  
...  
Keyword(s):  
Immune Response ◽  
Clinical Evidence ◽  
Scientific Evidence ◽  
Great Hope ◽  
Pubmed Database ◽  
Long Time ◽  
Immunological Factors ◽  
New Perspective ◽  
Helminth Therapy

Background: Multiple Sclerole (MS) is a progressive neurodegenerative disease that, in its most common form, evolves in outbreaks and compromises the patient’s quality of life and functionality. In a long time, a way of attenuating symptoms and preventing the progression of this pathology has been studied, however, drug therapies, until now, have not shown good accuracy. In this context, the exogenous use of helminths as non-drug therapy for MS has been considered, therefore, this study aims to demonstrate the recent results of studies on such therapies and verify whether there is scientific evidence of a good clinical, immunological and exam response. image of patients with MS. Methods: Bibliographic review in the PUBMED database Results: The four large studies carried out on the topic demonstrated evidence that the immune response induced by helminths decreases the activity of the immunological factors that contribute to the progression of MS, however the small control groups and unfavorable environments impaired the conclusions of the studies . Conclusions: Although the studies have no yet to demonstrate reliable clinical evidence about exogenous helminth therapy, it is undeniable that the good immune response induced by the parasites is a great hope that motivates the continuation of studies in the area.

Jansky-Bielschowsky syndrome, a lysosomal disease: First diagnosed cash in Oman

1992 ◽  
Vol 50 (1) ◽  
pp. 632-633
Author(s):  
Line Buhl ◽  
David Muirhead
Keyword(s):  
Mental Retardation ◽  
Clinical Picture ◽  
Neurological Disorder ◽  
Clinical Presentation ◽  
Neuronal Ceroid Lipofuscinosis ◽  
Infantile Form ◽  
Lysosomal Disease ◽  
Juvenile Form ◽  
Progressive Encephalopathy ◽  
Lysosomal Diseases

There are four lysosomal diseases of which the neuronal ceroid lipofuscinosis is the rarest. The clinical presentation and their characteric abnormal ultrastructure subdivide them into four types. These are known as the Infantile form (Santavuori-Haltia), Late infantile form (Jansky-Bielschowsky), Juvenile form (Batten-Spielmeyer-Voght) and the Adult form (Kuph's).An 8 year old Omani girl presented wth myclonic jerks since the age of 4 years, with progressive encephalopathy, mental retardation, ataxia and loss of vision. An ophthalmoscopy was performed followed by rectal suction biopsies (fig. 1). A previous sibling had died of an undiagnosed neurological disorder with a similar clinical picture.

Clinic of gastritis with preserved and increased secretory function of the stomach

1936 ◽  
Vol 32 (7) ◽  
pp. 808-817
Author(s):  
S. O. Badylkes ◽  
V. Z. Kudashevich ◽  
E. O. Eingorn
Keyword(s):  
Chronic Gastritis ◽  
Clinical Picture ◽  
Secretory Function ◽  
Plastic Characteristic ◽  
Long Time ◽  
Clinical Concept

The clinical concept "gastritis" has existed for a long time. Nevertheless, the need to create a clinical picture of chronic gastritis has matured, and this is recognized by many authors. For example, they say: There is no plastic characteristic clinical picture of gastritis.

scholarly journals Chronic granulomatous ‘Aspergillus lung mass’

2020 ◽  
Vol 90 (3) ◽  
Author(s):  
Kavitha Venkatnarayan ◽  
Uma Devaraj ◽  
Uma Maheswari Krishnaswamy ◽  
Priya Ramachandran ◽  
Sreekar Balasundaram ◽  
...  
Keyword(s):  
Immune Response ◽  
Lung Disease ◽  
Respiratory Symptoms ◽  
Clinical Presentation ◽  
Wide Spectrum ◽  
Lung Mass ◽  
Pulmonary Aspergillosis ◽  
Histological Picture ◽  
Life Threatening ◽  
Disseminated Disease

The diverse clinicopathological spectrum of pulmonary aspergillosis is a consequence of varying levels of invasiveness of this ubiquitous fungus, which largely depends on the host immune response and pre-existing lung disease. The clinical presentation of pulmonary aspergillosis spans a wide spectrum from hypersensitivity to life threatening angio-invasive and disseminated disease. We report the case of a young immunocompetent male with no underlying lung disease, who presented with an incidentally detected ‘infective mass’ lesion in the lung associated with minimal respiratory symptoms. The diagnostic challenges posed by the unusual clinical, radiological and histological picture as well as the therapeutic dilemmas faced are discussed in this report.

scholarly journals Tuberculosis Characterization in a Special Population of Kidney Transplant Recipients

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Barbara Reis-Santos ◽  
Ethel Leonor Noia Maciel
Keyword(s):  
Kidney Transplant ◽  
Clinical Presentation ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Careful Evaluation ◽  
Tb Control ◽  
Health History ◽  
Sociodemographic Data ◽  
Clinical Records ◽  
Active Disease

Setting. Tuberculosis clinical presentation is not typical in kidney transplant recipients and the diagnosis of active disease is usually delayed. Objective. To characterize tuberculosis presentation in Brazilian's kidney transplant recipients. Study Design. We analyzed the clinical records of tuberculosis cases regarding sociodemographic data and health history. Results. Thirteen TB cases were identified among 843 transplant recipients. The average time for TB development after transplantation was 4 years. Eight subjects presented pulmonary disease, seven patients required hospitalization Alertness to the possibility of TB and the careful evaluation for possible TB of all kidney transplant recipients with unexplained is vital, as is the related work of transplant and TB control teams and four died as a consequence of TB. Conclusion. The severe consequences of TB in posttransplantation can become critical.

scholarly journals Hepatitis and Meningoencephalitis due to Enterovirus in a Toddler

2018 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Mohammad Ali Raza Qizalbash ◽  
Rida Zahra ◽  
Adnan Adil Mithwani ◽  
Anwar Adil Mithwani ◽  
Muaaz Adil Mithwani
Keyword(s):  
Acute Hepatitis ◽  
Clinical Picture ◽  
Clinical Presentation ◽  
Viral Infections ◽  
Coxsackie Virus ◽  
Watery Diarrhea ◽  
Case Presentation

Background: Acute hepatitis caused by viral organisms which are typically implicated in the cases of encephalitis are rarely reported in literature. The presentation of enteroviral meningoencephalitis predominated with the clinical picture of hepatitis has rarely been recorded in populations other than neonates. Case Presentation: A male 2-year-old, presenting with a fever of 38 to 40 °C with chills and rigors, lethargy and drowsiness for 6 days. Along with the nausea, vomiting and watery diarrhea, he developed mouth ulcers (peri-oral vesicles) during the stay at the hospital. After extensive workup he was later diagnosed with meningoencephalitis and acute hepatitis due to Coxsackie virus A. After a stay of more than a month he was successfully treated and discharge. Conclusion: A more thorough evaluation should be carried out for atypical viral infections presenting with clinical presentation of hepatitis and meningoencephalitis.

scholarly journals 2,2’4,4’-Tetrabromodiphenyl Ether (PBDE-47) Modulates the Intracellular miRNA Profile, sEV Biogenesis and Their miRNA Cargo Exacerbating the LPS-Induced Pro-Inflammatory Response in THP-1 Macrophages

2021 ◽  
Vol 12 ◽  
Author(s):  
Valeria Longo ◽  
Alessandra Longo ◽  
Giorgia Adamo ◽  
Antonino Fiannaca ◽  
Sabrina Picciotto ◽  
...  
Keyword(s):  
Immune Response ◽  
Inflammatory Response ◽  
Innate Immune Response ◽  
De Novo ◽  
In Silico Analysis ◽  
Innate Immune ◽  
Macrophage Cell ◽  
Intracellular Expression ◽  
Different Levels ◽  
Silico Analysis

The 2,2’4,4’-tetrabromodiphenyl ether (PBDE-47) is one of the most prominent PBDE congeners detected in the environment and in animal and human tissues. Animal model experiments suggested the occurrence of PBDE-induced immunotoxicity leading to different outcomes and recently we demonstrated that this substance can impair macrophage and basophil activities. In this manuscript, we decided to further examine the effects induced by PBDE-47 treatment on innate immune response by looking at the intracellular expression profile of miRNAs as well as the biogenesis, cargo content and activity of human M(LPS) macrophage cell-derived small extracellular vesicles (sEVs). Microarray and in silico analysis demonstrated that PBDE-47 can induce some epigenetic effects in M(LPS) THP-1 cells modulating the expression of a set of intracellular miRNAs involved in biological pathways regulating the expression of estrogen-mediated signaling and immune responses with particular reference to M1/M2 differentiation. In addition to the cell-intrinsic modulation of intracellular miRNAs, we demonstrated that PBDE-47 could also interfere with the biogenesis of sEVs increasing their number and selecting a de novo population of sEVs. Moreover, PBDE-47 induced the overload of specific immune related miRNAs in PBDE-47 derived sEVs. Finally, culture experiments with naïve M(LPS) macrophages demonstrated that purified PBDE-47 derived sEVs can modulate macrophage immune response exacerbating the LPS-induced pro-inflammatory response inducing the overexpression of the IL-6 and the MMP9 genes. Data from this study demonstrated that PBDE-47 can perturb the innate immune response at different levels modulating the intracellular expression of miRNAs but also interfering with the biogenesis, cargo content and functional activity of M(LPS) macrophage cell-derived sEVs.

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